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SOX9 Expression Is Superior to Other Stem Cell Markers K19 and EpCAM in Predicting Prognosis in Hepatocellular Carcinoma.
Ruzinova, Marianna B. MD, PhD *; Ma, Changqing MD, PhD *; Brunt, Elizabeth M. MD *; Goss, Charles W. PhD +; Vachharajani, Neeta MBBS ++; Chapman, William C. MD ++; Liu, Ta-Chiang MD, PhD *
doi : 10.1097/PAS.0000000000001990
Volume 47(1) pgs. 1-146 January 2023
AB Various stem cell markers (eg, epithelial cell adhesion molecule [EpCAM], cytokeratin 19 [K19]) have been reported as predictors of poor prognosis in hepatocellular carcinoma (HCC).
Distinctive Nested Glomoid Neoplasm: Clinicopathologic Analysis of 20 Cases of a Mesenchymal Neoplasm With Frequent GLI1 Alterations and Indolent Behavior.
Papke, David J. Jr MD, PhD *; Dickson, Brendan C. MD, MSc +,++; Oliveira, Andre M. MD, PhD [S]; Sholl, Lynette M. MD *; Fletcher, Christopher D.M. MD, FRCPath *
doi : 10.1097/PAS.0000000000001979
AB Recently, it has been recognized that a subset of primary soft tissue neoplasms with GLI1 gene alterations exhibit nested architecture and can mimic glomus tumors or well-differentiated neuroendocrine tumors.
A Clinicopathologic and Molecular Analysis of Fumarate Hydratase-deficient Pheochromocytoma and Paraganglioma.
Fuchs, Talia L. PhD, FRCPA *,+,++; Luxford, Catherine PhD +,[S]; Clarkson, Adele BSc *,[//]; Sheen, Amy BSc *,[//]; Sioson, Loretta BSc *,[//]; Elston, Marianne PhD, FRACP [P]; Croxson, Michael S. FRACP #; Dwight, Trisha PhD [S]; Benn, Diana E. PhD +,[S]; Tacon, Lyndal PhD, FRACP +,[S],**; Field, Michael FRACP ++; Ahadi, Mahsa S. MD, FRCPA *,+,[//]; Chou, Angela PhD, FRCPA *,+,[//]; Clifton-Bligh, Roderick J. PhD, FRACP +,[S],**; Gill, Anthony J. MD, FRCPA *,+,[//]
doi : 10.1097/PAS.0000000000001945
AB Up to 40% of pheochromocytomas (PCCs) and paragangliomas (PGLs) are hereditary. Germline mutations/deletions in fumarate hydratase (FH) cause hereditary leiomyomatosis and renal cell carcinoma syndrome which manifests predominantly with FH-deficient uterine/cutaneous leiomyomas and renal cell carcinomas (RCCs)-tumors characterized by loss of immunohistochemical (IHC) expression of FH and/or positive staining for S-(2-succino)-cysteine.
Fibromyxoid Nephrogenic Adenoma: A Series of 43 Cases Reassessing Predisposing Conditions, Clinical Presentation, and Morphology.
Li, Lin MD, PhD *; Williamson, Sean R. MD +; Castillo, Rosa P. MD ++,[S]; Delma, Katiana S. HT *; Gonzalgo, Mark L. MD, PhD [S],[//]; Epstein, Jonathan I. MD [P],#,**; Kryvenko, Oleksandr N. MD *,[S],[//],++
doi : 10.1097/PAS.0000000000001986
AB Nephrogenic adenoma is a benign epithelial lesion of the genitourinary tract that arises from the reimplantation and proliferation of shed renal tubular cells in areas of urothelial injury and denudation.
Wnt Family Member 9b (Wnt9b) Is a Sensitive and Specific Marker for Triple-negative Breast Carcinoma Including Metaplastic Carcinoma.
Shaker, Nada MD *; Shafi, Saba MD *; Parkinson, Bryce DO *; Chen, Wei MD, PhD *; Parwani, Anil V. MD, PhD *; Ding, Qingqing MD, PhD +; Li, Zaibo MD, PhD *
doi : 10.1097/PAS.0000000000002001
AB Wnt9b was recently identified as a highly sensitive and specific marker for breast carcinomas. Due to the limited number of triple-negative breast carcinomas (TNBCs) in previous study, we further explored Wnt9b's utility in breast carcinoma, especially in TNBCs including metaplastic carcinomas.
