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In the Literature
doi : 10.1093/cid/ciac595
Clinical Infectious Diseases, Volume 75, Issue 5, 1 September 2022, Pages i–ii
Whole-Blood 3-Gene Signature as a Decision Aid for Rifapentine-based Tuberculosis Preventive TherapyÂ
Hung Ling Huang, Jung Yu Lee, Yu Shu Lo, I Hsin Liu, Sing Han Huang, Yu Wei Huang, Meng Rui Lee, Chih Hsin Lee, Meng Hsuan Cheng, Po Liang Lu, Jann Yuan Wang, Jinn Moon Yang, Inn Wen Chong
doi : 10.1093/cid/ciac003
Clinical Infectious Diseases, Volume 75, Issue 5, 1 September 2022, Pages 743–752
Systemic drug reaction (SDR) is a major safety concern with weekly rifapentine plus isoniazid for 12 doses (3HP) for latent tuberculosis infection (LTBI). Identifying SDR predictors and at-risk participants before treatment can improve cost-effectiveness of the LTBI program.
Herpes Simplex Virus 2 Meningitis in Adults: A Prospective, Nationwide, Population-Based Cohort StudyÂ
Anna Jakobsen, Marie Thaarup Skov, Lykke Larsen, Pelle Trier Petersen, Christian Brandt, Lothar Wiese, Birgitte Rønde Hansen, Hans Rudolf Lüttichau, Malte Mose Tetens, Jannik Helweg-Larsen, Merete Storgaard, Henrik Nielsen, Jacob Bodilsen
doi : 10.1093/cid/ciab1071
Clinical Infectious Diseases, Volume 75, Issue 5, 1 September 2022, Pages 753–760
Data on the clinical presentation are scarce and prognostic factors of herpes simplex virus type 2 (HSV-2) meningitis remain unknown.
Use of Tenofovir Diphosphate Levels to Predict Viremia During the Postpartum Period in Women Living With Human Immunodeficiency Virus (HIV): A Nested Case-Control StudyÂ
Jasantha Odayar, Catherine Orrell, Tamsin K Phillips, Nai Chung Hu, Siti Kabanda, Thokozile R Malaba, Joanna Allerton, Lubbe Wiesner, Nei yuan Hsiao, Jose Castillo-Mancilla, Maia Lesosky, Landon Myer
doi : 10.1093/cid/ciab1068
Clinical Infectious Diseases, Volume 75, Issue 5, 1 September 2022, Pages 761–767
There are few data on the utility of tenofovir diphosphate (TFV-DP) in dried blood spots (DBSs) to predict future viral load (VL) in postpartum women with HIV on antiretroviral therapy (ART).
Whole Genome Sequencing Assessing Impact of Diabetes Mellitus on Tuberculosis Mutations and Type of Recurrence in IndiaÂ
Vidya Mave, Liang Chen, Uma Devi Ranganathan, Dileep Kadam, Vijay Vishwanathan, Rahul Lokhande, Siva Kumar S, Anju Kagal, Neeta N Pradhan, Shri Vijay Bala Yogendra Shivakumar, Mandar S Paradkar, Sona Deshmukh, Jeffrey A Tornheim, Hardy Kornfeld, Maha Farhat, Amita Gupta, Chandrasekaran Padmapriyadarsini, Nikhil Gupte, Jonathan E Golub, Barun Mathema, Barry N Kreiswirth
doi : 10.1093/cid/ciab1067
Clinical Infectious Diseases, Volume 75, Issue 5, 1 September 2022, Pages 768–776
Evidence describing the impact of diabetes mellitus (DM) on the recurrence and mutation rate of Mycobacterium tuberculosis (Mtb) is limited.
