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Association between periodontitis and peripheral markers of innate immunity activation and inflammation
José Dopico, João Botelho, Alberto Ouro, Clara DomÃnguez, Vanessa Machado, Marta Aramburu-Nuñez, AntÃa Custodia, Teresa Blanco, MarÃa Vázquez-Reza, Daniel Romaus-Sanjurjo, Juan Blanco, Rogelio Leira, Tomás Sobrino, Yago Leira
doi : 10.1002/JPER.22-0216
Immune response leading to increased systemic inflammation is one of the mechanisms linking periodontitis to chronic inflammatory diseases. The aim of this study was to compare the expression of toll-like receptors 2 and 4 in monocytes and neutrophils (TLR2M, TLR2N, TLR4M, and TLR4N) and its endogenous ligands (cellular fibronectin [cFN] and heat shock protein 60 [HSP60]) in patients with and without periodontitis.
Impact of scaling and root planing on salivary and serum plasminogen activator inhibitor-1 expression in patients with periodontitis with and without type 2 diabetes mellitus
Sanjeela R. Guru, Suchetha Aghanashini
doi : 10.1002/JPER.22-0129
Plasminogen activator inhibitor-1 (PAI-1) is significantly enhanced in insulin resistance and inflammation and ascribed as a proinflammatory marker. This study aimed to compare and correlate salivary and serum PAI-1 and alpha 2-macroglobulin (α2MG) in patients with periodontitis with and without type 2 diabetes mellitus (T2DM) and also appraise the consequence of periodontal treatment on these biomarkers.
Proportional relationship between periodontal inflamed surface area, clinical attachment loss, and glycated hemoglobin level in patients with type 2 diabetes mellitus on insulin therapy and on oral antidiabetic therapy
Simna Pattayil, Rosamma Joseph Vadakkekuttical, Chandni Radhakrishnan, Harikumar Kanakkath, Thayyil Sivaraman Hrishi
doi : 10.1002/JPER.22-0085
Treatment of diabetes includes oral antidiabetic drugs (OAD), insulin, or their combinations. Insulin can achieve faster glycemic control and have anabolic action on bone.
Retrospective exploratory study of smoking status and e-cigarette use with response to non-surgical periodontal therapy
Chandni Shah, Birte Holtfreter, Francis J. Hughes, Luigi Nibali
doi : 10.1002/JPER.21-0702
To compare periodontal treatment responses in electronic cigarette (e-cigarette) users, non-smokers, former and current smokers.
Effect of supragingival plaque control on recurrent periodontitis and clinical stability among individuals under periodontal maintenance therapy: 10-year follow-up
Fernando Oliveira Costa, Adriana Moreira Costa, José Roberto Cortelli, Sheila Cavalca Cortelli, Amanda Almeida Costa, Rafael Paschoal Esteves Lima, Gustavo Henrique Mattos Pereira, Alcione Maria Soares Dutra Oliveira, Peterson Antônio Dutra Oliveira, LuÃÂs Otávio Miranda Cota
doi : 10.1002/JPER.22-0301
The aim of this study was to evaluate the effect of supragingival plaque control on the recurrence of periodontitis (RP) and the achievement of a stable periodontal clinical endpoint after 10Â years of periodontal maintenance therapy (PMT).
Depth of mucosal tunnel in peri-implant health during 12-month follow-up in patients with controlled periodontitis
Cho-Ying Lin, Pe-Yi Kuo, Meng-Yao Chiu, Hom-Lay Wang
doi : 10.1002/JPER.21-0680
The association between thickness of peri-implant mucosa, known as mucosal tunnel (MT) and related clinical parameters in bone-level implants has not been investigated.
Antibody response to BNT162b2 mRNA vaccine in gingival crevicular fluid
Pingping Han, Corey S. Moran, Srinivas Sulugodu Ramachandra, Laurence J. Walsh, Sašo Ivanovski
doi : 10.1002/JPER.22-0152
This prospective cohort study aimed to evaluate the antibody responses in non-invasive gingival crevicular fluid (GCF) and unstimulated whole saliva to the SARS-CoV-2 Spike unit 1 receptor-binding domain (S1-RBD) protein following administration of the mRNA BNT162b2 vaccine.
