American Journal of Clinical Nutrition




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Expanding the already strong rationale for prenatal multiple micronutrient supplementation in low- and middle-income countries

Reynaldo Martorell

doi : 10.1093/ajcn/nqac243

The American Journal of Clinical Nutrition, Volume 116, Issue 5, November 2022, Pages 1191–1192

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Costs, cost-effectiveness, and context

Reina Engle-Stone, Katherine P Adams

doi : 10.1093/ajcn/nqac254

The American Journal of Clinical Nutrition, Volume 116, Issue 5, November 2022, Pages 1193–1194

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Food substitutions revisited

Daniel B Ibsen, Christina C Dahm

doi : 10.1093/ajcn/nqac222

The American Journal of Clinical Nutrition, Volume 116, Issue 5, November 2022, Pages 1195–1198

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Dietary advice for women trying to conceive: Can we do better than standard guidance?

Audrey J Gaskins

doi : 10.1093/ajcn/nqac247

The American Journal of Clinical Nutrition, Volume 116, Issue 5, November 2022, Pages 1199–1200

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Is dietary choline intake related to dementia and Alzheimer's disease risks? Results from the Framingham Heart Study

Jing Yuan, Xue Liu, Chunyu Liu, Alvin F A Ang, Joseph Massaro, Sherral A Devine, Sanford H Auerbach, Jan Krzysztof Blusztajn, Rhoda Au, Paul F Jacques

doi : 10.1093/ajcn/nqac193

The American Journal of Clinical Nutrition, Volume 116, Issue 5, November 2022, Pages 1201–1207

The positive association of choline for cognition has been reported in both animal and human studies, yet the associations of choline with the risks of incident dementia or Alzheimer's disease (AD) in humans is unclear.

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Hydrogen intake relieves alcohol consumption and hangover symptoms in healthy adults: a randomized and placebo-controlled crossover study

Xiang Lv, Yuanfeng Lu, Guoyong Ding, Xiao Li, Xinxin Xu, Aihua Zhang, Guohua Song

doi : 10.1093/ajcn/nqac261

The American Journal of Clinical Nutrition, Volume 116, Issue 5, November 2022, Pages 1208–1218

Alcohol-induced hangover represents a significant, yet understudied, global hazard and a large socioeconomic burden.

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Coffee consumption and risk of endometrial cancer: a pooled analysis of individual participant data in the Epidemiology of Endometrial Cancer Consortium (E2C2)

Marta Crous-Bou, Mengmeng Du, Marc J Gunter, Veronica W Setiawan, Leo J Schouten, Xiao-ou Shu, Nicolas Wentzensen, Kimberly A Bertrand, Linda S Cook, Christine M Friedenreich, Susan M Gapstur, Marc T Goodman, Torukiri I Ibiebele, Carlo La Vecchia, Fabio Levi, Linda M Liao, Eva Negri, Susan E McCann, Kelly O'Connell, Julie R Palmer, Alpa V Patel, Jeanette Ponte, Peggy Reynolds, Carlotta Sacerdote, Rashmi Sinha, Amanda B Spurdle, Britton Trabert, Piet A van den Brandt, Penelope M Webb, Stacey Petruzella, Sara H Olson, Immaculata De Vivo on behalf of the Epidemiology of Endometrial Cancer Consortium (E2C2)

doi : 10.1093/ajcn/nqac229

The American Journal of Clinical Nutrition, Volume 116, Issue 5, November 2022, Pages 1219–1228

Epidemiologic studies suggest that coffee consumption may be inversely associated with risk of endometrial cancer (EC), the most common gynecological malignancy in developed countries. Furthermore, coffee consumption may lower circulating concentrations of estrogen and insulin, hormones implicated in endometrial carcinogenesis. Antioxidants and other chemopreventive compounds in coffee may have anticarcinogenic effects. Based on available meta-analyses, the World Cancer Research Fund (WCRF) concluded that consumption of coffee probably protects against EC.

