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Confronting a Painful Reality: The Call for Improved Pain Research.
Nathan, Naveen MD
Opportunities for Improving Basic and Translational Pain Research.
Oshinsky, Michael L. PhD; Bachman, Julia L. PhD; Mohapatra, Durga P. PhD
Improving Preclinical Development of Novel Interventions to Treat Pain: Insanity Is Doing the Same Thing Over and Over and Expecting Different Results.
Eisenach, James C. MD *; Rice, Andrew S. C. MD +
doi : 10.1213/ANE.0000000000006249
AB Preclinical pain research has applied state-of-the-art methods over the past 40 years to describe, characterize, and image molecules, cells, and circuits in rodents to understand the pathophysiology of chronic pain.
When It Rains, It Pours: Obstetric Anesthesia Workload.
Nathan, Naveen MD
Using Mean Anesthesia Workload to Plan Anesthesia Workforce Allocations: The "Flaw of Averages".
Ginosar, Yehuda BSc, MBBS *,+; Wimpfheimer, Ariel BMedSc ++; Weissman, Charles MD +,[S]
Obstetric Anesthesia Procedure-Based Workload and Facility Utilization of Society of Obstetric Anesthesia and Perinatology Centers of Excellence Designated Institutions.
Im, Mary MD *; Riley, Edward T. MD *; Hoang, Dan DO *; Lim, Grace MD, MS +; Zakowski, Mark MD ++; Carvalho, Brendan MBBCh, FRCA *
doi : 10.1213/ANE.0000000000006112
Optimal workload and staffing for obstetric anesthesia services have yet to be determined. We surveyed Society of Obstetric Anesthesia and Perinatology (SOAP) Centers of Excellence (COE) for Obstetric Anesthesia Care institutions to evaluate procedure-based obstetric anesthesia workload and facility use.
Hot Off the Press! Commentary on "Maternal Fever Associated With Continuous Spinal Versus Epidural Labor Analgesia: A Single-Center Retrospective Study".
Baron, Elvera L. MD, PhD *; Katz, Daniel MD +
Maternal Fever Associated With Continuous Spinal Versus Epidural Labor Analgesia: A Single-Center Retrospective Study.
Seiler, F. Arran MD *; Scavone, Barbara M. MD *,+; Shahul, Sajid MD *; Arnolds, David E. MD, PhD *
doi : 10.1213/ANE.0000000000005905
Neuraxial labor analgesia is associated with elevations in maternal temperature; the mechanism responsible is unknown. Proposed mechanisms have included infection, altered thermoregulation, and inflammation, potentially triggered by local anesthetics.
Streamlining Preoperative Assessment: An Epic Challenge.
Bader, Angela M. MD, MPH *,+
Identification of Preanesthetic History Elements by a Natural Language Processing Engine.
Suh, Harrison S. BS *; Tully, Jeffrey L. MD +; Meineke, Minhthy N. MD ++; Waterman, Ruth S. MD, MS +; Gabriel, Rodney A. MD, MAS +,[S]
doi : 10.1213/ANE.0000000000006152
Methods that can automate, support, and streamline the preanesthesia evaluation process may improve resource utilization and efficiency. Natural language processing (NLP) involves the extraction of relevant information from unstructured text data.
Predictors and Hospital Outcomes in Pregnant Patients Undergoing Extracorporeal Membrane Oxygenation: A Nationwide Study.
van den Bosch, Oscar F. C. MD *; Chaudhry, Rabail MD *; Wicker, James MD +; Mubashir, Talha MD ++; Limb, Daniel MD ++; Jogendran, Rohit MD [S]; Munshi, Laveena MD [//]; Balki, Mrinalini MD *,[P],#,**
doi : 10.1213/ANE.0000000000006210
Extracorporeal membrane oxygenation (ECMO) is increasingly used in patients with severe cardiorespiratory collapse. Although prior large database reviews of ECMO use in the peripartum population exist, they do not stratify by ECMO indication nor do they include obstetric conditions such as preeclampsia.
