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Moroccan medicinal plants traditionally used for the treatment of skin diseases: From ethnobotany to clinical trials
Mohammed Ajjoun , Loubna Kharchoufa , Ilyass Alami Merrouni , Mostafa Elachouri
doi : 10.1016/j.jep.2022.115532
Volume 297, 28 October 2022, 115532
Skin diseases are among the most common human health affections. A healthy skin promotes a healthy body that can be achieved through modern, allopathic and natural medicines. Therefore, medicinal plants can be a reliable therapy in treating skin diseases in humans through a diverse range of bioactive molecules they contain.
Therapeutic and palliative role of a Unani herbal decoction in COVID-19 and similar respiratory viral illnesses: Phytochemical & pharmacological perspective
Mohammad Fazil a,1, Sadia Nikhat
doi : 10.1016/j.jep.2022.115526
Volume 297, 28 October 2022, 115526
Outbreaks of respiratory viral infections like Severe Acute Respiratory Syndrome, Middle-East Respiratory Syndrome, and Coronavirus Disease-2019 have been a regular occurrence in the past 100 years. A significant proportion of the morbidity and mortality in influenza is attributed to the co-morbidities and complications induced by the disease, involving the vital organs and physiological functions.
Natural essential oils: A promising strategy for treating cardio-cerebrovascular diseases
Yu Long a,1, Dan Li a,1, Shuang Yu a,1, Yu-lu Zhang a, Song-yu Liu a, Jin-yan Wan a, Ai Shi a, Jie Deng a, Jing Wen a, Xiao-qiu Li a, Ying Ma a, Nan Li a,*, Ming Yang b
doi : 10.1016/j.jep.2022.115421
Volume 297, 28 October 2022, 115421
Essential oils (EO) are volatile compounds obtained from different parts of natural plants, and have been used in national, traditional and folk medicine to treat various health problems all over the world. Records indicate that in history, herbal medicines rich in EO have been widely used for the treatment of CVDs in many countries, such as China.
Psoriasis treatment using Indigo Naturalis: Progress and strategy
Qianhui Zhang a, Jin Xie a, Gefei Li a, Fang Wang b, Junzhi Lin c, Ming Yang b, Aiai Du c,**, Dingkun Zhang a,*, Li Han
doi : 10.1016/j.jep.2022.115522
Volume 297, 28 October 2022, 115522
In recent years, there are increasing that the number of patients with psoriasis day by day, and it has become a common disease endangering public health. However, there is no specific cure for psoriasis or control of recurrence.
An optimized herbal combination for the treatment of liver fibrosis: Hub genes, bioactive ingredients, and molecular mechanisms
Qianqian Zhao a, Jinwei Bai b, Yiwei Chen a, Xin Liu a, Shangfeng Zhao a, Guixia Ling b, Shubing Jia a, Fei Zhai b,*, Rongwu Xiang
doi : 10.1016/j.jep.2022.115567
Volume 297, 28 October 2022, 115567
Liver fibrosis is a chronic liver disease that can lead to cirrhosis, liver failure, and hepatocellular carcinoma, and it is associated with long-term adverse outcomes and mortality. As a primary resource for complementary and alternative medicine, traditional Chinese medicine (TCM) has accumulated a large number of effective formulas for the treatment of liver fibrosis in clinical practice. However, studies on how to systematically optimize TCM formulas are still lacking.
Elsholtzia: A genus with antibacterial, antiviral, and anti-inflammatory advantages
Shuqi Chen b, Jixin Chen c, Yifan Xu a, Xinhua Wang a,**, Jing Li
doi : 10.1016/j.jep.2022.115549
Volume 297, 28 October 2022, 115549
The genus Elsholtzia (family Labiaceae) is an important source of folk traditional Chinese medicine, mainly used to relieve the symptoms of cold, fever, pneumonia and so on. However, currently available data on its traditional and pharmacological advantages have not been comprehensively reviewed.
Promising traditional Chinese medicine for the treatment of cholestatic liver disease process (cholestasis, hepatitis, liver fibrosis, liver cirrhosis)
Chunlei Wei , Jing Qiu, Yuyi Wu, Ziqiang Chen, Ziwei Yu, Zecheng Huang, Ke Yang, Huiling Hu *, Fang Liu
doi : 10.1016/j.jep.2022.115550
Volume 297, 28 October 2022, 115550
Cholestatic liver disease (CLD) is mainly characterized by cholestasis. If not treated, it will deteriorate to cholestatic hepatitis, liver fibrosis, liver cirrhosis, and even liver failure. CLD has a high clinical incidence, and limited treatment with single therapy. In the long-term clinical exploration, traditional Chinese medicine (TCM) has been corroborated with unique therapeutic effects on the CLD process.