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Identifying cancer cachexia in patients without weight loss information: machine learning approaches to address a real-world challenge

Liangyu Yin, Jiuwei Cui, Xin Lin, Na Li, Yang Fan, Ling Zhang, Jie Liu, Feifei Chong, Chang Wang, Tingting Liang, Xiangliang Liu, Li Deng, Mei Yang, Jiami Yu, Xiaojie Wang, Minghua Cong, Zengning Li, Min Weng, Qinghua Yao, Pingping Jia, Zengqing Guo, Wei Li, Chunhua Song, Hanping Shi, Hongxia Xu

doi : 10.1093/ajcn/nqac251

The American Journal of Clinical Nutrition, Volume 116, Issue 5, November 2022, Pages 1229–1239

Diagnosing cancer cachexia relies extensively on patient-reported historic weight, and failure to accurately recall this information can lead to severe underestimation of cancer cachexia.

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Low-carbohydrate vegan diets in diabetes for weight loss and sustainability: a randomized controlled trial

David J A Jenkins, Peter J H Jones, Mohammad M H Abdullah, Benoit Lamarche, Dorothea Faulkner, Darshna Patel, Sandhya Sahye-Pudaruth, Melanie Paquette, Balachandran Bashyam, Sathish C Pichika, Meaghan E Kavanagh, Pooja Patel, Fred Liang, Ramon Brown, Tiffany Zhao, Mila Phan, Gajuna Mathiyalagan, Shilpa Tandon, Vladmir Vuksan, Elena Jovanovski, John L Sievenpiper, Cyril W C Kendall, Lawrence A Leiter, Robert G Josse

doi : 10.1093/ajcn/nqac203

The American Journal of Clinical Nutrition, Volume 116, Issue 5, November 2022, Pages 1240–1250

Low-carbohydrate, high animal fat and protein diets have been promoted for weight loss and diabetes treatment. We therefore tested the effect of a low-carbohydrate vegan diet in diabetes as a potentially healthier and more ecologically sustainable low-carbohydrate option.

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Systematic literature review: should a bedtime snack be used to treat hyperglycemia in type 2 diabetes?

Lauren A Roach, William Woolfe, Beenu Bastian, Elizabeth P Neale, Monique E Francois

doi : 10.1093/ajcn/nqac245

The American Journal of Clinical Nutrition, Volume 116, Issue 5, November 2022, Pages 1251–1264

Consuming a bedtime snack is often recommended for people with type 2 diabetes.

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An integrated assessment of environmental sustainability and nutrient availability of food consumption patterns in Latin America and the Caribbean

Abrania Marrero, Emma Anderson, Camila de la Vega, Vanessa Beltran, Sebastien Haneuse, Christopher Golden, Josiemer Mattei

doi : 10.1093/ajcn/nqac220

The American Journal of Clinical Nutrition, Volume 116, Issue 5, November 2022, Pages 1265–1277

In Latin America and the Caribbean (LAC), historical shifts away from traditional, plant-sourced food production and consumption patterns may undermine both nutritional status and environmental sustainability. Although agricultural intensification and increasingly animal-centric dietary preferences in the region are well-documented, their influence on environmental degradation remains unknown.

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Diet, but not food type, significantly affects micronutrient and toxic metal profiles in urine and/or plasma; a randomized, controlled intervention trial

Leonidas Rempelos, Juan Wang, Marcin Barański, Anthony Watson, Nikolaos Volakakis, Catherine Hadall, Gultakin Hasanaliyeva, Eleni Chatzidimitriou, Amelia Magistrali, Hannah Davis, Vanessa Vigar, Dominika Średnicka-Tober, Steven Rushton, Kristin S Rosnes, Per O Iversen, Chris J Seal, Carlo Leifert

doi : 10.1093/ajcn/nqac233

The American Journal of Clinical Nutrition, Volume 116, Issue 5, November 2022, Pages 1278–1290

Observational studies have linked Mediterranean Diets (MedDiets) and organic food consumption with positive health outcomes, which may be explained by higher mineral micronutrient and phenolic intake and lower dietary exposure to toxic compounds.

