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A Rare Manifestation of a Rare Disease: The Importance of Thinking Outside the Box in a Patient With Complex Dermatomyositis
Megan Milne, Catherine Sims, D. Ryan Anderson, Andrew Johannemann, David Leverenz, Lisa Criscione-Schreiber, Kaveh Ardalan
doi : 10.1002/acr.24905
Traversing the Challenges Facing Meaningful Interpretation of Randomized Controlled Trials With Concurrent Economic Evaluations
Jennifer C. Davis, Cassandra Adjetey
doi : 10.1002/acr.24899
Reactogenicity of the Messenger RNA SARS–CoV-2 Vaccines Associated With Immunogenicity in Patients With Autoimmune and Inflammatory Disease
Monica M. Yang, Kimberly E. Taylor, Diana Paez, Alex Carividi, Emanuel Demissie, Niti Pawar, Alia A. El-Qunni, Lily E. McMorrow, Rebecca E. Schriefer, Katherine Huang, Baylee Kinnett, Michael Klebert, Alem Haile, Jane A. O'Halloran, Rachel M. Presti, Wooseob Kim, Ali H. Ellebedy, Matthew A. Ciorba, Michael A. Paley, Parakkal Deepak, Alfred H. J. Kim, Patricia Katz, Mehrdad Matloubian, Mary Nakamura, Lianne S. Gensler
doi : 10.1002/acr.24894
Little is known regarding the reactogenicity and related SARS–CoV-2 vaccine response in patients with chronic inflammatory disease (CID). Our objective was to characterize the adverse event profile of CID patients following SARS–CoV-2 vaccination and understand the relationship between reactogenicity and immunogenicity of SARS–CoV-2 vaccines.
Rapid Review of Medication Taking (Adherence) Among Patients With Rheumatic Diseases During the COVID-19 Pandemic
Nevena Rebić, Jamie Y. Park, Ria Garg, Ursula Ellis, Ayano Kelly, Eileen Davidson, Mary A. De Vera
doi : 10.1002/acr.24744
We aimed to identify, appraise, synthesize, and contextualize rapidly emerging reports on medication taking (adherence) among patients with rheumatic diseases during the COVID-19 pandemic.
Cost-Effectiveness of Group-Based Outpatient Physical Therapy After Total Knee Replacement: Results From the Economic Evaluation Alongside the ARENA Multicenter Randomized Controlled Trial
Estela C. Barbosa, Vikki Wylde, Joanna Thorn, Emily Sanderson, Erik Lenguerrand, Neil Artz, Ashley W. Blom, Elsa M. R. Marques
doi : 10.1002/acr.24903
To assess the cost-utility and cost-effectiveness of a group-based outpatient physical therapy intervention delivered 6 weeks after primary total knee replacement (TKR) compared with usual care, alongside the Activity-Orientated Rehabilitation Following Knee Arthroplasty (ARENA) multicenter, randomized, controlled trial.
Associations Between Baseline and Longitudinal Semiautomated Quantitative Joint Space Width at the Hip and Incident Hip Osteoarthritis: Data From a Community-Based Cohort
Amanda E. Nelson, Jacquelyn A. Smith, Carolina Alvarez, Liubov Arbeeva, Jordan B. Renner, Louise B. Murphy, Joanne M. Jordan, Yvonne M. Golightly, Jeffrey Duryea
doi : 10.1002/acr.24742
To evaluate quantitative joint space width (JSW) at 10-, 30-, and 50-degree locations in relation to incident radiographic and symptomatic hip osteoarthritis (HOA) in a community-based cohort.
Increased Frailty in Individuals With Osteoarthritis and Rheumatoid Arthritis and the Influence of Comorbidity: An Analysis of the UK Biobank Cohort
Michael J. Cook, Suzanne M. M. Verstappen, Mark Lunt, Terence W. O'Neill
doi : 10.1002/acr.24747
To determine the association between osteoarthritis (OA), rheumatoid arthritis (RA), and frailty and to determine whether comorbidities interact with OA and RA to further increase the likelihood of frailty.
Delayed Gadolinium-Enhanced Magnetic Resonance Imaging of Cartilage Values in Hips With Bone Marrow Lesions
Carly E. Jones, Jolanda Cibere, Hong Qian, Honglin Zhang, Yimeng Guo, David Russell, Bruce B. Forster, Hubert Wong, John M. Esdaile, David R. Wilson
doi : 10.1002/acr.24733
Bone marrow lesions (BMLs) are associated with painful and progressive osteoarthritis (OA). Quantitative magnetic resonance imaging (MRI) has been used to study early cartilage degeneration in knees with BML, but similar work has not been done in hips. The purpose of this study was to compare mean delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) relaxation values (T1Gd) in hips with BML to hips without BML in a population-based study. Reduced T1Gd suggests depleted glycosaminoglycan. Our hypothesis was that mean T1Gd is lower in hips with BML compared to hips without BML.
