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American Academy of Periodontology best evidence consensus statement on the use of biologics in clinical practice
Gustavo Avila-Ortiz, Jeanne Ambruster, Shayan Barootchi, Leandro Chambrone, Chia-Yu Chen, Douglas R. Dixon, Maria L. Geisinger, William V. Giannobile, Katie Goss, John C. Gunsolley, Rick H. Heard, David M. Kim, George A. Mandelaris, Alberto Monje, Marc L. Nevins, Angela Palaiologou-Gallis, Paul S. Rosen, E. Todd Scheyer, Fernando Suarez-Lopez del Amo, Lorenzo Tavelli, Diego Velasquez, Hom-Lay Wang, Brian L. Mealey
doi : 10.1002/JPER.22-0361
A biologic is a therapeutic agent with biological activity that is administered to achieve an enhanced regenerative or reparative effect. The use of biologics has progressively become a core component of contemporary periodontal practice.
Efficacy of biologics in root coverage and gingival augmentation therapy: An American Academy of Periodontology best evidence systematic review and network meta-analysis
Leandro Chambrone, Shayan Barootchi, Gustavo Avila-Ortiz
doi : 10.1002/JPER.22-0075
The aim of this systematic review was to assess the efficacy of three biologics, namely autologous blood-derived products (ABPs), enamel matrix derivatives (EMD) and recombinant human platelet-derived growth factor BB (rhPDGF-BB), in root coverage and gingival augmentation therapy.
Efficacy of biologics for the treatment of periodontal infrabony defects: An American Academy of Periodontology best evidence systematic review and network meta-analysis
Lorenzo Tavelli, Chia-Yu (Jennifer) Chen, Shayan Barootchi, David M. Kim
doi : 10.1002/JPER.22-0120
A large variety of biomaterials, biologics and membranes have been utilized in the past 40 years for the regenerative treatment of periodontal infrabony defects. Biologic agents have progressively gained popularity among clinicians and are routinely used for periodontal regeneration.
Efficacy of biologics for alveolar ridge preservation/reconstruction and implant site development: An American Academy of Periodontology best evidence systematic review
Fernando Suárez-López del Amo, Alberto Monje
doi : 10.1002/JPER.22-0069
The use of biologics may be indicated for alveolar ridge preservation (ARP) and reconstruction (ARR), and implant site development (ISD). The present systematic review aimed to analyze the effect of autologous blood-derived products (ABPs), enamel matrix derivative (EMD), recombinant human platelet-derived growth factor-BB (rhPDGF-BB), and recombinant human bone morphogenetic protein-2 (rhBMP-2), on the outcomes of ARP/ARR and ISD therapy (i.e., alveolar ridge augmentation [ARA] and maxillary sinus floor augmentation [MSFA]).
Periodontitis is a potential risk factor for transient ischemic attack and minor ischemic stroke in young adults: A nationwide population-based cohort study
Yao-Tung Lee, Chia-Fen Tsai, Yu-Chun Yen, Li-Kai Huang, Shu-Ping Chao, Li-Yu Hu, Cheng-Che Shen, Hsin-Chien Lee
doi : 10.1002/JPER.21-0528
This study aims to determine whether periodontitis is a risk factor for transient ischemic attack (TIA) in young adults.
Influence of vestibular depth on the outcomes of root coverage therapy: A prospective case series study
Gonzalo Blasi, Alberto Monje, Jesus Muñoz-Peñalver, Thomas W. Oates, Gustavo Avila-Ortiz, Jose Nart
doi : 10.1002/JPER.21-0638
The purpose of this study was to investigate the influence of vestibular depth (VD) on the outcomes of root coverage therapy.
Prevalence of periodontal disease in young Moroccans: A national survey
Jamila Kissa, Bouchra El Houari, Khadija Amine, Sihame Chemlali, Nadia Khlil, Salwa Mikou, Amina Gharibi, Imane El Ouadnassi, Chouaib Rifki, Jasim M. Albandar
doi : 10.1002/JPER.22-0103
There are few large surveys of periodontal disease in young age cohorts, and national surveys in Africa do not exist. This study assessed the prevalence and severity of periodontal disease in a national survey of adolescents and young adults in Morocco.
Comparative evaluation of 1% melatonin gel in the treatment of intrabony defect: A randomized controlled clinical trial
Noopur P. Gonde, Surekha R. Rathod, Abhay P. Kolte
doi : 10.1002/JPER.21-0515
The present study aims to evaluate and compare the efficacy of locally delivered 1% melatonin gel as an adjunct to non-surgical periodontal therapy (NSPT) in treatment of intrabony defect in Stage III periodontitis, clinically, and radiographically using cone-beam computed tomography (CBCT).