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Scaling up prenatal nutrition could reduce the global burden of noncommunicable diseases in the next generation: a modeling analysis

Mia M Blakstad, Wafaie W Fawzi, Marcia C Castro, Andrew Thompson, Mandana Arabi, Goodarz Danaei

doi : 10.1093/ajcn/nqac214

The American Journal of Clinical Nutrition, Volume 116, Issue 5, November 2022, Pages 1291–1302

Nutritional conditions during pregnancy may influence the epigenetic development of an individual and consequently their later-life risk of noncommunicable disease (NCD). Improving nutrition for pregnant females may therefore serve the dual purpose of directly improving pregnancy outcomes and preventing NCDs in the next generation.

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Cost-effectiveness of universal iron supplementation and iron-containing micronutrient powders for anemia among young children in rural Bangladesh: analysis of a randomized, placebo-controlled trial

Edifofon Akpan, Sheikh J Hossain, Angela Devine, Sabine Braat, Mohammed I Hasan, S M Mulk Uddin Tipu, Mohammad Saiful Alam Bhuiyan, Jena D Hamadani, Beverley-Ann Biggs, Sant-Rayn Pasricha, Natalie Carvalho

doi : 10.1093/ajcn/nqac225

The American Journal of Clinical Nutrition, Volume 116, Issue 5, November 2022, Pages 1303–1313

Universal provision of iron supplements or iron-containing multiple micronutrient powders (MNPs) is widely used to prevent anemia in young children in low- and middle-income countries. The BRISC (Benefits and Risks of Iron Interventions in Children) trial compared iron supplements and MNPs with placebo in children <2 y old in rural Bangladesh.

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Preventive small-quantity lipid-based nutrient supplements reduce severe wasting and severe stunting among young children: an individual participant data meta-analysis of randomized controlled trials

Kathryn G Dewey, Charles D Arnold, K Ryan Wessells, Elizabeth L Prado, Souheila Abbeddou, Seth Adu-Afarwuah, Hasmot Ali, Benjamin F Arnold, Per Ashorn, Ulla Ashorn, Sania Ashraf, Elodie Becquey, Kenneth H Brown, Parul Christian, John M Colford, Jr, Sherlie J L Dulience, Lia C H Fernald, Emanuela Galasso, Lotta Hallamaa, Sonja Y Hess, Jean H Humphrey, Lieven Huybregts, Lora L Iannotti, Kaniz Jannat, Anna Lartey, Agnes Le Port, Jef L Leroy, Stephen P Luby, Kenneth Maleta, Susana L Matias, Mduduzi N N Mbuya, Malay K Mridha, Minyanga Nkhoma, Clair Null, Rina R Paul, Harriet Okronipa, Jean-Bosco Ouédraogo, Amy J Pickering, Andrew J Prendergast, Marie Ruel, Saijuddin Shaikh, Ann M Weber, Patricia Wolff, Amanda Zongrone, Christine P Stewart

doi : 10.1093/ajcn/nqac232

The American Journal of Clinical Nutrition, Volume 116, Issue 5, November 2022, Pages 1314–1333

Meta-analyses show that small-quantity lipid-based nutrient supplements (SQ-LNSs) reduce child wasting and stunting. There is little information regarding effects on severe wasting or stunting.

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The roles of sleep and eating patterns in adiposity gain among preschool-aged children

Amy R Goetz, Ishita Jindal, Jennette P Moreno, Maurice R Puyau, Anne L Adolph, Salma Musaad, Nancy F Butte, Fida Bacha

doi : 10.1093/ajcn/nqac197

The American Journal of Clinical Nutrition, Volume 116, Issue 5, November 2022, Pages 1334–1342

Short sleep durations are related to risks for obesity in preschool children. However, the underlying mechanism or mechanisms are not clear.

