American Journal of Clinical Nutrition




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As White House conference approaches, now is the time for a national plan to address the link between hunger, nutrition education, and health

Congressman James P McGovern

doi : 10.1093/ajcn/nqac228

The American Journal of Clinical Nutrition, Volume 116, Issue 4, October 2022, Pages 841–842

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A new series in The American Journal of Clinical Nutrition: new developments from federal colleagues

Joel B Mason, Christopher P Duggan

doi : 10.1093/ajcn/nqac227

The American Journal of Clinical Nutrition, Volume 116, Issue 4, October 2022, Page 843

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Diversifying your diet portfolio: potential impacts of dietary diversity on the gut microbiome and human health

Kathleen A Lee-Sarwar, Lourdes Ramirez

doi : 10.1093/ajcn/nqac198

The American Journal of Clinical Nutrition, Volume 116, Issue 4, October 2022, Pages 844–845

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Dietary acrylamide and human cancer; even after 20 years of research an open question

Janneke G F Hogervorst, Leo J Schouten

doi : 10.1093/ajcn/nqac192

The American Journal of Clinical Nutrition, Volume 116, Issue 4, October 2022, Pages 846–847

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A complex triad determining metabolic health: diet, host, and microbiome interaction

Joscha Vonderlin, Frank Tacke

doi : 10.1093/ajcn/nqac180

The American Journal of Clinical Nutrition, Volume 116, Issue 4, October 2022, Pages 848–850

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WIC, the full package, not simply the food package!

Elizabeth Metallinos-Katsaras

doi : 10.1093/ajcn/nqac177

The American Journal of Clinical Nutrition, Volume 116, Issue 4, October 2022, Pages 851–852

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Weight gain acceleration by glucose-based infant formula

Jennie C Brand-Miller

doi : 10.1093/ajcn/nqac191

The American Journal of Clinical Nutrition, Volume 116, Issue 4, October 2022, Pages 853–854

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Seaweed proteins are nutritionally valuable components in the human diet

Daman Reynolds, Jeff Caminiti, Scott Edmundson, Song Gao, Macdonald Wick, Michael Huesemann

doi : 10.1093/ajcn/nqac190

The American Journal of Clinical Nutrition, Volume 116, Issue 4, October 2022, Pages 855–861

The global population is expected to reach 11 billion people by the year 2100 and will require sustainable sources of dietary protein. Most dietary protein originates from animal and terrestrial plant agriculture, which leads to deforestation, water pollution, and greenhouse gas emissions.

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The human gut microbiota and glucose metabolism: a scoping review of key bacteria and the potential role of SCFAs

Marie S A Palmnäs-Bédard, Giuseppina Costabile, Claudia Vetrani, Sebastian Åberg, Yommine Hjalmarsson, Johan Dicksved, Gabriele Riccardi, Rikard Landberg

doi : 10.1093/ajcn/nqac217

The American Journal of Clinical Nutrition, Volume 116, Issue 4, October 2022, Pages 862–874

The gut microbiota plays a fundamental role in human nutrition and metabolism and may have direct implications for type 2 diabetes and associated preconditions.

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A healthy plant-based diet was associated with slower cognitive decline in African American older adults: a biracial community-based cohort

Xiaoran Liu, Klodian Dhana, Lisa L Barnes, Christy C Tangney, Puja Agarwal, Neelum Aggarwal, Thomas M Holland, Todd Beck, Denis A Evans, Kumar B Rajan

doi : 10.1093/ajcn/nqac204

The American Journal of Clinical Nutrition, Volume 116, Issue 4, October 2022, Pages 875–886

African American (AA) adults have about twice the risk of developing dementia compared with white adults. However, evidence on dietary modification in preventing cognitive decline from diverse populations focusing on AA adults is minimal.

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Individualized high dairy protein + walking program supports bone health in pregnancy: a randomized controlled trial

Maude Perreault, Michelle F Mottola, Stephanie A Atkinson, BHIP study team

doi : 10.1093/ajcn/nqac182

The American Journal of Clinical Nutrition, Volume 116, Issue 4, October 2022, Pages 887–896

Pregnancy induces bone mineral mobilization, which may be further compromised if diet and physical activity are suboptimal.

