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Clinical trials for renal allograft tolerance induction through combined hematopoietic stem cell transplantation: A narrative review
Kiyohiko Hotta, Takayuki Hirose, Tatsuo Kawai
doi : 10.1111/iju.15035
During the last four decades, development of effective immunosuppressants has significantly improved short-term results of organ transplantation. However, long-term results have not been satisfactory due to chronic rejection or complications caused by immunosuppressive drugs.
PDE5 inhibitors and male reproduction: Is there a place for PDE5 inhibitors in infertility clinics or andrology laboratories?
Fotios Dimitriadis, Aris Kaltsas, Athanasios Zachariou, Charalampos Mamoulakis, Chara Tsiampali, Ioannis Giannakis, Minas Paschopoulos, Athanasios Papatsoris, Dimitrios Loutradis, Panagiota Tsounapi, Atsushi Takenaka, Nikolaos Sofikitis
doi : 10.1111/iju.15046
The objective of this review study is to evaluate the therapeutic role of PDE5 inhibitors (PDE5is) in the amelioration of oligoasthenospermia in infertile males. PDE5is have a beneficial influence on the secretory function of the Leydig and Sertoli cells, the biochemical environment within the seminiferous tubule, the contractility of the testicular tunica albuginea, and the prostatic secretory function.
Molecular mechanisms of resistance to tyrosine kinase inhibitor in clear cell renal cell carcinoma
Yohei Sekino, Jun Teishima, Gangning Liang, Nobuyuki Hinata
doi : 10.1111/iju.15042
Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cell carcinoma (RCC).
miRNAs in prostate cancer: Intercellular and extracellular communications
Fumihiko Urabe, Yusuke Yamamoto, Takahiro Kimura
doi : 10.1111/iju.15043
Prostate cancer is the most prevalent male cancer in Western Europe and North America. Although new drugs were recently approved, clinical challenges such as accurately predicting and screening drug-resistant prostate cancer remain.
Editorial Comment to miRNAs in prostate cancer: Intercellular and extracellular communications
Yusuke Goto MD, PhD
doi : 10.1111/iju.15058
Validation of new baseline renal function predictive model in robotic-assisted partial nephrectomy cohort
Laura E Geldmaker, Bryce A Baird, Giovanni A Gonzalez Albo, Daniela A Haehn, Christian A Ericson, Mikolaj A Wieczorek, Colleen T Ball, David D Thiel
doi : 10.1111/iju.15006
To validate a new baseline estimated glomerular filtration rate (NB-GFR) formula in a cohort of robotic-assisted partial nephrectomies (RAPN).
Editorial Comment from Dr Shao to Validation of new baseline renal function predictive model in robotic-assisted partial nephrectomy cohort
Zhiqiang Shao MD
doi : 10.1111/iju.15028
Editorial Comment from Dr Ambrosini et al. to Validation of new baseline renal function predictive model in robotic-assisted partial nephrectomy cohort
Francesca Ambrosini, Carlo Terrone, Guglielmo Mantica
doi : 10.1111/iju.15031
Predictors of renal function after adrenalectomy in patients with Cushing or subclinical Cushing syndrome
Ryohei Kufukihara, Toshikazu Takeda, Kyohei Hakozaki, Yota Yasumizu, Nobuyuki Tanaka, Kazuhiro Matsumoto, Shinya Morita, Takeo Kosaka, Ryuichi Mizuno, Hiroshi Asanuma, Kazutoshi Miyashita, Isao Kurihara, Mototsugu Oya
doi : 10.1111/iju.15007
The postoperative course of renal function remains unclear in Cushing syndrome. We examined changes in renal function after adrenalectomy in patients with Cushing syndrome and attempted to identify predictors of renal impairment.
Prostate-specific antigen level, biopsy grade group, and tumor-capsular contact length on magnetic resonance imaging are independently associated with an extraprostatic extension
Satoshi Washino, Koichi Ito, Tomoaki Miyagawa
doi : 10.1111/iju.15012
To define the clinicopathological and radiological factors independently associated with the existence of an extraprostatic extension in radical prostatectomy specimens.
Improved survival in real-world patients with advanced urothelial carcinoma: A multicenter propensity score-matched cohort study comparing a period before the introduction of pembrolizumab (2003–2011) and a more recent period (2016–2020)
Satoru Taguchi, Taketo Kawai, Tohru Nakagawa, Jimpei Miyakawa, Kenjiro Kishitani, Kazuma Sugimoto, Yu Nakamura, Jun Kamei, Daisuke Obinata, Kenya Yamaguchi, Tomoyuki Kaneko, Kanae Yoshida, Sachi Yamamoto, Shigenori Kakutani, Koichiro Kanazawa, Yuriko Sugihara, Mayuko Tokunaga, Akihiko Matsumoto, Yukari Uemura, Yoshiyuki Akiyama, Yuta Yamada, Yusuke Sato, Daisuke Yamada, Yutaka Enomoto, Hiroaki Nishimatsu, Akira Ishikawa, Yoshinori Tanaka, Yasushi Nagase, Tetsuya Fujimura, Hiroshi Fukuhara, Satoru Takahashi, Haruki Kume
doi : 10.1111/iju.15014
Although the treatment strategy for advanced urothelial carcinoma (aUC) has drastically changed since pembrolizumab was introduced in 2017, studies revealing current survival rates in aUC are lacking. This study aimed to assess (1) the improvement in survival among real-world patients with aUC after the introduction of pembrolizumab and (2) the direct survival-prolonging effect of pembrolizumab.
