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Privacy and Security — Protecting Patients’ Health Information
Sharona Hoffman, J.D., L.L.M., S.J.D.
doi : 10.1056/NEJMp2201676
Vol. 387 No. 21
Protecting Care for All — Gender-Affirming Care in Section 1557 and Beyond
Megan Lane, M.D., Anna R. Kirkland, J.D., Ph.D., and Daphna Stroumsa, M.D., M.P.H.
doi : 10.1056/NEJMp2212586
Protecting Transgender Health and Challenging Science Denialism in Policy
Meredithe McNamara, M.D., Christina Lepore, B.A., and Anne Alstott, J.D.
doi : 10.1056/NEJMp2213085
Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk
Aruna Das Pradhan, M.D., M.P.H., Robert J. Glynn, Sc.D., Jean-Charles Fruchart, Ph.D., Jean G. MacFadyen, B.A., Elaine S. Zaharris, B.A., Brendan M. Everett, M.D., M.P.H., Stuart E. Campbell, B.A., Ryu Oshima, M.S., R.Ph., Pierre Amarenco, M.D., Dirk J. Blom, M.D., Ph.D., Eliot A. Brinton, M.D., Robert H. Eckel, M.D.,
doi : 10.1056/NEJMoa2210645
High triglyceride levels are associated with increased cardiovascular risk, but whether reductions in these levels would lower the incidence of cardiovascular events is uncertain. Pemafibrate, a selective peroxisome proliferator–activated receptor α modulator, reduces triglyceride levels and improves other lipid levels.
Lifting Universal Masking in Schools — Covid-19 Incidence among Students and Staff
Tori L. Cowger, Ph.D., M.P.H., Eleanor J. Murray, Sc.D., M.P.H., Jaylen Clarke, M.Sc., Mary T. Bassett, M.D., M.P.H., Bisola O. Ojikutu, M.D., M.P.H., Sarimer M. Sánchez, M.D., M.P.H., Natalia Linos, Sc.D., and Kathryn T. Hall, Ph.D., M.P.H.
doi : 10.1056/NEJMoa2211029
In February 2022, Massachusetts rescinded a statewide universal masking policy in public schools, and many Massachusetts school districts lifted masking requirements during the subsequent weeks.
Defibrillation Strategies for Refractory Ventricular Fibrillation
Sheldon Cheskes, M.D., P. Richard Verbeek, M.D., Ian R. Drennan, A.C.P., Ph.D., Shelley L. McLeod, Ph.D., Linda Turner, Ph.D., Ruxandra Pinto, Ph.D., Michael Feldman, M.D., Ph.D., Matthew Davis, M.D., Christian Vaillancourt, M.D., Laurie J. Morrison, M.D., Paul Dorian, M.D., and Damon C. Scales, M.D., Ph.D.
doi : 10.1056/NEJMoa2207304
Despite advances in defibrillation technology, shock-refractory ventricular fibrillation remains common during out-of-hospital cardiac arrest. Double sequential external defibrillation (DSED; rapid sequential shocks from two defibrillators) and vector-change (VC) defibrillation (switching defibrillation pads to an anterior–posterior position) have been proposed as defibrillation strategies to improve outcomes in patients with refractory ventricular fibrillation.
Efficacy and Safety of Bepirovirsen in Chronic Hepatitis B Infection
Man-Fung Yuen, M.D., Ph.D., D.Sc., Seng-Gee Lim, M.B., B.S., M.D., Robert Plesniak, M.D., Ph.D., Keiji Tsuji, M.D., Ph.D., Harry L.A. Janssen, M.D., Ph.D., Cristina Pojoga, M.D., Ph.D., Adrian Gadano, M.D., Ph.D., Corneliu P. Popescu, M.D., Ph.D., Tatyana Stepanova, M.Sc., Tarik Asselah, M.D., Ph.D., Gheorghe Diaconescu, M.D., Ph.D., Hyung Joon Yim, M.D., Ph.D.,
doi : 10.1056/NEJMoa2210027
Bepirovirsen is an antisense oligonucleotide that targets all hepatitis B virus (HBV) messenger RNAs and acts to decrease levels of viral proteins.
Climate Change and Vectorborne Diseases
Madeleine C. Thomson, Ph.D., and Lawrence R. Stanberry, M.D., Ph.D.
doi : 10.1056/NEJMra2200092
Focused Cardiac Ultrasonography for Right Ventricular Size and Systolic Function
Gabriel Prada, M.D., Aliaksei Pustavoitau, M.D., M.H.S., Seth Koenig, M.D., Carol Mitchell, Ph.D., Raymond F. Stainback, M.D., and José L. DÃaz-Gómez, M.D.
doi : 10.1056/NEJMvcm2004089
Pyogenic Granuloma
David Komakech, M.B., Ch.B., and Brian Ssenkumba, M.B., Ch.B.
doi : 10.1056/NEJMicm2204602
Case 36-2022: A 30-Year-Old Woman with Decreased Vision and Headache
Michael Levy, M.D., Ph.D., Bart K. Chwalisz, M.D., Benjamin M. Kozak, M.D., Michael K. Yoon, M.D., Helen A. Shih, M.D., and Anna M. Stagner, M.D.
doi : 10.1056/NEJMcpc2211355
The Fibrates Story — A Tepid End to a PROMINENT Drug
Salim S. Virani, M.D., Ph.D.
doi : 10.1056/NEJMe2213208
Universal Masking Policies in Schools and Mitigating the Inequitable Costs of Covid-19
Julia Raifman, Sc.D., and Tiffany Green, Ph.D.
doi : 10.1056/NEJMe2213556
Defibrillation after Cardiac Arrest — Is It Time to Change Practice?
Comilla Sasson, M.D., Ph.D., and Jason Haukoos, M.D.
doi : 10.1056/NEJMe2213562
Audio Interview: Making Choices about Covid-19
Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., and Stephen Morrissey, Ph.D.
doi : 10.1056/NEJMe2215241
IARC Perspective on Oral Cancer Prevention
Véronique Bouvard, Ph.D., Suzanne T. Nethan, M.D.S., Deependra Singh, Ph.D., Saman Warnakulasuriya, Ph.D., Ravi Mehrotra, M.D., Ph.D., Anil K. Chaturvedi, M.P.H., Ph.D., Tony Hsiu-Hsi Chen, Ph.D., Olalekan A. Ayo-Yusuf, M.P.H., Ph.D., Prakash C. Gupta, Ph.D., Alexander R. Kerr, D.D.S., Wanninayake M. Tilakaratne, Ph.D., Devasena Anantharaman, Ph.D.,
doi : 10.1056/NEJMsr2210097