Evaluation of Serum Mucorales Polymerase Chain Reaction (PCR) for the Diagnosis of Mucormycoses: The MODIMUCOR Prospective TrialÂ
Laurence Millon, Denis Caillot, Ana Berceanu, Stéphane Bretagne, Fanny Lanternier, Florent Morio, Valérie Letscher-Bru, Frédéric Dalle, Blandine Denis, Alexandre Alanio, David Boutoille, Marie Elisabeth Bougnoux, Françoise Botterel, Taieb Chouaki, Amandine Charbonnier, Florence Ader, Damien Dupont, Anne Pauline Bellanger, Steffi Rocchi, Emeline Scherer, Houssein Gbaguidi-Haore, Raoul Herbrecht
doi : 10.1093/cid/ciab1066
Clinical Infectious Diseases, Volume 75, Issue 5, 1 September 2022, Pages 777–785
Early diagnosis and prompt initiation of specific antifungal treatment are essential for improving the prognosis of mucormycosis. We aimed to assess the performance of serum Mucorales quantitative polymerase chain reaction (qPCR) for the early diagnosis and follow-up of mucormycosis.
Phase IIa Proof-of-Concept Evaluation of the Antiviral Efficacy, Safety, Tolerability, and Pharmacokinetics of the Next-Generation Maturation Inhibitor GSK3640254Â
Christoph D Spinner, Franco Felizarta, Giuliano Rizzardini, Patrick Philibert, Essack Mitha, Pere Domingo, Christoph J Stephan, Michelle DeGrosky, Veronica Bainbridge, Joyce Zhan, Teodora Pene Dumitrescu, Jerry L Jeffrey, Jianfeng Xu, Fiona Halliday, Jianjun Gan, Mark Johnson, Martin Gartland, Samit R Joshi, Max Lataillade
doi : 10.1093/cid/ciab1065
Clinical Infectious Diseases, Volume 75, Issue 5, 1 September 2022, Pages 786–794
GSK3640254 (GSK’254) is a next-generation human immunodeficiency virus type 1 (HIV-1) maturation inhibitor with pharmacokinetics (PK) supporting once-daily therapy.
Impact of Letermovir Primary Cytomegalovirus Prophylaxis on 1-Year Mortality After Allogeneic Hematopoietic Cell Transplantation: A Retrospective Cohort StudyÂ
Yiqi Su, Anat Stern, Eleni Karantoni, Tamara Nawar, Gyuri Han, Phaedon Zavras, Henry Dumke, Christina Cho, Roni Tamari, Brian Shaffer, Sergio Giralt, Ann Jakubowski, Miguel Angel Perales, Genovefa Papanicolaou
doi : 10.1093/cid/ciab1064
Clinical Infectious Diseases, Volume 75, Issue 5, 1 September 2022, Pages 795–804
Cytomegalovirus (CMV)–seropositive (R+) hematopoietic cell transplant (HCT) recipients have a survival disparity compared with CMV-seronegative recipient/donor (R–D–) pairs. We hypothesized that primary letermovir prophylaxis (LET) may abrogate this disparity. We investigated the relationship between LET and mortality at 1 year post-HCT.
Cryptic Plasmodium inui and Plasmodium fieldi Infections Among Symptomatic Malaria Patients in ThailandÂ
Chaturong Putaporntip, Napaporn Kuamsab, Sunee Seethamchai, Urassaya Pattanawong, Rattanaporn Rojrung, Surasuk Yanmanee, Chew Weng Cheng, Somchai Jongwutiwes
doi : 10.1093/cid/ciab1060
Clinical Infectious Diseases, Volume 75, Issue 5, 1 September 2022, Pages 805–812
Some nonhuman primate Plasmodium species including P. knowlesi and P. cynomolgi can cross-transmit from macaque natural hosts to humans under natural infection. This study aims to retrospectively explore other simian Plasmodium species in the blood samples of symptomatic malaria patients in Thailand.
Combination Therapy for Mycoplasma genitalium, and New Insights Into the Utility of parC Mutant Detection to Improve CureÂ
Lenka A Vodstrcil, Erica L Plummer, Michelle Doyle, Gerald L Murray, Kaveesha Bodiyabadu, Jorgen S Jensen, David Whiley, Emma Sweeney, Deborah A Williamson, Eric P F Chow, Christopher K Fairley, Catriona S Bradshaw
doi : 10.1093/cid/ciab1058
Clinical Infectious Diseases, Volume 75, Issue 5, 1 September 2022, Pages 813–823
Mycoplasma genitalium (MG) infection is challenging to cure because of rising antimicrobial resistance and limited treatment options.
