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Editor’s view
Nathalie van der Velde
doi : 10.1093/ageing/afac305
Age and Ageing, Volume 51, Issue 12, December 2022, afac305
Genomics and multimorbidity
Jane A H Masoli, Luke C Pilling, Timothy M Frayling
doi : 10.1093/ageing/afac285
Age and Ageing, Volume 51, Issue 12, December 2022, afac285
Multimorbidity has increased in prevalence world-wide. It is anticipated to affect over 1 in 6 of the UK population by 2035 and is now recognised as a global priority for health research.
Health care for older adults in Europe: how has it evolved and what are the challenges?
Andreas E Stuck, Tahir Masud
doi : 10.1093/ageing/afac287
Age and Ageing, Volume 51, Issue 12, December 2022, afac287,
Geriatric medicine has evolved to an accepted specialty in 23 European countries. Despite much heterogeneity of postgraduate geriatric curricula, European societies have succeeded in defining a common core curriculum with a list of minimum training requirements for obtaining the specialty title of geriatric medicine.
Advance care planning—factors influencing stability of preferences
Anna Steel, Lucy Owen
doi : 10.1093/ageing/afac294
Age and Ageing, Volume 51, Issue 12, December 2022, afac294
Should we take Mum to market? Quality and funding in the care home sector
Stephen Allan, Lisa Irvine, Wilco P Achterberg
doi : 10.1093/ageing/afac223
Age and Ageing, Volume 51, Issue 12, December 2022, afac223
Outcomes and care priorities for older people living with frailty and advanced chronic kidney disease: a multi-professional scoping review
Helen Hurst, Hannah M L Young, Andrew C Nixon, Paula Ormandy, Alison Brettle, The scoping review author collaborative for outcomes and care priorities for older people with ACKD
doi : 10.1093/ageing/afac296
Age and Ageing, Volume 51, Issue 12, December 2022, afac296
The growing older population with advanced chronic kidney disease (ACKD stages 4–5) poses a challenge for healthcare worldwide. The high prevalence of frailty and associated adverse health outcomes highlights concerns for management and interventions specific to this population.
The minimal important change for measures of balance and postural control in older adults: a systematic review
Daniel C Low, Gregory S Walsh
doi : 10.1093/ageing/afac284
Age and Ageing, Volume 51, Issue 12, December 2022, afac284
The minimal important change and analogous terms (MIC) can provide a measure of change in health outcome variables that is associated with a level of importance for participant/patient.
Effectiveness of interventions in older adults with cognitive frailty: a systematic review and meta-analysis of randomised controlled trials
Lufang Zheng, Cong Wang, Yiming Qiu, Xin Li, Xueyan Zhang, Meishuang Zhang, Tianjiao Ma, Guichen Li, Li Chen
doi : 10.1093/ageing/afac286
Age and Ageing, Volume 51, Issue 12, December 2022, afac286
interventions targeting older adults with cognitive frailty have grown rapidly in recent years with inconsistent findings. However, there is no meta-analysis that has synthesised pooled estimates.
Optimal stroke preventive strategy for patients aged 80 years or older with atrial fibrillation: a systematic review with traditional and network meta-analysis
Kun-Han Lee, Ying-Fan Chen, Wan-Yu Yeh, Jiunn-Tyng Yeh, Tzu-Han Yang, Chian-Ying Chou, Yuh-Lih Chang, Wei-Ting Wang, Chern-En Chiang, Chen-Huan Chen, Hao-Min Cheng
doi : 10.1093/ageing/afac292
Age and Ageing, Volume 51, Issue 12, December 2022, afac292
An optimal antithrombotic strategy for patients aged 80Â years or older with atrial fibrillation (AF) remains elusive.
The impact of dementia, frailty and care home characteristics on SARS-CoV-2 incidence in a national cohort of Welsh care home residents during a period of high community prevalence
Chris Emmerson, Joseph Hollinghurst, Laura North, Richard Fry, Ashley Akbari, Ciarán Humphreys, Mike B Gravenor, Ronan A Lyons
doi : 10.1093/ageing/afac250
Age and Ageing, Volume 51, Issue 12, December 2022, afac250
dementia may increase care home residents’ risk of COVID-19, but there is a lack of evidence on this effect and on interactions with individual and care home-level factors.