Integration of metabolomics and transcriptomics to reveal anti-chronic myocardial ischemia mechanism of Gualou Xiebai decoction
Fengyun Zhang a,b, Bailu Duan c,**, Zhenxiang Zhou c, Lintao Han a,b, Ping Huang b,c, Yan Ye a,b, Qiong Wang b,c, Fang Huang c, Jingjing Li
doi : 10.1016/j.jep.2022.115530
Volume 297, 28 October 2022, 115530
Gualou Xiebai decoction (GLXB), a well-known classic traditional Chinese medicine formula, is a recorded and proven therapy for the management of cardiac diseases. However, its pharmacological characteristics and mechanism of action are unclear.
Safety assessment of marigold flavonoids from marigold inflorescence residue
Di Wu a,b, Juanjuan Wu b, Xinying Cheng b, Jianrui Qian b, Ruiliang Du c, Shusheng Tang c, Yunhe Lian b,*, Yanjiang Qiao
doi : 10.1016/j.jep.2022.115520
Volume 297, 28 October 2022, 115520
Marigold flavonoids, extracted from marigold (Tagetes erecta L.) inflorescence residues, have attracted significant attention with respect to antioxidant, anti-inflammatory and chelating properties. However, the toxicity of marigold flavonoids have not yet been fully investigated.
Integrating network pharmacology and experimental models to investigate the efficacy of QYHJ on pancreatic cancer
Pei-wen Yang a,b,1, Pan-ling Xu a,c,1, Chien-shan Cheng a,b,d, Ju-ying Jiao a,b, Yuan Wu d, Shu Dong a,b, Jing Xie a,b,*, Xiao-yan Zhu
doi : 10.1016/j.jep.2022.115516
Volume 297, 28 October 2022, 115516
The Qingyihuaji decoction (QYHJ) is composed of seven herbs: Scutellaria barbata D.Don (Banzhilian, HSB), Gynostemma pentaphyllum (Thunb.) Makino (Jiaogulan, GP), Oldenlandia diffusa (Willd.) Roxb. (Baihuasheshecao, HDH), Ganoderma lucidum (Leyss. ex Fr.) Karst. (Lingzhi, GL), Myristica fragrans Houtt. (Doukou, AK), and Amorphophallus kiusianus (Makino) Makino (Sheliugu, RA), and Coix lacryma-jobi var. ma-yuen (Rom.Caill.) Stapf (Yiyiren, CL). QYHJ has been reported to exhibit clinical efficacy in the treatment of pancreatic adenocarcinoma (PAAD). However, the molecular mechanism remains unclear.
Inhibitory effect of Mexican oregano (Lippia graveolens Kunth) extracts on digestive enzymes in vitro, and beneficial impact on carbohydrates and lipids absorption in vivo
Claudia I. Gamboa-G Ì�omez a, Mayra Denise-Herrera b, Luis E. Simental-MendÃa a, Alejandro Zamilpa-Alvarez c, Manas Ì�es Gonz Ì�alez-Cortazar c, Gerardo MartÃnez-Aguilar a, Pablo Alvarado-Aguilar a, Elisa P. Morales-Castro a, Jos Ì�e A. Ì�Avila-Soto a, Juan A. Amador-Herrera a, Fernando Guerrero-Romero
doi : 10.1016/j.jep.2022.115527
Volume 297, 28 October 2022, 115527
Although Mexican oregano inhibits digestive enzymes in vitro its effect on the absorption of carbohydrates and lipids in vivo has not been addressed.
Multi-target mechanisms against coronaviruses of constituents from Chinese Dagang Tea revealed by experimental and docking studies
Liyun Zhao a, Xubing Qin a, Tingting Lin a, Fuda Xie a, Liyuan Yao a,c, Yulin Li a, Binhong Xiong a, Zhifang Xu a, Yongchang Ye b, Hongfeng Chen a, Sheng-Xiang Qiu
doi : 10.1016/j.jep.2022.115528
Volume 297, 28 October 2022, 115528
The leaves of Eurya chinensis（Chinese Dagang Tea）have been consumed as herbal tea for centuries in Guangdong, China, and have also been used to prevent influenza and treat colds and fevers in traditional Chinese medicine. However, there are no reports on the chemical profile and efficacy of its leaves for the treatment of fever and viral infections.
