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Changing the Name of Diabetes Insipidus: A Position Statement of the Working Group for Renaming Diabetes Insipidus
Hiroshi Arima, Timothy Cheetham, Mirjam Christ-Crain, Deborah Cooper, Juliana Drummond, Mark Gurnell, Miles Levy, Ann McCormack, John Newell-Price, Joseph G Verbalis, John Wass, The Working Group for Renaming Diabetes Insipidus
doi : 10.1210/clinem/dgac547
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 1, January 2023
Recent data show that patients with a diagnosis of diabetes insipidus (DI) are coming to harm. Here we give the rationale for a name change to arginine vasopressin deficiency and resistance for central and nephrogenic DI, respectively.
Liraglutide for Weight Management in Children and Adolescents With Prader–Willi Syndrome and Obesity
Gwenaëlle Diene, Moris Angulo, Paula M Hale, Cecilie H Jepsen, Paul L Hofman, Anita Hokken-Koelega, Chethana Ramesh, Serap Turan, Maïthé Tauber Author Notes
doi : 10.1210/clinem/dgac549
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 1, January 2023
Prader–Willi syndrome (PWS) is characterized by lack of appetite control and hyperphagia, leading to obesity. Pharmacological options for weight management are needed.
Plasma Metabolomics Reveals Systemic Metabolic Alterations of Subclinical and Clinical Hypothyroidism
Feifei Shao, Rui Li, Qian Guo, Rui Qin, Wenxiu Su, Huiyong Yin, Limin Tian
doi : 10.1210/clinem/dgac555
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 1, January 2023
Clinical hypothyroidism (CH) and subclinical hypothyroidism (SCH) have been linked to various metabolic comorbidities but the underlying metabolic alterations remain unclear. Metabolomics may provide metabolic insights into the pathophysiology of hypothyroidism.
Genetic Dissection of Primary Aldosteronism in a Patient With MEN1 and Ipsilateral Adrenocortical Carcinoma and Adenoma
Stéfanie Parisien-La Salle, Gilles Corbeil, Zaki El-Haffaf, Caroline Duranceau, Mathieu Latour, Pierre I Karakiewicz, André Lacroix, Isabelle Bourdeau
doi : 10.1210/clinem/dgac564
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 1, January 2023, Pages 26–32
Adrenal tumors are found in up to 40% of patients with multiple endocrine neoplasia type 1 (MEN1). However, adrenocortical carcinomas (ACC) and primary aldosteronism (PA) are rare in MEN1.
Aldosterone, Renin, and Aldosterone-to-Renin Ratio Variability in Screening for Primary Aldosteronism
Elisabeth Ng, Stella May Gwini, Renata Libianto, Kay Weng Choy, Zhong X Lu, Jimmy Shen, James C G Doery, Peter J Fuller, Jun Yang
doi : 10.1210/clinem/dgac568
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 1, January 2023, Pages 33–41
The plasma aldosterone concentration (PAC), renin, and aldosterone-to-renin ratio (ARR) are used to screen for primary aldosteronism (PA). Substantial intra-individual variability of PAC and ARR using plasma renin activity in the context of usual antihypertensive therapy has been described, but there is no data on ARR variability calculated using direct renin concentration (DRC).
Differences in HDL-Bound Apolipoproteins in Patients With Advanced Liver Fibrosis Due to Nonalcoholic Fatty Liver Disease
Fernando Bril, Ryan W Pearce, Timothy S Collier, Michael J McPhaul
doi : 10.1210/clinem/dgac565
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 1, January 2023, Pages 42–51
The mechanisms leading to increased cardiovascular disease in patients with nonalcoholic fatty liver disease (NAFLD) and advanced liver fibrosis remain incompletely understood.
Novel Variants and Phenotypes in NEUROG3-Associated Syndrome
Karn Wejaphikul, Khomsak Srilanchakon, Wuttichart Kamolvisit, Supavadee Jantasuwan, Kanokwan Santawong, Siraprapa Tongkobpetch, Thanakorn Theerapanon, Alisara Damrongmanee, Nattaphorn Hongsawong, Nuthapong Ukarapol, Prapai Dejkhamron, Vichit Supornsilchai, Thantrira Porntaveetus, Vorasuk Shotelersuk
doi : 10.1210/clinem/dgac554
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 1, January 2023, Pages 52–58
Biallelic pathogenic variants in the NEUROG3 gene cause malabsorptive diarrhea, insulin-dependent diabetes mellitus (IDDM), and rarely hypogonadotropic hypogonadism. With only 17 reported cases, the clinical and mutational spectra of this disease are far from complete.
