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In the Literature
Stan Deresinski
doi : 10.1093/cid/ciac839
Clinical Infectious Diseases, Volume 76, Issue 2, 15 January 2023, Pages i–ii
Twice-Daily Oral Zinc in the Treatment of Patients With Coronavirus Disease 2019: A Randomized Double-Blind Controlled Trial
Saoussen Ben Abdallah, Yosra Mhalla, Imen Trabelsi, Adel Sekma, Rim Youssef, Khaoula Bel Haj Ali, Houda Ben Soltane, Hajer Yacoubi, Mohamed Amine Msolli, Nejla Stambouli, Kaouthar Beltaief, Mohamed Habib Grissa, Meriem Khrouf, Zied Mezgar, Chawki Loussaief, Wahid Bouida, Rabie Razgallah, Karima Hezbri, Asma Belguith, Naouel Belkacem, Zohra Dridi, Hamdi Boubaker, Riadh Boukef, Semir Nouira
doi : 10.1093/cid/ciac807
Clinical Infectious Diseases, Volume 76, Issue 2, 15 January 2023, Pages 185–191
Zinc supplementation has been considered a potential therapy for coronavirus disease 2019 (COVID-19). We aimed to examine zinc efficacy in adult patients with COVID-19 infection.
A Potential Role for Zinc to Enhance Treatment for Coronavirus Disease 2019 (COVID-19)?
Marco Vinceti, Tommaso Filippini, Susan Fairweather-Tait
doi : 10.1093/cid/ciac849
Clinical Infectious Diseases, Volume 76, Issue 2, 15 January 2023, Pages 192–193
Characterizing the Rise of Disseminated Gonococcal Infections in California, July 2020–July 2021
Eric C Tang, Kelly A Johnson, Lizzete Alvarado, Nicole O Burghardt, Cindy Hernandez, Edwin Lopez, Tazima Jenkins-Barnes, Bryan Hughes, Krysta L Salas, Kathleen R Jacobson
doi : 10.1093/cid/ciac805
Clinical Infectious Diseases, Volume 76, Issue 2, 15 January 2023, Pages 194–200
California has experienced an increase in reported cases of disseminated gonococcal infection (DGI). Given significant morbidity associated with DGI and the ability of Neisseria gonorrhoeae to rapidly develop antibiotic resistance, characterization of these cases can inform diagnosis, management, and prevention of DGI.
Booster Vaccination Against SARS-CoV-2 Induces Potent Immune Responses in People With Human Immunodeficiency Virus
Sarah Fidler, Julie Fox, Timothy Tipoe, Stephanie Longet, Tom Tipton, Movin Abeywickrema, Sandra Adele, Jasmini Alagaratnam, Mohammad Ali, Parvinder K Aley, Suhail Aslam, Anbhu Balasubramanian, Anna Bara, Tanveer Bawa, Anthony Brown, Helen Brown, Federica Cappuccini, Sophie Davies, Jamie Fowler, Leila Godfrey, Anna L Goodman, Kathrine Hilario, Carl-Philipp Hackstein, Moncy Mathew, Yama F Mujadidi, Alice Packham, Claire Petersen, Emma Plested, Katrina M Pollock, Maheshi N Ramasamy, Hannah Robinson, Nicola Robinson, Patpong Rongkard, Helen Sanders, Teona Serafimova, Niamh Spence, Anele Waters, Danielle Woods, Panagiota Zacharopoulou, Eleanor Barnes, Susanna Dunachie, Philip Goulder, Paul Klenerman, Alan Winston, Adrian V S Hill, Sarah C Gilbert, Miles Carroll, Andrew J Pollard, Teresa Lambe, Ane Ogbe, John Frater
doi : 10.1093/cid/ciac796
Clinical Infectious Diseases, Volume 76, Issue 2, 15 January 2023, Pages 201–209
People with human immunodeficiency virus (HIV) on antiretroviral therapy (ART) with good CD4 T-cell counts make effective immune responses following vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). There are few data on longer term responses and the impact of a booster dose.
