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The development of acne vulgaris due to face masks during the pandemic, risk awareness and attitudes of a group of university students
Ayşe Tunçer Vural MD
doi : 10.1111/jocd.15120
Recent work conducted with healthcare workers and middle-aged populations has recognized the association between acne vulgaris (AV) and mask-wearing.
An application of AR in cosmetological industry after coronavirus disease-19 pandemic
Yoo Jung Seo MA, Ki Han Kwon PhD
doi : 10.1111/jocd.15222
The consumption pattern in the beauty Industry has been changed due to the coronavirus disease-19 (COVID-19) crisis. As hygiene issues were raised, non-face-to-face communication was emphasized, and within this framework, the use of augmented reality (AR) emerged as one of the hottest topics in the industry.
A cross-sectional study on the use of big data for the past H1N1 influenza epidemic in obesity after COVID-19: Focused on the body slimming cream and leptin via DTC gene test
Jinkyung Lee MS, Ki Han Kwon PhD
doi : 10.1111/jocd.14585
Based on the big data of 2010, 2011, and 2012, when H1N1 influenza was prevalent around the world in the past, this study investigated the obesity rate, weight change, and dietary methods of Korean dieters based on the historical situation of the past H1N1 influenza epidemic in Republic of Korea.
Papular skin reaction after the administration of the Ad26Cov2-S vaccine
Antonella Tammaro MD, PhD, Ganiyat Adenike Ralitsa Adebanjo MD, Francesca Romana Parisella MD, Verdiana Zollo MD, Michele Pezza MD, Gabriella De Marco MD, PhD
doi : 10.1111/jocd.15224
Cutaneous adverse events following the inactivated and mRNA COVID-19 vaccines: Correspondence
Pathum Sookaromdee PhD, Viroj Wiwanitkit MD
doi : 10.1111/jocd.15278
Cutaneous reactions following booster dose of COVID-19 mRNA vaccination: What we should know?
Luca Potestio MD, Alessia Villani MD, Gabriella Fabbrocini MD, Fabrizio Martora MD
doi : 10.1111/jocd.15331
Current therapeutic insights regarding problematic fingernails and toenails in the Republic of Korea
Soo Jin Lee MS, Ki Han Kwon PhD
doi : 10.1111/jocd.14384
Problematic nails and toenails are infected by germs and increasingly have many causes.
Insulin resistance and idiopathic hirsutism: A systematic review, meta-analysis, and meta-regression
Mina Amiri PhD, Leila Mahmoudieh MD, Ali Sheidaei PhD, Aida Fallahzadeh MD, Fahimeh Ramezani Tehrani MD
doi : 10.1111/jocd.15070
This study aimed to evaluate the Standardized Mean Difference (SMD) of insulin resistance parameters in women with IH, compared to healthy and polycystic ovary syndrome (PCOS) controls.
Complementary and integrative remedies in the treatment of chronic pruritus: A review of clinical trials
Mohammad Mahdi Parvizi MD, PhD, MPH, Mohammad Hossein Salami MD, Arezoo Moini Jazani MD, PhD, Rojan Javaheri MD, Amir Mohammad Jaladat MD, PhD, Farhad Handjani MD
doi : 10.1111/jocd.15094
Chronic pruritus is one of the most common conditions in dermatology and a common manifestation in many systemic diseases.
Update on pharmacology, actions, dosimetry and regimens of oral glucocorticoids in dermatology
Kabir Sardana MD, DNB, MNAMS, Soumya Sachdeva MD, DNB
doi : 10.1111/jocd.15108
Glucocorticoids are arguably the most widely used and misused drug in dermatology. There have been recent updates in its mode of action which can impact on its judicious use.
Drug delivery of natural products through nano-carriers for effective vitiligo therapy: A compendia review
Abdul Qadir Ph.D, Shehla Nasar Mir Najib Ullah Ph.D, Samreen Jahan M. Pham, Asad Ali M. Pham, Nausheen Khan M. Pham
doi : 10.1111/jocd.15158
Vitiligo is a depigmenting illness that causes white areas on the skin. Vitiligo's pathogenetic genesis is based on the melanocyte's autoimmune destruction, in which oxidative stress causes melanocyte molecular, organelle, and exposure of antigen, as well as melanocyte cell death, and so plays a role in vitiligo progression.
Minimally invasive procedures for the management of female pattern hair loss
Daniel Fernandes Melo MSc, MD, Rita Fernanda Cortez de Almeida MD, Simone Carolina Frattini MSc, MD, Leopoldo Duailibe Nogueira Santos MD, Paulo Müller Ramos PhD, MD
doi : 10.1111/jocd.15160
Female Pattern Hair Loss (FPHL) is one of the most common types of hair loss in women. It is characterized by progressive follicular miniaturization leading to diffuse hair thinning over the midfrontal scalp with a negative impact on quality of life.
Plant polyphenols as green sunscreen ingredients: A systematic review
Shin Yi Ng BSc, Vicit Rizal Eh Suk PhD, Lai Ti Gew PhD
doi : 10.1111/jocd.15170
Excessive exposure to ultraviolet radiation has harmful effects on human skin. At present, synthetic and mineral types of sunscreens used to protect against these harmful damages have been reported to cause negative health and environmental effects.
Current status and development potential of scalp healthcare in the COVID-19 blue era: A critical review focused on Republic of Korea
Eun Jung Shin MA, Ki Han Kwon PhD
doi : 10.1111/jocd.15196
The purpose of this paper was to review the literature focusing on the scalp health of the Korean people in the COVID-19 blue era and the possibility of significant development as an academic.
Surgical repair for deformities of the nail unit
Fang Li MD, Xiao-Qing Wang MD, Meng-Xi Liu MD, Hoi-Shiwn Wong MD, Zhen-Ru Liu MD, Yuan Zhou MD, Da-Guang Wang MD
doi : 10.1111/jocd.15198
The nail apparatus is the largest and most complex skin appendage. Defects in this unit can result in significant functional insufficiency and cosmetic disfigurement.
Herbal nanocosmecuticals: A review on cosmeceutical innovation
Purva Vaishampayan MPharm, Meenal M. Rane PhD
doi : 10.1111/jocd.15238
Cosmeceuticals are drugs, cosmetics, or a combination of both. Cosmeceuticals are personal care products that not only beautify but also need to have healing, therapeutic, and disease-fighting characteristics.
Research trends and hotspot analysis of fractional carbon dioxide laser: A bibliometric and visualized analysis via Citespace
Boya Zou BM, Wenyue Zheng BM, Hongju Pan BM, Bin Yang MD, PhD, Zhenfeng Liu MD, PhD
doi : 10.1111/jocd.15267
There is limited basic research on carbon dioxide (CO2) fractional laser, indicating blind spots in CO2 fractional laser treatment of certain diseases. This study aimed to organize previous literature, summarize the current research, and speculate on possible future development.
The efficacy and safety of fractional lasers for alopecia in mono and adjunctive therapy: A systematic review and meta-analysis
Ye-Lin Gao, Yuan Zhang, Jing-Cao Zheng, Yan-Ling Li MD
doi : 10.1111/jocd.15293
Hair loss is affecting over half of the population worldwide, leading to noticeable psychotic disorders in a considerable proportion of patients. The current treatments remain unpredictable and disappointing.
Natural results of scalp micropigmentation: A review
Jae Hyun Park MD PhD, Yeh Hong Ho MD, Kotchamol Manonukul MD
doi : 10.1111/jocd.15297
Scalp micropigmentation has developed rapidly in recent years to the extent that it is now considered a major means of hair loss treatment along with medication and hair transplantation.
Review of the literature on the efficacy and safety of a new cosmetic topical treatment containing Pistacia lentiscus and hyaluronic acid for the treatment of nail plate damages
Michela Starace PhD, Corinne Granger MD, Miriam Anna Carpanese MD, Aurora Alessandrini PhD, Francesca Bruni MD, Bianca Maria Piraccini PhD
doi : 10.1111/jocd.15302
The objective of our study is the review of the literature on the efficacy and safety of a novel water-soluble nail strengthened (WSNS) containing hyaluronic acid and Pistacia lentiscus used for the improvement of nail plate diseases.
Topical cetirizine for treating androgenetic alopecia: AÂ systematic review
Xiaomei Chen MD, Hongmei Xiang BSN, Ming Yang MD
doi : 10.1111/jocd.15309
Cetirizine, a widely used agent for allergic disorders, has recently been topically used for treating androgenetic alopecia (AGA). We aimed to summarize the current evidence regarding the effectiveness and safety of topical cetirizine for treating AGA.
Comprehensive review of oral minoxidil in alopecia
Jay D. Modha MD, Yashdeep Singh Pathania MD
doi : 10.1111/jocd.15324
There have been various treatment modalities available for alopecia in the form of topical and systemic with a variable response. The compliance of the patients is important in reaping results in alopecia. Minoxidil has come a long-way finding its use from topical formulations to systemic at lower dose in different alopecia.
Systemic immunotherapy for the treatment of warts: AÂ literature review
Ghada Farouk Mohammed MD, Mohammed Saleh Al-Dhubaibi MD, Saleh Salem Bahaj MD, Ahmed Ibrahim Abd Elneam MD
doi : 10.1111/jocd.15330
Immunotherapy has emerged as a critical therapeutic tool for the treatment of warts. Immunotherapy for warts is currently restricted to recalcitrant lesions. A small number of regimens appear to be extremely effective. Furthermore, there is a scarcity of evidence-based research.