The effect of Cassia fistula L. syrup in geriatrics constipation in comparison with the lactulose: A randomized clinical trial
Farangiz Sepehr a, Hoda Shirafkan b, Catherine Behzad c, Zahra Memariani a, Seyyed Ali Mozaffarpur
doi : 10.1016/j.jep.2022.115466
Volume 297, 28 October 2022, 115466
Cassia fistula is widely used in traditional Persian Medicine as a mild laxative. The rate of chronic constipation increases above the age of 60.
Chemical composition and anti-inflammatory activity of the essential oils of Piper gaudichaudianum and Piper mikanianum
Krissie D. Soares a, S �ergio A.L. Bordignon b, Miriam A. Apel
doi : 10.1016/j.jep.2022.115533
Volume 297, 28 October 2022, 115533
Inflammation is the body's normal protective response to injury and is stimulated by pathogens, toxic compounds, damaged cells or radiation, promoting healing and restoring homeostasis to the injured tissue. Leaves of Piper gaudichaudianum Kunth, known as “pariparoba� are widely used in folk medicine for the relief of toothache, while the fresh roots are used as anti-inflammatory and to treat liver disorders.
Network pharmacology identification and in Vivo validation of key pharmacological pathways of Phyllanthus reticulatus (Euphorbiaceae) leaf extract in liver cancer treatment
Yunli Tang a,b,1, Luyao Sun a,1, Jiangcun Wei b,1, Chen Sun a, Caiyu Gan b, Xiaofang Xie a, Chenyan Liang b,*, Cheng Peng a,**, Huaien Wu b, Zuowen Zheng b, Zhirui Pan b, Yuhua Huang
doi : 10.1016/j.jep.2022.115479
Volume 297, 28 October 2022, 115479
Phyllanthus reticulatus (Euphorbiaceae) is a medicinal plant that has been used in Zhuang medicine since ancient times. Traditionally, it has the effect of removing toxins and detumescence and can be used to treat hepatitis in China and India. Our previous studies have proved that the ethyl acetate extract of its leaves (PRPE) has an anti-hepatoma effect.
Galloylquinic acid derivatives from Byrsonima fagifolia leaf extract and potential antifungal activity
Miriam Sannomiya a,**, Clenilson Martins Rodrigues b, Giovanna Castro Araújo Oliveira a, Juliana Cajado Souza Carvalho c, LetÃcia Serafim da Costa d, Cristina de Castro Spadari d, Marcelo Jos Ì�e Pena Ferreira c, Wagner Vilegas e, Kelly Ishida
doi : 10.1016/j.jep.2022.115534
Volume 297, 28 October 2022, 115534
Byrsonima fagifolia Niedenzu (Malpighiaceae) and other Byrsonima species are popularly employed in Brazilian traditional medicine in the form of preparations as cicatrizing, anti-inflammatory, and antimicrobial.
Evaluation of the in vitro and in vivo anti-inflammatory activity of Gymnosporia montana (Roth). Benth leaves
Goutami G. Ambati a, Kamalender Yadav b, Ruchika Maurya b,c, K.K. Kondepudi b, Mahendra Bishnoi b, Sanjay M. Jachak
doi : 10.1016/j.jep.2022.115539
Volume 297, 28 October 2022, 115539
Gymnosporia montana (Roth) Benth an herbaceous shrub used in Indian traditional medicine their leaves decoction was used as mouthwash to get relieve from toothache, hence it is also known as Dantakashta in Sanskrit language which means the plant used for tooth problems.
Clinical pharmacokinetics of kavalactones after oral dosing of standardized kava extract in healthy volunteers
Siva Rama Raju Kanumuri a,b,c, Jessica Mamallapalli c,d, Robyn Nelson c,e, Christopher R. McCurdy a,b,c,d, Carol A. Mathews c,e, Chengguo Xing c,d,**, Abhisheak Sharma
doi : 10.1016/j.jep.2022.115514
Volume 297, 28 October 2022, 115514
Piper methysticum G. Forst. (Piperaceae), commonly known as kava, has been used as a traditional beverage for centuries for its relaxing properties. Kavalactones are considered to be the major constituents responsible for kava's beneficial effects. Despite the extensive use of kava, clinical pharmacokinetic data is not available in the literature; therefore, the findings of this study will be critical for the dosage calculations for future clinical evaluation of kava.
