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The War-Zone Mentality — Mental Health Effects of Gun Violence in U.S. Children and Adolescents
James Garbarino, Ph.D.
doi : 10.1056/NEJMp2209422
Vol. 387 No. 13
Intradermal Vaccination for Monkeypox — Benefits for Individual and Public Health
John T. Brooks, M.D., Peter Marks, M.D., Ph.D., Robert H. Goldstein, M.D., Ph.D., and Rochelle P. Walensky, M.D., M.P.H.
doi : 10.1056/NEJMp2211311
Product Hopping in the Drug Industry — Lessons from Albuterol
Olivier J. Wouters, Ph.D., William B. Feldman, M.D., D.Phil., M.P.H., and S. Sean Tu, J.D., Ph.D.
doi : 10.1056/NEJMp2208613
A Hidden Crisis
Sadie T. Velasquez, M.D., James Cleveland, Ph.D., M.S.N., R.N., David O. Diaz, D.D.S., Diane Ferguson, R.N., Rebecca Moote, Pharm.D., Kathryn Parke, D.N.P., R.N., Bridgett Piernik-Yoder, Ph.D., George Folz, B.F.A.*, and Joseph A. Zorek, Pharm.D.
doi : 10.1056/NEJMp2209491
Sickle Cell Disease and Gene Therapy — Patient and Physician Perspectives
Michael DeBaun, M.D., M.P.H., Matthew Heeney, M.D., Terry Jackson, Ph.D., Dan Longo, M.D., Melesa Love, Trinity Love, Phillip Okwo, Alexis Thompson, M.D., M.P.H., Cassandra Trimnell, and Teonna Woolford
doi : 10.1056/NEJMp2212269
Multicenter, Randomized Trial of a Bionic Pancreas in Type 1 Diabetes
doi : 10.1056/NEJMoa2205225
Currently available semiautomated insulin-delivery systems require individualized insulin regimens for the initialization of therapy and meal doses based on carbohydrate counting for routine operation. In contrast, the bionic pancreas is initialized only on the basis of body weight, makes all dose decisions and delivers insulin autonomously, and uses meal announcements without carbohydrate counting.
Bronchodilators in Tobacco-Exposed Persons with Symptoms and Preserved Lung Function
MeiLan K. Han, M.D., Wen Ye, Ph.D., Di Wang, M.S., Emily White, M.S., Mehrdad Arjomandi, M.D., Igor Z. Barjaktarevic, M.D., Stacey-Ann Brown, M.D., Russell G. Buhr, M.D., Alejandro P. Comellas, M.D., Christopher B. Cooper, M.D., Gerard J. Criner, M.D., Mark T. Dransfield, M.D.,
doi : 10.1056/NEJMoa2204752
Many persons with a history of smoking tobacco have clinically significant respiratory symptoms despite an absence of airflow obstruction as assessed by spirometry. They are often treated with medications for chronic obstructive pulmonary disease (COPD), but supporting evidence for this treatment is lacking.
Acetazolamide in Acute Decompensated Heart Failure with Volume Overload
Wilfried Mullens, M.D., Ph.D., Jeroen Dauw, M.D., Pieter Martens, M.D., Ph.D., Frederik H. Verbrugge, M.D., Ph.D., Petra Nijst, M.D., Ph.D., Evelyne Meekers, M.D., Katrien Tartaglia, M.Sc., Fabien Chenot, M.D., Samer Moubayed, M.D., Riet Dierckx, M.D., Ph.D., Philippe Blouard, M.D., Pierre Troisfontaines, M.D.,
doi : 10.1056/NEJMoa2203094
Whether acetazolamide, a carbonic anhydrase inhibitor that reduces proximal tubular sodium reabsorption, can improve the efficiency of loop diuretics, potentially leading to more and faster decongestion in patients with acute decompensated heart failure with volume overload, is unclear.
GPRC5D-Targeted CAR T Cells for Myeloma
Sham Mailankody, M.B., B.S., Sean M. Devlin, Ph.D., Jonathan Landa, D.O., Karthik Nath, M.B., B.S., Ph.D., Claudia Diamonte, B.S.N., R.N., O.C.N., Elizabeth J. Carstens, M.D., Douglas Russo, M.S., Romany Auclair, M.D., Lisa Fitzgerald, M.S.N., Briana Cadzin, B.S.N., R.N., Xiuyan Wang, Ph.D., Devanjan Sikder, Ph.D.,
doi : 10.1056/NEJMoa2209900
B-cell maturation antigen (BCMA)–directed chimeric antigen receptor (CAR) T-cell therapies have generated responses in patients with advanced myeloma, but relapses are common. G protein–coupled receptor, class C, group 5, member D (GPRC5D) has been identified as an immunotherapeutic target in multiple myeloma. Preclinical studies have shown the efficacy of GPRC5D-targeted CAR T cells, including activity in a BCMA antigen escape model.
Lepromatous Leprosy
Shekhar Neema, M.D., and Santosh Battula, M.B., B.S.
doi : 10.1056/NEJMicm2202533
Autosomal Dominant Osteopetrosis
Torcato Meira, M.D., Ph.D., and Joao P. Soares-Fernandes, M.D.
doi : 10.1056/NEJMicm2202055
Case 30-2022: A Newborn Girl with Hypoglycemia
Sarbattama Sen, M.D., Sjirk J. Westra, M.D., Juan D. Matute, M.D., Jordan S. Sherwood, M.D., Frances A. High, M.D., Ph.D., and Melanie C. Kwan, M.D.
doi : 10.1056/NEJMcpc2201243
Seeking Simpler Solutions with Diabetes Technology
Jennifer Sherr, M.D., Ph.D.
doi : 10.1056/NEJMe2210686
RETHINCking COPD — Bronchodilators for Symptomatic Tobacco-Exposed Persons with Preserved Lung Function?
Don D. Sin, M.D., M.P.H.
doi : 10.1056/NEJMe2210347
New Decongestion Strategies in an Evolving Heart Failure Landscape
G. Michael Felker, M.D.
doi : 10.1056/NEJMe2209997
Audio Interview: Assessing Bivalent Vaccines against Covid-19
Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., and Stephen Morrissey, Ph.D.
doi : 10.1056/NEJMe2212736