Clinical commentary about foreign body complications over 20 years after polymethyl-methacrylate face implants and control of late sequelae with Polynucleotides Highly Purified Technology (PN-HPT®)
Isabella Pia Palmieri MD, Mauro Raichi MD
doi : 10.1111/jocd.14950
Mainly in the past, foreign body complications, including granuloma, were pretty frequent after semi-permanent polymethyl-methacrylate (PMMA) implants.
Algorithm proposal for hair transplantation in fibrosing alopecia pattern distributidon
Alba Gómez-Zubiaur MD, Cristian Valenzuela MD, Juan José Andrés-Lencina MD, Ana RodrÃguez-Villa MD, Jose MarÃ�a Ricart MD
doi : 10.1111/jocd.15124
Fibrosing alopecia pattern distribution (FAPD) is a recently described disease, wherein the clinical, trichoscopic, and histologic characteristics of non-scarring alopecia, such as androgenic alopecia, and lichenoid inflammatory cicatricial alopecia are reported.
Dupilumab for alopecia areata treatment: A double-edged sword?
Peng Jin MD, Li Wei BS, Qinqin Zhang MSc, Tingting Gao BS, Jianxue Bai MSc, Liang Dong MD, Lili Zhi MSc
doi : 10.1111/jocd.15136
Alopecia areata (AA), which is a common and inflammatory hair loss and one of the most frequent dermatological conditions with higher incidence worldwide, the complex interplay involved multiple factors was contributed to the pathogenesis that consists of immune privilege losing and destruction with autoimmune-mediated in hair follicle also the abnormal regulation of inflammatory pathways was highlighted, although it was remained unclear to date.(J Am Acad Dermatol, 78, 2018, 1) Some treatment options for AA were proposed with great advances in recent years, but the options and efficacy were limited, such as platelet-rich plasma, JAK–STAT inhibitor, PDE4 inhibitor, and others, also the good response with regrow hair of cytokine-targeted therapy like dupilumab, ustekinumab was shown.(
Liquid vitamin E injection for cosmetic facial rejuvenation: A disaster report of lipogranuloma
Bahareh Abtahi-Naeini M.D, Fereshte Rastegarnasab M.D, Ali Saffaei Pharm.D, BCCP
doi : 10.1111/jocd.15294
The use of vitamin E for Facial rejuvenation is a dangerous practice and is associated with potential local, and sometimes systemic and life-threatening complications. Clinicians should be aware of complications induced by the injection of illegal products for tissue augmentation. Also, regulatory organizations should monitor illegal beauty centers and enact restrictive laws.
Ultrasonographic observation of the masseter muscle after injection of different botulinum toxin type A
Zhujun Li MD, Zirong Li BN, Yunzhu Li MD, Ruijia Dong MD, Cheng Chen MD, Jiuzuo Huang MD, Zenan Xia MD, Nanze Yu MD, Xiao Long MD
doi : 10.1111/jocd.15106
Botulinum toxin type A (BoNT-A) injection is a popular cosmetic procedure in East Asian countries, and there are multiple types of toxins on the market. Whether different toxin types induce different changes in the masseter has not been studied.
Sterile abscess due to hyaluronic acid: A new diagnosis and a proposal for treatment-A series of eight cases
Gabriela Munhoz MD, Fernanda Aquino Cavallieri MD, Laila Klotz de Almeida Balassiano MD, Maria Fernanda Tembra MD, José Marcos T. Cunha MD, PhD, Alessandro C. O. Silveira MD, Marcos Vinicius Rust Moreira MD, Marcia Ramos-e-Silva MD, PhD
doi : 10.1111/jocd.15135
In recent years, fillers procedures with hyaluronic acid (HA) have grown significantly. Despite HA relative safety, the number of cases of complications after injections has grown, and in many of which, we are not aware of or have little control over.
Safety of the inferolateral orbital access for filling the temporal region with the fanning technique
Gladstone Eustaquio de Lima Faria MD, Alyne Queiroga Bastos MD, Clarissa L. Vilela MD, Luciana Zattar MD, Ricardo Frota Boggio MD, PhD
doi : 10.1111/jocd.15146
The anatomical complexity of the temporal region makes it so treatments with fill-ins are challenging due to high vascular risk. Techniques which provide safer procedures must be encouraged.
A split-face comparative performance evaluation of injectable hyaluronic acid-based preparations HCC and CPM-HA20G in healthy females
Aletta de Wit MD, Pieter S. Siebenga MD, PhD, Ruscha W. Wijdeveld, Petra C. Koopmans PhD, Jani A. J. van Loghem MD, PhD
doi : 10.1111/jocd.15157
Skin revitalizers are used for skin quality improvement purposes. Hyaluronan hybrid cooperative complexes (HCC, Profhilo®, IBSA Pharmaceuticals) are an anti-aging treatment with a large amount of pure hyaluronic acid (HA) based on stable, cooperative, and hybrid complexes.
A study of combination unilateral subcutaneous botulinum toxin a treatment for androgenetic alopecia
Kai Tian MD, Suyue Gao MD, Zou Jia MD, Wushuang Xu MD, Ke Li PhD, Lijun Wu PhD
doi : 10.1111/jocd.15179
To observe the efficacy of unilateral subcutaneous injection of botulinum toxin A combined with finasteride and minoxidil in the treatment of androgenic alopecia.
Types of periocular wrinkles based on anatomical and contractile characteristics of participating periocular muscles: A modified classification method and personalized injection technique
Yilin Li MD, Lei Cai MD, PhD, Xinyu Zhang MD, Bo Yin MD, PhD, Xi Gong DDS, Facheng Li MD, PhD, Xuefeng Han MD, PhD
doi : 10.1111/jocd.15197
Clinical classification methods for periocular wrinkles based on participating muscle behavior are lacking, and traditional treatment lacks detailed and individualized methods.
Microneedle delivery of botulinum toxin type A combined with hyaluronic acid for the synergetic management of multiple sternal keloids with oily skin: A retrospective clinical investigation
Shunuo Zhang BS, Yuan Peng MD, Hua Fan MD, Yixin Zhang PhD, MD, Peiru Min MD
doi : 10.1111/jocd.15216
For the treatment of sternal keloids, corticosteroid therapy has side effects including abnormal sebum secretion and acne.
Lipoteichoic acid and molecular weight of hyaluronic acid could explain the late inflammatory response trigger by hyaluronic acid fillers
Marta Moran MD, Francisco Nieto-Lopez PhD, Javier Rueda-Carrasco PhD
doi : 10.1111/jocd.15243
Hyaluronic acid is a safe dermal filler, but sometimes late granuloma is generated. This adverse effect is an inflammatory process, and its causes are not clear.
Five-point liquid rhinoplasty: Results from a retrospective analysis of a novel standardized technique and considerations on safety
Leonard Nenad Josipovic MD, Sonja Sattler MD, Thilo L. Schenck MD, Gerhard Sattler MD
doi : 10.1111/jocd.15326
Nonsurgical aesthetic improvement of the nose with hyaluronic acid (HA) fillers is becoming increasingly popular but comes with important safety considerations.
Dynamic ultrasound evaluation of body fillers and biostimulators in the buttocks of fresh-frozen specimen
Rosa M. Sigrist MD, Maria Gabriela Ortiz de Noronha MD, Shirley Schnaider Borelli MD, Solange Pistori Teixeira PhD, MD, Hamilton Luiz Xavier Funes PhD, MD, Luciana M. Lourenço PhD, MD
doi : 10.1111/jocd.15333
Ultrasound imaging is a useful tool to study the injection of fillers and biostimulators in the body.
2940-nm erbium:YAG laser versus 980-nm diode laser in the treatment of multiple seborrheic keratoses: A prospective comparative randomized study
Mai Abdelraouf Osman MD
doi : 10.1111/jocd.15096
Seborrheic keratoses (SKs) are the most common benign epithelial tumors encountered in clinical practice. Complications associated with traditional treatments of SKs urge the scientists to seek alternative treatment modalities.
Efficacy and safety of combined fractional ablative CO2 laser and 5 fluorouracil in the treatment of acral vitiligo: An open, uncontrolled study
Ragia Weshahy MD, Mahmoud F. Abdelhamid MD, Khadiga S. Sayed MD, Eman D. El Desouky MD, Shahenda A. Ramez MD
doi : 10.1111/jocd.15116
Acral lesions of vitiligo are most likely recalcitrant to the known lines of treatment. Ablative fractional CO2 has shown efficacy in treatment of vitiligo in combination with other modalities.
Efficacy of alpha hydroxy acid combined with intense pulsed light in the treatment of acne vulgaris: A meta-analysis
Qiao Huang MD, Dongyu Chen MD, Suyue Pan MD, Min Hu MD, Pu Wang MD, Hongxin Wang MD, Wenlong Fan MD, Xiaoyu Yang MD, Yuqing He PhD
doi : 10.1111/jocd.15186
Acne patients frequently receive combination therapy. However, there has been no rigorous review of the efficacy of combining alpha hydroxy acid with IPL for acne vulgaris treatment.
Endo-Radiofrequency subcision for acne scars treatment: AÂ case series study
Mohammad Ali Nilforoushzadeh MD, Maryam Heidari-Kharaji PhD, Tannaz Fakhim MD, Elham Torkamaniha PhD, Maryam Nouri MD, Shohreh Rafiee MD, Masoumeh Roohaninasab MD, Elham Behrangi MD, Fariba Jaffary MD
doi : 10.1111/jocd.15195
Acne scars have important psychosocial suffering for patients. Several interventions have been utilized to treat acne scars that have different degrees of efficacy and side effect.
