International Journal of Rheumatic Diseases




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Current aspects for the treatment of axial spondyloarthritis

Chiao-Hsin Ku, Yung-Heng Lee, James Cheng-Chung Wei, Jürgen Braun

doi : 10.1111/1756-185X.14473

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Current treatment strategies and recommendations in psoriatic arthritis

Pei-En Kao, Yung-Heng Lee, Kevin Sheng-Kai Ma, Amy Ker, Ying-Ying Leung

doi : 10.1111/1756-185X.14474

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Calprotectin in psoriatic arthritis: Inflammation and beyond

Jin-Xian Huang, Yung-Heng Lee, Meng-Yu Ko, James Cheng-Chung Wei

doi : 10.1111/1756-185X.14470

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Vitamin D�A prominent immunomodulator to prevent COVID-19 infection

Sumel Ashique, Kirti Gupta, Gaurav Gupta, Neeraj Mishra, Sachin Kumar Singh, Sheetu Wadhwa, Monica Gulati, Harish Dureja, Flavia Zacconi, Brian G. Oliver, Keshav Raj Paudel, Philip M. Hansbro, Dinesh Kumar Chellappan, Kamal Dua

doi : 10.1111/1756-185X.14477

COVID-19 remains a life-threatening infectious disease worldwide. Several bio-active agents have been tested and evaluated in an effort to contain this disease. Unfortunately, none of the therapies have been successful, owing to their safety concerns and the presence of various adverse effects.

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Are Janus kinase inhibitors safe and effective in treating the key clinical domains of psoriatic arthritis? A systematic review and meta-analysis

Patricia Harkins, Eoghan Burke, Catherine Swales, Alan Silman, Richard Conway

doi : 10.1111/1756-185X.14447

Psoriatic arthritis (PsA), is a complex inflammatory arthropathy with a heterogenous spectrum of disease presentation.

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The impact of nail psoriasis on disease activity, quality of life, and clinical variables in patients with psoriatic arthritis: A cross-sectional multicenter study

Gizem Cengiz, Kemal Nas, YaÅŸar Keskin, Erkan Kılıç, Betül Sargin, Sevtap Acer Kasman, Hakan Alkan, Nilay Sahin, Nihan Cüzdan Balta, Ä°lknur Albayrak Gezer, Dilek Keskin, Cevriye MülkoÄŸlu, Hatice ReÅŸorlu, Åžebnem Ataman, Ajda Bal, Merve Baykul, Mehmet Tuncay Duruöz, Okan KüçükakkaÅŸ, Ozan Volkan Yurdakul, Meltem Alkan MelikoÄŸlu, Fikriye Figen Ayhan, Hatice Bodur, Mustafa ÇaliÅŸ, Erhan Çapkin, Gül Devrimsel, Kevser Gök, Sami Hizmetli, Ayhan Kamanlı, Hilal Ecesoy, Ã–znur Kutluk, Nesrin Åžen, Ã–mer Faruk Åžendur, Ä°brahim TekeoÄŸlu, Murat Toprak, Sena Tolu, Tiraje Tuncer

doi : 10.1111/1756-185X.14442

Nail involvement is common in psoriatic arthritis. This study assesses clinical characteristics, nail psoriasis prevalence, and impact of nail psoriasis on disease activity in patients with psoriatic arthritis (PsA).

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Two clusters of systemic lupus erythematosus patients with muscle involvement in a Chinese cohort

Liling Zhao, Wenyan Huang, Haiting Wang, Jie Chen, Danting Zhang, Xiaodong Wang, Fangfang Sun, Shuang Ye

doi : 10.1111/1756-185X.14443

This study aimed to depict the clinical features, including myositis specific or associated antibody (MSA/MAA) profile of systemic lupus erythematosus (SLE) patients with muscle involvement in a Chinese cohort.

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Management of patients with low back pain admitted to hospital: An observational study of usual care

Alla Melman, Chris G. Maher, Chris Needs, Bethan Richards, Eileen Rogan, Min Jiat Teng, Gustavo C. Machado

doi : 10.1111/1756-185X.14449

Knowledge gaps exist around diagnostic and treatment approaches for patients admitted to hospital with low back pain.