Dentist’s Visits and Risk of Brain Abscess: A Nationwide, Population-Based Case-Control StudyÂ
Jacob Bodilsen, Jannik Helweg Larsen, Jens Otto Jarløv, Morten Ziebell, Svend Ellermann-Eriksen, Ulrik S Justesen, Niels Frimodt-Møller, Niels Obel, Lars Haukali Omland
doi : 10.1093/cid/ciab1054
Clinical Infectious Diseases, Volume 75, Issue 5, 1 September 2022, Pages 824–829
Brain abscesses are frequently caused by oral cavity bacteria, but whether dental status and invasive dental procedures are important risk factors is unknown.
High-Quality Large-Scale Clinical Studies on Brain Abscess: Finally!Â
Pierre Tattevin
doi : 10.1093/cid/ciab1063
Clinical Infectious Diseases, Volume 75, Issue 5, 1 September 2022, Pages 830–831
Effectiveness of 13-Valent Pneumococcal Conjugate Vaccine Against Medically Attended Lower Respiratory Tract Infection and Pneumonia Among Older AdultsÂ
Joseph A Lewnard, Katia J Bruxvoort, Heidi Fischer, Vennis X Hong, Lindsay R Grant, Luis Jódar, Alejandro Cané, Bradford D Gessner, Sara Y Tartof
doi : 10.1093/cid/ciab1051
Clinical Infectious Diseases, Volume 75, Issue 5, 1 September 2022, Pages 832–841
Among older adults, 13-valent pneumococcal conjugate vaccine (PCV13) has been found efficacious against nonbacteremic pneumonia associated with vaccine-serotype pneumococci. However, the burden of lower respiratory tract infection (LRTI) and pneumonia preventable by direct immunization of older adults continues to be debated.
How “Subclinicalâ€� is Subclinical Tuberculosis? An Analysis of National Prevalence Survey Data from ZambiaÂ
Logan Stuck, Aimee Claire van Haaster, Pascalina Kapata-Chanda, Eveline Klinkenberg, Nathan Kapata, Frank Cobelens
doi : 10.1093/cid/ciab1050
Clinical Infectious Diseases, Volume 75, Issue 5, 1 September 2022, Pages 842–848
Pulmonary tuberculosis infection can manifest in different states, including subclinical tuberculosis. It is commonly defined as confirmed tuberculosis without the classic symptoms (commonly, persistent cough for ≥2 weeks). This narrow definition likely poses limitations for surveillance and control measures
Household Contact Tracing With Intensified Tuberculosis and Human Immunodeficiency Virus Screening in South Africa: A Cluster-Randomized TrialÂ
Neil A Martinson, Limakatso Lebina, Emily L Webb, Andrew Ratsela, Ebrahim Varavia, Anthony Kinghorn, Sanjay G Lala, Jonathan E Golub, Zama Bosch, Kegaugetswe P Motsomi, Peter MacPherson
doi : 10.1093/cid/ciab1047
Clinical Infectious Diseases, Volume 75, Issue 5, 1 September 2022, Pages 849–856
Household contact tracing for tuberculosis (TB) may facilitate diagnosis and access to TB preventive treatment (TPT). We investigated whether household contact tracing and intensive TB/human immunodeficiency virus (HIV) screening would improve TB-free survival.
Identifying Sepsis From Foodborne Hospitalization: Incidence and Hospitalization Cost by PathogenÂ
Jae Wan Ahn, Elaine Scallan Walter, Alice E White, R Brett McQueen, Sandra Hoffmann
doi : 10.1093/cid/ciab1045
Clinical Infectious Diseases, Volume 75, Issue 5, 1 September 2022, Pages 857–866
Sepsis causes a major health burden in the United States. To better understand the role of sepsis as a driver of the burden and cost of foodborne illness in the United States, we estimated the frequency and treatment cost of sepsis among US patients hospitalized with 31 pathogens commonly transmitted through food or with unspecified acute gastrointestinal illness (AGI).
