New England Journal of Medicine




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Public Carry versus Public Health — The Harms to Come from the Supreme Court’s Decision in Bruen

Michael R. Ulrich, J.D., M.P.H.

doi : 10.1056/NEJMp2210269

Vol. 387 No. 14

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A Grim New Reality — Intimate-Partner Violence after Dobbs and Bruen

Elizabeth Tobin-Tyler, J.D.

doi : 10.1056/NEJMp2209696

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The Macro-Harm of Micro-Geography

Dorothy R. Novick, M.D.

doi : 10.1056/NEJMp2207381

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Atrial Fibrillation and Catheter Ablation

Elliott M. Antman, M.D., Jane A. Leopold, M.D., William H. Sauer, M.D., and Paul C. Zei, M.D., Ph.D.

doi : 10.1056/NEJMp2212526

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Gun Violence in the United States

Garen J. Wintemute, M.D., M.P.H., Daniel Müller, M.A., and Kyle Bolstad, B.A.

doi : 10.1056/NEJMp2209472

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Cerebral Embolic Protection during Transcatheter Aortic-Valve Replacement

Samir R. Kapadia, M.D., Raj Makkar, M.D., Martin Leon, M.D., Mohamed Abdel-Wahab, M.D., Thomas Waggoner, D.O., Steffen Massberg, M.D., Wolfgang Rottbauer, M.D., Ph.D., Samuel Horr, M.D., Lars Sondergaard, M.D., Juhana Karha, M.D., Robert Gooley, M.B., B.S., Ph.D., Lowell Satler, M.D.,

doi : 10.1056/NEJMoa2204961

Transcatheter aortic-valve replacement (TAVR) for the treatment of aortic stenosis can lead to embolization of debris. Capture of debris by devices that provide cerebral embolic protection (CEP) may reduce the risk of stroke.

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Trial of Intravenous Immune Globulin in Dermatomyositis

Rohit Aggarwal, M.D., Christina Charles-Schoeman, M.D., Joachim Schessl, M.D., Zsuzsanna Bata-Csörgő, M.D., Dr.Sc., Mazen M. Dimachkie, M.D., Zoltan Griger, M.D., Ph.D., Sergey Moiseev, M.D., Chester Oddis, M.D., Elena Schiopu, M.D., Jiri Vencovský, M.D., Dr.Sc., Irene Beckmann, Elisabeth Clodi, Ph.D.,

doi : 10.1056/NEJMoa2117912

Intravenous immune globulin (IVIG) for the treatment of dermatomyositis has not been extensively evaluated.

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A Bivalent Omicron-Containing Booster Vaccine against Covid-19

Spyros Chalkias, M.D., Charles Harper, M.D., Keith Vrbicky, M.D., Stephen R. Walsh, M.D., Brandon Essink, M.D., Adam Brosz, M.D., Nichole McGhee, B.S., Joanne E. Tomassini, Ph.D., Xing Chen, Sc.D., Ying Chang, M.S., Andrea Sutherland, M.D., M.P.H., David C. Montefiori, Ph.D.,

doi : 10.1056/NEJMoa2208343

The safety and immunogenicity of the bivalent omicron-containing mRNA-1273.214 booster vaccine are not known.

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Efficacy and Safety of an Extravascular Implantable Cardioverter–Defibrillator

Paul Friedman, M.D., Francis Murgatroyd, F.R.C.P., Lucas V.A. Boersma, M.D., Ph.D., Jaimie Manlucu, M.D., David O’Donnell, M.B., B.S., Bradley P. Knight, M.D., Nicolas Clémenty, M.D., Ph.D., Christophe Leclercq, M.D., Ph.D., Anish Amin, M.D., Béla P. Merkely, M.D., Ph.D., D.Sc., Ulrika M. Birgersdotter-Green, M.D., Joseph Y.S. Chan, M.B., B.S.,

doi : 10.1056/NEJMoa2206485

The extravascular implantable cardioverter–defibrillator (ICD) has a single lead implanted substernally to enable pause-prevention pacing, antitachycardia pacing, and defibrillation energy similar to that of transvenous ICDs. The safety and efficacy of extravascular ICDs are not yet known.

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Prevention of and Emergency Response to Drowning

Deborah C. Girasek, Ph.D., M.P.H., and Stephen Hargarten, M.D., M.P.H.

doi : 10.1056/NEJMra2202392

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Toxic Megacolon Due to Fulminant Clostridioides difficile Infection

Sumanth K. Bandaru, M.D.

doi : 10.1056/NEJMicm2202891

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Erythema Ab Igne

Binod K. Khaitan, M.B., B.S., M.D., and Rhea Ahuja, M.B., B.S., M.D.

doi : 10.1056/NEJMicm2203401

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Thinking Outside the Heart

Ryan A. Denu, M.D., Ph.D., Daniel H. Solomon, M.D., M.P.H., Richard N. Mitchell, M.D., Ph.D., Yee-Ping Sun, M.D., and Joseph Loscalzo, M.D., Ph.D.

doi : 10.1056/NEJMcps2206178

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Does Capturing Debris during TAVR Prevent Strokes?

John D. Carroll, M.D., and Jeffrey L. Saver, M.D.

doi : 10.1056/NEJMe2210185

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Intravenous Immune Globulin Therapy in Dermatomyositis

Anthony A. Amato, M.D.

doi : 10.1056/NEJMe2209117

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Audio Interview: Infectious Disease in Africa

Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., John N. Nkengasong, Ph.D., and Stephen Morrissey, Ph.D.

doi : 10.1056/NEJMe2213168

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Circulating Cell-free DNA and Screening for Trisomies

Mary E. Norton, M.D.

doi : 10.1056/NEJMcibr2209405

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From the Eyeball Test to the Algorithm — Quality of Life, Disability Status, and Clinical Decision Making in Surgery

Charles E. Binkley, M.D., Joel Michael Reynolds, Ph.D., and Andrew Shuman, M.D.

doi : 10.1056/NEJMms2207408

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Durability of Booster mRNA Vaccine against SARS-CoV-2 BA.2.12.1, BA.4, and BA.5 Subvariants

doi : 10.1056/NEJMc2210546

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Effectiveness and Durability of the BNT162b2 Vaccine against Omicron Sublineages in South Africa

doi : 10.1056/NEJMc2210093

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Anti-Spike Mucosal IgA Protection against SARS-CoV-2 Omicron Infection

doi : 10.1056/NEJMc2209651

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Phase 1–2 Trial of AAVS3 Gene Therapy in Patients with Hemophilia B

doi : 10.1056/NEJMc2210918

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Genetically Modified Porcine-to-Human Cardiac Xenotransplantation

doi : 10.1056/NEJMc2210401

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Accountable Care’s Reach in Medicare

doi : 10.1056/NEJMc2211025

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