Prevalence and outcomes of atrial fibrillation in older people living in care homes in Wales: a routine data linkage study 2003–2018
Leona A Ritchie, Stephanie L Harrison, Peter E Penson, Ashley Akbari, Fatemeh Torabi, Joe Hollinghurst, Daniel Harris, Oluwakayode B Oke, Asangaedem Akpan, Julian P Halcox, Sarah E Rodgers, Gregory Y H Lip, Deirdre A Lane
doi : 10.1093/ageing/afac252
Age and Ageing, Volume 51, Issue 12, December 2022, afac252
To determine atrial fibrillation (AF) prevalence and temporal trends, and examine associations between AF and risk of adverse health outcomes in older care home residents.
Protective responses of older adults for avoiding injury during falls: evidence from video capture of real-life falls in long-term care
Stephen N Robinovitch, Aleksandra Dojnov, Vicki Komisar, Yijian Yang, Nataliya Shishov, Ying Yu, Ian Bercovitz, Michael D Cusimano, Clemens Becker, Dawn C Mackey, Helen Chong
doi : 10.1093/ageing/afac273
Age and Ageing, Volume 51, Issue 12, December 2022, afac273
falls are common in older adults, and any fall from standing height onto a rigid surface has the potential to cause a serious brain injury or bone fracture. Safe strategies for falling in humans have traditionally been difficult to study.
Does the association between smoking and mortality differ due to frailty status? A secondary analysis from the Mexican Health and Aging Study
Daniela Patiño-Hernández, Óliver Guillermo Pérez-Bautista, Mario Ulises Pérez-Zepeda, Carlos Cano-Gutiérrez
doi : 10.1093/ageing/afac280
Age and Ageing, Volume 51, Issue 12, December 2022, afac280
despite the well-known adverse health effects of smoking, evidence of these effects on frail individuals is still scarce.
Effects of chain ownership and private equity financing on quality in the English care home sector: retrospective observational study
Sharvari Patwardhan, Matthew Sutton, Marcello Morciano
doi : 10.1093/ageing/afac222
Age and Ageing, Volume 51, Issue 12, December 2022, afac222
the structure of care homes markets in England is changing with the emergence of for-profit homes organised in chains and financed by private equity. Previous literature shows for-profit homes were rated lower quality than not-for-profit homes when inspected by the national regulator, but has not considered new forms of financing.
Association between walking energy utilisation and longitudinal cognitive performance in older adults
Pei-Lun Kuo, Yang An, Alden L Gross, Qu Tian, Vadim Zipunnikov, Adam P Spira, Amal A Wanigatunga, Eleanor M Simonsick, Luigi Ferrucci, Susan M Resnick, Jennifer A Schrack
doi : 10.1093/ageing/afac240
Age and Ageing, Volume 51, Issue 12, December 2022, afac240
Human motor function is optimised for energetic efficiency, however, age-related neurodegenerative changes affects neuromotor control of walking. Energy utilisation has been associated with motor performance, but its association with cognitive performance is unknown.
Developing a care home data platform in Scotland: a mixed methods study of data routinely collected in care homes
Susan D Shenkin, Lucy Johnston, Jo Hockley, David A G Henderson
doi : 10.1093/ageing/afac265
Age and Ageing, Volume 51, Issue 12, December 2022, afac265
care homes collect extensive data about their residents, and their care, in multiple ways, for multiple purposes. We aimed to (i) identify what data are routinely collected and (ii) collate care home managers’ views and experiences of collecting, using and sharing data.
Dementia and hearing-aid use: a two-way street
Graham Naylor, Lauren Dillard, Martin Orrell, Blossom C M Stephan, Oliver Zobay, Gabrielle H Saunders
doi : 10.1093/ageing/afac266
Age and Ageing, Volume 51, Issue 12, December 2022, afac266
Hearing-aid use may reduce risk of dementia, but cognitive impairment makes use more challenging. An observed association between reduced hearing-aid use and incident dementia could reflect either or both of these causal paths. The objective was to examine the effects of each path while minimising contamination between paths.
Fall-related health service use in Stepping On programme participants and matched controls: a non-randomised observational trial within the 45 and Up Study
Serene S Paul, Saman Khalatbari-Soltani, Xenia Dolja-Gore, Lindy Clemson, Stephen R Lord, Lara Harvey, Anne Tiedemann, Jacqueline C T Close, Cathie Sherrington
doi : 10.1093/ageing/afac272
Age and Ageing, Volume 51, Issue 12, December 2022, afac272
Falls and fall-related health service use among older adults continue to increase. The New South Wales Health Department, Australia, is delivering the Stepping On fall prevention programme at scale. We compared fall-related health service use in Stepping On participants and matched controls.