JAK/STAT3 Signaling Activation Related to Distinct Clinicopathologic Features in Systemic ALK- Anaplastic Large Cell Lymphomas: New Insights into Their Heterogeneity.
Wang, Jian-chao MD *; Zhong, Li-hua MD *; Lin, Wei-qing MD *; Zhang, Wen-fang MD *; Xi, Yan-feng MD, PhD +; Liu, Yue-ping MD, PhD ++; Zhu, Qiong MD *; Liu, Wei MD *; Zhu, Wei-feng MBBS *; Chen, Yan-ping MD, PhD *; Chen, Gang MD *
doi : 10.1097/PAS.0000000000001995
AB Systemic anaplastic lymphoma kinase (ALK)-negative anaplastic large cell lymphoma (ALCL) is a group of heterogenous CD30+ T-cell non-Hodgkin lymphomas. Previous studies have highlighted the importance of JAK/STAT3 signaling activation in the molecular pathogenesis of ALK- ALCLs.
GLI1-Rearranged Enteric Tumor: Expanding the Spectrum of Gastrointestinal Neoplasms With GLI1 Gene Fusions.
Jessurun, Jose MD *; Orr, Christine MD *; McNulty, Samantha N. PhD +; Hagen, Catherine E. MD ++; Alnajar, Hussein MD *; Wilkes, David PhD [S]; Kudman, Sarah MS [S]; Al Assaad, Majd MD *,[S]; Dorsaint, Princesca MS [S],[//]; Ohara, Kentaro MD, PhD *,[S]; He, Feng BA *; Chu, Kenrry MD *; Yin, Yong Mei MD [P]; Xiang, Jenny Zhaoying PhD [S],#; Qin, Lihui MD *; Sboner, Andrea PhD *,[S],[//]; Elemento, Olivier PhD [S],[//]; Yantiss, Rhonda K. MD *; Graham, Rondell P. MD ++; Poizat, Flora MD **; Mosquera, Juan Miguel MD, MSc *,[S]
doi : 10.1097/PAS.0000000000001950
AB GLI1 encodes a transcription factor that targets cell cycle regulators affecting stem cell proliferation. GLI1 gene fusions were initially described in pericytomas with a t[7;12] translocation and more recently in gastric plexiform fibromyxomas and gastroblastomas.
Proteomic Identification and Clinicopathologic Characterization of Splenic Amyloidosis.
Chiu, April MD *; Dasari, Surendra PhD +; Kurtin, Paul J. MD *; Theis, Jason D. BS *; Vrana, Julie A. PhD *; Rech, Karen L. MD *; Dao, Linda N. MD *; Howard, Matthew T. MD *; Dalland, Joanna C. MD *; McPhail, Ellen D. MD *
doi : 10.1097/PAS.0000000000001948
AB The spleen is a commonly encountered specimen in surgical pathology. However, little is known about the incidence, morphologic pattern, and clinical features of spleens involved by amyloidosis.
Targeted Mutational Profiling Reveals Clonal Relationships in Metachronous Occurrence of Classic Hodgkin and Mediastinal Large B-Cell Lymphomas.
Singh, Kunwar MD *; Lezama, Lhara S. MD +; Kurzer, Jason MD, PhD *; Oak, Jean MD, PhD *; Schultz, Liora M. MD ++; Walkush, Ann ++; Cheng, Tse-Chang MD +; Chen, Everett H. MD +; May, William A. MD [S]; Chang, Cheryl [//]; Link, Michael P. MD ++; Advani, Ranjana H. MD [//]; Suarez, Carlos J. MD, MSc *; Natkunam, Yasodha MD, PhD *
doi : 10.1097/PAS.0000000000001956
AB Classic Hodgkin lymphoma (CHL) patients may infrequently present with a prior or recurrent disease with discordant histology resembling non-Hodgkin lymphomas. These include primary mediastinal large B-cell lymphoma (PMBL), diffuse large B-cell lymphoma (DLBCL), or mediastinal gray-zone lymphoma (MGZL).
Sporadic and Familial Adenomatous Polyposis-associated Foveolar-type Adenoma of the Stomach.
