New England Journal of Medicine




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Confronting Health Worker Burnout and Well-Being

Vivek H. Murthy, M.D., M.B.A.

doi : 10.1056/NEJMp2207252

Vol. 387 No. 7

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Tecovirimat and the Treatment of Monkeypox — Past, Present, and Future Considerations

Adam Sherwat, M.D., John T. Brooks, M.D., Debra Birnkrant, M.D., and Peter Kim, M.D.

doi : 10.1056/NEJMp2210125

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From Survival to Survivorship — Framing Traumatic Injury as a Chronic Condition

Juan P. Herrera-Escobar, M.D., M.P.H., and Jeffrey C. Schneider, M.D.

doi : 10.1056/NEJMp2205162

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Professionals as Targets in the Culture Wars

Scott E. Hadland, M.D., M.P.H.

doi : 10.1056/NEJMp2205560

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Lower versus Higher Glycemic Criteria for Diagnosis of Gestational Diabetes

Caroline A. Crowther, M.D., Deborah Samuel, B.Ed., Lesley M.E. McCowan, M.D., Richard Edlin, Ph.D., Thach Tran, Ph.D., and Christopher J. McKinlay, Ph.D. for the GEMS Trial Group*

doi : 10.1056/NEJMoa2204091

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Randomized Trial of Metformin, Ivermectin, and Fluvoxamine for Covid-19

Carolyn T. Bramante, M.D., M.P.H., Jared D. Huling, Ph.D., Christopher J. Tignanelli, M.D., John B. Buse, M.D., Ph.D., David M. Liebovitz, M.D., Jacinda M. Nicklas, M.D., M.P.H., Kenneth Cohen, M.D., Michael A. Puskarich, M.D., Hrishikesh K. Belani, M.D., M.P.H., Jennifer L. Proper, B.S., Lianne K. Siegel, Ph.D., Nichole R. Klatt, Ph.D.,

doi : 10.1056/NEJMoa2201662

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Clinical Spectrum of Children with Acute Hepatitis of Unknown Cause

Chayarani Kelgeri, M.D., Michael Couper, M.B., Ch.B., Girish L. Gupte, M.D., Alexandra Brant, M.Sc., Mitul Patel, M.D., Lauren Johansen, M.B., B.S., Joseph Valamparampil, M.D., Evelyn Ong, F.R.C.S., Hermien Hartog, Ph.D., M.T.P.R. Perera, M.D., Darius Mirza, M.S., F.R.C.S., Indra van Mourik, M.D.,

doi : 10.1056/NEJMoa2206704

Since January 2022, there has been an increase in reports of cases of acute hepatitis of unknown cause in children. Although cases have been reported across multiple continents, most have been reported in the United Kingdom. Investigations are ongoing to identify the causative agent or agents.

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A Case Series of Children with Acute Hepatitis and Human Adenovirus Infection

L. Helena Gutierrez Sanchez, M.D., Henry Shiau, M.D., Julia M. Baker, Ph.D., Stephanie Saaybi, M.D., Markus Buchfellner, M.D., William Britt, M.D., Veronica Sanchez, Ph.D., Jennifer L. Potter, M.P.H., L. Amanda Ingram, M.P.H., David Kelly, M.D., Xiaoyan Lu, M.S., Stephanie Ayers-Millsap, M.P.H., Wesley G. Willeford, M.D., Negar Rassaei, M.D., Julu Bhatnagar, Ph.D., Hannah Bullock, Ph.D., Sarah Reagan-Steiner, M.D., Ali Martin, B.S., Michael E. Rogers, D.O., M.P.H., Anna M. Banc-Husu, M.D., Sanjiv Harpavat, M.D., Ph.D., Daniel H. Leung, M.D., Elizabeth A. Moulton, M.D., Ph.D., Daryl M. Lamson, B.S., Kirsten St. George, Ph.D., Aron J. Hall, D.V.M., Umesh Parashar, M.D., Adam MacNeil, Ph.D., Jacqueline E. Tate, Ph.D., and Hannah L. Kirking, M.D.

doi : 10.1056/NEJMoa2206294

Human adenoviruses typically cause self-limited respiratory, gastrointestinal, and conjunctival infections in healthy children. In late 2021 and early 2022, several previously healthy children were identified with acute hepatitis and human adenovirus viremia.

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Neuromyelitis Optica Spectrum Disorder

Dean M. Wingerchuk, M.D., and Claudia F. Lucchinetti, M.D.

doi : 10.1056/NEJMra1904655

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Gallbladder Volvulus

Tina Tian, M.D., and Horacio Hojman, M.D.

doi : 10.1056/NEJMicm2118625

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Rice Bodies in Tenosynovitis Due to Psoriatic Arthritis

Mauricio Kahn, M.D., and Molly Fleece, M.D.

doi : 10.1056/NEJMicm2118312

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Case 25-2022: A 25-Year-Old Woman with Headache and Blurred Vision

Christina M. Marra, M.D., Saurabh Rohatgi, M.D., Allyson K. Bloom, M.D., Kristopher T. Kahle, M.D., Ph.D., and Amelia K. Haj, M.D., Ph.D.

doi : 10.1056/NEJMcpc2201241

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Drawing the Line on Glycemia in Pregnancy

Michael F. Greene, M.D.

doi : 10.1056/NEJMe2208339

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Time to Stop Using Ineffective Covid-19 Drugs

Salim S. Abdool Karim, M.B., Ch.B., Ph.D., and Nikita Devnarain, Ph.D.

doi : 10.1056/NEJMe2209017

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Acute Hepatitis in Children in 2022 — Human Adenovirus 41?

Saul J. Karpen, M.D., Ph.D.

doi : 10.1056/NEJMe2208409

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Audio Interview: Responding to Monkeypox

Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., Demetre C. Daskalakis, M.D., M.P.H., and Stephen Morrissey, Ph.D.

doi : 10.1056/NEJMe2210967

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Rapid Nanopore Sequencing–Based Screen for Aneuploidy in Reproductive Care

doi : 10.1056/NEJMc2201810

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Japanese Encephalitis in Australia — A Sentinel Case

doi : 10.1056/NEJMc2207004

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Albuterol–Budesonide Fixed-Dose Combination Rescue Inhaler for Asthma

doi : 10.1056/NEJMc2209189

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Treatment for Mild Chronic Hypertension during Pregnancy

doi : 10.1056/NEJMc2207889

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Frostbite — Diagnosis and Therapy

doi : 10.1056/NEJMc2209190

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