Advances in Nutrition




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COP27 Climate Change Conference: Urgent Action Needed for Africa and the World: Wealthy nations must step up support for Africa and vulnerable countries in addressing past, present and future impacts of climate change

Laurie Laybourn-Langton, Joy Muhia, Maha El-Adawy, Siaka Sidibé, Chris Zielinski

doi : 10.1093/advances/nmac106

Advances in Nutrition, Volume 13, Issue 6, November 2022, Pages 2067–2069

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Flavan-3-ols and Cardiometabolic Health: First Ever Dietary Bioactive Guideline

Kristi M Crowe-White, Levi W Evans, Gunter G C Kuhnle, Dragan Milenkovic, Kim Stote, Taylor Wallace, Deepa Handu, Katelyn E Senkus

doi : 10.1093/advances/nmac105

Advances in Nutrition, Volume 13, Issue 6, November 2022, Pages 2070–2083,

Guideline recommendation for a plant bioactive such as flavan-3-ols is a departure from previous recommendations because it is not based on deficiencies but rather improvement in health outcomes.

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Perspective: Assessing Tolerance to Nondigestible Carbohydrate Consumption

Hannah D Holscher, Bruno P Chumpitazi, Wendy J Dahl, George C Fahey, Jr, DeAnn J Liska, Joanne L Slavin, Kristin Verbeke

doi : 10.1093/advances/nmac091

Advances in Nutrition, Volume 13, Issue 6, November 2022, Pages 2084–2097

Human intestinal enzymes do not hydrolyze nondigestible carbohydrates (NDCs), and thus, they are not digested and absorbed in the small intestine.

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Perspective: Human Milk Composition and Related Data for National Health and Nutrition Monitoring and Related Research

Jaspreet K C Ahuja, Kellie O Casavale, Ying Li, Kathryn E Hopperton, Subhadeep Chakrabarti, Erin P Hines, Stephen P J Brooks, Genevieve S Bondy, Amanda J MacFarlane, Hope A Weiler, Xianli Wu, Michael M Borghese, Namanjeet Ahluwalia, Winnie Cheung, Ashley J Vargas, Sonia Arteaga, Tania Lombo, Mandy M Fisher, Deborah Hayward, Pamela R Pehrsson

doi : 10.1093/advances/nmac099

Advances in Nutrition, Volume 13, Issue 6, November 2022, Pages 2098–2114

National health and nutrition monitoring is an important federal effort in the United States and Canada, and the basis for many of their nutrition and health policies.

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Poultry Consumption and Human Health: How Much Is Really Known? A Systematically Searched Scoping Review and Research Perspective

Gavin Connolly, Caroline M Clark, Robyn E Campbell, Adam W Byers, Jason B Reed, Wayne W Campbell

doi : 10.1093/advances/nmac074

Advances in Nutrition, Volume 13, Issue 6, November 2022, Pages 2115–2124

This scoping review was conducted to systematically search and chronicle scientific literature pertinent to poultry intake and human health. The protocol (uploaded to Open Science Framework, https://osf.io/2k7bj/) was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for scoping reviews guidelines. Articles with observational and experimental research, narrative and systematic reviews, and meta-analyses were included.

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Saturated Fatty Acid Intake and Risk of Type 2 Diabetes: An Updated Systematic Review and Dose–Response Meta-Analysis of Cohort Studies

Zahra Gaeini, Zahra Bahadoran, Parvin Mirmiran

doi : 10.1093/advances/nmac071

Advances in Nutrition, Volume 13, Issue 6, November 2022, Pages 2125–2135

This systematic review and meta-analysis was conducted to pool findings of cohort studies that investigated hazards of type 2 diabetes mellitus (T2DM) in relation to intakes of SFAs.

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Consumption of Nuts and Seeds and Health Outcomes Including Cardiovascular Disease, Diabetes and Metabolic Disease, Cancer, and Mortality: An Umbrella Review

Rajiv Balakrishna, Tonje Bjørnerud, Mitra Bemanian, Dagfinn Aune, Lars T Fadnes

doi : 10.1093/advances/nmac077

Advances in Nutrition, Volume 13, Issue 6, November 2022, Pages 2136–2148

Consumption of nuts and seeds is associated with a range of health outcomes. Summarizing the best evidence on essential health outcomes from the consumption of nuts is essential to provide optimal recommendations.