Bone Health in Adults With Prader–Willi Syndrome: Clinical Recommendations Based on a Multicenter Cohort Study
Denise H van Abswoude, Karlijn Pellikaan, Anna G W Rosenberg, Kirsten Davidse, Muriel Coupaye, Charlotte Høybye, Tania P Markovic, Graziano Grugni, Antonino Crinò, Assumpta Caixà s, Christine Poitou, Helena Mosbah, Tessa Weir, Leo A van Vlimmeren, Joost P H J Rutges, Luuk W L De Klerk, M Carola Zillikens, Aart J van der Lely, Laura C G de Graaff
doi : 10.1210/clinem/dgac556
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 1, January 2023, Pages 59–84
Prader–Willi syndrome (PWS) is a rare complex genetic syndrome, characterized by delayed psychomotor development, hypotonia, and hyperphagia.
Maternal Glycaemic and Insulinemic Status and Newborn DNA Methylation: Findings in Women With Overweight and Obesity
Marion Lecorguillé, Fionnuala M McAuliffe, Patrick J Twomey, Karien Viljoen, John Mehegan, Cecily C Kelleher, Matthew Suderman, Catherine M Phillips
doi : 10.1210/clinem/dgac553
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 1, January 2023, Pages 85–98
Maternal dysglycaemia and prepregnancy obesity are associated with adverse offspring outcomes. Epigenetic mechanisms such as DNA methylation (DNAm) could contribute.
Lower Blood Oxygen Saturation is Associated With Microvascular Complications in Individuals With Type 1 Diabetes
Jens Christian Laursen, Hatice Isik Mizrak, Huda Kufaishi, Sofie Korsgaard Hecquet, Elisabeth Buur Stougaard, Ninna Hahn Tougaard, Marie Frimodt-Møller, Tine Willum Hansen, Christian Stevns Hansen, Peter Rossing
doi : 10.1210/clinem/dgac559
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 1, January 2023, Pages 99–106
Blood oxygen saturation (SpO2) is lower in type 1 diabetes (T1D) compared with nondiabetic controls. Hypoxia (low tissue oxygenation) is thought to be a risk factor for progression of diabetic complications, but it is unknown whether hypoxemia (low SpO2) is associated with diabetic complications.
Distinct Clinical Features of Post-COVID-19 Vaccination Early-onset Graves’ Disease
Luigi di Filippo, Laura Castellino, Agnese Allora, Stefano Frara, Roberto Lanzi, Francesca Perticone, Fanny Valsecchi, Alberto Vassallo, Raffaele Giubbini, Clifford J Rosen, Andrea Giustina
doi : 10.1210/clinem/dgac550
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 1, January 2023, Pages 107–113
Several case reports of Graves’ disease (GD) occurrence after COVID-19 vaccination that are possibly related to the autoimmune syndrome induced by adjuvants (ASIA) were published recently.
Idiopathic Hirsutism and Metabolic Status: A Population-based Prospective Cohort Study
Leila Mahmoudieh, Mina Amiri, Maryam Rahmati, Ali Siamak Habibi Moeini, Farzaneh Sarvghadi, Fereidoun Azizi, Fahimeh Ramezani Tehrani
doi : 10.1210/clinem/dgac538
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 1, January 2023, Pages 114–123
A limited number of studies have investigated the impact of idiopathic hirsutism (IH) on cardiometabolic parameters with contradictory and inconclusive results. This study aimed to explore the effect of IH on metabolic outcomes.
Evaluating the Progression to Hypothyroidism in Preconception Euthyroid Thyroid Peroxidase Antibody–Positive Women
Sofia Gill, Versha Cheed, Victoria A H Morton, Dayna Gill, Kristien Boelaert, Shiao Chan, Arri Coomarasamy, Rima K Dhillon-Smith
doi : 10.1210/clinem/dgac525
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 1, January 2023, Pages 124–134,
Thyroid peroxidase antibody (TPOAb) positivity is prevalent in women of reproductive age and predisposes to thyroid dysfunction, particularly hypothyroidism, which has adverse effects on pregnancy.
