New England Journal of Medicine




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Supporting, Not Reporting — Emergency Department Ethics in a Post-Roe Era

Katie Watson, J.D., Maureen Paul, M.D., Susan Yanow, M.S.W., and Jay Baruch, M.D.

doi : 10.1056/NEJMp2209312

Vol. 387 No. 10

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Will EMTALA Be There for People with Pregnancy-Related Emergencies?

Sara Rosenbaum, J.D., Alexander Somodevilla, J.D., L.L.M., and Maria Casoni, M.P.H.

doi : 10.1056/NEJMp2209893

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Science, Competing Values, and Trade-offs in Public Health — The Example of Covid-19 and Masking

Sarah C. Dupont, M.D., M.P.H., and Sandro Galea, M.D., Dr.P.H.

doi : 10.1056/NEJMp2207670

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Open-Source Automated Insulin Delivery in Type 1 Diabetes

Mercedes J. Burnside, M.B., Ch.B., Dana M. Lewis, B.A., Hamish R. Crocket, Ph.D., Renee A. Meier, Ph.D., Jonathan A. Williman, Ph.D., Olivia J. Sanders, R.N., Craig A. Jefferies, M.D., Ann M. Faherty, R.N., Ryan G. Paul, Ph.D., Claire S. Lever, M.N., Sarah K.J. Price, M.N., Carla M. Frewen, R.N.,

doi : 10.1056/NEJMoa2203913

Open-source automated insulin delivery (AID) systems are used by many patients with type 1 diabetes. Data are needed on the efficacy and safety of an open-source AID system.

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Closed-Loop Therapy and Preservation of C-Peptide Secretion in Type 1 Diabetes

Charlotte K. Boughton, Ph.D., Janet M. Allen, R.N., Julia Ware, M.D., Malgorzata E. Wilinska, Ph.D., Sara Hartnell, B.Sc., Ajay Thankamony, M.Phil., Tabitha Randell, M.D., Atrayee Ghatak, M.D., Rachel E.J. Besser, Ph.D., Daniela Elleri, Ph.D., Nicola Trevelyan, M.D., Fiona M. Campbell, M.D.,

doi : 10.1056/NEJMoa2203496

Whether improved glucose control with hybrid closed-loop therapy can preserve C-peptide secretion as compared with standard insulin therapy in persons with new-onset type 1 diabetes is unclear.

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Trial of Anti-BDCA2 Antibody Litifilimab for Systemic Lupus Erythematosus

Richard A. Furie, M.D., Ronald F. van Vollenhoven, M.D., Kenneth Kalunian, M.D., Sandra Navarra, M.D., Juanita Romero-Diaz, M.D., Victoria P. Werth, M.D., Xiaobi Huang, Ph.D., George Clark, B.S., Hua Carroll, M.D., Adam Meyers, M.S., Cristina Musselli, M.D., Catherine Barbey, Ph.D.,

doi : 10.1056/NEJMoa2118025

Antibody-binding of blood dendritic cell antigen 2 (BDCA2), which is expressed exclusively on plasmacytoid dendritic cells, suppresses the production of type I interferon that is involved in the pathogenesis of systemic lupus erythematosus (SLE). The safety and efficacy of subcutaneous litifilimab, a humanized monoclonal antibody that binds to BDCA2, in patients with SLE have not been extensively studied.

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Routine Functional Testing or Standard Care in High-Risk Patients after PCI

Duk-Woo Park, M.D., Do-Yoon Kang, M.D., Jung-Min Ahn, M.D., Sung-Cheol Yun, Ph.D., Yong-Hoon Yoon, M.D., Seung-Ho Hur, M.D., Cheol Hyun Lee, M.D., Won-Jang Kim, M.D., Se Hun Kang, M.D., Chul Soo Park, M.D., Bong-Ki Lee, M.D., Jung-Won Suh, M.D.,

doi : 10.1056/NEJMoa2208335

There are limited data from randomized trials to guide a specific follow-up surveillance approach after myocardial revascularization. Whether a follow-up strategy that includes routine functional testing improves clinical outcomes among high-risk patients who have undergone percutaneous coronary intervention (PCI) is uncertain.

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Personality Disorders

Carla Sharp, Ph.D.

doi : 10.1056/NEJMra2120164

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Inhalational Induction

Christopher Conley, M.D., Karolina Brook, M.D., Joseph Louca, M.D., Amy Haber, M.D., Ala Nozari, M.D., Ph.D., and Rafael Ortega, M.D.

doi : 10.1056/NEJMvcm2202144

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Gallstone Ileus

Yuan Tao Lai, B.Sc., and Po Hsuan Wu, M.D.

doi : 10.1056/NEJMicm2204208

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Arrhythmogenic Right Ventricular Cardiomyopathy

Jocelyn McCullough, D.O., and Rohan G. Perera, M.D.

doi : 10.1056/NEJMicm2119255

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Case 27-2022: A 32-Year-Old Man with Confusion, Headache, and Fever

Nagagopal Venna, M.D., Pamela W. Schaefer, M.D., and Eli M. Miloslavsky, M.D.

doi : 10.1056/NEJMcpc2201246

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On the Path toward Expanding Treatment Options for Diabetes

Sue A. Brown, M.D.

doi : 10.1056/NEJMe2209840

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CLOuDs Disperse — Top-Notch Glucose Control and Residual C-Peptide Secretion

Jan Bolinder, M.D., Ph.D.

doi : 10.1056/NEJMe2209740

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Progress toward Better Treatment of Lupus

Daniel J. Wallace, M.D.

doi : 10.1056/NEJMe2208772

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Surveillance Stress Testing “POST-PCI� — A Future Class III Recommendation?

Jacqueline E. Tamis-Holland, M.D.

doi : 10.1056/NEJMe2210021

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Audio Interview: Rolling Out New Covid-19 Vaccines

Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., and Stephen Morrissey, Ph.D.

doi : 10.1056/NEJMe2211875

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The Human “Contaminome� and Understanding Infectious Disease

Patricia J. Simner, Ph.D., and Steven L. Salzberg, Ph.D.

doi : 10.1056/NEJMcibr2208625

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Race Correction and the X-Ray Machine — The Controversy over Increased Radiation Doses for Black Americans in 1968

Itai Bavli, Ph.D., and David S. Jones, M.D., Ph.D.

doi : 10.1056/NEJMms2206281

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Risk of BA.5 Infection among Persons Exposed to Previous SARS-CoV-2 Variants

doi : 10.1056/NEJMc2209479

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