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Prenatal metabolomic profiles mediate the effect of maternal obesity on early childhood growth trajectories and obesity risk: the Conditions Affecting Neurocognitive Development and Learning in Early Childhood (CANDLE) Study

Zunsong Hu, Luhang Han, Jiawang Liu, Jay H Fowke, Joan C Han, David Kakhniashvili, Kaja Z LeWinn, Nicole R Bush, W Alex Mason, Qi Zhao

doi : 10.1093/ajcn/nqac244

The American Journal of Clinical Nutrition, Volume 116, Issue 5, November 2022, Pages 1343–1353

Maternal prepregnancy obesity is an important risk factor for offspring obesity, which may partially operate through prenatal programming mechanisms.

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A randomized dietary intervention to increase colonic and peripheral blood SCFAs modulates the blood B- and T-cell compartments in healthy humans

Paul A Gill, Jane G Muir, Peter R Gibson, Menno C van Zelm

doi : 10.1093/ajcn/nqac246

The American Journal of Clinical Nutrition, Volume 116, Issue 5, November 2022, Pages 1354–1367

SCFAs have immune-modulating effects in animal models of disease. However, there is limited evidence that this may occur in humans.

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Characterization of diet-dependent temporal changes in circulating short-chain fatty acid concentrations: A randomized crossover dietary trial

Jerusa Brignardello, Sofia Fountana, Joram Matthias Posma, Edward S Chambers, Jeremy K Nicholson, Julien Wist, Gary Frost, Isabel Garcia-Perez, Elaine Holmes

doi : 10.1093/ajcn/nqab211

The American Journal of Clinical Nutrition, Volume 116, Issue 5, November 2022, Pages 1368–1378,

Production of SCFAs from food is a complex and dynamic saccharolytic fermentation process mediated by both human and gut microbial factors. Knowledge of SCFA production and of the relation between SCFA profiles and dietary patterns is lacking.

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Theory and performance of substitution models for estimating relative causal effects in nutritional epidemiology

Georgia D Tomova, Mark S Gilthorpe, Peter W G Tennant

doi : 10.1093/ajcn/nqac188

The American Journal of Clinical Nutrition, Volume 116, Issue 5, November 2022, Pages 1379–1388

Estimating relative causal effects (i.e., “substitution effects�) is a common aim of nutritional research. In observational data, this is usually attempted using 1 of 2 statistical modeling approaches: the leave-one-out model and the energy partition model. Despite their widespread use, there are concerns that neither approach is well understood in practice.

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Vitamin D status, genetic factors, and risks of cardiovascular disease among individuals with type 2 diabetes: a prospective study

Zhenzhen Wan, Tingting Geng, Rui Li, Xue Chen, Qi Lu, Xiaoyu Lin, Liangkai Chen, Yanjun Guo, Liegang Liu, Zhilei Shan, An Pan, JoAnn E Manson, Gang Liu

doi : 10.1093/ajcn/nqac183

The American Journal of Clinical Nutrition, Volume 116, Issue 5, November 2022, Pages 1389–1399

The presence of a threshold effect has been proposed, suggesting that beneficial effects from vitamin D supplementation may only be present when the vitamin D concentration is below a particular threshold.

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Vitamin D status and prevalence of metabolic syndrome by race and Hispanic origin in US adults: findings from the 2007–2014 NHANES

Namanjeet Ahluwalia, Ramkripa Raghavan, Guangyu Zhang, Sameera A Talegawkar, Paul F Jacques

doi : 10.1093/ajcn/nqac234

The American Journal of Clinical Nutrition, Volume 116, Issue 5, November 2022, Pages 1400–1408

Vitamin D status has been found to be inversely associated with metabolic syndrome (MetS) in some studies. Vitamin D status varies by race and ethnicity, and the association of MetS with vitamin D status in US adults and by race and Hispanic origin has not been evaluated extensively.