Human Immunodeficiency Virus and Cardiac End-Organ Damage in Women: Findings From an Echocardiographic Study Across the United States
Sanyog G Shitole, Jason M Lazar, Cynthia C Taub, Andrea C Furlani, Deborah J Konkle-Parker, Jodie Dionne-Odom, Margaret A Fischl, Igho Ofotokun, Adaora A Adimora, Elizabeth F Topper, Yasmeen Golzar, Seble G Kassaye, Deborah Gustafson, Kathryn Anastos, David B Hanna, Xiaonan Xue, Phyllis C Tien, Robert C Kaplan, Jorge R Kizer
doi : 10.1093/cid/ciac795
Clinical Infectious Diseases, Volume 76, Issue 2, 15 January 2023, Pages 210–219
People with human immunodeficiency virus (HIV) have been reported to have increased risk of clinical and subclinical cardiovascular disease. Existing studies have focused on men and often have been uncontrolled or lacked adequate HIV-negative comparators.
Maternal Antibody Response and Transplacental Transfer Following Severe Acute Respiratory Syndrome Coronavirus 2 Infection or Vaccination in Pregnancy
Sebastian Otero, Emily S Miller, Ashwin Sunderraj, Elisheva D Shanes, Allie Sakowicz, Jeffery A Goldstein, Leena B Mithal
doi : 10.1093/cid/ciac793
Clinical Infectious Diseases, Volume 76, Issue 2, 15 January 2023, Pages 220–228
Pregnant persons are at increased risk of severe coronavirus disease 2019 (COVID-19) and adverse obstetric outcomes. Understanding maternal antibody response, duration, and transplacental transfer after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and COVID-19 vaccination is important to inform public health recommendations.
Transmission of Carbapenem-Resistant Klebsiella pneumoniae in US Hospitals
Courtney L Luterbach, Liang Chen, Lauren Komarow, Belinda Ostrowsky, Keith S Kaye, Blake Hanson, Cesar A Arias, Samit Desai, Jason C Gallagher, Elizabeth Novick, Stephen Pagkalinawan, Ebbing Lautenbach, Glenn Wortmann, Robert C Kalayjian, Brandon Eilertson, John J Farrell, Todd McCarty, Carol Hill, Vance G Fowler, Jr, Barry N Kreiswirth, Robert A Bonomo, David van Duin, for the Multi-Drug Resistant Organism Network Investigators Network Investigators and the Antibacterial Resistance Leadership Group
doi : 10.1093/cid/ciac791
Clinical Infectious Diseases, Volume 76, Issue 2, 15 January 2023, Pages 229–237
Carbapenem-resistant Klebsiella pneumoniae (CRKp) is the most prevalent carbapenem-resistant Enterobacterales in the United States. We evaluated CRKp clustering in patients in US hospitals.
Bronchial Washing Using a Thin Versus a Thick Bronchoscope to Diagnose Pulmonary Tuberculosis: A Randomized Trial
Jung Seop Eom, Seyeon Park, Hyojin Jang, Saerom Kim, Wan Ho Yoo, Soo Han Kim, Jeongha Mok
doi : 10.1093/cid/ciac789
Clinical Infectious Diseases, Volume 76, Issue 2, 15 January 2023, Pages 238–244
This study was performed to evaluate the efficacy of using a thin bronchoscope for the diagnosis of pulmonary tuberculosis (PTB).
Association of Treated and Untreated Chronic Hepatitis C With the Incidence of Active Tuberculosis Disease: A Population-Based Cohort Study
Davit Baliashvili, Henry M Blumberg, David Benkeser, Russell R Kempker, Shaun Shadaker, Francisco Averhoff, Lia Gvinjilia, Natalia Adamashvili, Matthew Magee, George Kamkamidze, Mamuka Zakalashvili, Tengiz Tsertsvadze, Lali Sharvadze, Mamuka Chincharauli, Nestan Tukvadze, Neel R Gandhi
doi : 10.1093/cid/ciac786
Clinical Infectious Diseases, Volume 76, Issue 2, 15 January 2023, Pages 245–251
Hepatitis C virus (HCV) infection causes dysregulation and suppression of immune pathways involved in the control of tuberculosis (TB) infection. However, data on the role of chronic hepatitis C as a risk factor for active TB are lacking. We sought to evaluate the association between HCV infection and the development of active TB.
