New England Journal of Medicine




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Impending Relief for Medicare Beneficiaries — The Inflation Reduction Act

Stacie B. Dusetzina, Ph.D., and Haiden A. Huskamp, Ph.D.

doi : 10.1056/NEJMp2211223

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The On- and Off-Ramps of Oncology Accelerated Approval

Lola A. Fashoyin-Aje, M.D., M.P.H., Gautam U. Mehta, M.D., Julia A. Beaver, M.D., and Richard Pazdur, M.D.

doi : 10.1056/NEJMp2208954

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Atrial Fibrillation — What Is It and How Is It Treated?

Elliott M. Antman, M.D., Jane A. Leopold, M.D., William H. Sauer, M.D., and Paul C. Zei, M.D., Ph.D.

doi : 10.1056/NEJMp2212939

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Two Phase 3, Randomized, Controlled Trials of Ruxolitinib Cream for Vitiligo

David Rosmarin, M.D., Thierry Passeron, M.D., Ph.D., Amit G. Pandya, M.D., Pearl Grimes, M.D., John E. Harris, M.D., Ph.D., Seemal R. Desai, M.D., Mark Lebwohl, M.D., Mireille Ruer-Mulard, M.D., Julien Seneschal, M.D., Ph.D., Albert Wolkerstorfer, M.D., Ph.D., Deanna Kornacki, Ph.D., Kang Sun, Ph.D.,

doi : 10.1056/NEJMoa2118828

Vitiligo is a chronic autoimmune disease that causes skin depigmentation. A cream formulation of ruxolitinib (an inhibitor of Janus kinase 1 and 2) resulted in repigmentation in a phase 2 trial involving adults with vitiligo.

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Blood-Pressure Targets in Comatose Survivors of Cardiac Arrest

Jesper Kjaergaard, M.D., D.M.Sc., Jacob E. Møller, M.D., D.M.Sc., Henrik Schmidt, M.D., D.M.Sc., Johannes Grand, M.D., Ph.D., Simon Mølstrøm, M.D., Britt Borregaard, R.N., Ph.D., Søren Venø, M.D., Laura Sarkisian, M.D., Ph.D., Dmitry Mamaev, M.D., Lisette O. Jensen, M.D., D.M.Sc., Benjamin Nyholm, M.D., Dan E. Høfsten, M.D., Ph.D.,

doi : 10.1056/NEJMoa2208687

Evidence to support the choice of blood-pressure targets for the treatment of comatose survivors of out-of-hospital cardiac arrest who are receiving intensive care is limited.

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Oxygen Targets in Comatose Survivors of Cardiac Arrest

Henrik Schmidt, M.D., D.M.Sc., Jesper Kjaergaard, M.D., D.M.Sc., Christian Hassager, M.D., D.M.Sc., Simon Mølstrøm, M.D., Johannes Grand, M.D., Ph.D., Britt Borregaard, Ph.D., Laust E. Roelsgaard Obling, M.D., Søren Venø, M.D., Laura Sarkisian, M.D., Ph.D., Dmitry Mamaev, M.D., Lisette O. Jensen, M.D., D.M.Sc., Benjamin Nyholm, M.D.,

doi : 10.1056/NEJMoa2208686

The appropriate oxygenation target for mechanical ventilation in comatose survivors of out-of-hospital cardiac arrest is unknown.

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Intermittently Scanned Continuous Glucose Monitoring for Type 1 Diabetes

Lalantha Leelarathna, Ph.D., Mark L. Evans, M.D., Sankalpa Neupane, Ph.D., Gerry Rayman, M.D., Sarah Lumley, M.R.C.G.P., Iain Cranston, F.R.C.P., Parth Narendran, Ph.D., Katharine Barnard-Kelly, Ph.D., Christopher J. Sutton, Ph.D., Rachel A. Elliott, Ph.D., Vicky P. Taxiarchi, Ph.D., Georgios Gkountouras, Ph.D.,

doi : 10.1056/NEJMoa2205650

In persons with type 1 diabetes and high glycated hemoglobin levels, the benefits of intermittently scanned continuous glucose monitoring with optional alarms for high and low blood glucose levels are uncertain.

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Myocarditis

Cristina Basso, M.D., Ph.D.

doi : 10.1056/NEJMra2114478

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Tinea Nigra

Jason B. Lee, M.D., and Ziv Schwartz, M.D.

doi : 10.1056/NEJMicm2204411

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Dysphagia Due to Diffuse Idiopathic Skeletal Hyperostosis

Jihye Park, M.D., and Hyung-Youl Park, M.D., Ph.D.

doi : 10.1056/NEJMicm2202181

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Case 32-2022: A 76-Year-Old Man with Postoperative Cardiogenic Shock and Diffuse Rash

Akshay S. Desai, M.D., M.P.H., David M. Dudzinski, M.D., Matthew T. Stib, M.D., Steven T. Chen, M.D., M.P.H., Christopher Newton-Cheh, M.D., M.P.H., Kimberly G. Blumenthal, M.D., and James R. Stone, M.D., Ph.D.

doi : 10.1056/NEJMcpc2201245

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New Hope for Patients with Vitiligo

Liv Eidsmo, M.D., Ph.D.

doi : 10.1056/NEJMe2211886

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Oxygenation and Blood-Pressure Targets in the ICU after Cardiac Arrest — One Step Forward

Niklas Nielsen, M.D., Ph.D., and Markus B. Skrifvars, M.D., Ph.D.

doi : 10.1056/NEJMe2211024

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Audio Interview: Covid-19: Where Are We Heading?

Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., and Stephen Morrissey, Ph.D.

doi : 10.1056/NEJMe2213773

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Integrins in Health and Disease

Susanna C. Fagerholm, Ph.D.

doi : 10.1056/NEJMcibr2209679

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Work Hours and Depression in U.S. First-Year Physicians

doi : 10.1056/NEJMc2210365

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IL-1RA Antibodies in Myocarditis after SARS-CoV-2 Vaccination

doi : 10.1056/NEJMc2205667

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Brentuximab Vedotin in Advanced Hodgkin’s Lymphoma

doi : 10.1056/NEJMc2211125

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Anti-BDCA2 Antibody for Cutaneous Lupus Erythematosus

doi : 10.1056/NEJMc2211121

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Once-Weekly Dulaglutide for Treatment of Youths with Type 2 Diabetes

doi : 10.1056/NEJMc2211623

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Case 23-2022: A 49-Year-Old Man with Hypoglycemia

doi : 10.1056/NEJMc2211625

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