Rooibos (Aspalathus linearis) alters secretome trace amine profile of probiotic and commensal microbes in vitro
L. Pretorius a, A.D. Van Staden b,c, T.A. Kellermann c, N. Henning c, C. Smith
doi : 10.1016/j.jep.2022.115548
Volume 297, 28 October 2022, 115548
Aspalathus linearis (Burm.f.) R. Dahlgren (rooibos) tea is anecdotally renowned for its calming effect in the context of gastrointestinal discomfort, but little scientific support is available to elucidate potential mechanisms of action.
Antidiabetic effects of Psidium x durbanensis Baijnath & Ramcharun ined. (Myrtaceae) leaf extract on streptozotocin-induced diabetes in rats
Kingsley C. Mbara a, Sanjeev Rambharose b, Himansu Baijnath c, Manimbulu Nlooto d,e, Peter M. O. Owira
doi : 10.1016/j.jep.2022.115542
Volume 297, 28 October 2022, 115542
Psidium guajava L. leaves are used to treat diabetes in South African folkloric medicine and in other parts of the world. Psidium x durbanensis Baijnath & Ramcharun ined. (PD) is a natural sterile hybrid and congener of Psidium guajava that is expected to share the medicinal properties of the genus Psidium and is widely distributed in South Africa.
Sanhuang Xiexin decoction ameliorates DSS-induced colitis in mice by regulating intestinal inflammation, intestinal barrier, and intestinal flora
Xueyuan Wu a,b, Shu Fu a, Miao Jiang a, Jing Wang c, Huaqiao Tang d, Chunlin Fang b, Wen Li a,*, Chaomei Fu
doi : 10.1016/j.jep.2022.115537
Volume 297, 28 October 2022, 115537
Sanhuang Xiexin decoction (SXD) is a widely applicated traditional Chinese medicine (TCM) with a significant intestinal anti-inflammatory effect.
In vitro dual activity of Aloe marlothii roots and its chemical constituents against Plasmodium falciparum asexual and sexual stage parasites
Sephora Mutombo Mianda a, Luke Invernizzi a, Mari ̈ette E. van der Watt b,c, Janette Reader b, Phanankosi Moyo a,b, Lyn-Mari �e Birkholtz b,**, Vinesh J. Maharaj
doi : 10.1016/j.jep.2022.115551
Volume 297, 28 October 2022, 115551
Aloe marlothii A.Berger (Xanthorrhoeaceae) is indigenous to southern African countries where its aqueous preparations are used in traditional medicine to treat several ailments including hypertension, respiratory infections, venereal diseases, chest pain, sore throat and malaria.
Gu Sui Bu (Drynaria fortunei J. Sm.) antagonizes glucocorticoid-induced mineralization reduction in zebrafish larvae by modulating the activity of osteoblasts and osteoclasts
Cheng-Huan Peng a,b,c, Wen-Ying Lin a, Chia-Ying Li d, Kameshwara Kumar Dharini b, Chih-Yu Chang e, Jo-Ting Hong e, Ming-Der Lin b
doi : 10.1016/j.jep.2022.115565
Volume 297, 28 October 2022, 115565
Gu Sui Bu (GSB), the dried rhizome of Drynaria fortunei J. Sm., is widely used in traditional Chinese medicine for treating fractures and osteoporosis. Although glucocorticoids are widely prescribed in modern medicine, the efficacy of GSB in treating glucocorticoid-induced osteoporosis (GIOP) remains unclear.
Effect of methanolic extract of Mimosa malacophylla A.Gray in vero and HEK-293 cell lines, and in the morphology of kidney and bladder of rats with induced urolithiasis
Gloria A. Guill Ì�en-Mel Ì�endez a,1, Adolfo Soto-DomÃnguez a,1, MarÃa de Jesús Loera-Arias a,1, Uziel Castillo-Vel Ì�azquez b, Sheila A. Villa-Cedillo a, Edgar I. Pi ̃na-Mendoza a, Eduardo Estrada- Castill Ì�on c, Abelardo Ch Ì�avez-Montes d, Alfredo Gonz Ì�alez-Alcocer a, Eduardo M. Becerra-VerdÃn e, Alfonso Casta ̃neda-MartÃnez e, Raymundo A. P Ì�erez-Hern Ì�andez d,*, Daniel Salas-Trevi ̃no
doi : 10.1016/j.jep.2022.115552
Volume 297, 28 October 2022, 115552
Urolithiasis is the presence of stones in the kidney, ureters, bladder and/or urethra; it is the third most frequent disease of the urinary tract. Mimosa malacophylla A. Gray, is a species distributed in northern Mexico, where people traditionally use it for its diuretic effect, and to treat kidney diseases; however, no scientific reports have been found in relation to its antiurolithic properties.