Effects of fish oil-derived n-3 polyunsaturated fatty acid on body composition, muscle strength and physical performance in older people: a secondary analysis of a randomised, double-blind, placebo-controlled trial
Dengfeng Xu, Yifei Lu, Xian Yang, Da Pan, Yuanyuan Wang, Shiyu Yin, Shaokang Wang, Guiju Sun Author Notes
doi : 10.1093/ageing/afac274
Age and Ageing, Volume 51, Issue 12, December 2022, afac274
the effects regarding n-3 polyunsaturated fatty acid (n-3 PUFA) supplementation on sarcopenia have been explored by several clinical trials. Nonetheless, the use of n-3 PUFA for improving body composition, muscle strength and physical performance in older people is conflicting.
Factors associated with informal caregiver’s ability to continue care: a subgroup analysis
Shanshan Wang, Johanna de Almeida Mello, Anja Declercq
doi : 10.1093/ageing/afac275
Age and Ageing, Volume 51, Issue 12, December 2022, afac275
maintaining informal caregiver’s ability to continue care can prevent early institutionalisation and decrease health care costs, contributing to sustainable health care. This study aims to identify factors associated with informal caregiver’s ability to continue care across several degrees of cognitive decline and risk of burden.
Development and validation of a deep learning algorithm based on fundus photographs for estimating the CAIDE dementia risk score
Rong Hua, Jianhao Xiong, Gail Li, Yidan Zhu, Zongyuan Ge, Yanjun Ma, Meng Fu, Chenglong Li, Bin Wang, Li Dong, Xin Zhao, Zhiqiang Ma, Jili Chen, Xinxiao Gao, Chao He, Zhaohui Wang, Wenbin Wei, Fei Wang, Xiangyang Gao, Yuzhong Chen, Qiang Zeng, Wuxiang Xie
doi : 10.1093/ageing/afac282
Age and Ageing, Volume 51, Issue 12, December 2022, afac282
the Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE) dementia risk score is a recognised tool for dementia risk stratification. However, its application is limited due to the requirements for multidimensional information and fasting blood draw. Consequently, an effective and non-invasive tool for screening individuals with high dementia risk in large population-based settings is urgently needed.
The impact of frailty on patient-reported outcomes following hip and knee arthroplasty
Michael J Cook, Mark Lunt, Darren M Ashcroft, Timothy Board, Terence W O’Neill
doi : 10.1093/ageing/afac288
Age and Ageing, Volume 51, Issue 12, December 2022, afac288
to determine the impact of frailty on patient-reported outcomes following hip and knee arthroplasty.
Asymptomatic orthostatic hypotension and risk of falls in community-dwelling older people
Paul Claffey, Laura Pérez-Denia, Amanda Lavan, Rose Anne Kenny, Ciarán Finucane, Robert Briggs
doi : 10.1093/ageing/afac295
Age and Ageing, Volume 51, Issue 12, December 2022, afac295
Many older people with orthostatic hypotension (OH) may not report typical symptoms of dizziness, light-headedness or unsteadiness. However, the relationships between OH and falls in the absence of typical symptoms are not yet established.
Frailty and the impacts of the COVID-19 pandemic on community-living middle-aged and older adults: an analysis of data from the Canadian Longitudinal Study on Aging (CLSA)
Lauren E Griffith, Jacqueline McMillan, David B Hogan, Sina Pourfarzaneh, Laura N Anderson, Susan Kirkland, Nicole E Basta, Edwin van den Heuvel, Parminder Raina, The Canadian Longitudinal Study on Aging (CLSA) Team
doi : 10.1093/ageing/afac289
Age and Ageing, Volume 51, Issue 12, December 2022, afac289
frailty imparts a higher risk for hospitalisation, mortality and morbidity due to COVID-19 infection, but the broader impacts of the pandemic and associated public health measures on community-living people with frailty are less known.
Ultrasound-derived muscle assessment system for older adults: a promising muscle mass estimation tool
Xinyi Tang, Songya Huang, Li Huang, Ziyan Feng, Ziyao Wang, Jirong Yue, Li Qiu
doi : 10.1093/ageing/afac298
Age and Ageing, Volume 51, Issue 12, December 2022, afac298
Quantitative assessment of muscle mass is a critical step in sarcopenia disease management. Expanding upon the use of ultrasound in foetal growth assessment, we established and validated an ultrasound-derived muscle assessment system for older adults at a risk of sarcopenia.