Effectiveness of Messenger RNA-1273 Vaccine Booster Against Coronavirus Disease 2019 in Immunocompetent Adults
Ana Florea, Lina S Sy, Lei Qian, Bradley K Ackerson, Yi Luo, Julia E Tubert, Gina S Lee, Jennifer H Ku, Katia J Bruxvoort, Carla A Talarico, Sijia Qiu, Yun Tian, Hung Fu Tseng
doi : 10.1093/cid/ciac785
Clinical Infectious Diseases, Volume 76, Issue 2, 15 January 2023, Pages 252–262
We conducted a prospective cohort study at Kaiser Permanente Southern California to evaluate the relative vaccine effectiveness (rVE) of a booster dose vs 2-dose primary series of messenger RNA (mRNA)-1273 in immunocompetent individuals.
Co-administration of Oral Cholera Vaccine With Oral Polio Vaccine Among Bangladeshi Young Children: A Randomized Controlled Open Label Trial to Assess Interference
Md Taufiqul Islam, Kashmira Date, Ashraful Islam Khan, Taufiqur Rahman Bhuiyan, Zahid Hasan Khan, Shamim Ahmed, Motaher Hossain, Fatema Khaton, K Zaman, Nigel A J McMillan, Abhijeet Anand, Qian An, Chenhua Zhang, William C Weldon, Alexander Yu, Stephen Luby, Firdausi Qadri
doi : 10.1093/cid/ciac782
Clinical Infectious Diseases, Volume 76, Issue 2, 15 January 2023, Pages 263–270
Cholera remains a public health threat for low- and middle-income countries, particularly in Asia and Africa. Shancholâ„¢, an inactivated oral cholera vaccine (OCV) is currently in use globally.
Associations of Immunogenicity and Reactogenicity After Severe Acute Respiratory Syndrome Coronavirus 2 mRNA-1273 Vaccine in the COVE and TeenCOVE Trials
Uma Siangphoe, Lindsey R Baden, Hana M El Sahly, Brandon Essink, Kashif Ali, Gary Berman, Joanne E Tomassini, Weiping Deng, Rolando Pajon, Roderick McPhee, Avika Dixit, Rituparna Das, Jacqueline M Miller, Honghong Zhou, for the COVE and TeenCOVE Study Groups
doi : 10.1093/cid/ciac780
Clinical Infectious Diseases, Volume 76, Issue 2, 15 January 2023, Pages 271–280
The reactogenicity and immunogenicity of coronavirus disease 2019 (COVID-19) vaccines are well studied. Little is known regarding the relationship between immunogenicity and reactogenicity of COVID-19 vaccines.
Impact of Enterococcus faecalis Endocarditis Treatment on Risk of Relapse
Pierre Danneels, Jean-François Hamel, Léa Picard, Schéhérazade Rezig, Pauline Martinet, Aurélien Lorleac’h, Jean-Philippe Talarmin, Rodolphe Buzelé, Thomas Guimard, Gwenaël Le Moal, Julia Brochard-Libois, Aurélie Beaudron, Julien Letheulle, Cyrielle Codde, Rachel Chenouard, David Boutoille, Adrien Lemaignen, Louis Bernard, Vincent Cattoir, Vincent Dubée, the EFEMER study group
doi : 10.1093/cid/ciac777
Clinical Infectious Diseases, Volume 76, Issue 2, 15 January 2023, Pages 281–290
Enterococcus faecalis infective endocarditis (EFIE) is characterized by a higher frequency of relapses than other infective endocarditis. The role of the treatment on its occurrence remains poorly understood. The aim of this study was to investigate whether the antibiotic regimen could impact the risk of relapse in EFIE.