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Prunes preserve hip bone mineral density in a 12-month randomized controlled trial in postmenopausal women: the Prune Study

Mary Jane De Souza, Nicole C A Strock, Nancy I Williams, Hang Lee, Kristen J Koltun, Connie Rogers, Mario G Ferruzzi, Cindy H Nakatsu, Connie Weaver

doi : 10.1093/ajcn/nqac189

The American Journal of Clinical Nutrition, Volume 116, Issue 4, October 2022, Pages 897–910

Dietary consumption of prunes has favorable impacts on bone health, but more research is necessary to improve upon study designs and refine our understandings.

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Dietary exposure to acrylamide and breast cancer risk: results from the NutriNet-Santé cohort

Alice Bellicha, Gaëlle Wendeu-Foyet, Xavier Coumoul, Meriem Koual, Fabrice Pierre, Françoise Guéraud, Laurent Zelek, Charlotte Debras, Bernard Srour, Laury Sellem, Emmanuelle Kesse-Guyot, Chantal Julia, Pilar Galan, Serge Hercberg, Mélanie Deschasaux-Tanguy, Mathilde Touvier

doi : 10.1093/ajcn/nqac167

The American Journal of Clinical Nutrition, Volume 116, Issue 4, October 2022, Pages 911–919

Acrylamide is classified as a probable human carcinogen by the International Agency for Research on Cancer but epidemiologic evidence on the carcinogenicity of acrylamide from dietary sources is limited.

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Healthy dietary patterns and risk of cardiovascular disease in US Hispanics/Latinos: the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

Yi-Yun Chen, Guo-Chong Chen, Nathaniel Abittan, Jiaqian Xing, Yasmin Mossavar-Rahmani, Daniela Sotres-Alvarez, Josiemer Mattei, Martha Daviglus, Carmen R Isasi, Frank B Hu, Robert Kaplan, Qibin Qi

doi : 10.1093/ajcn/nqac199

The American Journal of Clinical Nutrition, Volume 116, Issue 4, October 2022, Pages 920–927

Multiple dietary patterns have been recommended by the 2015–2020 Dietary Guidelines for Americans for the prevention of cardiovascular disease (CVD). The adherence to these patterns and its relation with risk of CVD remain unclear in the US Hispanic/Latino population.

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Short-chain fatty acids are key mediators of the favorable effects of the Mediterranean diet on intestinal barrier integrity: data from the randomized controlled LIBRE trial

Benjamin Seethaler, Nguyen K Nguyen, Maryam Basrai, Marion Kiechle, Jens Walter, Nathalie M Delzenne, Stephan C Bischoff

doi : 10.1093/ajcn/nqac175

The American Journal of Clinical Nutrition, Volume 116, Issue 4, October 2022, Pages 928–942

The Mediterranean diet is associated with the prevention of diabetes, cardiovascular disease, and cancer, all of which are linked to intestinal barrier impairment.

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Effects of a low FODMAP diet on the colonic microbiome in irritable bowel syndrome: a systematic review with meta-analysis

Daniel So, Amy Loughman, Heidi M Staudacher

doi : 10.1093/ajcn/nqac176

The American Journal of Clinical Nutrition, Volume 116, Issue 4, October 2022, Pages 943–952

A low fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) diet is increasingly used to manage symptoms in irritable bowel syndrome (IBS). Although this approach may alter the colonic microbiome, the nature of these changes has not been comprehensively synthesized.

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The Effect of Fiber Supplementation on Chronic Constipation in Adults: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials

Alice van der Schoot, Candice Drysdale, Kevin Whelan, Eirini Dimidi

doi : 10.1093/ajcn/nqac184

The American Journal of Clinical Nutrition, Volume 116, Issue 4, October 2022, Pages 953–969

Chronic constipation is a prevalent disorder that remains challenging to treat. Studies suggest increasing fiber intake may improve symptoms, although recommendations on the fiber type, dose, and treatment duration are unclear.