Homeostatic regulation of the aryl hydrocarbon receptor-cytochrome P450 1a axis by Scutellaria baicalensis-Coptis chinensis herb pair and its main constituents
Mengmeng Song a,1, Xianjie Sheng a,1, Jianrong Zhang a, Xinru Li a, Qianyun Dai a, Yan Chen a, An Kang
doi : 10.1016/j.jep.2022.115545
Volume 297, 28 October 2022, 115545
Scutellaria baicalensis (SB) and Coptis chinensis (CC) are widely used traditional Chinese medicine (TCM) for “heat-clearing and damp-drying� and “purging fire and detoxifying�.
A novel therapeutic approach for IPF: Based on the “Autophagy - Apoptosis� balance regulation of Zukamu Granules in alveolar macrophages
Siyu Li a, Guoxiu Liu a, Min Gu a, Yixuan Li a, Yanan Li a, Zhihong Ji b, Keao Li b, Yanping Wang d,**, Huaqiang Zhai a,c,*, Yongyan Wang
doi : 10.1016/j.jep.2022.115568
Volume 297, 28 October 2022, 115568
Zukamu Granules (ZKMG) is one of the representative Uygur patent drugs widely used in China, which is included in the National Essential Drugs List (2018 edition). As the first choice for common cold treatment in Uygur medicine theory, it has unique anti-inflammatory and antitussive efficacy.
Mahuang Xixin Fuzi decoction ameliorates apoptosis via the mitochondrial-mediated signaling pathway in MCM cells
Jia Yang a,1, Qihui Sun a,1, Qingyun Ma a, Qinhui Yu a, Xiaoyun Liu a,b, Yanliang Liu a, Yuxiu Han a, Yong Yang a,b,*, Rong Rong
doi : 10.1016/j.jep.2022.115538
Volume 297, 28 October 2022, 115538
Mahuang Xixin Fuzi Decoction (MXF), as a classical prescription of traditional Chinese medicine (TCM), has been used to treat the symptoms of fever, nasal congestion and headache in elderly people for almost a thousand years.
The antinociceptive and anti-inflammatory potential and pharmacokinetic study of significant alkamides ingredients from Asarum Linn
Hanze Liu , Suli Li , Xiaohan Huan , Yujuan Xie , Zhejun Xie , Yuting Sun , Ning Cao , Qi Xie , Yaru Wang , Hanxue Wang , Xuemei Cheng , Huida Guan , Changhong Wang
doi : 10.1016/j.jep.2022.115569
Volume 297, 28 October 2022, 115569
Asari Radix et Rhizoma (ARR), including 3 major plants of genus Asarum Linn, A. heterotropoides Fr. Schmidt var. mandshuricum (Maxim.) Kitag., A. sieboldii Miq. f. sieboldii and A. sieboldii Miq f. seoulense (Nakai) C. Y. Cheng et C. S. Yang, is one of the most important traditional herbal medicine in Asia with tremendous pharmacological activities.
Pharmacokinetics-derived absorbed components responsible for Guizhi-Fuling capsule target PI3K/Akt-Erk to exert an anti-dysmenorrhea effect
Qiulong Zhao a,c,d,1, Jiaxin Cheng a,1, Xiaokun Bian b,1, Chunxue Wang a,1, Yi Xu c, Hongxiang Ding c, Hui Ren c, Yiying Zhang c, Min Xu d, Chenxiao Shan d, Hui Yan a,*, Jinao Duan c, Dawei Qian c,**, Xi Huang
doi : 10.1016/j.jep.2022.115525
Volume 297, 28 October 2022, 115525
Guizhi-Fuling capsule (GZFL), a well-known herbal remedy, has been widely used to treat primary dysmenorrhea (PD). Hence, systematic identifying multiple active ingredients and the involved mechanism is essential and urgently needed for GZFL.