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Effects of Fish-Oil Consumption on Psychological Function Outcomes in Psychosis: A Systematic Review and Dose–Response Meta-Analysis of Randomized Controlled Trials

Mohsen Montazer, Soraiya Ebrahimpour-Koujan, Pamela J Surkan, Leila Azadbakht

doi : 10.1093/advances/nmac083

Advances in Nutrition, Volume 13, Issue 6, November 2022, Pages 2149–2164

Research on the effects of fish oil on clinical symptoms and psychosocial functioning in people with psychosis has been inconsistent.

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Consumption of Dairy Products and the Risk of Overweight or Obesity, Hypertension, and Type 2 Diabetes Mellitus: A Dose–Response Meta-Analysis and Systematic Review of Cohort Studies

Yifei Feng, Yang Zhao, Jiong Liu, Zelin Huang, Xingjin Yang, Pei Qin, Chuanqi Chen, Xinping Luo, Yang Li, Yuying Wu, Xi Li, Hao Huang, Fulan Hu, Dongsheng Hu, Yu Liu, Ming Zhang

doi : 10.1093/advances/nmac096

Advances in Nutrition, Volume 13, Issue 6, November 2022, Pages 2165–2179

Dairy products have been suggested to be related to the prevention of overweight or obesity, hypertension, and type 2 diabetes mellitus (T2DM).

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Dose-Response Effect of Coenzyme Q10 Supplementation on Blood Pressure among Patients with Cardiometabolic Disorders: A Grading of Recommendations Assessment, Development, and Evaluation (GRADE)-Assessed Systematic Review and Meta-Analysis of Randomized Controlled Trials

Dan Zhao, Ying Liang, Suming Dai, Shanshan Hou, Zhihao Liu, Meitong Liu, Xiaoxi Dong, Yiqiang Zhan, Zezhong Tian, Yan Yang

doi : 10.1093/advances/nmac100

Advances in Nutrition, Volume 13, Issue 6, November 2022, Pages 2180–2194

Previous studies have shown beneficial effects of coenzyme Q10 (CoQ10) supplementation on blood pressure (BP). However, the optimal intake of CoQ10 for BP regulation in patients with cardiometabolic disorders is unknown, and its effect on circulating CoQ10 is also unclear.

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High Adherence to the Mediterranean Diet is Associated with Higher Physical Fitness in Adults: a Systematic Review and Meta-Analysis

Bruno Bizzozero-Peroni, Javier Brazo-Sayavera, Vicente Martínez-Vizcaíno, Rubén Fernández-Rodríguez, José F López-Gil, Valentina Díaz-Goñi, Iván Cavero-Redondo, Arthur E Mesas

doi : 10.1093/advances/nmac104

Advances in Nutrition, Volume 13, Issue 6, November 2022, Pages 2195–2206

Although prior research has synthesized the relationships between the Mediterranean diet (MD) and components of physical fitness (PF) in adults, they are limited and inconclusive.

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Diet and Esophageal Cancer Risk: An Umbrella Review of Systematic Reviews and Meta-Analyses of Observational Studies

Xianpeng Qin, Guiqing Jia, Xiaogang Zhou, Zhou Yang

doi : 10.1093/advances/nmac087

Advances in Nutrition, Volume 13, Issue 6, November 2022, Pages 2207–2216

Diet may play an important role in the occurrence of esophageal cancer (EC). The aim of this umbrella review was to grade the evidence for the association between dietary factors and EC risk.