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Tryptophan oxidation in young children with environmental enteric dysfunction classified by the lactulose rhamnose ratio

Nirupama Shivakumar, Jean W Hsu, Sindhu Kashyap, Tinku Thomas, Anura V Kurpad, Farook Jahoor

doi : 10.1093/ajcn/nqac171

The American Journal of Clinical Nutrition, Volume 116, Issue 4, October 2022, Pages 970–979

In young children, associations between linear growth faltering, environmental enteric dysfunction (EED), and the plasma kynurenine (Kyn)/tryptophan (Trp) ratio (KTR) have led to the proposal that higher Trp catabolism in response to intestinal/systemic inflammation limits Trp availability for protein synthesis, resulting in impaired growth.

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Association between adherence to the EAT-Lancet diet and risk of cancer and cardiovascular outcomes in the prospective NutriNet-Santé cohort

Florine Berthy, Joséphine Brunin, Benjamin Allès, Léopold K Fezeu, Mathilde Touvier, Serge Hercberg, Pilar Galan, Philippe Pointereau, Denis Lairon, Julia Baudry, Emmanuelle Kesse-Guyot

doi : 10.1093/ajcn/nqac208

The American Journal of Clinical Nutrition, Volume 116, Issue 4, October 2022, Pages 980–991

The EAT-Lancet commission proposed, in 2019, a planetary, healthy, and universal dietary pattern. However, this diet has rarely been studied in relation to various health outcomes.

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Relative validity of a mobile AI-technology–assisted dietary assessment in adolescent females in Vietnam

Phuong Hong Nguyen, Lan Mai Tran, Nga Thu Hoang, Duong Thuy Thi TrÆ°Æ¡ng, Trang Huyen Thi Tran, Phuong Nam Huynh, Bastien Koch, Peter McCloskey, Rohit Gangupantulu, Gloria Folson, Boateng Bannerman, Alejandra Arrieta, Bianca C Braga, Joanne Arsenault, Annalyse Kehs, Frank Doyle, David Hughes, Aulo Gelli

doi : 10.1093/ajcn/nqac216

The American Journal of Clinical Nutrition, Volume 116, Issue 4, October 2022, Pages 992–1001

There is a gap in data on dietary intake of adolescents in low- and middle-income countries (LMICs). Traditional methods for dietary assessment are resource intensive and lack accuracy with regard to portion-size estimation. Technology-assisted dietary assessment tools have been proposed but few have been validated for feasibility of use in LMICs.

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Lactose-reduced infant formula with corn syrup solids and obesity risk among participants in the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC)

Christopher E Anderson, Shannon E Whaley, Michael I Goran

doi : 10.1093/ajcn/nqac173

The American Journal of Clinical Nutrition, Volume 116, Issue 4, October 2022, Pages 1002–1009

The Special Supplemental Nutrition Program for Women, Infants, and Children (WIC), a federal nutrition assistance program supporting low-income families, serves half of United States–born infants, most of whom are issued infant formula by age 2 mo. Obesity prevalence is high among children of low-income households, particularly formula-fed children.

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Body composition trajectories from birth to 5 years and hepatic fat in early childhood

Catherine C Cohen, Kylie K Harrall, Stephanie P Gilley, Wei Perng, Katherine A Sauder, Ann Scherzinger, Kartik Shankar, Shikha S Sundaram, Deborah H Glueck, Dana Dabelea

doi : 10.1093/ajcn/nqac168

The American Journal of Clinical Nutrition, Volume 116, Issue 4, October 2022, Pages 1010–1018

Adiposity is an established risk factor for pediatric nonalcoholic fatty liver disease (NAFLD), but little is known about the influence of body composition patterns earlier in life on NAFLD risk.

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An agent-based model of child sugar-sweetened beverage consumption: implications for policies and practices

Matt Kasman, Ross A Hammond, Rob Purcell, Benjamin Heuberger, Travis R Moore, Anna H Grummon, Allison J Wu, Jason P Block, Marie-France Hivert, Emily Oken, Ken Kleinman

doi : 10.1093/ajcn/nqac194

The American Journal of Clinical Nutrition, Volume 116, Issue 4, October 2022, Pages 1019–1029

A strong body of evidence links young children's intake of sugar-sweetened beverages (SSBs) with myriad negative outcomes.