Non-invasive system delivering microwaves energy for unwanted fat reduction and submental skin tightening: Clinical evidence
Benedetta Salsi MD, Irene Fusco PhD
doi : 10.1111/jocd.15205
Cervicomental contour represents an important aesthetic problem.
Effects of microneedling with 5% minoxidil topical solution combination therapy in treatment of androgenetic alopecia
Lingling Jia MD, Jiachao Xiong MD, Rong Guo MD, Yufei Li MD, Hua Jiang MD
doi : 10.1111/jocd.15263
Microneedling (MN) therapy is one of minimal invasive operations with needles rolled over skin to puncturing the epidermis, and it is becoming a widely used treatment during various dermatological diseases includes androgenetic alopecia (AGA).
Combination radiofrequency microneedling and carbon dioxide laser for acne scarring: A systematic review and retrospective case series across two centers
Rishi Mandavia MSc, Massimiliano Cariati PhD, Sepideh Shahidi BSc, Cheka Spencer MSc, Michael Somenek MD, Tatiana Lapa MSc
doi : 10.1111/jocd.15276
Combination radiofrequency (RF) microneedling with fractional ablative carbon dioxide (CO2) laser is a new approach for acne scar treatment. Aims: (1) to systematically review the literature on the safety and effectiveness of this treatment for acne scarring; (2) to assess safety and effectiveness in a 2-center case series.
Microneedling with cutaneous delivery of topical agents for the treatment of melasma: A systematic review
Jenifer Brasil dos Santos BSc, Luis Phillipe Nagem Lopes BSc, Gabriela Gomes de Lima BSc, Renata Teixeira da Silva MD, Bárbara da Silva e Souza Lorca PhD, Gláucia Miranda Pinheiro MSc, Zaida Maria Faria de Freitas PhD
doi : 10.1111/jocd.15287
Melasma is an acquired hyperpigmentation disorder. Microneedling is an alternative treatment for melasma especially by improving penetration of pharmacological agents into the skin.
Low-level green laser promotes wound healing after carbon dioxide fractional laser therapy
Chengchen Gong MD, Yongzhou Lu MD, Chuanlong Jia MD, Nan Xu MD
doi : 10.1111/jocd.15298
The carbon dioxide (CO2) fractional laser resurfacing has become one of the hottest therapies for dermatoses.
Endolift laser as new non-surgical technique for nose remodeling
Elaheh Lotfi MD, Najmeh Ahramiyanpour MD, Somayeh Khosravi MD, Bahareh Salehi MD, Dirk Gröne MD
doi : 10.1111/jocd.15303
In the last few years, facial rejuvenation has moved to less invasive or non-surgical techniques because their effects are visible immediately after the treatment, they have shorter recovery time and less pain and patients can go back to their normal life on the same day.
Treatment of sensitive skin by short-wave radiofrequency combined with intense pulsed light
Tingting Jin MD, Lei Pan MD, Ye Zhao MD, Sufan Wu PhD, Yi Sun PhD
doi : 10.1111/jocd.15322
Sensitive skin is a widespread dermatologic condition, and no optimal treatments have been established so far.
Efficacy of a retinoid complex plus anti-inflammatory component cream alone or in combination with prebiotic food supplement in adult acne: A randomized, assessor-blinded, parallel-group, multicenter trial on 184 women
Jana Kazandjieva MD, Jenya Dimitrova MD, Marina Sankeva MD, Daniel Yankov MD, Valeria Bocheva MD, Kamelia Kircheva MD, Veronika Gincheva MD, Klimentina Gospodinova MD, Reni Andasorova MD, Maya Milanova MD, Denitsa Jeleva MD, Petya Zlateva MD, Irida Vasileva MD, Rumyana Yankova MD, Svetlana Gotseva MD, Tsvetelina Dakova MD, Emiliya Zografova MD, Sonya Marina MD, Marieta Kateva MD, Valentina Broshtilova MD, Violina Todeva MD, Nikolay Tsankov MD, Zlatka Mitova MD, Natalia Boyanova MD, Massimo Milani MD
doi : 10.1111/jocd.15074
Adult female acne (AFA) nowadays is a very common skin condition affecting mainly women aged between 25 and 40. The treatment of AFA could be challenging.
Clinical observation and evaluation of CGF in the treatment of androgenic alopecia
Fangning Zhao MD, Lijun Hao MD, Xiaolei Jin MD
doi : 10.1111/jocd.15109
To evaluate the efficacy of concentrated growth factor (CGF) injections in patients with androgenic alopecia.
Effects of a grapeseed oil (Vitis vinifera L.) loaded dermocosmetic nanoemulgel on biophysical parameters of facial skin: A split-face, blinded, placebo-controlled study
Ramzi Shawahna PhD
doi : 10.1111/jocd.15161
Worldwide, grapes (Vitis vinifera L.; family: Vitaceae) are one of the most important fruits. Grapeseed oil is rich in bioactive constituents that could be beneficial to the health and aesthetic features of human skin.
Pigmentation control in pregnancy-induced melasma: Clinical assessment of a non-hydroquinone, non-retinol pigment-correcting serum
Elizabeth T. Makino BS, CCRA, MBA, Lily I. Jiang PhD, Thomas J. Stephens PhD, Mouna Mikati PhD, Rahul C. Mehta PhD
doi : 10.1111/jocd.15165
Melasma is an acquired disorder that results in irregular brown patches on the skin that can occur due to hormonal changes. Although pregnancy-induced melasma is usually temporary, it can become a chronic condition, with significant negative impact on quality of life (QoL).
Effect of facial application of essence containing royal jelly extract on stratum corneum moisture content: A placebo-controlled, double-blind, parallel-group study
Yuka Maeda MSc, Chizuru Fujikura MSc, Takashi Asama MSc, Masayuki Yagi BS, Nobuaki Okumura PhD, Ayanori Yamaki MSc, Akio Ohkuma MSc, Kayoko Numano MD
doi : 10.1111/jocd.15168
To evaluate the moisturizing function and other effects of royal jelly extract on the skin. The effects of applying an essence containing royal jelly extract on the skin of healthy Japanese males and females were examined.
Efficacy and safety of topical hydrogen peroxide 35% solution versus cryotherapy in the treatment of senile lentigo
Zohreh Tehranchinia MD, Fahimeh Salehi MD, Ghazal Zoghi MD, Reza M. Robati MD
doi : 10.1111/jocd.15174
Senile lentigines (SLs) are hyperpigmented macules that predominantly affect the elderly. We aimed to compare the efficacy and safety of hydrogen peroxide35% solution with cryotherapy in the treatment of SLs.
An open-label, 4-week, prospective clinical study evaluating the efficacy and safety of a novel targeted skin care line addressing five common skin conditions
Nikolaus Duschek MD, PhD, Mia Cajkovsky, Valentina Prinz MBA, Daniel Müller MD, Andrea Hundsamer MSc, Andreas Baierl MD, Nicholas Möllhoff MD, Monika Sulovsky MD, Konstantin Frank MD
doi : 10.1111/jocd.15223
Common skin conditions, such as irritated, dry, aging, and oily skin or dark eye circles with periorbital edema, usually do not require pharmaceutical therapy in form of dermatological drugs.
Efficacy and tolerability of a novel skin cream for improving periocular rhytids and dryness
Jacqueline M. Calkin MD, Alison A. Boudreaux MD, Barbara Taylor BA
doi : 10.1111/jocd.15249
A novel topical cream was developed to address the appearance of aging periorbital skin. The goal of this study was to evaluate the efficacy and tolerability of this product (Total Eye® Firm & Repair Cream; Colorescience, Inc., Carlsbad, CA) for improving periorbital wrinkles, dryness, laxity, and dark circles.
Clinical, dermoscopic, and histopathologic evaluation of topical methotrexate 1% hydrogel versus topical Calcipotriol 0.005% cream in the treatment of plaque psoriasis
Maha A. El Gayar MD, Dina Atwa MD, Germeen Girgis MD, Lamees Marie MBBCh
doi : 10.1111/jocd.15285
Psoriasis Vulgaris is a common immune-mediated skin disease. Its high prevalence, disability, chronicity, disfiguration, and associated comorbidities make it a challenge for physicians. Topical agents remain the mainstay of treatment for patients with mild to moderate psoriasis.
Dermoscopic evaluation of the efficacy of combination of topical spironolactone 5% and minoxidil 5% solutions in the treatment of androgenetic alopecia: A cross sectional-comparative study
Amr M. Ammar MD, Ahmed R. Elshahid MD, Hamdy A. Abdel-Dayem MD, Ahmed A. Mohamed MBBCh, Mohamed L. Elsaie MD
doi : 10.1111/jocd.15328
Androgenetic alopecia (AGA) is a common chronic dermatological illness that affects both men and women.
Bilirubin as a new antioxidant in melasma
Hoda Rahimi MD, Mina Mirnezami MD, Anousha Yazdabadi MBBS
doi : 10.1111/jocd.15240
Oxidative stress and its role in the pathogenesis of cutaneous diseases have been widely investigated.
Effectiveness of fat grafting in scar reduction: A systematic review and meta-analysis
Xiaoyuan Zhang B.S, Guangxue Li M.D
doi : 10.1111/jocd.15067
Scar brings great physical and mental pain to patients. Fat grafting may be a new and simple way to treat scar. This review aimed to systematically evaluate the correlation between fat grafting and scar reduction.