Injurious falls before, during and after dementia diagnosis: a population-based study
Lulu Zhang, Jiao Wang, Abigail Dove, Wenzhe Yang, Xiuying Qi, Weili Xu
doi : 10.1093/ageing/afac299
Age and Ageing, Volume 51, Issue 12, December 2022, afac299
the timing of incident injurious falls at different stages of dementia diagnosis is unclear.
Effects of a 12-week Vivifrail exercise program on intrinsic capacity among frail cognitively impaired community-dwelling older adults: secondary analysis of a multicentre randomised clinical trial
Juan Luis Sánchez-Sánchez, Philipe de Souto Barreto, Iván Antón-Rodrigo, Fernanda Ramón-Espinoza, Itxaso MarÃn-Epelde, Marina Sánchez-Latorre, Débora Moral-Cuesta, Ã�lvaro Casas-Herrero
doi : 10.1093/ageing/afac303
Age and Ageing, Volume 51, Issue 12, December 2022, afac303
The World Health Organisation recently defined the construct of intrinsic capacity (IC), a function-based marker of older adult’s health encompassing all mental and physical capacities of the individual. Multicomponent physical exercise (MCE) is a potential intervention capable to maintain/increase IC at older age; however, evidence is scarce on the effects of MCE on IC in cognitively impaired pre-frail/frail older adults.
Understanding Pathways into Care homes using Data (UnPiCD study): a retrospective cohort study using national linked health and social care data
Jennifer Kirsty Burton, Giorgio Ciminata, Ellen Lynch, Susan D Shenkin, Claudia Geue, Terence J Quinn
doi : 10.1093/ageing/afac304
Age and Ageing, Volume 51, Issue 12, December 2022, afac304
Pathways into care are poorly understood but important life events for individuals and their families. UK policy is to avoid moving-in to care homes from acute hospital settings. This assumes that moves from secondary care represent a system failure. However, those moving to care homes from community and hospital settings may be fundamentally different groups, each requiring differing care approaches.
The trajectory of family caregiving for older adults with dementia: difficulties and challenges
Jiong Tu, Haiyan Li, Bei Ye, Jing Liao
doi : 10.1093/ageing/afac254
Age and Ageing, Volume 51, Issue 12, December 2022, afac254
As the main source of informal care in China, family members bear a tremendous caregiving burden, particularly in relation to older people with dementia (PwDs). However, the continuous caregiving trajectory of family caregivers was unclear.
A realist evaluation of a multifactorial falls prevention programme in care homes
Paul A Leighton, Janet Darby, Frances Allen, Marie Cook, Rachel Evley, Chris Fox, Maureen Godfrey, Adam Gordon, John Gladman, Jane Horne, Kate Robertson, Pip Logan
doi : 10.1093/ageing/afac263
Age and Ageing, Volume 51, Issue 12, December 2022, afac263
Multifactorial falls programmes demonstrate clinical and cost-effectiveness, but the heterogeneity of the care home sector is a barrier to their implementation. A fuller appreciation of the relationship between care home context and falls programme delivery will guide development and support implementation.
Connecting in place: older adults’ experience of online mindfulness therapy during the COVID-19 pandemic
Adele Pacini, Annabel Stickland, Nuriye Kupeli
doi : 10.1093/ageing/afac270
Age and Ageing, Volume 51, Issue 12, December 2022, afac270
the negative consequences of COVID-19 distancing measures on older adults’ mental health and ability to access services have been well documented. Online cognitive behavioural therapy and mindfulness interventions for older adults, carried out during the COVID-19 pandemic, have shown that these interventions are feasible and have potential mental health benefits. However, little research has been carried out on older adults’ experiences of engaging with online psychological therapy, and specifically mindfulness therapy.
Simultaneously reassuring and unsettling: a longitudinal qualitative study of community anticipatory medication prescribing for older patients
Ben Bowers, Kristian Pollock, Stephen Barclay
doi : 10.1093/ageing/afac293
Age and Ageing, Volume 51, Issue 12, December 2022, afac293
The prescription of injectable anticipatory medications is widely accepted by clinicians to be key in facilitating effective last-days-of-life symptom control. Community end-of-life care and admission avoidance is particularly strongly advocated for older patients. However, patient and informal caregiver views and experiences of anticipatory medication have been little studied to date.
