New England Journal of Medicine




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The Law of Licensure and Quality Regulation

Nathan Cortez, J.D.

doi : 10.1056/NEJMp2201802

Vol. 387 No. 12

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Pushing Back with Pills — Enhancing Access to Reproductive Health Drugs after Dobbs

Lewis A. Grossman, J.D., Ph.D.

doi : 10.1056/NEJMp2209377

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The Seeds of Ignorance — Consequences of a Booming Betel-Nut Economy

William J. Moss, M.D.

doi : 10.1056/NEJMp2203571

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Glycemia Reduction in Type 2 Diabetes — Glycemic Outcomes

doi : 10.1056/NEJMoa2200433

The comparative effectiveness of glucose-lowering medications for use with metformin to maintain target glycated hemoglobin levels in persons with type 2 diabetes is uncertain.

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Glycemia Reduction in Type 2 Diabetes — Microvascular and Cardiovascular Outcomes

doi : 10.1056/NEJMoa2200436

Data are lacking on the comparative effectiveness of commonly used glucose-lowering medications, when added to metformin, with respect to microvascular and cardiovascular disease outcomes in persons with type 2 diabetes.

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Dapagliflozin in Heart Failure with Mildly Reduced or Preserved Ejection Fraction

Scott D. Solomon, M.D., John J.V. McMurray, M.D., Brian Claggett, Ph.D., Rudolf A. de Boer, M.D., David DeMets, Ph.D., Adrian F. Hernandez, M.D., Silvio E. Inzucchi, M.D., Mikhail N. Kosiborod, M.D., Carolyn S.P. Lam, M.D., Felipe Martinez, M.D., Sanjiv J. Shah, M.D., Akshay S. Desai, M.D.,

doi : 10.1056/NEJMoa2206286

Sodium–glucose cotransporter 2 (SGLT2) inhibitors reduce the risk of hospitalization for heart failure and cardiovascular death among patients with chronic heart failure and a left ventricular ejection fraction of 40% or less. Whether SGLT2 inhibitors are effective in patients with a higher left ventricular ejection fraction remains less certain.

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Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS

Timothy M. Miller, M.D., Ph.D., Merit E. Cudkowicz, M.D., Angela Genge, M.D., Pamela J. Shaw, M.B., B.S., M.D., Gen Sobue, M.D., Ph.D., Robert C. Bucelli, M.D., Ph.D., Adriano Chiò, M.D., Philip Van Damme, M.D., Ph.D., Albert C. Ludolph, M.D., Jonathan D. Glass, M.D., Jinsy A. Andrews, M.D., Suma Babu, M.B., B.S., M.P.H.,

doi : 10.1056/NEJMoa2204705

The intrathecally administered antisense oligonucleotide tofersen reduces synthesis of the superoxide dismutase 1 (SOD1) protein and is being studied in patients with amyotrophic lateral sclerosis (ALS) associated with mutations in SOD1 (SOD1 ALS).

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Burkitt’s Lymphoma

Mark Roschewski, M.D., Louis M. Staudt, M.D., Ph.D., and Wyndham H. Wilson, M.D., Ph.D.

doi : 10.1056/NEJMra2025746

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Jackstone Calculus in the Bladder

Jiyu Zhao, M.D., and Xianen Gu, M.Med.

doi : 10.1056/NEJMicm2119095

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Wellens’ Syndrome

Sakiko Honda, M.D., Ph.D., and Tatsuya Kawasaki, M.D., Ph.D.

doi : 10.1056/NEJMicm2201699

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Case 29-2022: A 33-Year-Old Man with Chronic Diarrhea and Autoimmune Enteropathy

Francis P. Colizzo, M.D., Stuti G. Shroff, M.B., B.S., Ph.D., Frances A. High, M.D., Ph.D., Yi-Bin Chen, M.D., and Sara Barmettler, M.D.

doi : 10.1056/NEJMcpc2201236

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After Metformin — Next Steps for Type 2 Diabetes with Low Cardiovascular Risk

Lars Rydén, M.D., and Eberhard Standl, M.D., Ph.D.

doi : 10.1056/NEJMe2210531

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DELIVERing Progress in Heart Failure with Preserved Ejection Fraction

Kenneth B. Margulies, M.D.

doi : 10.1056/NEJMe2210177

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Audio Interview: Can Vaccines Prevent Transmission of Covid-19?

Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., and Stephen Morrissey, Ph.D.

doi : 10.1056/NEJMe2212576

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Effects of Vaccination and Previous Infection on Omicron Infections in Children

doi : 10.1056/NEJMc2209371

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Trastuzumab Deruxtecan in HER2-Low Breast Cancer

doi : 10.1056/NEJMc2210368

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