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Unsaturated Fatty Acids in Mental Disorders: An Umbrella Review of Meta�Analyses

Xuping Gao, Xin Su, Xue Han, Huiyan Wen, Chen Cheng, Shiwen Zhang, Wanlin Li, Jun Cai, Lu Zheng, Junrong Ma, Minqi Liao, Wanze Ni, Tao Liu, Dan Liu, Wenjun Ma, Shasha Han, Sui Zhu, Yanbin Ye, Fang-fang Zeng

doi : 10.1093/advances/nmac084

Advances in Nutrition, Volume 13, Issue 6, November 2022, Pages 2217–2236

Unsaturated fatty acids might be involved in the prevention of and improvement in mental disorders, but the evidence on these associations has not been comprehensively assessed.

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Gastrointestinal Effects and Tolerance of Nondigestible Carbohydrate Consumption

Annemarie R Mysonhimer, Hannah D Holscher

doi : 10.1093/advances/nmac094

Advances in Nutrition, Volume 13, Issue 6, November 2022, Pages 2237–2276

Nondigestible carbohydrates (NDCs) are food components, including nonstarch polysaccharides and resistant starches.

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Orally Ingested Probiotics, Prebiotics, and Synbiotics as Countermeasures for Respiratory Tract Infections in Nonelderly Adults: A Systematic Review and Meta-Analysis

Julie L Coleman, Adrienne Hatch-McChesney, Stephanie D Small, Jillian T Allen, Elaine Sullo, Richard T Agans, Heather S Fagnant, Asma S Bukhari, J Philip Karl

doi : 10.1093/advances/nmac086

Advances in Nutrition, Volume 13, Issue 6, November 2022, Pages 2277–2295,

The impact of gut microbiota–targeted interventions on the incidence, duration, and severity of respiratory tract infections (RTIs) in nonelderly adults, and factors moderating any such effects, are unclear.

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The Effect of Prebiotics on Human Iron Absorption: A Review

Frederike M D Husmann, Michael B Zimmermann, Isabelle Herter-Aeberli

doi : 10.1093/advances/nmac079

Advances in Nutrition, Volume 13, Issue 6, November 2022, Pages 2296–2304

Iron deficiency remains the most common nutritional deficiency. Oral iron supplementation is the recommended first-line treatment and used as a preventive measure as well.

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The Effect of the Meat Factor in Animal-Source Foods on Micronutrient Absorption: A Scoping Review

Fabio Consalez, Molly Ahern, Peter Andersen, Marian Kjellevold

doi : 10.1093/advances/nmac089

Advances in Nutrition, Volume 13, Issue 6, November 2022, Pages 2305–2315

The EAT-Lancet Commission's planetary health guidelines suggest a reduction in the consumption of animal-source foods (ASFs) for better health and more sustainable food systems.

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Potential Mechanisms by Which Hydroxyeicosapentaenoic Acids Regulate Glucose Homeostasis in Obesity

Saame Raza Shaikh, Rafia Virk, Thomas E Van Dyke

doi : 10.1093/advances/nmac073

Advances in Nutrition, Volume 13, Issue 6, November 2022, Pages 2316–2328

Dysregulation of glucose metabolism in response to diet-induced obesity contributes toward numerous complications, such as insulin resistance and hepatic steatosis.

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The Combined Effects of Aspartame and Acesulfame-K Blends on Appetite: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Kirnjot Mehat, Yi Chen, Christopher Peter Corpe

doi : 10.1093/advances/nmac072

Advances in Nutrition, Volume 13, Issue 6, November 2022, Pages 2329–2340

Aspartame (Asp) and acesulfame-K (Ace-K) are nonnutritive sweeteners (NNSs) commonly used in combination to replace added sugars in reduced- or low-calorie foods and beverages.

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Scoping Review and Evidence Map of the Relation between Exposure to Dietary Sweetness and Body Weight-Related Outcomes in Adults

Kelly A Higgins, Rita Rawal, David J Baer, Lauren E O'Connor, Katherine M Appleton

doi : 10.1093/advances/nmac090

Advances in Nutrition, Volume 13, Issue 6, November 2022, Pages 2341–2356

Numerous governmental and health organizations recommend reduced intake of added sugars due to the health risks associated with excess intake, including the risk of obesity.