Narrative Review of Kratom, an Emerging Psychoactive Substance With Perianesthetic Implications.
Garmon, Emily H. MD, FASA *; Olson, Kandice MD +,++
doi : 10.1213/ANE.0000000000006177
AB Opioid overprescribing, with resultant overdose and death, has led to a national focus on alternative treatments for pain. With the decline in legal access to opioids, kratom has gained popularity as a legal, "natural," and easily accessible nonprescription analgesic for consumers wishing to self-medicate for pain, opioid use disorder, and other mental health conditions.
Incidence, Outcomes, and Risk Factors for Preincision Cardiac Arrest in Cardiac Surgery Patients.
Geube, Mariya A. MD, FASE *; Hsu, Albert MD *; Skubas, Nikolaos J. MD, DSc, FASE, FACC *; Liang, Chen MS +; Mi, Junhui MS +; Knuf, Kayla M. MD *; Marciniak, Donn MD *; Tong, Michael Zhen-Yu MD, MBA ++; Duncan, Andra E. MD, MS, FASE *
doi : 10.1213/ANE.0000000000006081
We examined the incidence, postoperative outcomes, and patient-related factors associated with preincision cardiac arrest in patients undergoing cardiac surgery.
Are Viscoelastic Tests Clinically Useful to Identify Platelet-Dependent Bleeding in High-Risk Cardiac Surgery Patients?.
Baryshnikova, Ekaterina PhD; Di Dedda, Umberto MD; Ranucci, Marco MD, FESC
doi : 10.1213/ANE.0000000000006231
Postoperative use of platelet function testing to rule out microvascular bleeding due to platelet dysfunction after cardiac surgery still lacks strong reference data and reliable cutoff values, yielding a clinically adequate sensitivity and specificity.
Decreased Electroencephalographic Alpha Power During Anesthesia Induction Is Associated With EEG Discontinuity in Human Infants.
Chao, Jerry Y. MD, MS *; Gutierrez, Rodrigo MD, PhD +; Legatt, Alan D. MD, PhD ++,[S],[//]; Yozawitz, Elissa G. MD ++,[P]; Lo, Yungtai PhD #; Adams, David C. MD **; Delphin, Ellise S. MD, MPH *; Shinnar, Shlomo MD, PhD ++,[P],#; Purdon, Patrick L. PhD ++
doi : 10.1213/ANE.0000000000005864
Electroencephalogram (EEG) discontinuity can occur at high concentrations of anesthetic drugs, reflecting suppression of electrocortical activity. This EEG pattern has been reported in children and reflects a deep state of anesthesia.
Barriers to Quality Perioperative Care Delivery in Low- and Middle-Income Countries: A Qualitative Rapid Appraisal Study.
Bedwell, Gillian J. MSc *; Dias, Priyanthi PhD +; Hahnle, Lina MBChB *; Anaeli, Amani PhD ++; Baker, Tim PhD [S],[//],[P]; Beane, Abi PhD #; Biccard, Bruce M. PhD **; Bulamba, Fred MMed +++; Delgado-Ramirez, Martha B. MD ++++,[S][S]; Dullewe, Nilmini P. BSc [//][//],[P][P]; Echeverri-Mallarino, Veronica MD [S][S]; Haniffa, Rashan PhD ##; Hewitt-Smith, Adam MBBS +++,***; Hoyos, Alejandra Sanin MSc [S][S]; Mboya, Erick A. MD +++; Nanimambi, Juliana MMed ++,***; Pearse, Rupert MD(Res) +; Pratheepan, Anton Premadas MBBS [P][P],++++++; Sunguya, Bruno PhD [S][S][S]; Tolppa, Timo BMBS [P][P],##; Uruthirakumar, Powsiga BSc [P][P],[//][//][//]; Vengadasalam, Sutharshan MS [P][P][P]; Vindrola-Padros, Cecilia PhD ###; Stephens, Timothy J. PhD +
doi : 10.1213/ANE.0000000000006113
Provision of timely, safe, and affordable surgical care is an essential component of any high-quality health system. Increasingly, it is recognized that poor quality of care in the perioperative period (before, during, and after surgery) may contribute to significant excess mortality and morbidity.