Five-Year Mortality for Adults Entering Human Immunodeficiency Virus Care Under Universal Early Treatment Compared With the General US PopulationÂ
Jessie K Edwards, Stephen R Cole, Tiffany L Breger, Lindsey M Filiatreau, Lauren Zalla, Grace E Mulholland, Michael A Horberg, Michael J Silverberg, M John Gill, Peter F Rebeiro, Jennifer E Thorne, Parastu Kasaie, Vincent C Marconi, Timothy R Sterling, Keri N Althoff, Richard D Moore, Joseph J Eron
doi : 10.1093/cid/ciab1030
Clinical Infectious Diseases, Volume 75, Issue 5, 1 September 2022, Pages 867–874
Mortality among adults with human immunodeficiency virus (HIV) remains elevated over those in the US general population, even in the years after entry into HIV care. We explore whether the elevation in 5-year mortality would have persisted if all adults with HIV had initiated antiretroviral therapy within 3 months of entering care.
Incidence and Duration of Pharyngeal Chlamydia Among a Cohort of Men Who Have Sex With MenÂ
Christine M Khosropour, Olusegun O Soge, Matthew R Golden, James P Hughes, Lindley A Barbee
doi : 10.1093/cid/ciab1022
Clinical Infectious Diseases, Volume 75, Issue 5, 1 September 2022, Pages 875–881
The prevalence of pharyngeal chlamydia is low, but its incidence and duration are unknown. A high incidence or duration may support the role of pharyngeal chlamydia in sustaining chlamydia transmission.
Evolution of Hepatitis B Virus (HBV) Serologic Markers Among Antiretroviral-Naive Young People Living With Human Immunodeficiency Virus Who Had Undergone Neonatal HBV Vaccination and Initiated Antiretroviral TherapyÂ
Yi Chia Huang, Hsin Yun Sun, Wang Huei Sheng, Szu Min Hsieh, Sung Hsi Huang, Guan Jhou Chen, Wang Da Liu, Sui Yuan Chang, Yi Ching Su, Li Hsin Su, Wen Chun Liu, Chien Ching Hung
doi : 10.1093/cid/ciab1020
Clinical Infectious Diseases, Volume 75, Issue 5, 1 September 2022, Pages 882–889
With initiation of antiretroviral therapy (ART) containing nucleos(t)ide reverse-transcriptase inhibitors (NRTIs) with anti–hepatitis B virus (HBV) activity, the evolution of HBV serologic markers among people living with human immunodeficiency virus (PLWH) who were born in the era of nationwide neonatal HBV vaccination is rarely investigated.
Effectiveness of BNT162b2 and mRNA-1273 Second Doses and Boosters for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection and SARS-CoV-2–Related Hospitalizations: A Statewide Report From the Minnesota Electronic Health Record ConsortiumÂ
Paul E Drawz, Malini DeSilva, Peter Bodurtha, Gabriela Vazquez Benitez, Anne Murray, Alanna M Chamberlain, R Adams Dudley, Stephen Waring, Anupam B Kharbanda, Daniel Murphy, Miriam Halstead Muscoplat, Victor Melendez, Karen L Margolis, Lynn McFarling, Roxana Lupu, Tyler N A Winkelman, Steven G Johnson
doi : 10.1093/cid/ciac110
Clinical Infectious Diseases, Volume 75, Issue 5, 1 September 2022, Pages 890–892
Using vaccine data combined with electronic health records, we report that mRNA boosters provide greater protection than a 2-dose regimen against SARS-CoV-2 infection and related hospitalizations. The benefit of a booster was more evident in the elderly and those with comorbidities.
Omicron Outbreak at a Private Gathering in the Faroe Islands, Infecting 21 of 33 Triple-Vaccinated Healthcare WorkersÂ
Gunnhild Helmsdal, Olga Kristina Hansen, Lars Fodgaard Møller, Debes Hammershaimb Christiansen, Maria Skaalum Petersen, Marnar FrÃðheim Kristiansen
doi : 10.1093/cid/ciac089
Clinical Infectious Diseases, Volume 75, Issue 5, 1 September 2022, Pages 893–896
There are concerns that the severe acute respiratory syndrome coronavirus 2 Omicron variant evades immune responses due to an unusually high number of mutations on the spike protein. Here, we report a superspreading event of Omicron infections among 21 of 33 triple-vaccinated healthcare workers who attended a private gathering.
