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Is It Burnout or Depression? Expanding Efforts to Improve Physician Well-Being
Srijan Sen, M.D., Ph.D.
doi : 10.1056/NEJMp2209540
Vol. 387 No. 18
Pharmaceutical Marketing Revisited — United States v. Biogen Idec
Troyen Brennan, M.D., M.P.H.
doi : 10.1056/NEJMp2210637
Climate, Pollution, and Children’s Health
Kari Nadeau, M.D., Ph.D., Frederica Perera, Dr.P.H., Ph.D., Renee N. Salas, M.D., M.P.H., and Caren G. Solomon, M.D., M.P.H.
doi : 10.1056/NEJMp2213408
Single-Dose Psilocybin for a Treatment-Resistant Episode of Major Depression
Guy M. Goodwin, F.Med.Sci., Scott T. Aaronson, M.D., Oscar Alvarez, M.R.C.Psych., Peter C. Arden, M.P.H., Annie Baker, R.G.N., James C. Bennett, M.Sc., Catherine Bird, M.Sc., Renske E. Blom, M.D., Christine Brennan, M.Sc., Donna Brusch, C.C.R.C., Lisa Burke, M.Sc., Kete Campbell-Coker, R.G.N.,
doi : 10.1056/NEJMoa2206443
In this phase 2 double-blind trial, we randomly assigned adults with treatment-resistant depression to receive a single dose of a proprietary, synthetic formulation of psilocybin at a dose of 25 mg, 10 mg, or 1 mg (control), along with psychological support.
Brentuximab Vedotin with Chemotherapy in Pediatric High-Risk Hodgkin’s Lymphoma
Sharon M. Castellino, M.D., Qinglin Pei, Ph.D., Susan K. Parsons, M.D., David Hodgson, M.D., Kathleen McCarten, M.D., Terzah Horton, M.D., Ph.D., Steve Cho, M.D., Yue Wu, M.S., Angela Punnett, M.D., Hema Dave, M.D., Tara O. Henderson, M.D., Bradford S. Hoppe, M.D.,
doi : 10.1056/NEJMoa2206660
In adults with advanced-stage Hodgkin’s lymphoma, the CD30-directed antibody–drug conjugate brentuximab vedotin combined with multiagent chemotherapy has been shown to have greater efficacy, but also more toxic effects, than chemotherapy alone. The efficacy of this targeted therapy approach in children and adolescents with Hodgkin’s lymphoma is unclear.
Early Amino Acids in Extremely Preterm Infants and Neurodisability at 2 Years
Frank H. Bloomfield, Ph.D., Yannan Jiang, Ph.D., Jane E. Harding, D.Phil., Caroline A. Crowther, M.D., and Barbara E. Cormack, Ph.D. for the ProVIDe Trial Group*
doi : 10.1056/NEJMoa2204886
Whether higher parenteral amino acid intake improves outcomes in infants with extremely low birth weight is unclear.
Evaluation of mRNA-1273 Vaccine in Children 6 Months to 5 Years of Age
Evan J. Anderson, M.D., C. Buddy Creech, M.D., M.P.H., Vladimir Berthaud, M.D., M.P.H., Arin Piramzadian, D.O., Kimball A. Johnson, M.D., Marcus Zervos, M.D., Fredric Garner, M.D., Carl Griffin, M.D., Khozema Palanpurwala, M.D., Mark Turner, M.D., Jeffrey Gerber, M.D., Ph.D., Richard L. Bennett, M.D.,
doi : 10.1056/NEJMoa2209367
The safety, reactogenicity, immunogenicity, and efficacy of the mRNA-1273 coronavirus disease 2019 (Covid-19) vaccine in young children are unknown.
Noninvasive Respiratory Support for Adults with Acute Respiratory Failure
Laveena Munshi, M.D., Jordi Mancebo, M.D., and Laurent J. Brochard, M.D.
doi : 10.1056/NEJMra2204556
The Zollinger–Ellison Syndrome
Quentin Binet, M.D., and Ivan Borbath, M.D., Ph.D.
doi : 10.1056/NEJMicm2203797
Scaphoid Shift Test in Scapholunate Ligament Injury
Tun H. Lui, F.H.K.A.M. (Ortho. Surg.), and Amanda M.Y. Slocum, F.H.K.A.M. (Ortho. Surg.)
doi : 10.1056/NEJMicm2202238
A Shear Decline
Marla Lipsyc-Sharf, M.D., Nathan T. Connell, M.D., M.P.H., John W. Ostrominski, M.D., Bruce D. Levy, M.D., and Joseph Loscalzo, M.D., Ph.D.
doi : 10.1056/NEJMcps2115778
Are We Too Reliant on Radiation Therapy for Children with Hodgkin’s Lymphoma?
Mark Roschewski, M.D., and Catherine M. Bollard, M.B., Ch.B., M.D.
doi : 10.1056/NEJMe2211587
Parenteral Protein in Extremely Preterm Infants — More Is Not Better
Camilia R. Martin, M.D.
doi : 10.1056/NEJMe2212522
Audio Interview: Caring for Hospitalized Patients with Covid-19
Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., C. Corey Hardin, M.D., and Stephen Morrissey, Ph.D.
doi : 10.1056/NEJMe2214245
Immune Imprinting and Protection against Repeat Reinfection with SARS-CoV-2
doi : 10.1056/NEJMc2211055
Lower versus Higher Glycemic Criteria for Diagnosis of Gestational Diabetes
doi : 10.1056/NEJMc2212585
Application of High-Sensitivity Troponin in Suspected Myocardial Infarction
doi : 10.1056/NEJMx220009
