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Building a National Public Health System in the United States
Margaret A. Hamburg, M.D., Mandy Cohen, M.D., M.P.H., Karen DeSalvo, M.D., M.P.H., Julie Gerberding, M.D., M.P.H., Joneigh Khaldun, M.D., M.P.H., David Lakey, M.D., Ellen MacKenzie, Ph.D., Sc.M., Herminia Palacio, M.D., M.P.H., and Nirav R. Shah, M.D., M.P.H.
doi : 10.1056/NEJMp2207374
Vol. 387 No. 5
A Preview of the Dangerous Future of Abortion Bans — Texas Senate Bill 8
Whitney Arey, Ph.D., Klaira Lerma, M.P.H., Anitra Beasley, M.D., M.P.H., Lorie Harper, M.D., M.S.C.I., Ghazaleh Moayedi, D.O., M.P.H., and Kari White, Ph.D., M.P.H.
doi : 10.1056/NEJMp2207423
The End of Roe v. Wade — States’ Power over Health and Well-Being
Zita Lazzarini, J.D., M.P.H.
doi : 10.1056/NEJMp2206055
Low-Dose Subcutaneous or Intravenous Monoclonal Antibody to Prevent Malaria
Richard L. Wu, M.D., Azza H. Idris, M.D., Ph.D., Nina M. Berkowitz, M.P.H., Myra Happe, Ph.D., Martin R. Gaudinski, M.D., Christian Buettner, Ph.D., Larisa Strom, M.P.H., Seemal F. Awan, M.D., LaSonji A. Holman, F.N.P., Floreliz Mendoza, R.N., Ingelise J. Gordon, R.N., Zonghui Hu, Ph.D.,
doi : 10.1056/NEJMoa2203067
New approaches for the prevention and elimination of malaria, a leading cause of illness and death among infants and young children globally, are needed.
Trial of Cinpanemab in Early Parkinson’s Disease
Anthony E. Lang, M.D., Andrew D. Siderowf, M.D., Eric A. Macklin, Ph.D., Werner Poewe, M.D., David J. Brooks, M.D., D.Sc., Hubert H. Fernandez, M.D., Olivier Rascol, M.D., Nir Giladi, M.D., Fabrizio Stocchi, M.D., Caroline M. Tanner, M.D., Ph.D., Ronald B. Postuma, M.D., David K. Simon, M.D., Ph.D.,
doi : 10.1056/NEJMoa2203395
Aggregated α-synuclein plays an important role in Parkinson’s disease pathogenesis. Cinpanemab, a human-derived monoclonal antibody that binds to α-synuclein, is being evaluated as a disease-modifying treatment for Parkinson’s disease.
Trial of Prasinezumab in Early-Stage Parkinson’s Disease
Gennaro Pagano, M.D., Ph.D., Kirsten I. Taylor, Ph.D., Judith Anzures-Cabrera, Ph.D., Maddalena Marchesi, M.D., Tanya Simuni, M.D., Kenneth Marek, M.D., Ph.D., Ronald B. Postuma, M.D., Nicola Pavese, M.D., Ph.D., Fabrizio Stocchi, M.D., Ph.D., Jean-Philippe Azulay, Ph.D., Brit Mollenhauer, M.D., Lydia López-Manzanares, M.D.,
doi : 10.1056/NEJMoa2202867
Aggregated α-synuclein plays an important role in the pathogenesis of Parkinson’s disease. The monoclonal antibody prasinezumab, directed at aggregated α-synuclein, is being studied for its effect on Parkinson’s disease.
Once-Weekly Dulaglutide for the Treatment of Youths with Type 2 Diabetes
Silva A. Arslanian, M.D., Tamara Hannon, M.D., Philip Zeitler, M.D., Ph.D., Lily C. Chao, M.D., Claudia Boucher-Berry, M.D., Margarita Barrientos-Pérez, M.D., Elise Bismuth, M.D., Sergio Dib, M.D., Ph.D., Jang Ik Cho, Ph.D., and David Cox, Ph.D. for the AWARD-PEDS Investigators*
doi : 10.1056/NEJMoa2204601
The incidence of type 2 diabetes mellitus is increasing among youths. Once-weekly treatment with dulaglutide, a glucagon-like peptide-1 receptor agonist, may have efficacy with regard to glycemic control in youths with type 2 diabetes.
Japanese Spotted Fever
Kosuke Ishizuka, M.D., and Makoto Sugaya, M.D., Ph.D.
doi : 10.1056/NEJMicm2119475
Left Atrial Thrombus
Akbarshakh Akhmerov, M.D., and Danny Ramzy, M.D., Ph.D.
doi : 10.1056/NEJMicm2117229
Diagnostic Aspirations
Hannah X. Chen, M.D., Ph.D., Manuela Cernadas, M.D., Sara O. Vargas, M.D., Bruce D. Levy, M.D., and Joseph Loscalzo, M.D.
doi : 10.1056/NEJMcps2203306
Monoclonal Antibodies — A Different Approach to Combat Malaria
Johanna P. Daily, M.D.
doi : 10.1056/NEJMe2207865
Monoclonal Antibodies for Malaria
Timothy Wells, Sc.D., and Cristina Donini, Pharm.D., Ph.D.
doi : 10.1056/NEJMe2208131
Monoclonal Antibody Therapy in Parkinson’s Disease — The End?
Alan Whone, F.R.C.P., Ph.D.
doi : 10.1056/NEJMe2207681
Audio Interview: Updated Covid-19 Vaccines and a Look at Monkeypox
Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., and Stephen Morrissey, Ph.D.
doi : 10.1056/NEJMe2210394
Efficacy of Antibodies and Antiviral Drugs against Omicron BA.2.12.1, BA.4, and BA.5 Subvariants
doi : 10.1056/NEJMc2207519
