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Hydrochlorothiazide Versus Chlorthalidone: What Is the Difference?.
Agarwal, Rajiv MD, MS
doi : 10.1161/CIRCULATIONAHA.122.061029
Volume 146(22) pgs. 1641-1732,e325-e325 November 29, 2022
Substrate Ablation by Multivein, Multiballoon Coronary Venous Ethanol for Refractory Ventricular Tachycardia in Structural Heart Disease.
Valderrabano, Miguel MD, PhD; Fuentes Rojas, Stephanie C. MD; Lador, Adi MD; Patel, Apoor MD; Schurmann, Paul A. MD; Tapias, Carlos MD; Rodriguez, Diego MD; Carlos Saenz, Luis MD; Malahjfi, Maan MD; Shah, Dipan J. MD; Mathuria, Nilesh MD; Dave, Amish S. MD, PhD
doi : 10.1161/CIRCULATIONAHA.122.060882
Ablation of ventricular tachycardia (VT) in the setting of structural heart disease often requires extensive substrate elimination that is not always achievable by endocardial radiofrequency ablation.
Impact of Earlier Diagnosis in Cardiac ATTR Amyloidosis Over the Course of 20 Years.
Ioannou, Adam MBBS, BSc ,*; Patel, Rishi K. MBBS, BSc ,*; Razvi, Yousuf MBChB, BSc; Porcari, Aldostefano MD; Sinagra, Gianfranco MD; Venneri, Lucia MD, PhD; Bandera, Francesco MD, PhD; Masi, Ambra MD; Williams, Georgina E. BSc; O'Beara, Sophie BSc (Hons); Ganesananthan, Sharmananthan BSc (Hons); Massa, Paolo MD; Knight, Daniel PhD; Martinez-Naharro, Ana PhD; Kotecha, Tushar PhD; Chacko, Liza MBBS, BSc; Brown, James MB, BChir; Rauf, Muhammad U. MBBS; Manisty, Charlotte MD, PhD; Moon, James MD, PhD; Lachmann, Helen MD; Wechelakar, Ashutosh MD; Petrie, Aviva MSc; Whelan, Carol MD; Hawkins, Philip N. MD, PhD; Gillmore, Julian D. MD, PhD ,+; Fontana, Marianna MD, PhD ,+
doi : 10.1161/CIRCULATIONAHA.122.060852
Diagnostic and therapeutic advances have led to much greater awareness of transthyretin cardiac amyloidosis (ATTR-CA). We aimed to characterize changes in the clinical phenotype of patients diagnosed with ATTR-CA over the past 20 years.
The Future for Patients With Transthyretin Cardiac Amyloidosis Is Looking Brighter.
Patel, Jignesh K. MD, PhD; Maurer, Mathew S. MD
Pathogenesis of Cardiomyopathy Caused by Variants in ALPK3, an Essential Pseudokinase in the Cardiomyocyte Nucleus and Sarcomere.
Agarwal, Radhika MD, PhD; Wakimoto, Hiroko MD, PhD; Paulo, Joao A. PhD; Zhang, Qi MD; Reichart, Daniel MD; Toepfer, Christopher PhD; Sharma, Arun PhD; Tai, Angela C. BA; Lun, Mingyue MD, PhD; Gorham, Joshua BA; DePalma, Steven R. PhD; Gygi, Steven P. PhD ,*; Seidman, J.G. PhD ,*; Seidman, Christine E. MD ,,,*
doi : 10.1161/CIRCULATIONAHA.122.059688
ALPK3 encodes [alpha]-kinase 3, a muscle-specific protein of unknown function. ALPK3 loss-of-function variants cause cardiomyopathy with distinctive clinical manifestations in both children and adults, but the molecular functions of ALPK3 remain poorly understood.
Hippo-Yap Signaling Maintains Sinoatrial Node Homeostasis.
Zheng, Mingjie PhD; Li, Rich G. PhD; Song, Jia MD; Zhao, Xiaolei PhD; Tang, Li MS; Erhardt, Shannon MS; Chen, Wen BS; Nguyen, Bao H. BS; Li, Xiao PhD; Li, Min PhD; Wang, Jianxin PhD; Evans, Sylvia M. PhD; Christoffels, Vincent M. PhD; Li, Na PhD; Wang, Jun PhD
doi : 10.1161/CIRCULATIONAHA.121.058777
The sinoatrial node (SAN) functions as the pacemaker of the heart, initiating rhythmic heartbeats. Despite its importance, the SAN is one of the most poorly understood cardiac entities because of its small size and complex composition and function.
Noninvasive Plaque Imaging to Accelerate Coronary Artery Disease Drug Development.
Figtree, Gemma A. MBBS(Hons), DPhil (Oxon); Adamson, Philip D. BHB, MB, ChB, PhD, MPH; Antoniades, Charalambos MD, PhD; Blumenthal, Roger S. MD; Blaha, Michael MD, MPH; Budoff, Matthew BS, MS; Celermajer, David S. MBBS(Hons), MSc, PhD, DSc; Chan, Mark Y. MBBS, MRCP, MHS, PhD; Chow, Clara K. MBBS, PhD; Dey, Damini PhD; Dwivedi, Girish MD, DM, MRCP, PhD, CCST; Giannotti, Nicola BSc, PhD; Grieve, Stuart M. BSc(Hons), MBBS, DPhil(Oxon); Hamilton-Craig, Christian MBBS, PhD; Kingwell, Bronwyn A. BSc, PhD; Kovacic, Jason C. MBBS, PhD; Min, James K. MD; Newby, David E. BA, BSc, BM, MRCP, MD; Patel, Sanjay MBBS(Hons), PhD; Peter, Karlheinz MD, PhD; Psaltis, Peter J. MBBS(Hons), PhD; Vernon, Stephen T. BMedSci, MBBS, PhD; Wong, Dennis T. BSc(Med), MBBS(Hons), PhD; Nicholls, Stephen J. MBBS, PhD
doi : 10.1161/CIRCULATIONAHA.122.060308
AB Coronary artery disease (CAD) remains the leading cause of adult mortality globally. Targeting known modifiable risk factors has had substantial benefit, but there remains a need for new approaches. Improvements in invasive and noninvasive imaging techniques have enabled an increasing recognition of distinct quantitative phenotypes of coronary atherosclerosis that are prognostically relevant.
Targeted Screening for Transthyretin Amyloid Cardiomyopathy in Patients With Atrial Fibrillation.
Prasad, Pooja MD; Howell, Stacey MD; Sanghai, Saket MD; Stecker, Eric MD; Henrikson, Charles A. MD, MPH; Masri, Ahmad MD, MS; Nazer, Babak MD
Correction to: Empagliflozin Inhibits Cardiac Late Sodium Current by Ca/Calmodulin-Dependent Kinase II.
