New England Journal of Medicine




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Medical Malpractice Law — Doctrine and Dynamics

David M. Studdert, LL.B., Sc.D., and Mark A. Hall, J.D.

doi : 10.1056/NEJMp2201675

Vol. 387 No. 17

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Abortion Access as a Racial Justice Issue

Katy Backes Kozhimannil, Ph.D., M.P.A., Asha Hassan, M.P.H., and Rachel R. Hardeman, Ph.D., M.P.H.

doi : 10.1056/NEJMp2209737

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Medicare’s National Coverage Determination for Aducanumab — A One-Off or a Pragmatic Path Forward?

Sanket S. Dhruva, M.D., M.H.S., Reshma Ramachandran, M.D., M.P.P., M.H.S., and Joseph S. Ross, M.D., M.H.S.

doi : 10.1056/NEJMp2210198

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What Covid Has Taught the World about Ethics

Ezekiel J. Emanuel, M.D., Ph.D., Ross E.G. Upshur, M.D., and Maxwell J. Smith, Ph.D.

doi : 10.1056/NEJMp2210173

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Migraine — Patient Perspectives

Cynthia E. Armand, M.D., Jeremy Fugerer, Laura Hughes, Elizabeth Loder, M.D., M.P.H., Delmaira Perez, Allan H. Ropper, M.D., and Anikah Salim

doi : 10.1056/NEJMp2213217

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Effect of Colonoscopy Screening on Risks of Colorectal Cancer and Related Death

Michael Bretthauer, M.D., Ph.D., Magnus Løberg, M.D., Ph.D., Paulina Wieszczy, Ph.D., Mette Kalager, M.D., Ph.D., Louise Emilsson, M.D., Ph.D., Kjetil Garborg, M.D., Ph.D., Maciej Rupinski, M.D., Ph.D., Evelien Dekker, M.D., Ph.D., Manon Spaander, M.D., Ph.D., Marek Bugajski, M.D., Ph.D., Øyvind Holme, M.D., Ph.D., Ann G. Zauber, Ph.D.,

doi : 10.1056/NEJMoa2208375

Although colonoscopy is widely used as a screening test to detect colorectal cancer, its effect on the risks of colorectal cancer and related death is unclear.

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Neoadjuvant Cemiplimab for Stage II to IV Cutaneous Squamous-Cell Carcinoma

Neil D. Gross, M.D., David M. Miller, M.D., Ph.D., Nikhil I. Khushalani, M.D., Vasu Divi, M.D., Emily S. Ruiz, M.D., M.P.H., Evan J. Lipson, M.D., Friedegund Meier, M.D., Yungpo B. Su, M.D., Paul L. Swiecicki, M.D., Jennifer Atlas, M.D., Jessica L. Geiger, M.D., Axel Hauschild, M.D.,

doi : 10.1056/NEJMoa2209813

In a pilot study involving patients with cutaneous squamous-cell carcinoma, a high percentage of patients had a pathological complete response with the use of two doses of neoadjuvant cemiplimab before surgery. Data from a phase 2 study are needed to confirm these findings.

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Racial and Ethnic Differences in Bystander CPR for Witnessed Cardiac Arrest

R. Angel Garcia, M.D., John A. Spertus, M.D., M.P.H., Saket Girotra, M.D., Brahmajee K. Nallamothu, M.D., M.P.H., Kevin F. Kennedy, B.S., Bryan F. McNally, M.D., M.P.H., Khadijah Breathett, M.D., Marina Del Rios, M.D., Comilla Sasson, M.D., Ph.D., and Paul S. Chan, M.D.

doi : 10.1056/NEJMoa2200798

Differences in the incidence of cardiopulmonary resuscitation (CPR) provided by bystanders contribute to survival disparities among persons with out-of-hospital cardiac arrest. It is critical to understand whether the incidence of bystander CPR in witnessed out-of-hospital cardiac arrests at home and in public settings differs according to the race or ethnic group of the person with cardiac arrest in order to inform interventions.

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Neonatal Docosahexaenoic Acid in Preterm Infants and Intelligence at 5 Years

Jacqueline F. Gould, Ph.D., Maria Makrides, Ph.D., Robert A. Gibson, Ph.D., Thomas R. Sullivan, Ph.D., Andrew J. McPhee, M.B., B.S., Peter J. Anderson, Ph.D., Karen P. Best, Ph.D., Mary Sharp, M.B., B.S., Jeanie L.Y. Cheong, M.D., Gillian F. Opie, M.B., B.S., Javeed Travadi, D.M., Jana M. Bednarz, G.Dip.,

doi : 10.1056/NEJMoa2206868

Docosahexaenoic acid (DHA) is a component of neural tissue. Because its accretion into the brain is greatest during the final trimester of pregnancy, infants born before 29 weeks’ gestation do not receive the normal supply of DHA. The effect of this deficiency on subsequent cognitive development is not well understood.

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Spontaneous Intracerebral Hemorrhage

Kevin N. Sheth, M.D.

doi : 10.1056/NEJMra2201449

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Necrotizing Myositis

Margarida Araújo, M.D., and Inês Manuel Gonçalves, M.D.

doi : 10.1056/NEJMicm2108439

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Spontaneous Hyphema

Parth R. Shah, F.R.A.N.Z.C.O.

doi : 10.1056/NEJMicm2201912

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Case 33-2022: An 11-Year-Old Girl with Redness of the Eyes

Ezra M. Cohen, M.D., Lucia Sobrin, M.D., M.P.H., Maria G. Figueiro Longo, M.D., Danielle B. Pier, M.D., Daniel R. Brown, M.D., Ph.D., and Anna M. Stagner, M.D.

doi : 10.1056/NEJMcpc2201235

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Understanding the Results of a Randomized Trial of Screening Colonoscopy

Jason A. Dominitz, M.D., M.H.S., and Douglas J. Robertson, M.D., M.P.H.

doi : 10.1056/NEJMe2211595

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Social Determinants of Sudden Cardiac Death

Walter K. Clair, M.D., M.P.H.

doi : 10.1056/NEJMe2210406

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Audio Interview: Assessing the Effect of Vaccination and Prior SARS-CoV-2 Infection

Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., and Stephen Morrissey, Ph.D.

doi : 10.1056/NEJMe2214027

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Mental Health Implications of Abortion Restrictions for Historically Marginalized Populations

Lucy Ogbu-Nwobodo, M.D., Ruth S. Shim, M.D., M.P.H., Sarah Y. Vinson, M.D., Elizabeth M. Fitelson, M.D., M. Antonia Biggs, Ph.D., Monica R. McLemore, Ph.D., M.P.H., R.N., Marilyn Thomas, Ph.D., M.P.H., Micaela Godzich, M.D., and Christina Mangurian, M.D.

doi : 10.1056/NEJMms2211124

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Protective Effect of Previous SARS-CoV-2 Infection against Omicron BA.4 and BA.5 Subvariants

doi : 10.1056/NEJMc2209306

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Total Knee Arthroplasty after Gene Therapy for Hemophilia B

doi : 10.1056/NEJMc2211173

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