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The Special Supplemental Nutrition Program for Women, Infants, and Children food package revisions and anemia in children aged 2–5 years

Namrata Sanjeevi, Jeanne H Freeland-Graves

doi : 10.1093/ajcn/nqac141

The American Journal of Clinical Nutrition, Volume 116, Issue 4, October 2022, Pages 1030–1037

The Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) provides nutritional assistance to low-income women and children in the United States. The WIC food package was revised to align more closely to dietary recommendations in October 2009. The revised package included more fruits, vegetables, whole grains, and low-fat milk.

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Intake of mother's milk by very-low-birth-weight infants and variation in DNA methylation of genes involved in neurodevelopment at 5.5 years of age

Jingxiong Xu, Jean Shin, Meghan McGee, Sharon Unger, Nicole Bando, Julie Sato, Marlee Vandewouw, Yash Patel, Helen M Branson, Tomas Paus, Zdenka Pausova, Deborah L O'Connor

doi : 10.1093/ajcn/nqac221

The American Journal of Clinical Nutrition, Volume 116, Issue 4, October 2022, Pages 1038–1048

Mechanisms responsible for associations between intake of mother's milk in very-low-birth-weight (VLBW, <1500 g) infants and later neurodevelopment are poorly understood. It is proposed that early nutrition may affect neurodevelopmental pathways by altering gene expression through epigenetic modification. Variation in DNA methylation (DNAm) at cytosine-guanine dinucleotides (CpGs) is a commonly studied epigenetic modification.

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Associations of dietary diversity with the gut microbiome, fecal metabolites, and host metabolism: results from 2 prospective Chinese cohorts

Congmei Xiao, Jia-ting Wang, Chang Su, Zelei Miao, Jun Tang, Yifei Ouyang, Yan Yan, Zengliang Jiang, Yuanqing Fu, Menglei Shuai, Wanglong Gou, Fengzhe Xu, Evan Y-W Yu, Yuhui Liang, Xinxiu Liang, Yunyi Tian, Jiali Wang, Feifei Huang, Bing Zhang, Huijun Wang, Yu-ming Chen, Ju-Sheng Zheng

doi : 10.1093/ajcn/nqac178

The American Journal of Clinical Nutrition, Volume 116, Issue 4, October 2022, Pages 1049–1058

Dietary diversity is essential for human health. The gut ecosystem provides a potential link between dietary diversity, host metabolism, and health, yet this mechanism is poorly understood.

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Discordance between postprandial plasma glucose measurement and continuous glucose monitoring

Souptik Barua, Raven A Wierzchowska-McNew, Nicolaas E P Deutz, Ashutosh Sabharwal

doi : 10.1093/ajcn/nqac181

The American Journal of Clinical Nutrition, Volume 116, Issue 4, October 2022, Pages 1059–1069

There has been growing interest in studying postprandial glucose responses using continuous glucose monitoring (CGM) in nondiabetic individuals. Accurate measurement of glucose responses to meals can facilitate applications such as precision nutrition and early detection of diabetes.

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Associations between plasma tryptophan and indole-3-propionic acid levels and mortality in patients with coronary artery disease

Qing Li, Yiran You, Yupeng Zeng, Xu Wang, Zhijun Pan, Juan Pang, Qian Chen, Yuqing Zhou, Yufeng Jin, Yan Yang, Wenhua Ling

doi : 10.1093/ajcn/nqac170

The American Journal of Clinical Nutrition, Volume 116, Issue 4, October 2022, Pages 1070–1077

Indole-3-propionic acid (IPA), a microbiota-produced tryptophan metabolite, has been shown to exhibit cardioprotective effects in animal models. However, the relation of IPA with cardiovascular risk in humans is currently unknown.

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A healthy plant–based diet is favorably associated with cardiometabolic risk factors among participants of South Asian ancestry

Shilpa N Bhupathiraju, Caleigh M Sawicki, Shatabdi Goon, Unjali P Gujral, Frank B Hu, Namratha R Kandula, Alka M Kanaya

doi : 10.1093/ajcn/nqac174

The American Journal of Clinical Nutrition, Volume 116, Issue 4, October 2022, Pages 1078–1090

Plant-based diets are recommended for chronic disease prevention, yet there has been little focus on plant-based diet quality among participants of South Asian ancestry who consume a predominantly plant-based diet.