Low Thrombin Generation in Users of a Contraceptive Containing Estetrol and Drospirenone
Laure Morimont, Maud Jost, Ulysse Gaspard, Jean-Michel Foidart, Jean-Michel Dogné, Jonathan Douxfils
doi : 10.1210/clinem/dgac511
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 1, January 2023, Pages 135–143
To compare the impact on thrombin generation of the new combined oral contraceptive containing 15 mg estetrol and 3 mg drospirenone with ethinylestradiol (30 or 20 mcg) associated either with 150 mcg levonorgestrel or with 3 mg drospirenone.
Twin Study: Genetic and Epigenetic Factors Affecting Circulating Adiponectin Levels
Mika Hasegawa, Jumpei Taniguchi, Hiromichi Ueda, Mikio Watanabe
doi : 10.1210/clinem/dgac532
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 1, January 2023, Pages 144–154
Clarification of the association among phenotypes, genetic, and environmental factors with clinical laboratory traits can reveal the cause of diseases and assist in developing methods for the prediction and prevention of diseases.
Long-term Burosumab Administration Is Safe and Effective in Adults With X-linked Hypophosphatemia
Thomas J Weber, Erik A Imel, Thomas O Carpenter, Munro Peacock, Anthony A Portale, Joel Hetzer, J Lawrence Merritt, II, Karl Insogna
doi : 10.1210/clinem/dgac518
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 1, January 2023, Pages 155–165
Burosumab was developed as a treatment option for patients with the rare, lifelong, chronically debilitating, genetic bone disease X-linked hypophosphatemia (XLH).
Reduced Sensitivity to Thyroid Hormones Is Associated With High Remnant Cholesterol Levels in Chinese Euthyroid Adults
Honglin Sun, Wei Zhu, Jia Liu, Yu An, Ying Wang, Guang Wang
doi : 10.1210/clinem/dgac523
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 1, January 2023, Pages 166–174
It remains unclear whether the thyroid system could regulate the atherogenic remnant cholesterol (RC) levels in euthyroid status.
Variety and Quantity of Dietary-Insoluble Fiber Intake From Different Sources and Risk of New-Onset Diabetes
Sisi Yang, Chengzhang Liu, Ziliang Ye, Chun Zhou, Mengyi Liu, Yanjun Zhang, Qimeng Wu, Zhuxian Zhang, Panpan He, Yuanyuan Zhang, Huan Li, Xianhui Qin
doi : 10.1210/clinem/dgac526
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 1, January 2023, Pages 175–183
The relationship between the variety and quantity of different sources of dietary-insoluble fiber intake and diabetes remain uncertain.
Dysbetalipoproteinemia Is Associated With Increased Risk of Coronary and Peripheral Vascular Disease
Martine Paquette, Sophie Bernard, Alexis Baass
doi : 10.1210/clinem/dgac503
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 1, January 2023, Pages 184–190
Dysbetalipoproteinemia (DBL) is a disorder in which remnant lipoproteins accumulate in the plasma due to a genetic apolipoprotein E dysfunction in conjunction with the presence of secondary metabolic factors
Inpatient Zoledronic Acid and Integrated Orthopedic and Fracture Liaison Services Improve Osteoporosis Treatment Rates
WuQiang Fan, Melissa Machado, Benjamin Z Leder, Lisa Beyer, Esteban Franco Garcia, Henry M Kronenberg, Smriti Cevallos, Josue Espinoza, Joel S Finkelstein, Marcy B Bolster
doi : 10.1210/clinem/dgac508
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 1, January 2023, Pages 191–197
Fragility fractures increase risks for future fractures, morbidity, and mortality. Available pharmacotherapy for underlying osteoporosis is safe and effective but underused.
Disorders of Salt and Water Balance After Pituitary Surgery
Emily K Brooks, Warrick J Inder
doi : 10.1210/clinem/dgac622
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 1, January 2023, Pages 198–208
Transsphenoidal surgery is the first-line treatment for many clinically significant pituitary tumors and sellar lesions. Although complication rates are low when performed at high-volume centers, disorders of salt and water balance are relatively common postoperatively.
Approach to Hypophosphatemic Rickets
Sarah A Ackah, Erik A Imel
doi : 10.1210/clinem/dgac488
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 1, January 2023, Pages 209–220
Hypophosphatemic rickets typically presents in infancy or early childhood with skeletal deformities and growth plate abnormalities. The most common causes are genetic (such as X-linked hypophosphatemia), and these typically will result in lifelong hypophosphatemia and osteomalacia.