Surgical management of facial congenital melanocytic nevi: Experiences and outcomes at an academic center
Yue Xie MD, Qiang Chen MD, Tianwu Li MD, Xionghui Ding PhD, Jun Xiao MD, Yan Liu MD, Lin Qiu PhD
doi : 10.1111/jocd.15104
Congenital melanocytic nevi (CMN), benign pigmented birthmarks caused by the mutation of melanocytic cells during embryofetal development, can cause aesthetic problem when it is located on the face.
Customized reconstruction with rotation Hemi-Keystone flap
Mahmoud A. Hifny MD, Tae Hwan Park MD, PhD
doi : 10.1111/jocd.15111
The keystone perforator flap has become a versatile alternative for reconstruction of cutaneous defects of various etiologies and in all age groups.
Roller microneedles transdermal delivery of compound lidocaine cream for enhancing the analgesic effect: A randomized self-controlled trial
Hanlin Hu MD, Lei Guo MD, Wanyue He MD, Hengshu Zhang MD, Ying Xiang BN, Xianqun Liu MN, Jing Zou MN, Xuemei Du MN, Chun Yan MN
doi : 10.1111/jocd.15114
The purpose of this article is to investigate whether the percutaneous delivery of compound lidocaine cream by roller microneedles can shorten the minimal effective onset time of anesthesia, enhance the intensity of anesthesia and prolong the analgesic time, so as to provide a theoretical basis for exploring a comfortable, safe and effective anesthesia method for photoelectric cosmetic surgery.
Clinical and dermoscopic evaluation of follicular unit transplantation vs. Mini-Punch grafting in the repigmentation of resistant and stable vitiligo: A comparative study
Mennah Mokhtar MSC, Amal Ahmad El-Ashmawy MD, Walid Ahmed Mostafa MD, Mohamed Mahmoud Gamei MD
doi : 10.1111/jocd.15127
Various surgical modalities and transplantation techniques had been evolved for the treatment of recalcitrant stable vitiligo. Each of these techniques has its own limitations and side effects. There are insufficient studies evaluating the efficacy of transplantation of hair follicle (HF) units as a surgical modality for vitiligo treatment in comparison with the classic mini-punch grafting.
The correlation between the severity of symptoms and the thickness of the fat fold in cellulite-affected areas�A pilot study
Anna KoÅ‚odziejczak PhD, Agata Jatczak MSc, Helena Rotsztejn PhD
doi : 10.1111/jocd.15129
The aim of the study was to assess the correlation between the cellulite severity and the thickness of the fat fold.
Restoration of appearance for women after aesthetic eyelash transplantation using a novel eyelash resection technique
Jian Chen MD, Bei Cui MD, Zhexiang Fan MD, Jiajing Yin MD, Qian Qu MD, Jin Wang MD, Bingcheng Liu MD, Ruosi Chen MD, Zhiqi Hu MD, PhD, Yong Miao MD, PhD
doi : 10.1111/jocd.15130
Hair transplantation based on the follicular unit extraction provides a new opportunity to improve the appearance of patients with congenital sparse eyelashes.
Applied anatomy of the layers and soft tissues of the forehead during minimally-invasive aesthetic procedures
Bruna Souza Felix Bravo MD, Raquel de Melo Carvalho MD, Lais Penedo MD, Julien Totti de Bastos MD, Mariana Calomeni Elias MD, Sebastian Cotofana MD, PhD, Konstantin Frank MD, Nicholas Moellhoff MD, Lysander Freitag MD, Michael Alfertshofer MD
doi : 10.1111/jocd.15131
An increasing demand of minimally-invasive aesthetic procedures of the forehead concomitantly leads to higher numbers of adverse events. Adequate application of anatomical knowledge is required to increase safety and efficacy of different minimally-invasive aesthetic procedures in this anatomical region.
A novel technique in reducing sebum production and improving atrophic acne scars
Punyaphat Sirithanabadeekul MD, Visanee Leetrakulwanna MD, Atchima Suwanchinda MD
doi : 10.1111/jocd.15137
Fractional microneedling radiofrequency (FMR) has gained popularity for the treatment of acne scars, owing to favorable outcomes and short downtimes. This study aimed to investigate FMR use in reducing facial sebum production and treating acne scars.
Dermoscopy as an efficient aid to diagnose pigmentary and vascular component of periorbital melanosis: A cross-sectional study
Namrata Chhabra MD, Soumil Khare MD (Dermatology), Divya Sachdev DDVL
doi : 10.1111/jocd.15141
Periorbital melanosis (POM) has a significant impact on quality of life. There is a dearth of literature regarding POM, especially in Asian population. Accurate classification of POM is contributory to the choice of therapy. The aim of this study was to assess the role of dermoscopy in etiologic classification of POM.
Dermoscopic classification of melasma: Concordance study and correlation with the melanophages count
Luciana de Abreu MD, MSc, Marcia Ramos-e-Silva MD, PhD, Leonardo Pereira Quintella MD, PhD, Alice Mota Buçard MD, Bruna Souza Félix Bravo MD, MSc, Andréia Munck de Almeida MD, Ana Carolina Martins Serra Moreira MD
doi : 10.1111/jocd.15145
Melasma is a common hypermelanosis characterized by symmetrical brownish macules, especially on the face. Histologic analysis demonstrates increased epidermal and dermal melanin. Dermoscopy is useful to estimate the depth of the melanin and may help in the diagnosis and classification of melasma, with therapeutic importance.
Oral isotretinoin versus acitretin in male patients with multiple recalcitrant common warts: A randomized, double-blinded placebo-control study
Ahmad Nofal MD, Mohamed M. Fawzy MD, Fatma Eldeeb MD, Esraa Elsayed Elhawary MD
doi : 10.1111/jocd.15173
Management of multiple recalcitrant common warts represents a therapeutic challenge. Both oral isotretinoin and acitretin have shown a promising efficacy in the treatment of various types of warts. However, a comparative study of the two medicines in wart treatment has not yet been conducted.
Hair loss treatment and restoration: Online interest trends and video-based social media content
Aditya K. Gupta MD, PhD, Deanna C. Hall PhD
doi : 10.1111/jocd.15194
Public interest in hair loss topics and treatments can be observed by examining online trends, such as those monitored by Google Trends. Social media has also gained the interest of the dermatology community.
Effect of platelet concentrate prepared by different methods on the healing of full-thickness skin defects
Liwen Huang PhD, Yunqing Dong MM, Changhui Li BS, Sheng Han BS, Biao Cheng PhD
doi : 10.1111/jocd.15204
Platelet-rich plasma and concentrated growth factors have been widely utilized in tissue regeneration. However, very few studies have focused on comparing the merits of these two materials in skin repair.
Awareness of vitiligo among multi-ethnic populations
Premjit Juntongjin MD, Sara Abouelsaad MD, Supanee Sugkraroek MD, Nimit Taechakraichana MD, Palita Lungchukiet MD, MSc, Winitra Nuallaong MD, MSc
doi : 10.1111/jocd.15211
Vitiligo is a common acquired pigmentary disorder reported worldwide. Although asymptomatic, vitiligo negatively affects the patients' quality of life because it provokes psychological stigmatization and social discrimination. There are several misconceptions regarding vitiligo.
Evaluation of efficacy of follicular unit extraction versus follicular unit extraction with platelet rich plasma in treatment of cicatricial alopecia
Ali Fouad Elariny MD, Nasser Ghozlan MD, Sherif Wasief MS, Aya Elsayed Moussa Master of Dermatology, Marwa Elsaeed Eldeeb MD
doi : 10.1111/jocd.15213
Follicular unit extraction (FUE) is a minimally invasive surgery that is becoming popular in hair restoration in cicatricial alopecia (CA).
Inflammatory complications after hair transplantation: Report of 10 cases
Sarra Saad MD, Bénédicte Cavelier-Balloy MD, Jack Smadja MD, Philippe Assouly MD, Pascal Reygagne MD
doi : 10.1111/jocd.15244
Androgenetic alopecia (AGA) is a pathology involving the aesthetic prognosis. Hair transplantation is among best treatments.
Liposuction to improve the dorsocervical fat pad in esthetic need: Anatomical study and clinical case series
Guanhuier Wang MD, Jianfang Zhao MD, PhD, Xinling Zhang MD, Shan Yang MD, Weiguang Zhang MD, PhD, Hongbin Xie MD
doi : 10.1111/jocd.15255
Patients are undergoing surgery to relieve the prominent dorsocervical fat pad because of their esthetic needs.
Retrospective study of the absorbable braided polydioxanone threads’ usefulness in the aged lower eyelids' rejuvenation
Galina Khan MD, Beom Jun Kim MD, Dong Gyu Kim MD, EunSoo Park MD, PhD
doi : 10.1111/jocd.15257
Tear trough deformity, hyperpigmentation, and skin laxity of the lower eyelid make individuals appear fatigued and elderly. Many patients prefer less invasive, cosmetic correction of the aged lower eyelid.
Brow gliding: A new non-surgical concept for almond upturned eyes
Ali Åžahan MD, Yıldıray Yeniay MD
doi : 10.1111/jocd.15275
The eyes are one of the most prominent features of the face. To date, a vast majority of procedures have been described for periorbital rejuvenation. Among them, non-surgical threading is an alternative and minimally invasive technique.
Nipple ulcers of the nipple retractor technique to correct inverted nipples: A retrospective multivariate analysis
Hairu Cao BN, Hayson Chenyu Wang MD, Wenyun Ting MD
doi : 10.1111/jocd.15281
A simple procedure using a nipple retractor to correct inverted nipples has been applied in clinical practice with stable and satisfactory aesthetic outcomes. Nipple ulceration and necrosis are rare and severe, with the causes unclear.
