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Detecting Colorectal Adenomas and Cancer Using Volatile Organic Compounds in Exhaled Breath: A Proof-of-Principle Study to Improve Screening.
Cheng, Hao Ran MD 1,2,3,*; van Vorstenbosch, Robert W.R. MSc 4,5,*; Pachen, Danielle M. Eng 4,5; Meulen, Lonne W.T. MD 1,3; Straathof, Jan Willem A. PhD 1,2; Dallinga, Jan W. PhD 4,5; Jonkers, Daisy M.A.E. PhD 1,4; Masclee, Ad A.M. PhD 1,4; Schooten, Frederik-Jan van PhD 4,5; Mujagic, Zlatan PhD 1,4,+; Smolinska, Agnieszka PhD 4,5,+
doi : 10.14309/ctg.0000000000000518
Volume 13(11) pgs. e00518-e00534 November 2022
Early detection of colorectal cancer (CRC) by screening programs is crucial because survival rates worsen at advanced stages. However, the currently used screening method, the fecal immunochemical test (FIT), suffers from a high number of false-positives and is insensitive for detecting advanced adenomas (AAs), resulting in false-negatives for these premalignant lesions.
Periodontal Treatment and Usual Care for Nonalcoholic Fatty Liver Disease: A Multicenter, Randomized Controlled Trial.
Kamata, Yohei DDS, PhD 1,*; Kessoku, Takaomi MD, PhD 2,*; Shimizu, Tomoko DDS, PhD 1,*; Sato, Satsuki DDS, PhD 1,*; Kobayashi, Takashi MD, PhD 2; Kurihashi, Takeo MD, PhD 3; Morozumi, Toshiya DDS, PhD 4; Iwasaki, Tomoyuki MD, PhD 5; Takashiba, Shogo DDS, PhD 6; Hatanaka, Kazu DDS, PhD 6; Hamada, Nobushiro DDS, PhD 7; Kodama, Toshiro DDS, PhD 8; Higurashi, Takuma MD, PhD 2; Taguri, Masataka MD, PhD 9; Yoneda, Masato MD, PhD 2; Usuda, Haruki MD, PhD 10; Wada, Koichiro MD, PhD 10; Nakajima, Atsushi MD, PhD 2; Minabe, Masato DDS, PhD 4
doi : 10.14309/ctg.0000000000000520
Periodontal disease is associated with nonalcoholic fatty liver disease (NAFLD). We evaluated periodontal treatment efficacy in patients with NAFLD and periodontal disease.
Beta-amyloid Deposition in Biliary Atresia Reduces Liver Regeneration by Inhibiting Energy Metabolism and Mammalian Target of Rapamycin Signaling.
Tian, Xinbei PhD 1,*; Wang, Ying PhD 1,2,3,*; Zhou, Ying PhD 4; Wu, Bo MM 1,4; Lu, Ying MM 2,4; Du, Jun MM 2,4; Wang, Weipeng PhD 1,4; Cai, Wei PhD 1,2,3,4,+; Xiao, Yongtao PhD +,1,2,3,4
doi : 10.14309/ctg.0000000000000536
Biliary atresia (BA) is a devastating obstructive bile duct disease found in newborns. This study aims to investigate the roles and involved mechanisms of beta-amyloid (A[beta]) in the pathogenesis of BA.
Gastric Cancer Screening in First-Degree Relatives: A Pilot Study in a Diverse Integrated Healthcare System.
Dong, Elizabeth Y. MD 1; Giap, Andrew Q. MD 2; Lustigova, Eva MPH 3; Wu, Bechien U. MD 1,3,4
doi : 10.14309/ctg.0000000000000531
Family history of gastric cancer has been shown as an independent risk factor of gastric cancer development and is associated with increased risk of progression to gastric cancer among patients with gastric intestinal metaplasia (GIM).
Overlapping Transcriptional Profile in Proton Pump Inhibitor Responsive and Nonresponsive Eosinophilic Esophagitis.
Hamilton, Matthew J. MD 1,*; Muftah, Mayssan MD 1,*; Goldin, Alison H. MD, MPH 1; Lo, Wai-Kit MD, MPH 1; Hsu Blatman, Karen S. MD 2; Chan, Walter W. MD, MPH 1,#; Srivastava, Amitabh MD 3,#
doi : 10.14309/ctg.0000000000000540
We compared esophageal mucosal gene transcript expression in proton pump inhibitor (PPI) responsive (PPI-R) eosinophilic esophagitis (EoE), PPI nonresponsive (PPI-NR) EoE, and healthy controls.
Eosinophil Peroxidase Staining Enhances the Diagnostic Utility of the Cytosponge in Eosinophilic Esophagitis.
Masuda, Mia Y. BS 1,2; Barshow, Suzanne M. MD 3; Garg, Shipra MD 4; Putikova, Arina BS 1; LeSuer, William E. BS 1; Alexander, Jeffrey A. MD 5; Katzka, David A. MD 5; Dellon, Evan S. MD, MPH 6; Kita, Hirohito MD 1,2; Horsley-Silva, Jennifer L. MD 7; Doyle, Alfred D. PhD 1; Wright, Benjamin L. MD 1,3
doi : 10.14309/ctg.0000000000000534
We aimed to assess the diagnostic utility of eosinophil peroxidase (EPX) staining on Cytosponge (CS) samples in eosinophilic esophagitis (EoE). METHODS: Esophageal biopsy (BX) samples from adult subjects with EoE were assessed using peak eosinophils per high-power field (eos/hpf), EPX, and the EoE histologic scoring system.