Effectiveness of Ultraviolet-C Disinfection on Hospital-Onset Gram-Negative Rod Bloodstream Infection: A Nationwide Stepped-Wedge Time-Series Analysis
Michihiko Goto, Shinya Hasegawa, Erin C Balkenende, Gosia S Clore, Nasia Safdar, Eli N Perencevich, VA-CDC Practice-Based Research Network
doi : 10.1093/cid/ciac776
Clinical Infectious Diseases, Volume 76, Issue 2, 15 January 2023, Pages 291–298
The effectiveness of enhanced terminal room cleaning with ultraviolet C (UV-C) disinfection in reducing gram-negative rod (GNR) infections has not been well evaluated. We assessed the association of implementation of UV-C disinfection systems with incidence rates of hospital-onset (HO) GNR bloodstream infection (BSI).
Development of a Human Immunodeficiency Virus Risk Prediction Model Using Electronic Health Record Data From an Academic Health System in the Southern United States
Charles M Burns, Leland Pung, Daniel Witt, Michael Gao, Mark Sendak, Suresh Balu, Douglas Krakower, Julia L Marcus, Nwora Lance Okeke, Meredith E Clement
doi : 10.1093/cid/ciac775
Clinical Infectious Diseases, Volume 76, Issue 2, 15 January 2023, Pages 299–306
Human immunodeficiency virus (HIV) pre-exposure prophylaxis (PrEP) is underutilized in the southern United States. Rapid identification of individuals vulnerable to diagnosis of HIV using electronic health record (EHR)-based tools may augment PrEP uptake in the region.
Decreased Human Immunodeficiency Virus Diagnosis Rates Among Black and Hispanic or Latino Men Who Have Sex With Men in US Jurisdictions Supported by the THRIVE Demonstration Project, 2014–2019
Kashif Iqbal, Xueyuan Dong, Weiming Zhu, Jeffrey Wiener, Kenneth L Dominguez, Mary R Tanner, Athena P Kourtis, Sonia Singh, Karen W Hoover
doi : 10.1093/cid/ciac774
Clinical Infectious Diseases, Volume 76, Issue 2, 15 January 2023, Pages 307–314
Black and Hispanic/Latino men who have sex with men (MSM) are disproportionately affected by human immunodeficiency virus (HIV). In the Targeted Highly Effective Interventions to Reverse the HIV Epidemic (THRIVE) demonstration project, 7 community collaboratives were developed to provide comprehensive HIV prevention services for these populations.
Risk of Psychiatric Disorders, Use of Psychiatric Hospitals, and Receipt of Psychiatric Medication in Patients With Brain Abscess in Denmark
Lars Haukali Omland, Jacob Bodilsen, Malte Mose Tetens, Jannik Helweg-Larsen, Jens Otto Jarløv, Morten Ziebell, Svend Ellermann-Eriksen, Ulrik Stenz Justesen, Niels Frimodt-Møller, Preben Bo Mortensen, Niels Obel
doi : 10.1093/cid/ciac773
Clinical Infectious Diseases, Volume 76, Issue 2, 15 January 2023, Pages 315–322
It is unknown whether patients diagnosed with brain abscess have an increased risk of psychiatric disorders.