Purse-string suture combined with subcision and dermal graft for the treatment of wide depressed scars and boxcars
Su-Ben Tsao MD, EMBA, Cheng-Chun Wu MD, Chien-Chih Lee MD
doi : 10.1111/jocd.15291
Dermal layer injuries can result in depressed or indented scars even when there is no subcutaneous injury. These scars can result from acne, chickenpox, trauma, or skin infection.
Depth control in follicular unit excision: A new classification from a detailed analysis of 30 patients undergoing FUE technique for hair restoration
Otávio Boaventura MD, Cleber Stuque MD
doi : 10.1111/jocd.15306
In follicular unit excision (FUE), the concept of depth control (DC) has been created to minimize the risk of hair follicle damage.
The effectiveness of drugs combined with individualized management for elderly patients with stage III pressure ulcers
Rui Shao MD, TingTing Du PhD, YongQiang Zhang PhD, Yan Li MD, Qiang Zhang PhD
doi : 10.1111/jocd.15312
To explore the effect of drugs in combination with individualized management for elderly patients with stage III pressure ulcers.
A giant penis-like vulval soft fibroma in a case of external genital malformation
Jingjing Liu MS, Yanhong Wu BS, Quanxin Qu MD
doi : 10.1111/jocd.15320
Soft fibroma is a common benign skin tumour. The size varies from 1 to 10 mm, and giant soft fibromas were rare. Mostly, the appearances of soft fibromas were pedicled, filiform and papular.
Artificial intelligence in melanoma: A systematic review
Shu Zhang MD, Yuanzhuo Wang MD, Qingyue Zheng MD, Jiarui Li MD, Jiuzuo Huang MD, Xiao Long MD
doi : 10.1111/jocd.15323
Melanoma accounts for the majority of skin cancer deaths. Artificial intelligence has been applied in many types of cancers, and in melanoma in recent years. However, no systematic review summarized the application of artificial intelligence in melanoma.
Anti-bacterial effects of functional cosmetics containing silver ions (Ag+) on problematic toenails in Republic of Korea
Soo Jin Lee MS, Ki Han Kwon PhD
doi : 10.1111/jocd.14451
Problematic toenails caused by various diseases that are infected by various bacteria are discolored or deformed if left unattended for a long time are gradually increasing in modern society.
Immunohistochemical expression of Axin-2, as an implication of the role of stem cell in scar pathogenesis and prognosis
Heba A. S. Bazid MD, Rehab Monir Samaka MD, Marwa E. A. Mousa MBBCH, Iman Seleit MD
doi : 10.1111/jocd.15075
Wound healing is a multi-phased process. A disruption in these phases could result in a persistent wound or an atypical scar.
Combining the use of two non-invasive instruments to confirm that a formula can improve skin luminance while respecting constitutive melanogenesis
Romain de Dormael MA, Audrey Gueniche PhD, Philippe Bastien PhD, Michèle Verschoore MD
doi : 10.1111/jocd.15086
Skin radiance products achieve perceivable benefits with different sort of mechanism of action.
Assessment of hearing loss in patients with rosacea
Havva Hilal Ayvaz MD, Mehmet Emre Sivrice MD, Emrah Atay MD
doi : 10.1111/jocd.15089
Rosacea is not only a skin condition but a systemic inflammatory disease that includes chronic inflammation, vascular alterations, and autoimmunity in pathogenesis.
Regulators CDCA8 as potential targets and biomarkers for the prognosis of human skin cutaneous melanoma
Rong Guo MD, Jianghui Ying MD, Lingling Jia MD, Ni Zhuang MD, Hua Jiang MD, Jiachao Xiong MD
doi : 10.1111/jocd.15091
Cutaneous melanoma (CM) is considered as the most malignant skin tumor with high distant metastasis and poor prognosis.
Is there a link between alopecia areata and gut?
Fatmanur Hacınecipoğlu MD, Müzeyyen Gönül MD, Şeyda Özdemir MD, Ömer Faruk Demir MD
doi : 10.1111/jocd.15095
There may be an association between increased intestinal permeability and the progression of alopecia areata (AA).
Dermatological uses of rice products: Trend or true?
Dina H. Zamil BS, Rujman M. Khan BS, Tara L. Braun MD, Zeena Y. Nawas MD
doi : 10.1111/jocd.15099
Rice has been used for cosmetic purposes for centuries and its benefits have been translated into modern-day skin careproducts.
Preparation, characterization, and evaluation of anti-tyrosinase activity of solid lipid nanoparticles containing Undecylenoyl phenylalanine (Sepiwhite®)
Homa Kabiri PharmD, Zahra Tayarani-Najaran PhD, Pouria Rahmanian-devin PhD, Mohadeseh Sadat Vaziri PharmD, Samira Nasirizadeh PhD, Shiva Golmohammadzadeh PhD, Hossein Kamali PhD
doi : 10.1111/jocd.15102
Hyperpigmentation is darkened patches or spots on the skin occurred by increased melanin. Undecylenoyl phenylalanine (Sepiwhite®), as a commercial lipophilic derivative of phenylalanine, is a powerful new brightener that can be used in the treatment of skin pigmentation disorders.
Exploring the clinical efficacy of a self-made acne prescription based on high-throughput sequencing
Liangyi Wang PhD, Jingdong Wu PhD, Xiaoqing Zhang PhD, Wei Gu PhD, Xiaoqing Han PhD
doi : 10.1111/jocd.15107
We used high-throughput sequencing on skin microbial flora to assess the effectiveness of an acne prescription to formulate evidence for clinical decision-making.
Investigation of the relationship between seborrheic dermatitis and metabolic syndrome parameters
Ayşe Akbaş MD, Fadime Kılınç MD, Sertaç Şener MD, Yıldız Hayran MD
doi : 10.1111/jocd.15121
Seborrheic dermatitis (SD) is a common, chronic inflammatory disease with relapses and remissions.
Peripheral blood IL-6 levels in systemic sclerosis patients: Correlation between IL-6 levels and clinical phenotypes
Xiao Lin MM, Mingming Ding MM, Tan Chen MM, Shuhui Min MM, Danfeng Wang MM, Guan Jiang PhD
doi : 10.1111/jocd.15133
Detect the expression of Interleukin-6 (IL-6) in the serum of patients with systemic sclerosis (SSc) and assess its association with clinical and laboratory features of the disease.
The influence of cosmetics dedicated to oily and acne-prone skin on skin parameters
Julita Zdrada MSc, Wiktoria OdrzywoÅ‚ek MSc, Anna Stolecka-Warzecha PhD, SÅ‚awomir WilczyÅ„ski PhD, Barbara BÅ‚oÅ„ska-Fajfrowska MD
doi : 10.1111/jocd.15143
Patient compliance with care recommendations is closely related to the role of cosmetics in delaying or preventing the side effects of medications used to treat acne.
miR-203 represses keratinocyte stemness by targeting survivin
Florian Labarrade MSc, Jean-Marie Botto PhD, Isabelle Marie Imbert PhD
doi : 10.1111/jocd.15147
The epidermis possesses the capacity to replace dying cells and to heal wounds, thanks to resident stem cells, which have self-renewal properties.
Effects of some medicinal plant extracts on dermal papilla cells
Vanuchawan Wisuitiprot BSc, MSc, Kornkanok Ingkaninan BSc, MSc, PhD, Wudtichai Wisuitiprot BSc, MSc, PhD, Jukkarin Srivilai BSc, MSc, PhD, Panlop Chakkavittumrong MD, Neti Waranuch BSc, MSc, PhD
doi : 10.1111/jocd.15148
Miniaturization of the hair follicles is evident on the balding scalp. Approved medications, topical minoxidil, and oral finasteride for the treatment of alopecia sometimes come with undesirable adverse effects. The study was to examine the bioactivity of medicinal plants for finding the promising source of anti-hair loss application.
Exploration of potential lipid biomarkers for age-induced hair graying by lipidomic analyses of hair shaft roots with follicular tissue attached
Yuchen Ma MS, Congfen He PhD
doi : 10.1111/jocd.15150
Age-induced hair graying (AIHG)is one of the visual hallmarks of aging, but its biological mechanism remains unclear. Changes in the hair-follicle lipid profiles associated with AIHG have not been defined.
Sensitive ex vivo human skin transdermal assay testing method with mass spectrometric analysis for cosmetics application
Tsze Yin Tan PhD, Hai Ning Wee PhD, Lye Siang Lee PhD, Hong Yu Han BSc, Chee Tian Ong BSc, M. Neela BSc, Jeyakumar Masilamani PhD, Thang T. Phan PhD, Jianhong Ching PhD
doi : 10.1111/jocd.15154
Cosmetics manufacturers are focused on cosmetic delivery systems into the skin, but the level of diffusion of the systems in the skin tissues is not well understood.
Relationship between histomorphological findings and platelet activation in psoriasis
Meryem İlkay Eren Karanis MD, İlknur Küçükosmanoğlu MD, Pembe Oltulu MD, Fahriye Kılınç MD, İlkay Özer MD
doi : 10.1111/jocd.15155
Elevated platelet count (PC), mean platelet volume (MPV), and Platelet Mass Index (PMI) are reported in patients with psoriasis, while platelet activation is associated with psoriasis severity.