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Calcium and magnesium in drinking water and risk of myocardial infarction and stroke—a population-based cohort study

Emilie Helte, Melle Säve-Söderbergh, Susanna C Larsson, Agneta Åkesson

doi : 10.1093/ajcn/nqac186

The American Journal of Clinical Nutrition, Volume 116, Issue 4, October 2022, Pages 1091–1100

The implication of calcium and magnesium in drinking water for cardiovascular disease is unclear.

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Maternal diet during pregnancy and child neurodevelopment up to age 3.5 years: the nationwide Étude Longitudinale Française depuis l'Enfance (ELFE) birth cohort

Blandine de Lauzon-Guillain, Chloé Marques, Manik Kadawathagedara, Jonathan Y Bernard, Muriel Tafflet, Sandrine Lioret, Marie Aline Charles

doi : 10.1093/ajcn/nqac206

The American Journal of Clinical Nutrition, Volume 116, Issue 4, October 2022, Pages 1101–1111

Dietary guidelines available to pregnant women are made to improve maternal health and fetal development. But their adequacy to sustain offspring neurodevelopment has remained understudied.

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Mediators of weight change in underserved patients with obesity: exploratory analyses from the Promoting Successful Weight Loss in Primary Care in Louisiana (PROPEL) cluster-randomized trial

James L Dorling, Corby K Martin, Qingzhao Yu, Wentao Cao, Christoph Höchsmann, John W Apolzan, Robert L Newton, Jr, Kara D Denstel, Emily F Mire, Peter T Katzmarzyk

doi : 10.1093/ajcn/nqac179

The American Journal of Clinical Nutrition, Volume 116, Issue 4, October 2022, Pages 1112–1122

Intensive lifestyle interventions (ILIs) stimulate weight loss in underserved patients with obesity, but the mediators of weight change are unknown.

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Dietary potassium intake, kidney function, and survival in a nationally representative cohort

Yoko Narasaki, Amy S You, Shaista Malik, Linda W Moore, Rachelle Bross, Mackenzie K Cervantes, Andrea Daza, Csaba P Kovesdy, Danh V Nguyen, Kamyar Kalantar-Zadeh, Connie M Rhee

doi : 10.1093/ajcn/nqac215

The American Journal of Clinical Nutrition, Volume 116, Issue 4, October 2022, Pages 1123–1134

In healthy adults, higher dietary potassium intake is recommended given that potassium-rich foods are major sources of micronutrients, antioxidants, and fiber. Yet among patients with advanced kidney dysfunction, guidelines recommend dietary potassium restriction given concerns about hyperkalemia leading to malignant arrhythmias and mortality.

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The effect of dechitinization on iron absorption from mealworm larvae (Tenebrio molitor) flour added to maize meals: stable-isotope studies in young females with low iron stores

Nikolin Hilaj, Michael B Zimmermann, Valeria Galetti, Christophe Zeder, Roberta Murad Lima, Laila Hammer, Adam Krzystek, Wilfried Andlauer, Diego Moretti

doi : 10.1093/ajcn/nqac210

The American Journal of Clinical Nutrition, Volume 116, Issue 4, October 2022, Pages 1135–1145

Edible insects have a low ecological footprint and could serve as an alternative dietary iron source. However, chitin, a major component of insects, avidly binds iron and might inhibit iron absorption.

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Absorption of iron from edible house crickets: a randomized crossover stable-isotope study in humans

Martin N Mwangi, Dennis G A B Oonincx, Marijke Hummel, Dessy A Utami, Lidyawati Gunawan, Margot Veenenbos, Christophe Zeder, Colin I Cercamondi, Michael B Zimmermann, Joop J A van Loon, Marcel Dicke, Alida Melse-Boonstra

doi : 10.1093/ajcn/nqac223

The American Journal of Clinical Nutrition, Volume 116, Issue 4, October 2022, Pages 1146–1156

Edible insects are a novel source of animal protein. Moreover, edible insects contain iron concentrations similar to meat, potentially making them a valuable iron source for human consumers. Yet, it is unknown to what extent iron from insects is absorbed in humans.