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Screening of key biomarkers in osteoporosis: Evidence from bioinformatic analysis

Hao Chen, Shaoshuo Li, Jianwei Wang, Yong Ma, Heng Yin

doi : 10.1111/1756-185X.14450

To analyze the expression characteristics of osteoporosis-related genes by bioinformatics and elucidate the pathogenesis of osteoporosis.

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Casticin promotes osteogenic differentiation of bone marrow stromal cells and improves osteoporosis in rats by regulating nuclear factor-κB/mitogen-activated protein kinase

Dong Zhang, Xuejia Li, Jianmin Li, Wanxin Liu, Ying Yu, Shuqiang Wang, Xiaojian Ye

doi : 10.1111/1756-185X.14451

Osteoporosis has influenced millions of people, especially postmenopausal women, which has become a big burden to the whole world. Although the diverse roles of casticin (CAS) on different diseases were identified, whether it was implicated with osteoporosis was unknown.

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Protein arginine methyltransferase 1 upregulates matrix metalloproteinase-2/9 expression via Zeste Homolog 2 to promote human rheumatoid arthritis fibroblast-like synovial cell survival and metastasis

Juan Liu, Yongsheng Li, Zhen Jiang, Yan Liu, Zhongcheng Wei

doi : 10.1111/1756-185X.14454

To explore the role of protein arginine methyltransferase 1 (PRMT1) in the development of rheumatoid arthritis (RA).

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Medications impact different aspects of the quality of life of patients with systemic lupus erythematosus

Khai Pang Leong, Joyce Ching-Wen Tan, Bernard Yu Hor Thong, Tsui Yee Lian, Ee Tzun Koh, Kok Ooi Kong, Weng Giap Law, Hiok Hee Chng, Grace Yin Lai Chan, Faith Li-Ann Chia, Justina Wei Lynn Tan, Hwee Siew Howe, The Tan Tock Seng Hospital (TTSH) Lupus Study Group

doi : 10.1111/1756-185X.14446

In this real-world observational study, we analyzed the effects of different drugs on the quality of life (QoL) of patients with systemic lupus erythematosus (SLE).

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Lower injection-site reactions and long-term safety, immunogenicity, and efficacy of etanercept biosimilar YLB113: Results from a post-hoc analysis of a double-blind, randomized, phase III comparative study and its open-label extension in patients with rheumatoid arthritis

Hisashi Yamanaka, Yoshiya Tanaka, Toshihiko Hibino, Gopalakrishnan Unmesh, Chirag Shah, Dhananjay Bakhle, Dimitris Stefanidis

doi : 10.1111/1756-185X.14462

YLB113 biosimilar was evaluated in an open-label extension single-arm study to assess long-term safety, efficacy, and immunogenicity in patients with rheumatoid arthritis (RA). We also report post-hoc results on the incidence of injection-site reactions (ISRs) and injection-site erythema (ISE) from a phase III study.

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Polydatin protects against gouty nephropathy by inhibiting renal tubular cell pyroptosis

Xingliang Shi, Lili Zhuang, Zeqing Zhai, Yi He, Erwei Sun

doi : 10.1111/1756-185X.14463

To investigate the protective effect and mechanism of polydatin (PD) against gouty nephropathy (GN) in mice.

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Risk-associated single nucleotide polymorphisms of mitochondrial D-loop mediate imbalance of cytokines and redox in rheumatoid arthritis

Jingnan Zhang, Jingjing Zhang, Ruixue Lai, Chenxing Peng, Zhanjun Guo, Cuiju Wang

doi : 10.1111/1756-185X.14465

We have identified rheumatoid arthritis (RA) risk-associated single nucleotide polymorphisms (SNPs) in the mitochondrial displacement loop (D-loop) including the major alleles of nucleotides 195T/C, 16260C/T, and 16519C/T as well as the minor alleles of nucleotides 146T/C and 150C/T previously.

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Construction and comprehensive analysis of the biological network related to rheumatoid arthritis-related interstitial lung disease

Wei Zhou, Xianghui Ma, Xiaodong Jia, Juan Zheng, Lili Yan, Yanfa Fu

doi : 10.1111/1756-185X.14466

Interstitial lung disease (ILD) is a severe manifestation of rheumatoid arthritis (RA), which is characterized by low survival time post-diagnosis. Thus, it is important to explore the role of gene regulation related with ILD.