Older adults’ experiences of implementing exergaming programs: a systematic review and qualitative meta-synthesis
Hongting Ning, Dian Jiang, Yan Du, Xiaoyang Li, Hongyu Zhang, Linan Wu, Xi Chen, Weihong Wang, Jundan Huang, Hui Feng
doi : 10.1093/ageing/afac251
Age and Ageing, Volume 51, Issue 12, December 2022, afac251
this study sought to systematically review and synthesize qualitative data to explore older adult exergame experiences and perceptions.
Enablers and barriers to nurse-facilitated geriatric teleconsultations in nursing homes: a qualitative descriptive multi-site study
Apphia Jia Qi Tan, Wei Ling Chua, Lisa McKenna, Laurence Lean Chin Tan, Yu Jun Lim, Sok Ying Liaw
doi : 10.1093/ageing/afac268
Age and Ageing, Volume 51, Issue 12, December 2022, afac268
Nurses play a major role in facilitating teleconsultations in nursing homes with remote physicians. Currently, evidence explicating their role in teleconsultations is lacking. As telemedicine usage grows, understanding the factors that enable or impede nurses’ role in teleconsultations allows for more support in the provision of patient care through this modality.
Excess deaths from Alzheimer’s disease and Parkinson’s disease during the COVID-19 pandemic in the USA
Siyuan Li, Lefei Han, Haoting Shi, Marc K C Chong, Shi Zhao, Jinjun Ran
doi : 10.1093/ageing/afac277
Age and Ageing, Volume 51, Issue 12, December 2022, afac277
COVID-19 pandemic has indirect impacts on patients with chronic medical conditions, which may increase mortality risks for various non-COVID-19 causes. This study updates excess death statistics for Alzheimer’s disease (AD) and Parkinson’s disease (PD) up to 2022 and evaluates their demographic and spatial disparities in the USA.
Use of prescription benzodiazepines and related drugs in family caregivers: a nation-wide register-based study
Tuija M Mikkola, Minna Mänty, Hannu Kautiainen, Mikaela B von Bonsdorff, Hannu Koponen, Teppo Kröger, Johan G Eriksson
doi : 10.1093/ageing/afac279
Age and Ageing, Volume 51, Issue 12, December 2022, afac279
objective indicators of sleep and mental health problems in family caregivers have rarely been reported.
Mood and physical activity are associated with appetite in hospitalised older men and women
Natalie J Cox, Fiona Howson, Kinda Ibrahim, Leanne Morrison, Avan A Sayer, Helen C Roberts, Sian M Robinson
doi : 10.1093/ageing/afac297
Age and Ageing, Volume 51, Issue 12, December 2022, afac297
The anorexia of ageing is important in the development of malnutrition, frailty and sarcopenia amongst the older population and is a particular problem for hospital inpatients. This study assessed appetite-related factors in a group of hospitalised older adults, to identify potential preventive strategies.
Targeted reduction of airborne viral transmission risk in long-term residential aged care
Amanda Brass, Andrew P Shoubridge, Nicolas Larby, Levi Elms, Sarah K Sims, Erin Flynn, Caroline Miller, Maria Crotty, Lito E Papanicolas, Steve L Wesselingh, Lidia Morawska, Scott C Bell, Steven L Taylor, Geraint B Rogers
doi : 10.1093/ageing/afac316
Age and Ageing, Volume 51, Issue 12, December 2022, afac316
COVID-19 has demonstrated the devastating consequences of the rapid spread of an airborne virus in residential aged care. We report the use of CO2-based ventilation assessment to empirically identify potential ‘super-spreader’ zones within an aged care facility, and determine the efficacy of rapidly implemented, inexpensive, risk reduction measures.
Hyponatremia due to hypopituitarism caused by cerebral aneurysm
Takahiro Ishikawa, Daiki Yamamoto, Tomonori Kato, Takahiro Mori, Toshio Machida, Masatsune Ogura
doi : 10.1093/ageing/afac291
Age and Ageing, Volume 51, Issue 12, December 2022, afac291
Dermoscopy of pediculosis pubis in an octogenarian man
Chuan-Ting MA, S I Liu, Yi-Ming Fan
doi : 10.1093/ageing/afac302
Age and Ageing, Volume 51, Issue 12, December 2022, afac302