Patient-reported outcomes of palatal donor site healing using four different wound dressing modalities following free epithelialized mucosal grafts: A four-arm randomized controlled clinical trial
Hussein S. Basma, Muhammad H. A. Saleh, Ramzi V. Abou-Arraj, Matthew Imbrogno, Andrea Ravida, Hom-Lay Wang, Peng Li, Nicolaas Geurs
doi : 10.1002/JPER.22-0172
The aim of this study was to compare the effects of four different commonly used wound dressings in improving patient reported outcomes (PROMS) after free epithelialized mucosal grafts (FEGs) harvesting.
Association between periodontal disease, tooth extraction, and medication-related osteonecrosis of the jaw in women receiving bisphosphonates: A national cohort-based study
Min-Jeong Kwoen, Jung-Hyun Park, Keun-Suh Kim, Jae-Ryun Lee, Jin-Woo Kim, Hyejin Lee, Hyo-Jung Lee
doi : 10.1002/JPER.21-0611
We investigated whether periodontal diseases contribute to the development of medication-related osteonecrosis of the jaw (MRONJ) in addition to tooth extraction, which is a major risk factor for MRONJ occurrence.
New evidence of genetic heterogeneity causing hereditary gingival fibromatosis and ALK and CD36 as new candidate genes
Renato Assis Machado, Rodrigo Soares de Andrade, Sabina Pena Borges Pêgo, Ana Cristina Victorino Krepischi, Ricardo D. Coletta, HercÃlio Martelli-Júnior
doi : 10.1002/JPER.22-0219
Hereditary gingival fibromatosis (HGF) is an uncommon genetic condition characterized by slow but progressive fibrous, non-hemorrhagic, and painless growth of the gingival tissues due to the increased deposition of collagen and other macromolecules of the extracellular matrix.
Ion release and local effects of titanium metal particles from dental implants: An experimental study in rats
Jorge Toledano-Serrabona, Octavi Camps-Font, Diogo Pompéu de Moraes, Mario Corte-RodrÃguez, MarÃa Montes-Bayón, Eduard Valmaseda-Castellón, Cosme Gay-Escoda, M. Ã�ngeles Sánchez-Garcés
doi : 10.1002/JPER.22-0091
The objective of this study was to evaluate the accumulation of ions in blood and organs caused by titanium (Ti) metal particles in a mandibular defect in rats, together with a description of the local reaction of oral tissues to this Ti alloy debris.
Regulation of gingival keratinocyte monocyte chemoattractant protein-1-induced protein (MCPIP)-1 and mucosa-associated lymphoid tissue lymphoma translocation protein (MALT)-1 expressions by periodontal bacteria, lipopolysaccharide, and interleukin-1β
Yigit Firatli, Erhan Firatli, Vuokko Loimaranta, Samira Elmanfi, Ulvi K. Gürsoy
doi : 10.1002/JPER.22-0093
The aim of this study was to evaluate oral bacteria- and interleukin (IL)-1β-induced protein and mRNA expression profiles of monocyte chemoattractant protein-1-induced protein (MCPIP)-1 and mucosa-associated lymphoid tissue lymphoma translocation protein (MALT)-1 in human gingival keratinocyte monolayers and organotypic oral mucosal models.
Baseline interleukin-10, CD163, and tumor necrosis factor-like weak inducer of apoptosis (TWEAK) gingival tissue levels in relation to clinical periodontal treatment outcomes: A 12-week follow-up study
Mustafa Yilmaz, Esra Demir, Mervi Gürsoy, Erhan Firatli, Ulvi Kahraman Gürsoy
doi : 10.1002/JPER.22-0242
The aim of this study was to examine the relationship between healing response after non-surgical periodontal treatment and baseline gingival tissue levels of M2 macrophage activation-related proteins CD163, interleukin (IL)-10, interferon (IFN)-γ, and tumor necrosis factor-like weak inducer of apoptosis (TWEAK), and the CD163/TWEAK ratio.