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Association between serum 25-hydroxy vitamin D concentrations and mortality among individuals with metabolic dysfunction–associated fatty liver disease: a prospective cohort study

Ji-Juan Zhang, Han-Cheng Yu, Yue Li, Yan-Bo Zhang, Ting-Ting Geng, Qi Lu, Yun-Fei Liao, Kun-Quan Guo, Liang Du, Hua-Ling Ruan, Kun Yang, Gang Liu, An Pan

doi : 10.1093/ajcn/nqac260

The American Journal of Clinical Nutrition, Volume 116, Issue 5, November 2022, Pages 1409–1417

The association between serum 25-hydroxyvitamin D [25(OH)D] concentrations and mortality among patients with metabolic dysfunction–associated fatty liver disease (MAFLD) or nonalcoholic fatty liver disease (NAFLD) remains unclear.

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Next-generation smart watches to estimate whole-body composition using bioimpedance analysis: accuracy and precision in a diverse, multiethnic sample

Jonathan P Bennett, Yong En Liu, Nisa N Kelly, Brandon K Quon, Michael C Wong, Cassidy McCarthy, Steven B Heymsfield, John A Shepherd

doi : 10.1093/ajcn/nqac200

The American Journal of Clinical Nutrition, Volume 116, Issue 5, November 2022, Pages 1418–1429

Novel advancements in wearable technologies include continuous measurement of body composition via smart watches. The accuracy and stability of these devices are unknown.

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Iron metabolism regulation in females and males exposed to simulated microgravity: results from the randomized trial Artificial Gravity Bed Rest—European Space Agency (AGBRESA)

Mathieu Horeau, Martine Ropert, Edwin Mulder, Jens Tank, Petra Frings-Meuthen, Gabriele Armbrecht, Olivier Loréal, Frédéric Derbré

doi : 10.1093/ajcn/nqac205

The American Journal of Clinical Nutrition, Volume 116, Issue 5, November 2022, Pages 1430–1440

Iron metabolism imbalance could contribute to physical deconditioning experienced by astronauts due to its essential role in energy metabolism, cellular respiration, and oxygen transport.

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Dietary patterns and fecundability in 2 prospective preconception cohorts

Sydney K Willis, Elizabeth E Hatch, Anne S D Laursen, Amelia K Wesselink, Ellen M Mikkelsen, Katherine L Tucker, Kenneth J Rothman, Sunni L Mumford, Lauren A Wise

doi : 10.1093/ajcn/nqac213

The American Journal of Clinical Nutrition, Volume 116, Issue 5, November 2022, Pages 1441–1451

Diet is increasingly recognized as an important determinant of human fertility, with most research focused on specific nutrients or food groups. However, there has been limited assessment of the effect of dietary patterns on fertility.

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Bias attributable to the use of a composite outcome in evaluating a cocoa extract supplement

doi : 10.1093/ajcn/nqac185

The American Journal of Clinical Nutrition, Volume 116, Issue 5, November 2022, Page 1452

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Reply to PC Ramírez and FA Diaz-Quijano

doi : 10.1093/ajcn/nqac187

The American Journal of Clinical Nutrition, Volume 116, Issue 5, November 2022, Pages 1452–1453

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Correction to: Stonehouse et al. Krill oil improved osteoarthritic knee pain in adults with mild to moderate knee osteoarthritis: a 6-month multicenter, randomized, double-blind, placebo-controlled trial. Am J Clin Nutr 2022;116:672–85

doi : 10.1093/ajcn/nqac262

The American Journal of Clinical Nutrition, Volume 116, Issue 5, November 2022, Page 1454

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Calendar of Events

doi : 10.1093/ajcn/nqac288

The American Journal of Clinical Nutrition, Volume 116, Issue 5, November 2022, Page 1455

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