Nathan Cortez, J.D.
doi : 10.1056/NEJMp2201802
Vol. 387 No. 12
Lewis A. Grossman, J.D., Ph.D.
doi : 10.1056/NEJMp2209377
William J. Moss, M.D.
doi : 10.1056/NEJMp2203571
doi : 10.1056/NEJMoa2200433
The comparative effectiveness of glucose-lowering medications for use with metformin to maintain target glycated hemoglobin levels in persons with type 2 diabetes is uncertain.
doi : 10.1056/NEJMoa2200436
Data are lacking on the comparative effectiveness of commonly used glucose-lowering medications, when added to metformin, with respect to microvascular and cardiovascular disease outcomes in persons with type 2 diabetes.
Scott D. Solomon, M.D., John J.V. McMurray, M.D., Brian Claggett, Ph.D., Rudolf A. de Boer, M.D., David DeMets, Ph.D., Adrian F. Hernandez, M.D., Silvio E. Inzucchi, M.D., Mikhail N. Kosiborod, M.D., Carolyn S.P. Lam, M.D., Felipe Martinez, M.D., Sanjiv J. Shah, M.D., Akshay S. Desai, M.D.,
doi : 10.1056/NEJMoa2206286
Sodium–glucose cotransporter 2 (SGLT2) inhibitors reduce the risk of hospitalization for heart failure and cardiovascular death among patients with chronic heart failure and a left ventricular ejection fraction of 40% or less. Whether SGLT2 inhibitors are effective in patients with a higher left ventricular ejection fraction remains less certain.
Timothy M. Miller, M.D., Ph.D., Merit E. Cudkowicz, M.D., Angela Genge, M.D., Pamela J. Shaw, M.B., B.S., M.D., Gen Sobue, M.D., Ph.D., Robert C. Bucelli, M.D., Ph.D., Adriano Chiò, M.D., Philip Van Damme, M.D., Ph.D., Albert C. Ludolph, M.D., Jonathan D. Glass, M.D., Jinsy A. Andrews, M.D., Suma Babu, M.B., B.S., M.P.H.,
doi : 10.1056/NEJMoa2204705
The intrathecally administered antisense oligonucleotide tofersen reduces synthesis of the superoxide dismutase 1 (SOD1) protein and is being studied in patients with amyotrophic lateral sclerosis (ALS) associated with mutations in SOD1 (SOD1 ALS).
Mark Roschewski, M.D., Louis M. Staudt, M.D., Ph.D., and Wyndham H. Wilson, M.D., Ph.D.
doi : 10.1056/NEJMra2025746
Jiyu Zhao, M.D., and Xianen Gu, M.Med.
doi : 10.1056/NEJMicm2119095
Sakiko Honda, M.D., Ph.D., and Tatsuya Kawasaki, M.D., Ph.D.
doi : 10.1056/NEJMicm2201699
Francis P. Colizzo, M.D., Stuti G. Shroff, M.B., B.S., Ph.D., Frances A. High, M.D., Ph.D., Yi-Bin Chen, M.D., and Sara Barmettler, M.D.
doi : 10.1056/NEJMcpc2201236
Lars Rydén, M.D., and Eberhard Standl, M.D., Ph.D.
doi : 10.1056/NEJMe2210531
Kenneth B. Margulies, M.D.
doi : 10.1056/NEJMe2210177
Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., and Stephen Morrissey, Ph.D.
doi : 10.1056/NEJMe2212576
doi : 10.1056/NEJMc2209371
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