Efficacy of urethral reconstruction for urethral stricture associated with hypospadias surgery in adults
Akio Horiguchi, Hiroshi Asanuma, Masayuki Shinchi, Tadashi Tabei, Kenichiro Ojima, Yusuke Hirano, Eiji Takahashi, Junichi Asakuma, Fumihiro Kimura, Keiichi Ito, Ryuichi Azuma
doi : 10.1111/iju.15015
We report our experience with urethral reconstruction for hypospadias surgery-related urethral stricture in terms of surgical and patient-reported outcomes.
Editorial Comment to Efficacy of urethral reconstruction for urethral stricture associated with hypospadias surgery in adults
Pankaj Joshi
doi : 10.1111/iju.15044
Predictive factors for the effectiveness of novel androgen receptor axis-targeted agents in patients with metastatic prostate cancer
Nishimoto Koshiro, Kenichi Nakajima, Masafumi Oyama, Go Kaneko, Satoru Takahashi, Hideyasu Matsuyama, Hiroaki Shiina, Tomohiko Ichikawa, Hiroyuki Horikoshi, Katsuyoshi Hashine, Yutaka Sugiyama, Takeshi Miyao, Manabu Kamiyama, Kenichi Harada, Akito Ito, Atsushi Mizokami, PROSTAT-BSI Investigators
doi : 10.1111/iju.15022
Novel androgen receptor axis-targeted agents (ARATAs) have been developed for mCRPC and improved overall survival (OS). Here, we aimed to find predictors who will receive the greatest benefits from ARATAs.
Choosing the best way for urinary decompression and developing a novel predictive model for septic shock using SOFA in these patients
Yu Xi Terence Law, Liang Shen, Vincent Wei Sheng Khor, Weiren Chen, Wei Jing Kelven Chen, Pradeep Durai, Vineet Gauhar, Kwok Ying Lie, King Chien Joe Lee
doi : 10.1111/iju.15023
To identify predictive factors for the development of sepsis/septic shock postdecompression of calculi-related ureteric obstruction using the Sequential Organ Failure Assessment (SOFA) score and to compare clinical outcomes and odd risk ratios of patients developing sepsis/septic shock following the insertion of percutaneous nephrostomy (PCN) versus insertion of retrograde ureteral stenting (RUS).
Editorial Comment to Choosing the best way for urinary decompression and developing a novel predictive model for septic shock using Sequential Organ Failure Assessment in these patients
Kazumi Taguchi MD, PhD
doi : 10.1111/iju.15040
Outcomes of artificial urinary sphincter implantation in patients with diabetes mellitus: A subgroup analysis
Yasuhiro Kaiho, Hitoshi Masuda, Mineo Takei, Takahiro Hirayama, Takeya Kitta, Minato Yokoyama, Naoki Kawamorita, Takahiko Mitsui, Haruo Nakagawa, Masatsugu Iwamura, Yoichi Arai
doi : 10.1111/iju.15025
To estimate the surgical and quality-of-life outcomes of artificial urinary sphincter implantation in patients with diabetes mellitus (DM). Subanalyses were performed using the same population as that in our previous multicenter, prospective, observational study.
Temporary reduction of immunosuppression enhances production of anti-S antibody against severe acute respiratory syndrome coronavirus 2 after vaccination in kidney transplant recipients
Masayoshi Miura, Maiko Fukumoto, Natsumi Komatsu, Reimi Shuto, Hiroshi Harada, Hajime Sasaki
doi : 10.1111/iju.15027
The study identified factors affecting anti-S immunoglobulin G production after vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in kidney transplant recipients.
Transperineal bulbovesical anastomosis for extensive posterior urethral stenoses after treatment of prostatic disease
Kenichiro Ojima, Akio Horiguchi, Masayuki Shinchi, Tadashi Tabei, Yusuke Hirano, Keiichi Ito, Ryuichi Azuma
doi : 10.1111/iju.15029
We report our surgical experience of transperineal bulbovesical anastomosis (BVA) for extensive posterior urethral stenosis (PUS).
Minimal residual membranous urethral length and membranous urethral length predict poor recovery from incontinence after robot-assisted radical prostatectomy and after open radical prostatectomy
Eiichiro Ohara, Naoki Kawamorita, Yohei Satake, Yasuhiro Kaiho, Koji Mitsuzuka, Hideo Saito, Shigeto Ishidoya, Yoichi Arai, Akihiro Ito
doi : 10.1111/iju.15030
To investigate how much minimal residual membranous urethral length (mRUL) and maximal urethral length (MUL) measured on MRI preoperatively affect postoperative urinary incontinence (PUI) and recovery in robot-assisted radical prostatectomy (RARP) and open radical prostatectomy (ORP).