Biological characteristics of adipose-derived stem cells from patients with progressive hemifacial atrophy: An in vivo study
Qiuni Gao MD, Zuoliang Qi MD, PHD, Xiaolei Jin MD, PHD, Zhenyu Yang MD, Panxi Yu MD, Xihang Yuan MD, Yuling Hu MD, Xiaonan Yang MD
doi : 10.1111/jocd.15162
In this study, we investigate the biological characteristics of ADSCs from patients with progressive hemifacial atrophy (PHA) in vivo and try to explore the theoretical support for cell-assisted lipotransfer in treating patients with PHA.
A Novel multi-fruit acids formula design on molecular basis for skin brightening via a system biology approach
Jiahong Guo PhD, Xiaoyu Ma PhD, Fernando Bouffard PhD, Sophia Yi Zhang PhD
doi : 10.1111/jocd.15163
Fruit acids have long been recognized as highly effective actives with world-wide popularity, covering skin peeling, anti-acne, anti-wrinkle applications, and skin depigmentation.
Inter-rater variability and consistency within four acne grading systems recommended in China, USA, and Europe
Ruixing Yu PhD, Wenmin Fei MD, Xiaoli Ning MS, Yong Cui MD
doi : 10.1111/jocd.15178
To investigate the correlation among different investigators (intrarater variation) in the assessment of acne vulgaris severity using Acne Grading System (AGS), International Improvement Grading System (IIGS), Investigator Global Assessment of acne (IGA), and Global Evaluation Acne (GEA), and to compare AGS and IIGS with the IGA recommended in the United States, and GEA in Europe.
Pro-Inflammatory versus Anti-Inflammatory cytokines in atopic dermatitis patients: A case control study
Azza Hamada Kiwan MBBCH, Hassan Abou Khodair Mohamed MD, Osama Abd El-Azim Hashim MD, Sabah Ibrahim Abd-Elraheem MD, Amr Mohamed Alkhrsawy MD
doi : 10.1111/jocd.15182
Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disorder with significant morbidity and impairment of life quality. Prevalence is increasing around the world; therefore, intensive research is ongoing to understand the mechanisms of development of AD and offer new treatment options for AD patients.
Assessment of health-related quality of life in patients with frontal fibrosing alopecia
Aida Varghaei MD, Anahita Rostami MD, Mahsa Yarmohamadi MD, Hamidreza Mahmoudi MD, Kamran Balighi MD, Maryam Daneshpazhooh MD
doi : 10.1111/jocd.15183
Frontal fibrosing alopecia (FFA) is a primary patterned cicatricial alopecia with different manifestations.
The first broad replication study of SNPs and a pilot genome-wide association study for androgenetic alopecia in Asian populations
In-Young Kim BS, Ji-Hye Kim BS, Ja-Eun Choi BS, So-Jin Yu BS, Joo Hee Kim BS, Soon Rye Kim BS, Mi Soo Choi MD, Myung Hwa Kim MD, PhD, Kyung-Won Hong PhD, Byung-Cheol Park MD, PhD
doi : 10.1111/jocd.15187
Many candidate genes for androgenetic alopecia (AGA) have been identified in studies of the Caucasians and some Asian populations.
The potential role of fibroblast-derived multi-peptide factors in activation of growth factors and β-Catenin in hair follicle cells
Jung-Min Shin, Young-Yoon Lee, Kyung Min Kim, Kyung Shin Won, Sang Bum Suh, Dongkyun Hong, Kyung Eun Jung, Chang-Deok Kim, Young-Joon Seo, Sung Bin Cho, Young Lee
doi : 10.1111/jocd.15188
Dermal fibroblasts play a pivotal role in hair follicle regeneration during wound repair. Recently, dermal fibroblast-conditioned medium (DFCM), which contains multi-peptide factors (MPFs), has been used to promote wound repair.
Systemic isotretinoin has an impact on hemoglobin, ferritin, urea, ceruloplasmin, albumin, uric acid levels, and neutrophil to lymphocyte ratio in acne patients
Mohammad Salem Hareedy MD, Khaled Mohamed Tawfik MD
doi : 10.1111/jocd.15199
Patients suffering from moderate-to-severe acne are commonly treated with systemin isotretinoin; however, a great controverse about its safety had been raised. The aim of the present study is to evaluate the effects of isotretinoin on hepatic, renal, and hematologic functions and to evaluate the potential oxidative stress in relation to isotretinoin therapy.
Evaluation of antibacterial and wound-healing activities of alcoholic extract of Boswellia carterii, in vitro and in vivo study
Shaimaa Obaid Hasson PhD, Adnan Mansour Jasim PhD, Sumod Abdul Kadhem Salman MSc, Sousan Akrami Msc, Morteza Saki PhD, Maryam Adil Hassan BSc
doi : 10.1111/jocd.15206
Today, despite the existence of various chemical and physical treatments for wound healing, the use of traditional medicine including herbal medicine is still widely used in most developed and developing countries.
The potential role of insulin-like growth factor 1 in acne vulgaris and its correlation with the clinical response before and after treatment with metformin
Waleed Albalat MD, Hend Darwish MD, Walaa H. Abd-Elaal MSc, Mohamed Hussein AbouHadeed MD, Reham Essam MD
doi : 10.1111/jocd.15210
Acne vulgaris (AV) is a complex and multifactorial inflammatory disease affecting the pilosebaceous follicles. Optimum treatment of AV is important to reduce the disease severity and recurrence.
Ixekizumab treatment in patients with moderate-to-severe plaque psoriasis in a real-world clinical setting
Neslihan Demirel Öğüt MD, Sema Koç Yıldırım MD, Ece ErbaÄŸcı MD, Fatma Aslı Hapa MD
doi : 10.1111/jocd.15217
The efficacy and safety reports of ixekizumab for moderate-to-severe plaque psoriasis may vary between clinical trials and real-world studies.
A dose-dependent protective effect of n-3 PUFAs in photoaging by promoting collagen production through MAPK pathway in SKH-1 mouse model
Huan Xue MSc, Shuzhan Shen MSc, Guorong Yan PhD, Yuling Yang MSc, Jiandan Li MSc, Ziwei Kang BS, Yajing Cao MD, Xiuli Wang MD, PhD, Peiru Wang MD, PhD
doi : 10.1111/jocd.15220
Dietary supplementation of n-3 polyunsaturated fatty acids (n-3 PUFAs) can inhibit inflammation and oxidation of photoaging, but the effect and mechanism on regulation of dermis collagen remains poorly elucidated. The destruction of dermal collagen plays a crucial role in the process of long-term ultraviolet radiation (UVR) induced-photoaging, especially leading to deterioration of skin appearance and function.
Clinical and metagenomic profiling of hormonal acne-prone skin in different populations
Nina Hrapovic MSc, Thibaud Richard Licentiate, Cyril Messaraa MSc, Xi Li PhD, Afrouz Abbaspour PhD, Susanne Fabre PhD, Alain Mavon PR, Björn Andersson PhD, Ia Khmaladze
doi : 10.1111/jocd.15225
Acne is one of the most common skin concerns of unknown etiology, often connected to the menstrual cycle in women, and possibly to the microbial profile and function.
Novel human skin surface antimicrobial peptide quantification method using a skin patch test chamber: A pilot study
Jinyong Lee PhD, Oh Sun Kwon MS, Yu Mi Shim MS, Sang Kyung Kim MS, Eui Taek Jeong MS, Jun Man Lim MS, Sun Gyoo Park MS
doi : 10.1111/jocd.15227
Antimicrobial peptides (AMPs) on the skin surface are related to the innate immunity of the skin in preventing external infection.
Novel application of a Co-Fermented postbiotics of TYCA06/AP-32/CP-9/collagen in the improvement of acne vulgaris�A randomized clinical study of efficacy evaluation
Hsieh-Hsun Ho PhD, Ching-Wei Chen PhD, Tsai-Hsuan Yi MS, Yu-Fen Huang MS, Yi-Wei Kuo MS, Jia-Hung Lin MS, Jui-Fen Chen PhD, Shin-Yu Tsai PhD, Leong-Perng Chan PhD, Chia-Hua Liang PhD
doi : 10.1111/jocd.15228
Acne vulgaris is a chronic inflammatory skin disease. If skin lesions are not treated well in time, they can leave a permanent impact on the appearance and a negative influence on personal confidence.
Hesperetin attenuates UVA-induced photodamage in human dermal fibroblast cells
Zhiyu Lu MD, Qingyue Xia MD, Yuxin Cheng MD, Qian Lu MD, Yueyue Li MD, Ni Zeng MD, Xingbao Luan MD, Yuan Li MD, Lipan Fan MD, Dan Luo MD, PhD
doi : 10.1111/jocd.15230
Ultraviolet A (UVA) radiation causes skin damage. Recently, natural compounds have become an interest to protect skin from UV-induced photodamages.
The effect of Medicago sativa extract and light on skin hypopigmentation disorders in C57/BL6 mice
Azal Hussein Najm Ubaydee MSc, Reem Issa PhD, Maha N. Abu Hajleh PhD, Bayan Y. Ghanim MSc, Faisal Al-Akayleh PhD, Nidal A. Qinna PhD
doi : 10.1111/jocd.15233
Vitiligo is a common depigmentation skin disease that affects the quality of life in many patients.
Histatin-1 alleviates high-glucose injury to skin keratinocytes through MAPK signaling pathway
Li Pan MMed, Xuanfen Zhang MD, Qiong Gao MMed
doi : 10.1111/jocd.15235
Damage to keratinocytes and other skin cells in a high-glucose environment has been proven to be an important reason for the poor wound healing ability of chronic diabetes mellitus.