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Chronotype Differences in Body Composition, Dietary Intake and Eating Behavior Outcomes: A Scoping Systematic Review

Carlien van der Merwe, Mirjam Münch, Rozanne Kruger

doi : 10.1093/advances/nmac093

Advances in Nutrition, Volume 13, Issue 6, November 2022, Pages 2357–2405

The timing and nutritional composition of food intake are important zeitgebers for the biological clocks in humans.

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Unraveling the Complex Interactions between the Fat Mass and Obesity-Associated (FTO) Gene, Lifestyle, and Cancer

Sepideh Abdollahi, Naeemeh Hasanpour Ardekanizadeh, Seyed Mohammad Poorhosseini, Maryam Gholamalizadeh, Zahra Roumi, Mark O Goodarzi, Saeid Doaei

doi : 10.1093/advances/nmac101

Advances in Nutrition, Volume 13, Issue 6, November 2022, Pages 2406–2419

Carcinogenesis is a complicated process and originates from genetic, epigenetic, and environmental factors.

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Current Insights in Nutrition Assessment and Intervention for Malnutrition or Muscle Loss in People with Lung Cancer: A Narrative Review

Nicole Kiss, Annie Curtis

doi : 10.1093/advances/nmac070

Advances in Nutrition, Volume 13, Issue 6, November 2022, Pages 2420–2432

Up to 70% of people with lung cancer may be affected by cancer-related malnutrition or muscle loss, depending on treatment modality and disease stage.

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Prevalence and Impact of Computed Tomography–Defined Sarcopenia on Survival in Patients with Human Papillomavirus–Positive Oropharyngeal Cancer: A Systematic Review

Anna Edwards, Brett G M Hughes, Teresa Brown, Judith Bauer

doi : 10.1093/advances/nmac076

Advances in Nutrition, Volume 13, Issue 6, November 2022, Pages 2433–2444

Sarcopenia is a known independent prognostic factor for decreased survival in patients with head and neck cancer; yet, its importance for the growing number of younger patients diagnosed with human papillomavirus (HPV)–positive oropharyngeal carcinoma (OPC+) has not been established.

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Association between Maternal Choline, Fetal Brain Development, and Child Neurocognition: Systematic Review and Meta-Analysis of Human Studies

Rima Obeid, Emma Derbyshire, Christiane Schön

doi : 10.1093/advances/nmac082

Advances in Nutrition, Volume 13, Issue 6, November 2022, Pages 2445–2457

We studied associations between prenatal and early postnatal choline intake, brain development, and neurocognitive function of children. We conducted a systematic review followed by a meta-analysis and critical appraisal of human studies published from 1997 to 2021.

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Fish and Fish-Based Products for Nutrition and Health in the First 1000 Days: A Systematic Review of the Evidence from Low and Middle-Income Countries

Kendra A Byrd, Jacqueline Shieh, Stephanie Mork, Lauren Pincus, Lydia O'Meara, Molly Atkins, Shakuntala H Thilsted

doi : 10.1093/advances/nmac102

Advances in Nutrition, Volume 13, Issue 6, November 2022, Pages 2458–2487,

Fish provide essential nutrients for the critical window of growth and development in the first 1000 d of life and are thus an attractive option for inclusion in nutrition-sensitive and nutrition-specific programming.

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Adverse Effects of Excessive Zinc Intake in Infants and Children Aged 0–3 Years: A Systematic Review and Meta-Analysis

Marena Ceballos-Rasgado, Nicola M Lowe, Simonette Mallard, Andrew Clegg, Victoria H Moran, Catherine Harris, Jason Montez, Maria Xipsiti

doi : 10.1093/advances/nmac088

Advances in Nutrition, Volume 13, Issue 6, November 2022, Pages 2488–2518

Zinc supplementation reduces morbidity, but evidence suggests that excessive intakes can have negative health consequences. Current guidelines of upper limits (ULs) of zinc intake for young children are extrapolated from adult data.