Editorial Comment from Dr Haga et al. to Minimal residual membranous urethral length and membranous urethral length predict poor recovery from incontinence after robot-assisted radical prostatectomy and after open radical prostatectomy
Nobuhiro Haga MD, PhD, Takeshi Miyazaki M.D, Naotaka Gunge MD, Yu Okabe M.D, Hiroshi Matsuzaki M.D
doi : 10.1111/iju.15049
Editorial Comment from Dr Kadonoo to Minimal residual membranous urethral length and membranous urethral length predict poor recovery from incontinence after robot-assisted radical prostatectomy and after open radical prostatectomy
Yoshifumi Kadono
doi : 10.1111/iju.15050
Association of financial toxicity with quality of life in testicular cancer survivors
Kunihisa Nezu, Shinichi Yamashita, Kenichi Kakimoto, Motohide Uemura, Takeshi Kishida, Koji Kawai, Terukazu Nakamura, Takayuki Goto, Takahiro Osawa, Kazuo Nishimura, Norio Nonomura, Hiromitsu Negoro, Takumi Shiraishi, Osamu Ukimura, Osamu Ogawa, Nobuo Shinohara, Yoshimi Suzukamo, Akihiro Ito, Yoichi Arai
doi : 10.1111/iju.15039
Most testicular cancer (TC) survivors have long-term survival. However, the association between financial toxicity (FT), which is an economic side effect of cancer treatment, and the quality of life (QOL) of TC survivors is still unclear. Thus, the impact of FT on the QOL of TC survivors was examined in a multi-institutional cross-sectional study.
Can trajectory nor-epinephrine infiltration reduce blood loss during percutaneous nephrolithotomy? A double-blinded randomized controlled trial
Waleed El-Shaer, Mohamed Salah Haggag, Alaa Elshaer, Islam Shaboob, Wael Kandeel, Basheer Elmohamady, Dina Saad Abdelmotaleb, Sally Abdel-Lateef
doi : 10.1111/iju.15036
To determine the efficacy and safety of trajectory infiltration with 1:150 000 Norepinephrine (NE) in reducing blood loss during percutaneous nephrolithotomy (PCNL).
A predictive score for detecting vesicoureteral reflux in children with their first Escherichia coli-induced urinary tract infection
Mari Kurokawa, Kenji Murata, Takayuki Hoshina, Kenji Furuno, Yoshitsugu Kaku, Junji Kishimoto, Shouichi Ohga
doi : 10.1111/iju.15041
In children with a first Escherichia coli-induced febrile urinary tract infection (fUTI), routine voiding cytourethrography (VCUG) is not recommended for detecting vesicoureteral reflux (VUR). Meanwhile, the sensitivity of renal and bladder ultrasound (RBUS) for detecting VUR is insufficient. Aiming to implement VCUG properly for children with a first E. coli-induced fUTI, we attempted to construct a predictive scoring system for the early screening of VUR.
Prospective randomized trial of 2 versus 12-weeks of postoperative antibiotics after percutaneous nephrolithotomy in complex patients with infection-related kidney stones
Ben H. Chew, Alina Reicherz, Amy E. Krambeck, Nicole L. Miller, Ryan S. Hsi, Kymora B. Scotland, David Miller, Ryan F. Paterson, Victor K. F. Wong, Michelle J. Semins, Dirk Lange
doi : 10.1111/iju.15045
Treatment of struvite kidney stones requires complete surgical stone removal combined with antibiotic therapy to eliminate urinary tract infections and preventive measures to reduce stone recurrence. The optimal duration of antibiotic therapy is unknown. We sought to determine if 2- or 12-weeks of antibiotics post percutaneous nephrolithotomy (PNL) for infection stones resulted in better outcomes for stone recurrence and positive urine cultures.
Editorial Comment to Prospective randomized trial of 2 vs 12-weeks of postoperative antibiotics after percutaneous nephrolithotomy in complex patients with infection-related kidney stones
Kazumi Taguchi
doi : 10.1111/iju.15084
Local dose (biologically effective dose ≥180 Gy2) is an important predictor of biochemical recurrence in patients undergoing low-dose-rate brachytherapy
Nobumichi Tanaka, Yasushi Nakai, Isao Asakawa, Kaori Yamaki, Makito Miyake, Shunta Hori, Takuya Owari, Tomomi Fujii, Kiyohide Fujimoto
doi : 10.1111/iju.15051
To evaluate prognostic factors of biochemical recurrence (BCR) in each risk group of prostate cancer patients who underwent low-dose-rate brachytherapy (LDR-BT).
Editorial Comment to Local dose (biological effective dose <180 Gy2) is an important predictor of biochemical recurrence in patients undergoing low-dose-rate brachytherapy
Nelson N Stone M.D.
doi : 10.1111/iju.15068
Japanese female urologists' work-life balance during the COVID-19 pandemic
Sachiyo Nishida, Hitomi Sasaki, Yoshiko Maeda, Masayuki Koyama, Katsuhito Miyazawa, Naoya Masumori
doi : 10.1111/iju.15048
