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Erbu Zhuyu decoction improves endometrial angiogenesis via uterine natural killer cells and the PI3K/Akt/eNOS pathway a mouse model of embryo implantation dysfunction
Mengmeng Shen, Yanfeng Liu, Xiaona Ma, Qingwen Zhu
doi : 10.1111/aji.13634
We investigated the effect of Erbu Zhuyu decoction (EBZY) on angiogenesis via uterine natural killer (uNK) cells and the PI3K/Akt/eNOS pathway in embryo implantation dysfunction (EID) mice.
TCR CDR3-antigen chemical complementarity associated with poor ovarian cancer outcomes: A vestigial immune response to early cancer antigens?
Vayda R. Barker, Mallika Varkhedi, Dhruv N. Patel, Monica Hsiang, Andrea Chobrutskiy, Boris I. Chobrutskiy, George Blanck
doi : 10.1111/aji.13639
Ovarian cancer continues to present significant challenges for early detection and treatment, indicating a need for novel approaches to improve disease outcomes. In this report, we applied a previously described algorithm for detecting chemical complementarity between candidate cancer antigens and complementarity determining region-3 (CDR3) amino acid sequences from tumor resident T-cell receptors.
Plasma IGFBP-1, Fas, kallistatin, and P-selectin as predictive biomarkers of histologic chorioamnionitis and associated intra-amniotic infection in women with preterm labor
Kyong-No Lee, Iseop Cho, Eun Mi Im, Eunji Oh, Kyo Hoon Park
doi : 10.1111/aji.13645
To determine whether altered levels of 13 plasma biomarkers, alone or in combination, could be independently associated with histologic chorioamnionitis (HCA) and microbial-associated HCA (defined as the presence of HCA along with microbial invasion) in women with preterm labor (PTL).
NKG2D-mediated cytotoxicity improves after primary surgery for high-grade serous ovarian cancer
Pernilla Israelsson, Emma Björk, Ivan Nagaev, Olga Nagaeva, Eva Lundin, Lucia Mincheva-Nilsson, Ulrika Ottander
doi : 10.1111/aji.13647
Tumors compromise the patients’ immune system to promote their own survival. We have previously reported that HGSC exosomes play a central role, downregulating NKG2D cytotoxicity.
Silencing P38 MAPK reduces cellular senescence in human fetal chorion trophoblast cells
Brett Goldman, Enkhtuya Radnaa, Talar Kechichian, Ramkumar Menon
doi : 10.1111/aji.13648
Amniochorion senescence generates mechanistic signals to initiate parturition. Activation of p38 mitogen-activated kinase (MAPK) in fetal amnion cells is a key mediator of senescence as well as epithelial-mesenchymal transition (EMT) of amnion cells. However, the impact of p38 MAPK in chorion trophoblast cells (CTCs) is unclear.
Placent�° of BCG-Vaccinated Women in early Pregnancy is Colonized with Non-Immunogenic Mycobacterial L-forms
Tanya Dimova, Violeta Dimitrova, Petar Grozdanov, Nadya Markova
doi : 10.1111/aji.13650
Long-lived mycobacterial L-forms (mL-forms) could be detected in the blood of BCG-vaccinated people. We have previously found mL-forms in term placentas and blood of neonates, delivered by healthy BCG-vaccinated mothers as first formal demonstration that BCG vaccination in the childhood of the woman could affect her placentobiome during pregnancy.
Circulating CD200 is increased in the secretory phase of women with endometriosis as is endometrial mRNA, and endometrial stromal cell CD200R1 is increased in spite of reduced mRNA
Matthew Hamilton, Victoria Turpin, Anmar Ayoub, Amir Reihani, Jorge Arredondo, Kjetil Ask, David A. Clark, Warren G. Foster
doi : 10.1111/aji.13655
Estrogen-dependent extrauterine implantation and growth of menstrual endometrial tissue affects roughly 10% of reproductive age women and depends on suppression of local innate immune defenses to prevent ectopic tissue rejection.
Matrix metalloproteinases in preterm prelabor rupture of membranes in the setting of chorioamnionitis: A scoping review
Lynsa M. Nguyen, David M. Aronoff, Alison J. Eastman
doi : 10.1111/aji.13642
Fetal or gestational membranes extend from the placenta to enclose the fetus and amniotic fluid. While the membranes spontaneously rupture at term in normal pregnancies, they can rupture prematurely before the onset of labor, termed preterm prelabor rupture of membranes (PPROM).
Oral immunocontraceptive vaccines: A novel approach for fertility control in wildlife
Jinpeng Yang, Ziyao Zhou, Gangshi Li, Zhiyou Dong, Qianlan Li, Keyi Fu, Haifeng Liu, Zhijun Zhong, Hualin Fu, Zhihua Ren, Wuyang Gu, Guangneng Peng
doi : 10.1111/aji.13653
The overabundant populations of wildlife have caused many negative impacts, such as human-wildlife conflicts and ecological degradation. The existing approaches like injectable immunocontraceptive vaccines and lethal methods have limitations in many aspects, which has prompted the advancement of oral immunocontraceptive vaccine.