Ultrasonography of Inflammatory and Structural Lesions in Hand Osteoarthritis: An Outcome Measures in Rheumatology Agreement and Reliability Study
Alexander Mathiessen, Hilde B. Hammer, Lene Terslev, Marion C. Kortekaas, Maria A. D'Agostino, Ida K. Haugen, George A. Bruyn, Georgios Filippou, Emilio Filippucci, Margreet Kloppenburg, Luana Mancarella, Peter Mandl, Ingrid Möller, Mohamed A. Mortada, Esperanza Naredo, Andrea Delle Sedie, Joseph Sexton, Ruth Wittoek, Annamaria Iagnocco, Karen Ellegaard, on behalf of the OMERACT Ultrasound Working Group
doi : 10.1002/acr.24734
To standardize and assess the reliability of ultrasonographic assessment of inflammatory and structural lesions in patients with hand osteoarthritis (OA).
Cartilage Topography Assessment With Local-Area Cartilage Segmentation for Knee Magnetic Resonance Imaging
Alexander Mathiessen, Erin L. Ashbeck, Emily Huang, Edward John Bedrick, C. Kent Kwoh, Jeffrey Duryea
doi : 10.1002/acr.24745
Local-area cartilage segmentation (LACS) software was developed to segment medial femur (MF) cartilage on magnetic resonance imaging (MRI). Our objectives were 1) to extend LACS to the lateral femur (LF), medial tibia (MT), and lateral tibia (LT), 2) to compare LACS to an established manual segmentation method, and 3) to visualize cartilage responsiveness over each cartilage plate.
Prescribing Patterns of Hydroxychloroquine and Glucocorticoids Among Lupus Patients After New-Onset End-Stage Renal Disease
Anna Broder, Wenzhu B. Mowrey, Ana Valle, Mimi Kim, Candace H. Feldman, Kazuki Yoshida, Karen H. Costenbader
doi : 10.1002/acr.24728
Optimal strategies for managing lupus medications after end-stage renal disease (ESRD) have not been addressed. The objective was to identify the current US-wide prescribing patterns of hydroxychloroquine (HCQ) and oral glucocorticoids (GS) among systemic lupus erythematosus (SLE) patients with incident ESRD enrolled in the US Renal Data System (USRDS) registry.
Patterns of Medication Use in Systemic Lupus Erythematosus: A Multicenter Cohort Study
Rangi Kandane-Rathnayake, Worawit Louthrenoo, Shue-Fen Luo, Yeong-Jian J. Wu, Yi-Hsing Chen, Vera Golder, Aisha Lateef, Jiacai Cho, Sandra V. Navarra, Leonid Zamora, Laniyati Hamijoyo, Sargunan Sockalingam, Yuan An, Zhanguo Li, Ricardo Montes, Shereen Oon, Yasuhiro Katsumata, Masayoshi Harigai, Yanjie Hao, Zhuoli Zhang, Madelynn Chan, Jun Kikuchi, Tsutomu Takeuchi, Fiona Goldblatt, Sean O'Neill, Sang-Cheol Bae, Chak S. Lau, Alberta Hoi, Chetan S. Karyekar, Mandana Nikpour, Eric F. Morand, for the Asia-Pacific Lupus Collaboration
doi : 10.1002/acr.24740
Evidence for the utility of medications in settings lacking randomized trial data can come from studies of treatment persistence. The present study was undertaken to examine patterns of medication use in systemic lupus erythematosus (SLE) using data from a large multicenter longitudinal cohort.
Incidence, Risk Factors, and Mortality of Clinical and Subclinical Rheumatoid Arthritis–Associated Interstitial Lung Disease: A Population-Based Cohort
Bilal F. Samhouri, Robert Vassallo, Sara J. Achenbach, Vanessa L. Kronzer, John M. Davis III, Elena Myasoedova, Cynthia S. Crowson
doi : 10.1002/acr.24856
To identify the incidence, risk factors, and outcomes of rheumatoid arthritis–associated interstitial lung disease (RA-ILD) and to assess time trends in the incidence and mortality in RA-ILD.
Associations of Rheumatoid Arthritis and Depressive Symptoms Over Time: Are There Differences by Education, Race/Ethnicity, and Gender?
Julia McQuillan, Jennifer A. Andersen, Terceira A. Berdahl, Jeff Willett
doi : 10.1002/acr.24730
To examine associations between changes in rheumatoid arthritis (RA) symptoms and depressive symptoms adjusted for other time-varying characteristics, and to test if these associations differed by education, race/ethnicity, or gender.
Proton-Pump Inhibitors and Risk of Calcium Pyrophosphate Deposition in a Population-Based Study
Jean W. Liew, Christine Peloquin, Sara K. Tedeschi, David T. Felson, Yuqing Zhang, Hyon K. Choi, Robert Terkeltaub, Tuhina Neogi
doi : 10.1002/acr.24876
There are no proven effective medical treatments to prevent calcium pyrophosphate crystal deposition (CPPD). Hypomagnesemia is a known CPPD risk factor. The present study was undertaken to carry out a real-world epidemiologic study on proton-pump inhibitor (PPI) use, which can cause hypomagnesemia, and CPPD risk.