Sex Differences in Subclinical Atherosclerosis and Systemic Immune Activation/Inflammation Among People With Human Immunodeficiency Virus in the United States
Markella V Zanni, Borek Foldyna, Sara McCallum, Tricia H Burdo, Sara E Looby, Kathleen V Fitch, Evelynne S Fulda, Patrick Autissier, Gerald S Bloomfield, Carlos D Malvestutto, Carl J Fichtenbaum, Edgar T Overton, Judith A Aberg, Kristine M Erlandson, Thomas B Campbell, Grant B Ellsworth, Anandi N Sheth, Babafemi Taiwo, Judith S Currier, Udo Hoffmann, Michael T Lu, Pamela S Douglas, Heather J Ribaudo, Steven K Grinspoon
doi : 10.1093/cid/ciac767
Clinical Infectious Diseases, Volume 76, Issue 2, 15 January 2023, Pages 323–334
Among people with HIV (PWH), sex differences in presentations of atherosclerotic cardiovascular disease (ASCVD) may be influenced by differences in coronary plaque parameters, immune/inflammatory biomarkers, or relationships therein.
Japanese Encephalitis Emergence in Australia: The Potential Population at Risk
Laith Yakob, Wenbiao Hu, Francesca D Frentiu, Narayan Gyawali, Leon E Hugo, Brian Johnson, Colleen Lau, Luis Furuya-Kanamori, Ricardo Soares Magalhaes, Gregor Devine
doi : 10.1093/cid/ciac794
Clinical Infectious Diseases, Volume 76, Issue 2, 15 January 2023, Pages 335–337
In Australia, Japanese encephalitis virus circulated in tropical north Queensland between 1995 and 2005. In 2022, a dramatic range expansion across the southern states has resulted in 30 confirmed human cases and 6 deaths. We discuss the outbreak drivers and estimate the potential size of the human population at risk.
Treatment of Nontuberculous Mycobacterial (NTM) Pulmonary Infection in the US Bronchiectasis and NTM Registry: Treatment Patterns, Adverse Events, and Adherence to American Thoracic Society/Infectious Disease Society of America Treatment Guidelines
Jennifer H Ku, Emily Henkle, Timothy R Aksamit, Alan Barker, Amanda E Brunton, Kevin L Winthrop, for the Bronchiectasis and NTM Research Registry investigators
doi : 10.1093/cid/ciac788
Clinical Infectious Diseases, Volume 76, Issue 2, 15 January 2023, Pages 338–341
Among 1038 participants with pulmonary Mycobacterium avium complex and 120 with Mycobacterium abscessus enrolled in the US Bronchiectasis and NTM Research Registry, less than half received antibiotic therapy in the 24 months before registry enrollment, of which less than half were guideline based. Adverse effects occurred in 21% of therapy recipients, of whom 33% discontinued therapy.
Remdesivir Resistance in Transplant Recipients With Persistent Coronavirus Disease 2019
John I Hogan, Ralf Duerr, Dacia Dimartino, Christian Marier, Sarah E Hochman, Sapna Mehta, Guiqing Wang, Adriana Heguy
doi : 10.1093/cid/ciac769
Clinical Infectious Diseases, Volume 76, Issue 2, 15 January 2023, Pages 342–345
New mutations conferring resistance to SARS-CoV-2 therapeutics have important clinical implications. We describe the first cases of an independently acquired V792I RNA-dependent RNA polymerase mutation developing in renal transplant recipients after remdesivir exposure. Our work underscores the need for augmented efforts to identify concerning mutations and address their clinical implications.
Should Linezolid Replace Clindamycin as the Adjunctive Antimicrobial of Choice in Group A Streptococcal Necrotizing Soft Tissue Infection and Toxic Shock Syndrome? A Focused Debate
Nicolás Cortés-Penfield, Jonathan H Ryder
doi : 10.1093/cid/ciac720
Clinical Infectious Diseases, Volume 76, Issue 2, 15 January 2023, Pages 346–350
Group A Streptococcus (GAS) necrotizing soft tissue infections and toxic shock syndrome remain high-mortality conditions. In vitro and animal model data, as well as multiple observational studies, suggest adjunctive clindamycin (ie, given with a beta-lactam) reduces invasive GAS infection mortality by inhibiting exotoxin production.