Protection of hair color with pomegranate peel extract-loaded liposomal formulation: Preparation, characterization, and ex-vivo activity studies
Sakine Tuncay Tanriverdi PhD, Evren Homan Gokce PhD, Simtac Bengi Filiz MSc, Fadime Aydin Kose PhD, Ozgen Ozer PhD
doi : 10.1111/jocd.15254
Pomegranate peel extract is known as a powerful antioxidant and due to preventing oxidation, it can reduce color change of dyed hair after washing.
Pro-inflammatory versus anti-inflammatory cytokines in psoriatic patients (case–control study)
Amaal Mohamed Elbana MBBCH, Emadeldin Elgamal MD, Osama Hashim MD, Tarek Mostafa Emran MD, Amr Abdelhady Alkhrsawy MD
doi : 10.1111/jocd.15262
Psoriasis (PsO) is a systemic autoimmune disease. Many pro-inflammatory and anti-inflammatory biomarkers have been associated with the pathogenetic process of psoriasis.
NOT SO “HAPPY BUMP�: A complication due to hyaluronic acid
Laila Klotz de Almeida Balassiano MD, Fernanda A. Cavallieri MD, Gabriela Munhoz MD, Maria Fernanda Tembra MD, Marcia Ramos-e-Silva MD, PhD
doi : 10.1111/jocd.15266
The use of hyaluronic acid (HA) as a dermal filler is considered safe. However, as new brands come to the market, reports of adverse events are becoming more and more common.
The role of cytokines and vitamin D in vitiligo pathogenesis
Amir Mohammad Beyzaee MD, Mohamad Goldust MD, Anant Patil MD, Ghasem Rahmatpour Rokni MD, Samira Beyzaee MD
doi : 10.1111/jocd.15272
Vitiligo is a pigment-related disease with a global prevalence of 0.2% to 1.8% associated with considerable burden on quality of life. The treatment is still a challenge because of relapses and/or incomplete re-pigmentation.
Characteristics and in vitro anti skin aging activity and UV radiation protection of morin loaded in niosomes
Neda Mohamadi PhD, Sara Soltanian PhD, Mahboobeh Raeiszadeh PhD, Mahtab moeinzadeh PhD, Mandana Ohadi PhD, Fatemeh Sharifi PhD, Abbas Pardakhty PhD, Fariba Sharififar PhD
doi : 10.1111/jocd.15273
One of the dermatologic problems in elderly people is skin aging, which is a natural and complex biological process. Morin is a flavonoid with high radical scavenging activity as well as antityrosinase effects but its low water solubility has restricted its application.
Involvement of high-mobility group box-1 and Dermoscopy in diagnosis of psoriasis severity
Noha Ezzat Mohamad MD, Noha Hashem MD, Samar Eltahlawy MD, Enas Gomaa MD
doi : 10.1111/jocd.15282
The diagnosis of psoriasis is usually established on clinical grounds but there is lacking of such diagnostic tools to stratify its severity.
Assessment of tissue E-cadherin and its proteolytic serum fragment in pemphigus vulgaris before and after remission: A case–control study
Randa Mohammed Youssef MD, Marwah Adly Saleh MD, Mona Mostafa Korany MD, Zeinab A. Nour MD, Mona El-Kalioby MD
doi : 10.1111/jocd.15284
E-cadherin is a classic cadherin that mediates keratinocyte adhesion.
Enhanced anti-wrinkle activity of adlay bran fermented with Lactobacillus brevis MJM60390
Huong Thi Nguyen BS, Yun-Hyeok Choi BD, PhD, Chun Whan Choi BD, PhD, Joo-Won Suh BS, PhD, Jinhua Cheng PhD
doi : 10.1111/jocd.15290
The aim of this study was to screen the lactic acid bacteria for fermentation of adlay bran and evaluate the anti-wrinkle effect of fermented and non-fermented adlay bran.
To explore the potential molecular mechanism of complex rose–bergamot essential oil on anti-anxiety with facial spots based on network pharmacology
Jin Xin BE, Xu Xu MS, Ding Qiaoling BE, Liu Liping PhD, Ma Kunqin MS, Zhang Yiping MS
doi : 10.1111/jocd.15296
To explore the potential mechanism of complex rose–bergamot essential oil against anxiety accompanied with facial spots through network pharmacology.
Serum immunoglobulin E and Interleukin-17 levels in patients with chronic plaque psoriasis: A case–control study
Amany A. Nassar MD, Noha M. Bakr MD, Enas H. I. Elyousefi MSc, Basma M. Elkholy MD, Manal M. Fawzy MD
doi : 10.1111/jocd.15299
Psoriasis is a skin disorder mainly mediated by T helper (Th)-1 and Th-17 cells. Recently, high serum immunoglobulin (Ig)-E levels were detected in psoriatic patients. The etiopathogenesis of IgE overproduction in psoriatic patients is still unknown, but IL-17 has been suggested to be responsible for this abnormality.
The SII reflects inflammation in acne vulgaris, but fails to determine categorical severity
Çağrı Turan MD, Nur Cihan Coşansu MD, Gülcan Yüksekal MD
doi : 10.1111/jocd.15301
Systemic Immune Inflammation Index (SII; calculated by multiplying neutrophil–lymphocyte ratio and platelet count) has been investigated as a marker of inflammation.
Evaluation of oral tranexamic acid as a novel treatment for melasma with a high benefit–risk ratio
Jordan Simpson BS, Lucy Peng BS, William Ting MD
doi : 10.1111/jocd.15305
Melasma is an acquired melanogenesis dysfunction resulting in chronic hyperpigmentation commonly affecting the face and other frequently sun-exposed areas of the body.
Chemical and mechanical accelerated and long-term stability evaluation of sunscreen formulation containing grape seed extract
Liudmila Yarovaya PhD, Neti Waranuch PhD, Wudtichai Wisuitiprot PhD, Watcharee Khunkitti PhD
doi : 10.1111/jocd.15308
Sunscreens and catechins from grape seed extract (GSE) are sensitive to various environmental factors and undergo certain changes over time that might affect the effectiveness of the final product.
Assessment of serum chemerin levels in acanthosis nigricans: A case–control study
Ahmed Abdelfattah Afify MD, Ghada Fathy MD, Menna Elzawahry MBBCh, Sara Ibrahim Taha MD
doi : 10.1111/jocd.15311
Acanthosis nigricans (AN) is an asymptomatic skin condition linked to several underlying systemic conditions. Chemerin is an adipokine that increases during inflammatory disorders such as metabolic syndrome (MetS).
Identification of lncRNA expression profiles in pediatric localized scleroderma
Yinv Gong PhD, Haimei Liu, Guomin Li, Li Sun MD
doi : 10.1111/jocd.15318
The role and potential molecular mechanism of inflammatory cells in pediatric localized scleroderma are poorly investigated.
Unraveling the relation between vitiligo, Interleukin 17, and serum amyloid A
Aliaa Abd Elsalam Ahmed MSc, Nancy Wadie Mikhael MD, Asmaa Adel Elfallah MD, Ahmed Mohammed Hamed MD
doi : 10.1111/jocd.15329
There is debate concerning the precise etiopathogenesis of vitiligo. According to certain theories, a series of inflammatory responses that mediate the loss of melanocytes are caused by both cellular and humoral immune responses.
Dermoscopy aids in differentiating primary cutaneous amyloidosis and post-inflammatory hyperpigmentation: A clinico-dermoscopic-histopathaological study
Solwan I. El-Samanoudy MD, Heba I. Gawdat MD, Kholoud M. Fouda MSc, Heba Ahmed Abdelkader MD
doi : 10.1111/jocd.15332
Primary cutaneous amyloidosis (PCA) and post-inflammatory hyperpigmentation (PIH) are common causes of cutaneous hyperpigmentation that are usually diagnosed clinically.