Chagas Disease Prevalence in a Cohort of Neurocysticercosis Patients in a Nonendemic SettingÂ
Katherine R McAleese, Janitzio J Guzmán, Lauren Thumm, Thomas B Nutman, Adrienne Showler, Elise M O’Connell
doi : 10.1093/cid/ciac076
Clinical Infectious Diseases, Volume 75, Issue 5, 1 September 2022, Pages 897–900
In a cohort of mostly Central American immigrants with confirmed neurocysticercosis (NCC), 3.1% were confirmed positive for Chagas disease (CD). The majority were diagnosed with NCC before age 50. Entry to care for NCC is an opportunity for early detection and possible treatment for CD in those from endemic areas.
Screening for Chagas Disease Should Be Included in Entry-to-Care Testing for At-Risk People With Human Immunodeficiency Virus (HIV) Living in the United StatesÂ
Eva H Clark, Carina Marquez, Jeffrey D Whitman, Caryn Bern
doi : 10.1093/cid/ciac154
Clinical Infectious Diseases, Volume 75, Issue 5, 1 September 2022, Pages 901–906
Chagas disease screening of at-risk populations is essential to identify infected individuals and facilitate timely treatment before end-organ damage occurs. Coinfected people with human immunodeficiency virus (PWH) are at risk for dangerous sequelae, specifically Trypanosoma cruzi reactivation disease.
Wrong Place at the Wrong MaritimeÂ
Marisa C Nielsen, Paula Clarner, Ping Ren
doi : 10.1093/cid/ciab905
Clinical Infectious Diseases, Volume 75, Issue 5, 1 September 2022, Pages 907–909
Bringing Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) to the Surface: Is There a Role for Fomites?Â
Peter Katona, Ravina Kullar, Kevin Zhang
doi : 10.1093/cid/ciac157
Clinical Infectious Diseases, Volume 75, Issue 5, 1 September 2022, Pages 910–916
Understanding the contribution of routes of transmission, particularly the role of fomites in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) transmission is important in developing and implementing successful public health infection prevention and control measures. This article will look at case reports, laboratory findings, animal studies, environmental factors, the need for disinfection, and differences in settings as they relate to SARS-CoV-2 transmission.
Enhanced Infection Prevention Measures Including Universal N95 Usage and Daily Testing: The Impact on SARS-CoV-2 Transmission in Cohorted Hospital Cubicles Through Successive Delta and Omicron WavesÂ
Liang En Wee, Karrie Kwan Ki Ko, Edwin Philip Conceicao, May Kyawt Aung, Myat Oo Aung, Yong Yang, Shalvi Arora, Indumathi Venkatachalam
doi : 10.1093/cid/ciac320
Clinical Infectious Diseases, Volume 75, Issue 5, 1 September 2022, Pages 917–919
Effectiveness of Booster mRNA Vaccines Against SARS-CoV-2 Infection in an Elderly Population, South Korea, October 2021–January 2022Â
Jia Kim, Young June Choe, Eun Jung Jang, Do Sang Lim, Yoo Yeon Kim, Ryu Kyung Kim, Seonju Yi, Sangwon Lee, Young Joon Park
doi : 10.1093/cid/ciac319
Clinical Infectious Diseases, Volume 75, Issue 5, 1 September 2022, Pages 920–921
Comparison of Neurodevelopmental Outcomes in Children With Group B Streptococcal Sepsis and MeningitisÂ
Hannah G Davies, Catherine P O’Sullivan, Hareth Al Janabi, Hilary Rattue, Caroline Trotter, Kyriaki Giorgakoudi, Mary Ramsay, Shamez Ladhani, Theresa Lamagni, Ifeanyichukwu O Okike, Kirsty Le Doare, Paul T Heath
doi : 10.1093/cid/ciac318
Clinical Infectious Diseases, Volume 75, Issue 5, 1 September 2022, Pages 922–923
World Health Organization (WHO) Standard Methods for Pneumococcal Carriage StudiesÂ
Paul Turner, Raquel Sá-Leão, Andrew Greenhill, Amanda Leach, Catherine Satzke
doi : 10.1093/cid/ciac221
Clinical Infectious Diseases, Volume 75, Issue 5, 1 September 2022, Pages 924–925