Evaluation of Open Access Websites for Anesthesia Education.
Evans, Faye M. MD *,+; Krotinger, Anna A. MBE ++; Lilaonitkul, Maytinee MBBS [S]; Khaled, Hiba F. MB BCh, BAO [//]; Pereira, Gretchen A. MHA *,++; Staffa, Steven J. MS *; Wolbrink, Traci A. MD, MPH *,+
doi : 10.1213/ANE.0000000000006183
While the prevalence of free, open access medical education resources for health professionals has expanded over the past 10 years, many educational resources for health care professionals are not publicly available or require fees for access.
Early Vasopressor Utilization Strategies and Outcomes in Critically Ill Patients With Severe Traumatic Brain Injury.
Toro, Camilo BA *,+; Ohnuma, Tetsu MD, MPH, PhD *,++,[S]; Komisarow, Jordan MD *,[//]; Vavilala, Monica S. MD [P]; Laskowitz, Daniel T. MD, MHS ++,[//],#; James, Michael L. MD ++,#; Mathew, Joseph P. MD, MHS, MBA ++; Hernandez, Adrian F. MD, MHS **; Goldstein, Ben A. PhD [S]; Sampson, John H. MD, PhD, MBA [//]; Krishnamoorthy, Vijay MD, MPH, PhD *,++,++
doi : 10.1213/ANE.0000000000005949
Early hypotension after severe traumatic brain injury (sTBI) is associated with increased mortality and poor long-term outcomes. Current guidelines suggest the use of intravenous vasopressors, commonly norepinephrine and phenylephrine, to support blood pressure after TBI.
Postoperative Analgesic Efficacy and Safety of Ropivacaine Plus Diprospan for Preemptive Scalp Infiltration in Patients Undergoing Craniotomy: A Prospective Randomized Controlled Trial.
Han, Xueye MD *; Ren, Tong MD +; Wang, Yang MD *; Ji, Nan MD +; Luo, Fang MD *
doi : 10.1213/ANE.0000000000005971
Preemptive injection of local anesthetics can prevent postoperative pain at the incision site, but the analgesic effect is insufficient and is maintained only for a relatively short period of time. Diprospan is a combination of quick-acting betamethasone sodium phosphate and long-acting betamethasone dipropionate.
Hypobaric Unilateral Spinal Anesthesia Versus General Anesthesia for Hip Fracture Surgery in the Elderly: A Randomized Controlled Trial.
Simonin, Marine MD *; Delsuc, Claire MD *; Meuret, Pascal MD *; Caruso, Liana MD *; Deleat-Besson, Robert MD *; Lamblin, Antoine MD *; Huriaux, Laetitia MD *; Abraham, Paul MD *; Bidon, Cyril MD *; Giai, Joris MD +,++,[S],[//]; Riche, Benjamin PhD +,++,[S],[//]; Rimmele, Thomas MD, PhD *,[P]
doi : 10.1213/ANE.0000000000006208
Hypotension during surgery is frequent in the elderly population and is associated with acute kidney and myocardial injury, which are, themselves, associated with increased 30-day mortality
Completion of an Enhanced Recovery Program in a Pediatric Ambulatory Surgery Center: A Quality Improvement Initiative.
Martin, Lynn D. MD, MBA *; Chiem, Jennifer L. MD +; Hansen, Elizabeth E. MD, PhD +; Low, Daniel K. BM, BS +; Reece, Kayla BSN, MSN ++; Casey, Corrie BSN, MSN ++; Wingate, Christina S. DNAP, CRNA +; Bezzo, Leah K. MSN, CRNA +; Merguerian, Paul A. MD, MS [S]; Parikh, Sanjay R. MD [//]; Susarla, Srinivas M. MD, DMD [P]; O'Reilly-Shah, Vikas N. MD, PhD +
doi : 10.1213/ANE.0000000000006256
Enhanced Recovery After Surgery (ERAS) was first established in 2001 focusing on recovery from complex surgical procedures in adults and recently expanded to ambulatory surgery.