Sodium-Glucose Cotransporter 2 Inhibitors and New-onset Type 2 Diabetes in Adults With Prediabetes: Systematic Review and Meta-analysis of Randomized Controlled Trials
Yuichiro Mori, O Kenrik Duru, Katherine R Tuttle, Shingo Fukuma, Daisuke Taura, Norio Harada, Nobuya Inagaki, Kosuke Inoue
doi : 10.1210/clinem/dgac591
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 1, January 2023, Pages 221–231
The preventive effect of sodium-glucose cotransporter 2 (SGLT2) inhibitors for new-onset diabetes was investigated in secondary analyses of several randomized controlled trials (RCTs). However, the results were inconsistent.
Effects of Coenzyme Q10 Supplementation on Lipid Profiles in Adults: A Meta-analysis of Randomized Controlled Trials
Zhihao Liu, Zezhong Tian, Dan Zhao, Ying Liang, Suming Dai, Meitong Liu, Shanshan Hou, Xiaoxi Dong, Zhaxinima, Yan Yang
doi : 10.1210/clinem/dgac585
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 1, January 2023, Pages 232–249
Previous meta-analyses have suggested that the effects of coenzyme Q10 (CoQ10) on lipid profiles remain debatable. Additionally, no meta-analysis has explored the optimal intake of CoQ10 for attenuating lipid profiles in adults.
From the Full KIGS Cohort: On Safety and Efficacy of Growth Hormone Treatment
Julio Abucham, Margaret C S Boguszewski
doi : 10.1210/clinem/dgac625
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 1, January 2023, Pages e1–e2
Understanding Prenatal and Postnatal Linear Growth
Selena Vanapruks, Youn Hee Jee
doi : 10.1210/clinem/dgac611
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 1, January 2023, Pages e3–e4
NIFTP Statistics—Now You See It, Now You Don’t
Chanchal Rana, Andrey Bychkov
doi : 10.1210/clinem/dgac569
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 1, January 2023, Pages e5–e6
Finding the Balance on Extent of Initial Thyroidectomy for Low-Risk Papillary Thyroid Carcinoma
Trevor E Angell, Daniel I Kwon
doi : 10.1210/clinem/dgac557
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 1, January 2023, Pages e7–e8
Prenatal Dexamethasone Treatment of Congenital Adrenal Hyperplasia: Are We Any Closer to Considering It Safe?
Margaret de Castro, Clarissa Silva Martins, Sonir R Antonini
doi : 10.1210/clinem/dgac524
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 1, January 2023, Pages e9–e10
Letter to the Editor From Nelson et al: “Understanding the Link Between Obesity and Severe COVID-19 Outcomes: Causal Mediation by Systemic Inflammatory Response�
Kaitlin Nelson, Jerilynn C Prior, Dharani Kalidasan, Cara Tanenbaum, Sonia Shirin, Claudie Berger, Azita Goshtasebi
doi : 10.1210/clinem/dgac619
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 1, January 2023, Pages e11–e12
Response to Letter to the Editor From Nelson et al: “Understanding the Link Between Obesity and Severe COVID-19 Outcomes: Causal Mediation by Systemic Inflammatory Response�
Andrea S Foulkes, Caitlin Selvaggi, Daniel Shinnick, Heidi Lumish, Tingyi Cao, Tanayott Thaweethai, Jing Qian, James B Meigs, Virginia A Triant, Ingrid V Bassett, Muredach P Reilly
doi : 10.1210/clinem/dgac620
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 1, January 2023, Page e13
Correction to “New Horizons: Revival of Lipoprotein (a) as a Risk Factor for Cardiovascular Disease�
doi : 10.1210/clinem/dgac607
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 1, January 2023, Page e14
Correction to: “Pharmacologic Weight Management in the Era of Adolescent Obesity�
doi : 10.1210/clinem/dgac581
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 1, January 2023, Page e15
Correction to: “Associations of Serum Vitamin B6 Status and Catabolism With All-Cause Mortality in Patients With T2DM�
doi : 10.1210/clinem/dgac552
The Journal of Clinical Endocrinology & Metabolism, Volume 108, Issue 1, January 2023, Page e16