Hemophagocytic Lymphohistiocytosis Associated With Cytomegalovirus Infection: 5 Cases and a Systematic Review of the Literature
Kevin Chevalier, Julien Schmidt, Paul Coppo, Lionel Galicier, Nicolas Noël, Olivier Lambotte
doi : 10.1093/cid/ciac649
Clinical Infectious Diseases, Volume 76, Issue 2, 15 January 2023, Pages 351–358
Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening disorder characterized by an uncontrolled, persistent, hyperimmune response. It can be triggered by an infectious, neoplastic, or autoimmune event.
Next-Generation Sequencing Supports Targeted Antibiotic Treatment for Culture Negative Orthopedic Infections
Ravina Kullar, Emanuele Chisari, James Snyder, Christopher Cooper, Javad Parvizi, Jason Sniffen
doi : 10.1093/cid/ciac733
Clinical Infectious Diseases, Volume 76, Issue 2, 15 January 2023, Pages 359–364
The isolation of an infective pathogen can be challenging in some patients with active, clinically apparent infectious diseases. Despite efforts in the microbiology lab to improve the sensitivity of culture in orthopedic implant-associated infections, the clinically relevant information often falls short of expectations.
A Six-year-old Girl With a Non-tender Cheek Swelling
H E Groves, I W Loh, R Lam, K Kazmi, H Branson, J N Riesel, I Kitai
doi : 10.1093/cid/ciac260
Clinical Infectious Diseases, Volume 76, Issue 2, 15 January 2023, Pages 365–367
Statin Use and Aspergillosis Risk—More than Meets the Eye?
Dimitrios P Kontoyiannis
doi : 10.1093/cid/ciac710
Clinical Infectious Diseases, Volume 76, Issue 2, 15 January 2023, Page 368
Prophylaxis in Lung Transplant Recipients
Joshua Malo, Bhupinder Natt, Sachin Chaudhary, Kenneth S Knox
doi : 10.1093/cid/ciac706
Clinical Infectious Diseases, Volume 76, Issue 2, 15 January 2023, Pages 368–369,
Gut Colonization and Antibiotic-Associated Diarrhea by Clostridium innocuum in Children and Adults
Yi-Ching Chen, Puo-Hsien Le, Yi-Hsin Wang, Tzu-Chun Chuang, Yuan-Ming Yeh, Cheng-Tang Chiu, Cheng-Hsun Chiu
doi : 10.1093/cid/ciac696
Clinical Infectious Diseases, Volume 76, Issue 2, 15 January 2023, Pages 369–371
Different Indications Between Fluoroquinolone and Amoxicillin
Chi-Kuei Hsu, Chih-Cheng Lai
doi : 10.1093/cid/ciac691
Clinical Infectious Diseases, Volume 76, Issue 2, 15 January 2023, Page 371
Safety of Dengue Vaccine?
Aravinda de Silva
doi : 10.1093/cid/ciac690
Clinical Infectious Diseases, Volume 76, Issue 2, 15 January 2023, Pages 371–372
Correction to: Salmonella typhi From Blood Cultures in the Democratic Republic of the Congo: A 10-Year Surveillance
doi : 10.1093/cid/ciac575
Clinical Infectious Diseases, Volume 76, Issue 2, 15 January 2023, Page 373
Correction to: Potential Influence of Menstrual Status and Sex Hormones on Female Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Cross-sectional Multicenter Study in Wuhan, China
doi : 10.1093/cid/ciac576
Clinical Infectious Diseases, Volume 76, Issue 2, 15 January 2023, Page 373
Correction to: Culture Conversion at 6 Months in Patients Receiving Delamanid-containing Regimens for the Treatment of Multidrug-resistant Tuberculosis
doi : 10.1093/cid/ciac346
Clinical Infectious Diseases, Volume 76, Issue 2, 15 January 2023, Page 374
Correction to: Leveraging Existing and Soon-to-Be-Available Novel Diagnostics for Optimizing Outpatient Antibiotic Stewardship in Patients With Respiratory Tract Infections
doi : 10.1093/cid/ciac547
Clinical Infectious Diseases, Volume 76, Issue 2, 15 January 2023, Page 374