Total flavonoids of Sophora flavescens and kurarinone ameliorated ulcerative colitis by regulating Th17/Treg cell homeostasis
Zhaocheng Li a, Minling Lin a, Yadi Li a, Jing Shao a, Ruiting Huang a, Yongyi Qiu a, Yi Liu b,**, Lei Chen
doi : 10.1016/j.jep.2022.115500
Volume 297, 28 October 2022, 115500
Ulcerative colitis (UC) is relevant to dysregulation of inflammation and immune processes. Sophora flavescens Aiton is a classic medicine widely used in the treatment of UC in ancient and modern China, alkaloids and flavonoids are the main components.
Systemic pharmacological verification of Guizhi Fuling decoction in treating endometriosis-associated pain
Yang Gao a, Wenjing Ji b, Man Lu a, Zhiheng Wang a, Xurui Jia c, Dawei Wang a, Peng Cao a, Chunping Hu a, Xiaoyan Sun a,*, Zhigang WangYang Gao a, Wenjing Ji b, Man Lu a, Zhiheng Wang a, Xurui Jia c, Dawei Wang a, Peng Cao a, Chunping Hu a, Xiaoyan Sun a,*, Zhigang Wang
doi : 10.1016/j.jep.2022.115540
Volume 297, 28 October 2022, 115540
Guizhi Fuling decoction (GZFL decoction) is a famous formula in the Synopsis of the Golden Chamber, which has a long history in treating endometriosis. However, its exact mechanism remains unclear.
Psoralen and isopsoralen from Psoraleae Fructus aroused hepatotoxicity via induction of aryl hydrocarbon receptor-mediated CYP1A2 expression
Cai Zhang , Jin-Quan Zhao , Jia-Xing Sun , Hui-Jun Li
doi : 10.1016/j.jep.2022.115577
Volume 297, 28 October 2022, 115577
Psoraleae Fructus (PF), a traditional Chinese medicine, has long been used to treat diseases such as cancer, osteoporosis and leukoderma. Psoralen and isopsoralen are main bioactive ingredients of PF with anti-tumor, anti-inflammatory, estrogen-like neuroprotection, etc., meanwhile they are also representative hepatotoxic components of PF.
Uncovering the efficacy and mechanisms of Genkwa flos and bioactive ingredient genkwanin against L. monocytogenes infection
Lei Xu a,1, Gejin Lu a,c,1, Baihe Zhan a, Lijuan Wei a,b, Xuming Deng a, Qiaoling Zhang a, Xue Shen d, Jianfeng Wang a,*, Haihua Feng
doi : 10.1016/j.jep.2022.115571
Volume 297, 28 October 2022, 115571
Genkwa flos (yuanhua in Chinese), the dried flower buds of the plant Daphne genkwa Siebold & Zucc., as a traditional herb widely used for the treatment of inflammation-related symptoms and diseases, with the efficacies of diuretic, phlegm-resolving and cough suppressant.
Calycosin mitigates chondrocyte inflammation and apoptosis by inhibiting the PI3K/AKT and NF-?B pathways
Xiaoqing Shi a,b,1, Lishi Jie a,b,1, Peng Wu a, Nongshan Zhang a, Jun Mao a, Peimin Wang a, Songjiang Yin
doi : 10.1016/j.jep.2022.115536
Volume 297, 28 October 2022, 115536
Shaoyao Gancao Decoction (SG-Tang), originated from the Treatise on Febrile Diseases, is often used to treat OA pain symptoms. Whereas its efficacy has been verified by several clinical studies, the underlying mechanism remained unclear.
Srolo Bzhtang reduces inflammation and vascular remodeling via suppression of the MAPK/NF-?B signaling pathway in rats with pulmonary arterial hypertension
Tingting Chen a,b, Shanshan Su c, Zhanting Yang b, Dejun Zhang d, Zhanqiang Li a,b,*, Dianxiang Lu
doi : 10.1016/j.jep.2022.115572
Volume 297, 28 October 2022, 115572
Srolo Bzhtang (SBT), which consists of Solms-laubachia eurycarpa, Bergenia purpurascens, Glycyrrhiza uralensis, and lac secreted by Laccifer lacca Kerr (Lacciferidae Cockerell), is a well-known traditional Tibetan medicinal formula and was documented to cure “lung-heat� syndrome by eliminating “chiba� in the ancient Tibetan medical work Four Medical Tantras (Rgyud bzhi).