Poor oral health status and adverse COVID-19 outcomes: A preliminary study in hospitalized patients
Camila Alves Costa, Ana Carolina Serafim Vilela, Suzane Aparecida Oliveira, Tiago Dias Gomes, Alex Alves Costa Andrade, Cláudio Rodrigues Leles, Nádia Lago Costa
doi : 10.1002/JPER.21-0624
Most of the common risk factors for severe outcomes of coronavirus disease 2019 (COVID-19) are correlated with poor oral health, tooth loss, and periodontitis. This has pointed to a possible relationship between oral and systemic health in COVID-19 patients. Hence, this study aimed to assess the dental and periodontal status of hospitalized COVID-19 patients and their associations with the incidence of adverse COVID-19 outcomes.
Circulating small extracellular vesicles from patients with periodontitis contribute to development of insulin resistance
Fei Wang, Linlin Peng, Fan Gu, Pei Huang, Bo Cheng, Gang Chen, Liuyan Meng, Zhuan Bian
doi : 10.1002/JPER.22-0035
Epidemiological studies have identified the role of periodontitis in the pathogenesis of type 2 diabetes, but the underlying mechanism is poorly understood. It is well-known that small extracellular vesicles are lipid bilayer vesicles derived from cells with a diameter around 30 to 200Â nm. The purpose of this study was to investigate whether periodontitis induced or exacerbated insulin resistance via circulating small extracellular vesicles.
Gingival landmarks and cutting points for gingival phenotype determination: A clinical and tomographic cross-sectional study
Diogo Moreira Rodrigues, Rodrigo Lima Petersen, José Rodrigo de Moraes, Eliane Porto Barboza
doi : 10.1002/JPER.21-0615
This cross-sectional study assessed the role of gingival landmarks (GLs) and cutting points (CPs) for gingival phenotype (GP) determination.
Raman microspectroscopy/micro-optical coherence tomography approach for chairside diagnosis of periodontal diseases: A pilot study
Arjun Saggu, Gopi Maguluri, John Grimble, Jesung Park, Hatice Hasturk, Nicusor Iftimia, Corneliu Sima
doi : 10.1002/JPER.21-0710
Our objective was to develop and test a combined Raman microspectroscopy (RMS) and micro-optical coherence tomography (μOCT) approach for chairside quantification of gingival collagen, DNA, epithelium, and connective tissue. We hypothesized that a high-resolution RMS/μOCT can characterize healthy and inflamed periodontal tissues for diagnosis and disease activity monitoring.
Macrophage migration inhibitory factor regulates specific innate immune sensor responses in gingival epithelial cells
Nutthapong Kantrong, Ana M. Chang, Shatha Bamashmous, Adeline M. Hajjar, Richard J. Bucala, Richard P. Darveau
doi : 10.1002/JPER.21-0598
The gingival epithelium protects periodontal tissues and the alveolar bone by maintaining a steady state of regulated inflammatory surveillance, also known as healthy homeostasis. Accordingly, the repertoire of receptors present within the gingival epithelium showcases its ability to recognize microbial colonization and contribute to bacterial sensing.
Construction of an end-to-end regression neural network for the determination of a quantitative index sagittal root inclination
Yixiong Lin, Mengru Shi, Dawei Xiang, Peisheng Zeng, Zhuohong Gong, Haiwen Liu, Quan Liu, Zhuofan Chen, Juan Xia, Zetao Chen
doi : 10.1002/JPER.21-0492
Immediate implant placement in the esthetic area requires comprehensive assessments with nearly 30 quantitative indexes. Most artificial intelligence (AI)-driven measurements of quantitative indexes depend on segmentation or landmark detection, which require extra labeling of images and contain possible intraclass errors.
L-arginine protects cementoblasts against hypoxia-induced apoptosis through Sirt1-enhanced autophagy
Lei Xu, Xi Tan, Siyu Bai, Hongyan Wu, Hong Luo, Yusi Ye, Lingli Fang, Hongwei Dai, Lan Huang
doi : 10.1002/JPER.21-0473
L-arginine (L-arg) can reduce apoptosis in a variety of cells. Cementoblast apoptosis is related to root resorption during orthodontic treatment. In the present study, we aimed to study the regulatory effect and potential mechanism of L-arg on cementoblast apoptosis and root resorption.