Letter to the editor regarding article “Gu L, Diaz SM, Lipner SR. Retrospective study of acne telemedicine and in-person visits at an academic center during the COVID-19 pandemic. J Cosmet Dermatol. 2022;21(1):36–38.â€�
Luca Potestio, Gabriella Fabbrocini, Alessia Villani
doi : 10.1111/jocd.15018
Washing with a body cleanser and topical application of a moisturizer containing a pseudo-ceramide and a eucalyptus extract are effective to improve mild atopic dermatitis in Thailand
Hiroshi Nojiri MS, Pakhawadee Palungwachira MD, Kanita Poommarapan MD, Niran Pawasuttikul MD, Kanokwan Lerttibat MD, Wachira Kunathathorn MD, Kazuhiro Kaizu PhD, Yutaka Takagi PhD, Thamthiwat Nararatwanchai MD, PhD
doi : 10.1111/jocd.15065
Adrenoceptors and rosacea: A review of current literature
Meng Tao MD, Min Li MD, Yunyi Liu MD, Peiyu Jiang MD, Yixuan Liu MD, Yue Zhang MD, Yang Xu MD, PhD
doi : 10.1111/jocd.15066
Knowledge, attitudes, and behaviors of nail technicians in detecting acral lentiginous melanoma
Adrienne K. Joseph BS, Amanda M. Walker BS, Melissa Irek BS, Emily Berry MSPH, Keith Argenbright MD, Heidi Jacobe MD, MSCS
doi : 10.1111/jocd.15068
The first study on combined carboxytherapy and minoxidil 20% in the treatment of Lichen planopilaris: A case series and literature review
Mohammad Ali Nilforoushzadeh MD, Maryam Heidari-Kharaji PhD, Elham Torkamaniha PhD, Sara Sadeghi MD, Farnoosh Seirafianpour MD, Mir Saeed Yekaninejad PhD, Elham Behrangi MD, Masoumeh Roohaninasab MD, Zeynab Amini PhD, Azadeh Goodarzi MD
doi : 10.1111/jocd.15079
Commentary on: Investigation of the relationship between inflammatory blood parameters and seborrheic dermatitis
Yanfei Li MD, Jing Tan BS, Qiri Mu MD, Yu Hou MD
doi : 10.1111/jocd.15080
Optical super-high magnification dermoscopy of pigmented and nonpigmented nodular basal cell carcinoma
Joanna Pogorzelska-DyrbuÅ› MD, PhD, Jacek C. Szepietowski MD, PhD, FRCP
doi : 10.1111/jocd.15082
Retaining even distribution of biostimulators microscopically and grossly: Key to prevent non-inflammatory nodules formation
Jui-Yu Lin MD, Nai-Jen Hsu MD, Chuan-Yuan Lin MD
doi : 10.1111/jocd.15101
Livedo racemosa presenting as first manifestation in a patient with multiple myeloma complicated with cryoglobulinemic vasculitis
Banu Farabi MD, Christian Toquica Gahona MD, Mehmet Fatih Atak MD, Hasret Gunduz MD, Banu Ismail Mendi MD, Mohamad Goldust MD
doi : 10.1111/jocd.15103
Crusted scabies in a child with down syndrome
Filiz Cebeci MD, Assoc. Prof, Vefa Aslı Turgut Erdemir MD, Prof, Mehmet Salih Gürel MD, Prof, Necmettin Akdeniz MD, Prof, Melek Aslan Kayıran MD, Assoc. Prof
doi : 10.1111/jocd.15105
Successfully treatment with Dupilumab for systemic contact dermatitis following hair dye in a patient with dermatomyositis
Peng Jin, Chen Yang, Jianxue Bai, Liang Dong, Lili Zhi
doi : 10.1111/jocd.15112
A scalp nodule with a gray purple pattern
Kouki Chaima MD, Mseddi Madiha PhD, Sellami Khadija MD, Turki Hamida PhD
doi : 10.1111/jocd.15115
Comparing combination low-dose oral minoxidil and topical minoxidil with oral minoxidil alone for the treatment of non-scarring alopecia: A retrospective chart review
Elizabeth J. Klein BA, Maria Karim BA, Jerry Shapiro MD, Kristen Lo Sicco MD
doi : 10.1111/jocd.15138
Demographic and clinical characteristics of hospitalized psoriasis patients
Zeinab Aryanian MD, Fatemeh Ijadi MD, Maryam Nasimi MD, Hamidreza Mahmoudi MD, Iman Menbari Oskouie MD, MPH, Nazanin Rahimdoost MD, Parvaneh Hatami MD, Nessa Aghazadeh Mohandesi MD
doi : 10.1111/jocd.15144
Percutaneous collagen induction (microneedling) for scarring alopecia in discoid lupus erythematosus of the scalp
Mariana Modesto Dantas de Andrade Lima MD, Marcela Benez MD, Shirley B. L. Gamonal PhD, MSc, MD, Daniel Fernandes Melo MSc, MD, Violeta Duarte Tortelly MSc, MD, Simone Frattini MSc, MD, Emerson Vasconcelos de Andrade Lima PhD, MD
doi : 10.1111/jocd.15149
Localized scabies crustose over the engrafted skin: Report of two cases
Ghazal Ahmed MD, DNB, Anju George C MBBS, Jemshi S. Rahim MBBS, Satyaki Ganguly MD, DNB
doi : 10.1111/jocd.15164
Lupus miliaris disseminatus faciei in a 10-year-old child: A case report and literature review
Keyun Tang BS, Hongzhong Jin MD
doi : 10.1111/jocd.15176
Treatment of solar lentigo with imiquimod 3.75% cream: AÂ dermoscopic study
Luca Di Bartolomeo MD, Fabrizio Guarneri MD, PhD, Giovanna Moretti MD
doi : 10.1111/jocd.15177
Early-onset nodules with trismus after hyaluronic acid filler injection for augmentation of temporal fossa: A case report
Wei-Cheng Fang MD, Chao-Wei Chang MD, Li-Wen Chiu MD, Cheng-Che E. Lan MD, PhD
doi : 10.1111/jocd.15191
An unpleasant segmental facial lesion: Unilateral nevoid telangiectasia
Paolo Custurone MD, Federica Li Pomi MD, Maria Lentini MD, PhD, Mario Vaccaro MD, PhD, Francesco Borgia MD, PhD
doi : 10.1111/jocd.15207
YouTube as a source of information on sunscreen: An analysis of content and quality
Noreen Mohsin BS, Loren E. Hernandez BS, Stephanie Magoon BA, Keyvan Nouri MD, MBA
doi : 10.1111/jocd.15226
Dyed basal cell carcinoma: A peculiar clinical and histopathological case
Iwona Chlebicka MD, PhD, Ewa Wójcik MD, Aleksandra A. Stefaniak MD, Zdzisław Woźniak MD, PhD, Jacek C. Szepietowski MD, PhD, FRCP
doi : 10.1111/jocd.15229
Dermoscopy of an unusual case of nevoid hyperkeratosis of the nipple and areola in an elderly male
Tugba Kevser Uzuncakmak MD, Muazzez Cigdem Oba MD, Pembe Gul Gunes MD
doi : 10.1111/jocd.15236
Possible ruxolitinib-induced acquired epidermodysplasia verruciformis and multiple non-melanoma skin cancers in a patient with polycythemia vera
Neslihan Demirel Öğüt MD, Bülent Mızrak MD
doi : 10.1111/jocd.15253
A novel method to correct pincer nail deformity
Yifan Wang MD, Jiadong Zhang MD, Ning Zhang MD, Yong Hu MD
doi : 10.1111/jocd.15259
Two siblings with the skin fragility woolly hair syndrome
Özge Aşkın MD, Defne Özkoca MD, Tuğba Kevser Uzunçakmak MD, Server Serdaroğlu MD
doi : 10.1111/jocd.15264
Commentary on “Assessment of hearing loss in patients with rosacea�
Yanfei Li MD, Jingxue Guo MSc, Qiuliang Zhao MD, Jing Tan BS, Jiaojiao Li MSc, Yu Hou MD, Qiri Mu MD
doi : 10.1111/jocd.15271
Eccrine syringofibroadenoma following venous insufficieny anddiabetic foot ulers: a case report
Farahnaz Bidari-Zerehpoosh MD, Mohammadreza Pourani MD, Elena Jamali MD, Azin Ayatollahi MD, Reza M. Robati MD
doi : 10.1111/jocd.15295
Spontaneous keloids during isotretinoin treatment for acne
Anca Chiriac MD, PhD, Uwe Wollina MD, PhD
doi : 10.1111/jocd.15300
A case of late-onset granuloma 10 years after illegal filler injection
Se Hoon Lee MD, Minah Cho MD, Yujin Han MD, Yu Ri Woo MD, PhD, Sang Hyun Cho MD, PhD, Jeong Deuk Lee MD, PhD, Hei Sung Kim MD, PhD
doi : 10.1111/jocd.15304
Eight-year sustained efficacy and safety of fractional CO2 laser combined with sun exposure in resistant nonsegmental vitiligo: Case report
Josiane Helou MD, Boutros Soutou MD
doi : 10.1111/jocd.15315
Concerning the characterization of systemic oxidative stress in epidemiological studies of melasma: Comments on “Bilirubin as a new antioxidant in melasma�
Ana Cláudia Cavalcante Espósito MD, MsC, PhD, Maria Paula Barbieri D′Elia MD, MsC, Daniel Cassiano MD, PhD, Hélio Amante Miot MD, PhD
doi : 10.1111/jocd.15316
A comparative study of the safety and efficacy of topical potassium hydroxide 30% versus topical trichloroacetic acid 30% in the treatment of pediatric plane warts
Attia Attia Ali Attia Alawady MSc, Hamed Mohamed Abdo MD, Mohamed Abd El Mawgood Amer MD, Ahmad Kamel Seddeik Abdel-Hameed MD
doi : 10.1111/jocd.15327
Aesthetic medicine�Quo Vadis?
Sebastian Cotofana MD, PhD, Sonja Sattler MD, Konstantin Frank MD, Claudia Hernandez MD, Tatjana Pavicic MD, Jeremy B. Green MD, Martina Kerscher MD, PhD, Peter Peng MD, Michael Gold MD, Rainer M. Pooth MD, PhD
doi : 10.1111/jocd.15334
Evaluation of efficacy of derma roller sizes vs topical application for administration of QR678 Neo® hair regrowth formulation in the treatment of androgenetic alopecia
Debraj Shome MD, FRCS, FACS, MBA, Harshal Tandel BDS, Vaibhav Kumar MDS, FRSPH, Rinky Kapoor MD
doi : 10.1111/jocd.15336
Rapid development of keratoacanthoma following chemical peel
Anne Birgitte Simonsen MD, PhD, Ida Bille Brahe RN, Charlotte Winther MD, Claus Zachariae MD, DMSci
doi : 10.1111/jocd.15346
An optimal approach for facial rejuvenation: AbobotulinumtoxinA And small-particle hyaluronic acid
MaurÃÂcio Shigueru Sato MD, Alessandra Romiti MD, Maria Alice Gabay MD
doi : 10.1111/jocd.15092