Patients' Perspectives on Shared Decision-Making About Medications in Psoriatic Arthritis: An Interview Study
Daniel Sumpton, Michael Oliffe, Barry Kane, Geraldine Hassett, Jonathan C. Craig, Ayano Kelly, Allison Tong
doi : 10.1002/acr.24748
Decision-making regarding medications to manage psoriatic arthritis (PsA) is complex because of multiple disease manifestations and comorbidities. Fear of side effects from systemic medications and misalignment in priorities between patients with PsA and rheumatologists makes shared decision-making challenging. We aimed to describe the perspectives of patients with PsA on shared decision-making regarding medication taking.
Progression From Subclinical Inflammation to Overt Spondyloarthritis in First-Degree Relatives of Patients in Association With HLA–B27: The Pre-Spondyloarthritis Cohort
Henriëtte M. Y. de Jong, Janneke J. H. de Winter, Irene E. van der Horst-Bruinsma, Dirk-Jan van Schaardenburg, Floris A. van Gaalen, Astrid M. van Tubergen, Angelique E. A. M. Weel, Robert B. M. Landewé, Dominique L. P. Baeten, Marleen G. H. van de Sande
doi : 10.1002/acr.24743
As first-degree relatives (FDRs) of HLA–B27–positive patients with axial spondyloarthritis (SpA) have an increased risk of developing axial SpA, the objectives were 1) to evaluate the presence of highly specific imaging features as well as clinical signs of SpA at baseline and after 1 year of follow-up, and 2) to describe the evolution toward clinical disease within 1 year of follow-up in a cohort of seemingly healthy FDRs of HLA–B27–positive axial SpA patients.
Juvenile Fibromyalgia in Patients With Juvenile Idiopathic Arthritis: Utility of the Pain and Symptom Assessment Tool
Melissa S. Tesher, Thomas B. Graham, Tracy Ting, Susmita Kashikar-Zuck, Niccola Lynch, Kristen Wroblewski, Jennifer E. Weiss
doi : 10.1002/acr.24739
To evaluate the proportion of children with juvenile idiopathic arthritis (JIA) who met criteria for comorbid juvenile fibromyalgia (FM) using the Pain and Symptom Assessment Tool (PSAT), and to identify clinical and demographic differences among JIA patients with and without juvenile FM.
Increase in Cannabis Use Among Adults With Rheumatic Diseases: Results From a 2014–2019 United States Observational Study
Kristin Wipfler, Teresa A. Simon, Patricia Katz, Frederick Wolfe, Kaleb Michaud
doi : 10.1002/acr.24752
Despite advances in treatments and outcomes among patients with rheumatic diseases, there is an unmet need in pain management. Cannabis has emerged as a potential opioid-sparing alternative, with arthritic pain as a commonly cited reason for medicinal cannabis use. However, little is known, and we set out to understand patterns of cannabis use in a US-wide rheumatic disease population.
Diagnostic Performance and Clinical Utility of Referral Rules to Identify Primary Care Patients at Risk of an Inflammatory Rheumatic Disease
Elke Theodora Antonia Maria van Delft, Deirisa Lopes Barreto, Annette Helena Maria van der Helm-van Mil, Celina Alves, Johanna Maria Wilhelmina Hazes, Tjallingius Martijn Kuijper, Angelique Elisabeth Adriana Maria Weel-Koenders
doi : 10.1002/acr.24789
To determine the diagnostic performance and clinical utility of the Rotterdam Early Arthritis Cohort (REACH) and the Clinical Arthritis Rule (CARE) referral rules in an independent population of unselected patients from primary care.
Impact of Nonpharmacologic Interventions Targeting Sleep Disturbances or Disorders in Patients With Inflammatory Arthritis: A Systematic Review and Meta-Analysis of Randomized Trials
Kristine M. Latocha, Katrine B. Løppenthin, Safa Al-Bazy, Tannie L. Albrechtsen, Helle E. Jensen, Mikkel Østergaard, Poul J. Jennum, Bente A. Esbensen, Robin Christensen
doi : 10.1002/acr.24731
Patients with inflammatory arthritis have a high risk of sleep disturbances and disorders. The objective was to evaluate the evidence of nonpharmacologic interventions targeting sleep disturbances or disorders in patients with inflammatory arthritis.
Medication interruptions during the COVID-19 pandemic: comment on the article by Dharia et al
Rujittika Mungmunpuntipantip, Viroj Wiwanitkit
doi : 10.1002/acr.24852
Treatment of sarcoidosis in US rheumatology practices: comment on the article by Hamman et al
doi : 10.1002/acr.24970
Mortality in ankylosing spondylitis according to treatment: comment on the article by Ben Shabat et al
Zhixiu Li, Mohammad K. Khan, Peter M. Villiger, Sjef van der Linden, Matthew A. Brown, Muhammad A. Khan
doi : 10.1002/acr.24773
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Niv Ben-Shabat, Aviv Shabat, Abdulla Watad, Khalaf Kridin, Nicola Luigi Bragazzi, Dennis McGonagle, Doron Comaneshter, Arnon D. Cohen, Howard Amital
doi : 10.1002/acr.24771