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Lesion probability map in cerebral vein thrombosis due to Behçet's disease

Ahmed Serkan Emekli, Faruk UÄŸur DoÄŸan, Tuncay Gündüz, Mine Sezgin, Esme EkizoÄŸlu, Nilüfer YeÅŸilot, OÄŸuzhan Çoban, GülÅŸen Akman, Murat Kürtüncü

doi : 10.1111/1756-185X.14455

Behçet's disease (BD) is a multisystemic inflammatory disease. Cerebral venous sinus thrombosis (CVST) is the second most common form of neuro-BD after parenchymal central nervous system involvement.

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Gouty sacroiliitis: A case report of an often-overlooked cause of inflammatory back pain

Qi-Hong Guo, Jun-Guang Lu, Bao-Lin Zheng, Ting Li, Shih-Hsuan Chen

doi : 10.1111/1756-185X.14438

Gout is a chronic disease caused by monosodium urate crystal deposition, typically affecting the big toe, midfoot, and ankle. As it rarely involves the sacroiliac joints, it could be easily misdiagnosed as spondylarthritis.

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Favorable pregnancy outcomes in two patients with systemic lupus erythematosus treated with belimumab

Si-Ru Wei, Zhen-Zhen Zhu, Jia Xu, Han-You Mo

doi : 10.1111/1756-185X.14445

Systemic lupus erythematosus (SLE) is associated with poor pregnancy outcomes and complications. Belimumab can significantly improve disease activity in patients with SLE. However, there is insufficient evidence to prove the absolute safety of belimumab treatment during pregnancy.

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Rheumatoid arthritis and Hailey-Hailey disease treated with methotrexate

Beatriz Mestre, Jorge Garcia, João Madruga Dias

doi : 10.1111/1756-185X.14456

We report a rare case of long-standing Hailey-Hailey disease in a Caucasian Portuguese 69-year-old woman, recently diagnosed with rheumatoid arthritis. The patient's skin lesions remained active and exudative despite topical and oral treatments with corticosteroids, tetracyclines, antifungals, and oral treatment with azathioprine.

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Case report: Successful treatment with tofacitinib and colchicine in a patient with Schnitzler syndrome

Man Li, Yu-Wen Chen, Amy Shen, Yong-Xin Xie, Yonglan Wu, Xianlin Zeng, Pui-Ying Leong

doi : 10.1111/1756-185X.14457

We report a case of late-onset Schnitzler syndrome successfully treated with Janus-activated kinase (JAK) inhibitors and colchicine. Schnitzler syndrome should be considered for recurrent chronic urticaria when accompanied by fever, fatigue, rapid weight loss, and poor response to antihistamine treatment.

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Scanning before injection for costochondritis: A case report of ultrasound imaging of Hodgkin's lymphoma with chest wall invasion

Wei-Ting Wu, Felice Galluccio, Ting-Syuan Lin, Ke-Vin Chang, Levent Özçakar

doi : 10.1111/1756-185X.14464

Non-traumatic costochondritis, which manifests as pain and tenderness over the anterior chest wall, may be associated with inflammatory arthritis affecting the upper costochondral and sternocostal joints.

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Reactive synovitis of the knee joint and COVID-19 vaccination: Commentary

Won Sriwijitalai, Viroj Wiwanitkit

doi : 10.1111/1756-185X.14461

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Response to commentary: Reactive synovitis of the knee joint and COVID-19 vaccination

Eliska Vanaskova, Tomas Novotny

doi : 10.1111/1756-185X.14459

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Generalizability of splint therapy for temporomandibular joint disorders in the era of precision medicine

Shu-Hao Hsu, Wei-Wei Liu, Yung-Heng Lee, Kevin Sheng-Kai Ma

doi : 10.1111/1756-185X.14468

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Comment on fecal calprotectin as a biomarker of microscopic bowel inflammation in patients with spondyloarthritis

Allen Pai, Yung-Heng Lee, Meng-Yu Ko, Po-Ku Chen

doi : 10.1111/1756-185X.14460

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Answer to “comment on fecal calprotectin as a biomarker of microscopic bowel inflammation in patients with spondyloarthritis�

Júlia Faria Campos, Gustavo Gomes Resende, Maria de Lourdes Abreu Ferrari

doi : 10.1111/1756-185X.14458

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Letter to the editor regarding “urate-lowering therapy for patients with gout on hemodialysis�

Yung-Shun Tsai, Yung-Heng Lee, Meng-Yu Ko

doi : 10.1111/1756-185X.14469

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