Hospital-, Anesthesiologist-, Surgeon-, and Patient-Level Variations in Neuraxial Anesthesia Use for Lower Limb Revascularization Surgery: A Population-Based Cross-Sectional Study.
Roberts, Derek J. MD, PhD, FRCSC *,+,++,[S]; Mor, Rahul BMSc [//]; Rosen, Michael N. BSc [//]; Talarico, Robert MSc [P]; Lalu, Manoj M. MD, PhD, FRCPC ++,#; Jerath, Angela MD, MSc, FRCPC, FANZCA [P],**,++,++++; Wijeysundera, Duminda N. MD, PhD, FRCPC, FAHA [P],**,++++,[S][S],[//][//]; McIsaac, Daniel I. MD, MPH, FRCPC +,++,[P],#
doi : 10.1213/ANE.0000000000006232
Although neuraxial anesthesia may promote improved outcomes for patients undergoing lower limb revascularization surgery, its use is decreasing over time. Our objective was to estimate variation in neuraxial (versus general) anesthesia use for lower limb revascularization at the hospital, anesthesiologist, surgeon, and patient levels, which could inform strategies to increase uptake.
Analgesic Effectiveness and Dorsal Root Ganglia Protein Modulation of a Peripheral Adenosine Monophosphate Kinase Alpha Activator (O304) Following Lumbar Disk Puncture in the Mouse.
Das, Vaskar PhD; Basovich, Michael B. MS; Kroin, Jeffrey S. PhD; Buvanendran, Asokumar MD; McCarthy, Robert J. PharmD
doi : 10.1213/ANE.0000000000006228
Disk herniation is a primary cause of radicular back pain. The purpose of this study was to evaluate the antiallodynic effective dose in 50% of the sample (ED50) and dorsal root ganglion (DRG) protein modulation of a peripheral direct adenosine monophosphate kinase alpha (AMPK[alpha]) activator (O304) in a murine model of lumbar disk puncture.
Early Detection and Correction of Cerebral Desaturation With Noninvasive Oxy-Hemoglobin, Deoxy-Hemoglobin, and Total Hemoglobin in Cardiac Surgery: A Case Series.
Calderone, Alexander MD *; Jarry, Stephanie MSc *; Couture, Etienne J. MD +,++,[S]; Brassard, Patrice PhD [S],[//]; Beaubien-Souligny, William MD, PhD [P]; Momeni, Mona MD, PhD #; Liszkowski, Mark MD **,++; Lamarche, Yoan MD ++,++++; Shaaban-Ali, Mohamed MD, PhD [S][S]; Matta, Basil MD, MA, FRCA, FFICM [//][//]; Rochon, Antoine MD *; Lebon, Jean-Sebastien MD *; Ayoub, Christian MD *; Martins, Maria Rosal MD *; Courbe, Athanase MD *; Deschamps, Alain MD, PhD *; Denault, Andre Y. MD, PhD *,++
doi : 10.1213/ANE.0000000000006155
AB Regional cerebral oxygen saturation (rSO2) obtained from near-infrared spectroscopy (NIRS) provides valuable information during cardiac surgery. The rSO2 is calculated from the proportion of oxygenated to total hemoglobin in the cerebral vasculature.
Anesthesia and Postoperative Cognitive Impairment: Types of Knowing.
Mutch, W. Alan C. MD
Intraoperative Neurosurgical Hyperglycemia and Infectious Complications: What Can We Actually Conclude?.
Weber, Garret MD; Abramowicz, Apolonia Elisabeth MD; Rhee, Amanda MD
In Response.
Kulikov, Alexander MD, PhD; Bilotta, Federico MD, PhD
Preoperative Gut Microbiota and Chronic Postoperative Pain in Cancer Survivors: More Research is Needed.
Stanhope, Jessica PhD
In Response.
Yao, Zhi-Wen MD; Zhao, Bing-Cheng MD; Liu, Ke-Xuan MD, PhD