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Human Milk Lipid Profiles around the World: A Systematic Review and Meta-Analysis

Zheqing Zhang, Yingyao Wang, Xiaoguang Yang, Yiyong Cheng, Hong Zhang, Xuebing Xu, Jin Zhou, Hengying Chen, Mengyang Su, Yuexin Yang, Yixiang Su

doi : 10.1093/advances/nmac097

Advances in Nutrition, Volume 13, Issue 6, November 2022, Pages 2519–2536

Reported breast milk lipid concentrations may vary with geographical region, postnatal age, and year of sample collection.

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Food Security Status of Indigenous Peoples in Canada According to the 4 Pillars of Food Security: A Scoping Review

Mojtaba Shafiee, Pardis Keshavarz, Ginny Lane, Punam Pahwa, Michael Szafron, Derek Jennings, Hassan Vatanparast

doi : 10.1093/advances/nmac081

Advances in Nutrition, Volume 13, Issue 6, November 2022, Pages 2537–2558

Food insecurity is a significant public health problem for Indigenous peoples in Canada. A comprehensive literature review is needed to organize the evidence according to the 4 pillars of food security (i.e., availability, access, utilization, and stability) and identify gaps in the published literature on this topic.

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A Scoping Review of the Environmental Impacts and Nutrient Composition of Plant-Based Milks

Andrew J Berardy, María Rubín-García, Joan Sabaté

doi : 10.1093/advances/nmac098

Advances in Nutrition, Volume 13, Issue 6, November 2022, Pages 2559–2572

Dairy milk is a ubiquitous nutrient-dense beverage and ingredient, especially in Western diets. However, consumers are increasingly seeking alternatives to dairy, called plant-based milks (PBMs), to avoid allergens, pursue a plant-based diet, or reduce their environmental impacts.

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Machine Learning in Nutrition Research

Daniel Kirk, Esther Kok, Michele Tufano, Bedir Tekinerdogan, Edith J M Feskens, Guido Camps

doi : 10.1093/advances/nmac103

Advances in Nutrition, Volume 13, Issue 6, November 2022, Pages 2573–2589

Data currently generated in the field of nutrition are becoming increasingly complex and high-dimensional, bringing with them new methods of data analysis.

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Applying Image-Based Food-Recognition Systems on Dietary Assessment: A Systematic Review

Kalliopi V Dalakleidi, Marina Papadelli, Ioannis Kapolos, Konstantinos Papadimitriou

doi : 10.1093/advances/nmac078

Advances in Nutrition, Volume 13, Issue 6, November 2022, Pages 2590–2619

Dietary assessment can be crucial for the overall well-being of humans and, at least in some instances, for the prevention and management of chronic, life-threatening diseases.

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A Systematic Review Examining Contributors to Misestimation of Food and Beverage Intake Based on Short-Term Self-Report Dietary Assessment Instruments Administered to Adults

Clare Whitton, César Ramos-García, Sharon I Kirkpatrick, Janelle D Healy, Satvinder S Dhaliwal, Carol J Boushey, Clare E Collins, Megan E Rollo, Deborah A Kerr

doi : 10.1093/advances/nmac085

Advances in Nutrition, Volume 13, Issue 6, November 2022, Pages 2620–2665

Error in self-reported food and beverage intake affects the accuracy of dietary intake data.

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Poor Reporting Quality in Basic Nutrition Research: A Case Study Based on a Scoping Review of Recent Folate Research in Mouse Models (2009–2021)

Esther Munezero, Nathalie A Behan, Stephanie G Diaz, Eva-Marie Neumann, Amanda J MacFarlane

doi : 10.1093/advances/nmac056

Advances in Nutrition, Volume 13, Issue 6, November 2022, Pages 2666–2678

Transparent reporting of nutrition research promotes rigor, reproducibility, and relevance to human nutrition.

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Fluoride

Fatemeh V Zohoori, Marilia Buzalaf

doi : 10.1093/advances/nmac050

Advances in Nutrition, Volume 13, Issue 6, November 2022, Pages 2679–2680

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Dietary Energy

Susan B Roberts, Valerie Flaherman

doi : 10.1093/advances/nmac092

Advances in Nutrition, Volume 13, Issue 6, November 2022, Pages 2681–2685

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