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LEWIS, STEVEN L. MD, FAAN
A Symptoms and Signs Approach to the Patient With Neuromuscular Weakness.
Silvestri, Nicholas J. MD, FAAN
doi : 10.1212/CON.0000000000001150
Muscle weakness is a common feature of many neuromuscular disorders. This article outlines a symptoms and signs approach to the patient presenting with neuromuscular weakness, highlighting key aspects of the clinical history and examination.
Lambert-Eaton Myasthenic Syndrome and Botulism.
Raja, Shruti M. MD
doi : 10.1212/CON.0000000000001205
This article reviews the pathophysiology, epidemiology, clinical features, diagnosis, and treatment of Lambert-Eaton myasthenic syndrome (LEMS) and botulism, presynaptic disorders of neuromuscular transmission in which rapid diagnosis improves long-term outcomes.
Diagnosis and Management of Myasthenia Gravis.
Hehir, Michael K. II MD; Li, Yuebing MD, PhD, FAAN
doi : 10.1212/CON.0000000000001161
This article reviews updated diagnostic procedures and currently available treatment modalities for myasthenia gravis (MG).
Inflammatory Myopathies.
Manousakis, Georgios MD, FAAN
doi : 10.1212/CON.0000000000001179
This article outlines the salient clinical, serologic, electrophysiologic, imaging, and histopathologic findings and treatment options for the idiopathic inflammatory myopathies, including those related to immune checkpoint inhibitors and SARS-CoV-2.
Inclusion Body Myositis.
Goyal, Namita A. MD, FAAN
doi : 10.1212/CON.0000000000001204
This article highlights the clinical and diagnostic features of inclusion body myositis (IBM) and provides recent insights into the pathomechanisms and therapeutic strategies of the disease.
The Dystrophinopathies.
Lee, Bo Hoon MD
doi : 10.1212/CON.0000000000001208
This article reviews the history, epidemiology, genetics, clinical presentation, multidisciplinary management, and established and emerging therapies for the dystrophinopathies.
The Limb-Girdle Muscular Dystrophies.
Johnson, Nicholas E. MD, FAAN; Statland, Jeffrey M. MD
doi : 10.1212/CON.0000000000001178
The limb-girdle muscular dystrophies (LGMDs) are a group of inherited muscle disorders with a common feature of limb-girdle pattern of weakness, caused by over 29 individual genes.
Myotonic Dystrophy.
Hamel, Johanna I. MD
doi : 10.1212/CON.0000000000001184
Myotonic dystrophy type 1 (DM1) and myotonic dystrophy type 2 (DM2) are genetic disorders affecting skeletal and smooth muscle, heart, brain, eyes, and other organs.
Facioscapulohumeral Muscular Dystrophy.
Mul, Karlien MD, PhD
doi : 10.1212/CON.0000000000001155
This article reviews the current knowledge on the clinical characteristics and disease mechanism of facioscapulohumeral muscular dystrophy (FSHD), as well as advances in targeted therapy development.
Metabolic Myopathies.
Tarnopolsky, Mark A. MD, PhD, FRCP
doi : 10.1212/CON.0000000000001182
Metabolic myopathies are disorders that affect skeletal muscle substrate oxidation. Although some drugs and hormones can affect metabolism in skeletal muscle, this review will focus on the genetic metabolic myopathies.
Muscle Channelopathies.
Trivedi, Jaya R. MD, FAAN
doi : 10.1212/CON.0000000000001183
This article describes the clinical features, diagnosis, pathophysiology, and management of nondystrophic myotonia and periodic paralysis.
Genetic-Based Treatment Strategies for Muscular Dystrophy and Congenital Myopathies.
Findlay, Andrew R. MD; Weihl, Conrad C. MD, PhD
doi : 10.1212/CON.0000000000001203
This article discusses the foundational concepts of genetic treatment strategies employed in neuromuscular medicine, as well as the importance of genetic testing as a requirement for applying gene-based therapy.
The Practice of Experimental Neurotherapeutics in Neuromuscular Disease.
Reoma, Lauren B. MD, FAAN; Nath, Avindra MD, MBBS, FAAN; Griggs, Robert C. MD, FAAN
doi : 10.1212/CON.0000000000001240
The discipline of experimental neurotherapeutics targets the process and operation of translating scientific discoveries into new treatments for neurologic diseases and has been instrumental in the progression of many areas of neurology.
Postreading Self-Assessment and CME Test.
Owens, James W. M. Jr MD, PhD; Zazulia, Allyson R. MD
Postreading Self-Assessment and CME Test-Preferred Responses.
Owens, James W. M. Jr MD, PhD; Zazulia, Allyson R. MD