Anti-inflammatory, antipyretic efficacy and safety of inhaled Houttuynia cordata thunb. essential oil formulation
Chun Fai Wong a, Cheuk Ka Poon a, Tsz Wai Ng a, Hok Him Pan a, Eng Cheng Khaw b, Ki Fong Tsang b, Yan Wing Mui b, Yuk Hong Lo b, Mui Fung Hao b,*, Chun Hay Ko
doi : 10.1016/j.jep.2022.115541
Volume 297, 28 October 2022, 115541
Houttuynia cordata Thunb. (H. cordata) is a well-known folk traditional Chinese medicine that is renowned for its use in the management of inflammatory respiratory diseases and pneumonia. Its essential oils have demonstrated their anti-inflammatory efficacy in vitro, however, their in vivo biological effects via inhalation have not been elucidated.
Efficacy and safety of the Chinese herbal medicine Xiao-qing-long-tang for allergic rhinitis: A systematic review and meta-analysis of randomized controlled trials
Yajie Yan a, Jiajun Zhang b, Haolan Liu b, Ze Lin c, Qiulan Luo d,e, Yunying Li d,e, Yan Ruan a,**, Shiqing Zhou
doi : 10.1016/j.jep.2022.115169
Volume 297, 28 October 2022, 115169
The classic Chinese herbal medicine formula Xiao-qing-long-tang (XQLT) is commonly recommended to manage allergic rhinitis (AR), but the treatment efficacy and safety of XQLT are uncertain.
Tribulus terrestris L. extract ameliorates atherosclerosis by inhibition of vascular smooth muscle cell proliferation in ApoE-/- mice and A7r5 cells via suppression of Akt/MEK/ERK signaling
Jing Zhang a,1, Wai-Rong Zhao a,1, Wen-Ting Shi a,1, Jun-Jie Tan b, Kai-Yu Zhang a, Jing-Yi Tang a, Xin-Lin Chen a,*, Zhong-Yan Zhou
doi : 10.1016/j.jep.2022.115547
Volume 297, 28 October 2022, 115547
Atherosclerosis (AS) is one of major threatens of death worldwide, and vascular smooth muscle cell (VSMC) proliferation is an important characteristic in the progression of AS. Tribulus terrestris L. is a well-known Chinese Materia Medica for treating skin pruritus, vertigo and cardiovascular diseases in traditional Chinese medicine. However, its anti-AS activity and inhibition effect on VSMC proliferation are not fully elucidated.
Exploring the potential targets of Sanshimao formula for hepatocellular carcinoma treatment by a method of network pharmacology combined with molecular biology
Qin Yu a,b,1, Zhe Chen c,1, Minglin Liu a, Yongbin Meng a, Xiaoyan Li a, Bai Li c,**, Juan Du
doi : 10.1016/j.jep.2022.115531
Volume 297, 28 October 2022, 115531
The Sanshimao (SSM) formula is an effective prescription for hepatocellular carcinoma (HCC) therapy in the clinical setting. This prescription is made up of four herbals, Maorenshen, Shijianchuan, Shishangbai and Shidachuan, which are used for detoxification and removing blood stasis. However, its mechanism in the treatment of HCC remains ambiguous.
A network pharmacology-based study on the mechanism of astragaloside IV alleviating renal fibrosis through the AKT1/GSK-3Ùƒ pathway
Xinwei Yu a, Qiming Xiao a, Xixi Yu a, Yu Cheng a, Hao Lin a, Zheng Xiang
doi : 10.1016/j.jep.2022.115535
Volume 297, 28 October 2022, 115535
Astragaloside IV, a glycoside derived from Astragalus membranaceus, has anti-renal fibrosis effects. However, its mechanism of action has not yet been fully elucidated.
TCM herbal prescription recommendation model based on multi-graph convolutional network
Wen Zhao a, Weikai Lu b, Zuoyong Li c, Chang’en Zhou a, Haoyi Fan d, Zhaoyang Yang a, Xuejuan Lin a,*, Candong Li
doi : 10.1016/j.jep.2022.115109
Volume 297, 28 October 2022, 115109
The recommendation of herbal prescriptions is a focus of research in traditional Chinese medicine (TCM). Artificial intelligence (AI) algorithms can generate prescriptions by analysing symptom data. Current models mainly focus on the binary relationships between a group of symptoms and a group of TCM herbs.