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Comparison between the Brazilian and 3 international gestational weight gain charts

Dayana R Farias, Thais R B Carrilho, Kathleen M Rasmussen, Jennifer A Hutcheon, Michael E Reichenheim, Denise C Barros, Silvana G N da Gama, Gilberto Kac

doi : 10.1093/ajcn/nqac164

The American Journal of Clinical Nutrition, Volume 116, Issue 4, October 2022, Pages 1157–1167

Little is known about the ability of the recently released Brazilian gestational weight gain (GWG) charts to predict the occurrence of adverse birth outcomes.

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Recreational physical activity before and during pregnancy and placental DNA methylation—an epigenome-wide association study

Sifang Kathy Zhao, Edwina H Yeung, Marion Ouidir, Stefanie N Hinkle, Katherine L Grantz, Susanna D Mitro, Jing Wu, Danielle R Stevens, Suvo Chatterjee, Fasil Tekola-Ayele, Cuilin Zhang

doi : 10.1093/ajcn/nqac111

The American Journal of Clinical Nutrition, Volume 116, Issue 4, October 2022, Pages 1168–1183

Physical activity (PA) prior to and during pregnancy may have intergenerational effects on offspring health through placental epigenetic modifications. We are unaware of epidemiologic studies on longitudinal PA and placental DNA methylation.

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Re: Effect of a ketogenic diet versus Mediterranean diet on glycated hemoglobin in individuals with prediabetes and type 2 diabetes mellitus: the interventional Keto-Med randomized crossover trial

Tro Kalayjian, Eric C Westman

doi : 10.1093/ajcn/nqac202

The American Journal of Clinical Nutrition, Volume 116, Issue 4, October 2022, Page 1184

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Reply to T Kalayjian and EC Westman

Christopher D Gardner, Matthew J Landry, Lucia Aronica, Kristen M Cunanan, Sun H Kim

doi : 10.1093/ajcn/nqac201

The American Journal of Clinical Nutrition, Volume 116, Issue 4, October 2022, Pages 1184–1185

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RE: Current WHO recommendation to reduce free sugar intake from all sources to below 10% of daily energy intake for supporting overall health is not well supported by available evidence

Bettina Hieronimus, Kimber L Stanhope

doi : 10.1093/ajcn/nqac211

The American Journal of Clinical Nutrition, Volume 116, Issue 4, October 2022, Page 1187

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Reply to B Hieronimus and K Stanhope

Rina Ruolin Yan, Chi Bun Chan, Jimmy Chun Yu Louie

doi : 10.1093/ajcn/nqac212

The American Journal of Clinical Nutrition, Volume 116, Issue 4, October 2022, Page 1186

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Correction to: Fabienne Delestre, Guillaume Lehéricey, Candice Estellat, M Hassimiou Diallo, Boris Hansel, Philippe Giral, Hypnosis reduces food impulsivity in patients with obesity and high levels of disinhibition: HYPNODIET randomized controlled clinical trial, The American Journal of Clinical Nutrition, Volume 115, Issue 6, June 2022, Pages 1637–1645, https://doi.org/10.1093/ajcn/nqac046

doi : 10.1093/ajcn/nqac226

The American Journal of Clinical Nutrition, Volume 116, Issue 4, October 2022, Page 1187

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Correction to: Rina Ruolin Yan, Chi Bun Chan, Jimmy Chun Yu Louie, Current WHO recommendation to reduce free sugar intake from all sources to below 10% of daily energy intake for supporting overall health is not well supported by available evidence, The American Journal of Clinical Nutrition, Volume 116, Issue 1, July 2022, Pages 15–39, https://doi.org/10.1093/ajcn/nqac084

doi : 10.1093/ajcn/nqac231

The American Journal of Clinical Nutrition, Volume 116, Issue 4, October 2022, Page 1187

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SEARCH ANNOUNCEMENT: Editors-in-Chief: Advances in Nutrition and The Journal of Nutrition

doi : 10.1093/ajcn/nqac239

The American Journal of Clinical Nutrition, Volume 116, Issue 4, October 2022, Page 1188

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Calendar of Events

doi : 10.1093/ajcn/nqac249

The American Journal of Clinical Nutrition, Volume 116, Issue 4, October 2022, Page 1189

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