Naka, Tomoaki MD, PhD *; Hashimoto, Taiki MD, PhD *; Cho, Hourin MD, PhD +,++; Tanabe, Noriko PhD ++; Yoshida, Teruhiko MD, PhD ++; Yatabe, Yasushi MD, PhD *,[S]; Yoshikawa, Takaki MD, PhD [//]; Abe, Seiichiro MD, PhD +; Sekine, Shigeki MD, PhD *,[S]
doi : 10.1097/PAS.0000000000001949
AB Gastric foveolar-type adenoma (FA) is a rare benign neoplasm occurring either sporadically or in patients with familial adenomatous polyposis (FAP). However, the molecular features of FA and the relationship between sporadic and syndromic lesions remain unclear. In this study, we performed clinicopathological, immunohistochemical, and genetic analyses of 18 sporadic and 30 FAP-associated FAs.
Sinonasal Amoebiasis: An Unexpected Cause of Sinonasal Necroinflammatory Disease.
McLean, Anne C. DMD, MS *,+; Bishop, Justin A. MD +; Guarner, Jeannette MD *; Montone, Kathleen T. MD ++; Morris, C. Paul MD, PhD [S],[//]; Sloan, Philip BDS, PhD [P]; Rooper, Lisa M. MD [S]
doi : 10.1097/PAS.0000000000001951
AB While amoebic infection is widely known as a cause of gastroenteritis, keratitis, and meningoencephalitis, amoebae are challenging to recognize at unexpected sites. Despite multiple case reports of sinonasal amoebiasis, amoebic infection is not regularly considered in the differential diagnosis of sinonasal necroinflammatory disease.
Core Needle Biopsy in Lymphoma Diagnosis: The Diagnostic Performance and the Role of the Multidisciplinary Approach in the Optimization of Results.
Goncalves, Marianne de C. MD, PhD *; de Oliveira, Claudia Regina G.C.M. MD, PhD *; Sandes, Alex F. MD, PhD +; Rodrigues, Celso A. MD, PhD ++; Novis, Yana MD [S]; Viana, Publio C.C. MD [//]; Serra, Marcia M.P. PhD [P]; Zerbini, Maria Claudia N. MD, PhD #
doi : 10.1097/PAS.0000000000001991
AB To compare the diagnostic accuracy of core needle biopsies (CNBs) and surgical excisional biopsies (SEBs), samples of lymphoid proliferation from a single institution from 2013 to 2017 (N=476) were divided into groups of CNB (N=218) and SEB (N=258).
Loss of Major Histocompatibility Complex Class I, CD8+ Tumor-infiltrating Lymphocytes, and PD-L1 Expression in Ovarian Clear Cell Carcinoma.
Lin, Shih-Yao MD *,+; Hang, Jen-Fan MD *,+,++; Lai, Chiung-Ru MD *,++; Chan, I-San MD [S]; Shih, Ying-Chu MD [S]; Jiang, Ling-Yu MD +,[S]; Chang, Yen-Hou MD +,[S]; Chen, Yi-Jen MD, PhD +,++,[S]
doi : 10.1097/PAS.0000000000001975
AB Ovarian clear cell carcinoma (OCCC), a chemoresistant ovarian cancer, shows a modest response to anti-programmed death-1/programmed death ligand-1 (PD-1/PD-L1) therapies.
Molecular Characterization of Adult Tumors Diagnosed as Cerebellar Glioblastomas Identifies Subgroups Associated With Prognosis.
Picart, Thiebaud MD, MSc *,+,++; Poncet, Delphine PharmD, PhD ++,[S],[//]; Barritault, Marc MD, PhD +,++,[S]; Bauchet, Luc MD, PhD [P],#,**; Zouaoui, Sonia PhD [P],#; Guyotat, Jacques MD, PhD *; Gabut, Mathieu PhD +,++; Fina, Frederic PhD ++; Honnorat, Jerome MD, PhD ++,++++,[S][S]; Figarella-Branger, Dominique MD, PhD ++,[//][//]; Pallud, Johan MD, PhD [P][P],##,***; Ducray, Francois MD, PhD +,++,++++; Meyronet, David MD, PhD +,++,[S]; French Brain Tumor Database; ANOCEF
doi : 10.1097/PAS.0000000000001996
AB Adult tumors diagnosed as cerebellar glioblastoma (cGBM) are rare and their optimal classification remains to be determined. The aim of this study was to identify subgroups of cGBM based on targeted molecular analysis. cGBM diagnosed between 2003 and 2017 were identified from the French Brain Tumor Database and reviewed according to the WHO 2021 classification.
Sebaceous Differentiation as Another Feature of Metatypical Adenoid Cystic Carcinoma: A Case Report and Letter to the Editor.
Ooms, Kaitlyn D.W. MD *; Chiosea, Simion MD +; Lamarre, Eric MD ++; Shah, Akeesha A. MD *
