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A Multiplex SNaPshot Assay is a Rapid and Cost-Effective Method for Detecting POLE Exonuclease Domain Mutations in Endometrial Carcinoma.
Devereaux, Kelly A. M.D., Ph.D.; Steiner, David F. M.D., Ph.D.; Ho, Chandler B.S.; Gomez, Adam J. M.D.; Gilks, Blake M.D.; Longacre, Teri A. M.D.; Zehnder, James L. M.D.; Howitt, Brooke E. M.D.; Suarez, Carlos J. M.D.
doi : 10.1097/PGP.0000000000000841
replicative DNA polymerase epsilon (POLE) mutation status in endometrial carcinomas (ECs) has important clinical implications given that the majority of "ultramutated" tumors harboring pathogenic exonuclease domain mutations in POLE (POLEmut) have a favorable prognosis, even among high-grade histotypes.
Uterine Leiomyosarcoma Associated With Leiomyoma With Bizarre Nuclei: Histology and Genomic Analysis of 2 Cases.
Fischer, Jean V. M.D.; Mejia-Bautista, Melissa M.D.; Vadasz, Brian M.D.; Yin, Ping Ph.D.; Bulun, Serdar M.D.; Tanner, Edward J. M.D.; Lu, Xinyan Ph.D.; Wei, Jian-Jun M.D.
doi : 10.1097/PGP.0000000000000837
AB Leiomyoma with bizarre nuclei (LM-BN) is a rare variant of leiomyoma with overall benign clinical course. It has histologic features showing focal or diffuse nuclear atypia surrounded by usual type leiomyoma.
The Potential Prognostic and Therapeutic Implications of Prolactin Receptor and Growth Hormone-releasing Hormone Receptor Expression in Uterine Leiomyosarcomas.
Jones, Terri E. M.D.; La, Hae-Sun M.D.; Upadhyay-Baskota, Swikrity M.D.; Bhargava, Rohit M.D.; Jones, Mirka W. M.D.
doi : 10.1097/PGP.0000000000000844
AB The management of uterine leiomyosarcomas (uLMS) remains challenging. The rate of recurrence and metastasis is high, with 5-yr survival reaching only 40% to 50% in patients with tumor confined to the uterus (FIGO stage I or II).
Leiomyo-adenomatoid Tumor of the Uterus: Finding the Rare in the Routine.
McGrath, Nathan M.B.B.S.; Aja-Okorie, Ugonna M.B.B.Ch. (Wits); Pather, Sugeshnee M.B.B.Ch. (Wits), F.C.Path. (S.A.) Anat, M.Med. (U.C.T.)
doi : 10.1097/PGP.0000000000000840
AB Leiomyo-adenomatoid tumour (LMAT) is a rare benign neoplasm and very few cases of LMAT of the uterus are documented in the literature. Uterine LMATs are usually detected incidentally during the histopathologic evaluation of routine myomectomy or hysterectomy specimens for leiomyomata. Thorough evaluation of the morphological features and a concise immunohistochemical panel allows for accurate classification of this benign neoplasm. (C)2022International Society of Gynecological Pathologists
First Case Report of a Uterine Angiolipoleiomyoma With KRAS and KIT Mutations.
Verocq, Camille M.D.; Noel, Jean-Christophe M.D., Ph.D.; Ouertani, Salah M.D.; D'Haene, Nicky M.D., Ph.D.; Catteau, Xavier M.D., Ph.D.
doi : 10.1097/PGP.0000000000000842
AB Angiolipoleiomyoma is a very rare lesion of the uterus. To the best of our knowledge, only 20 cases have been described in the literature. It is an insufficiently defined entity, which is not included in the WHO classification.
Postchemotherapy Endometrioid to Gastrointestinal Histotype Shift in Recurrent Endometrial Carcinoma.
Arciuolo, Damiano M.D.; Travaglino, Antonio M.D.; Santoro, Angela M.D., Ph.D.; Pedone Anchora, Luigi M.D.; Inzani, Frediano M.D., Ph.D.; Angelico, Giuseppe M.D., Ph.D.; D'Alessandris, Nicoletta M.D.; Scaglione, Giulia M.D.; Valente, Michele M.D.; Raffone, Antonio M.D.; Fanfani, Francesco M.D., Ph.D.; Zannoni, Gian F. M.D., Ph.D.
doi : 10.1097/PGP.0000000000000843
AB Herein, we report a case of low-grade endometrial endometrioid carcinoma recurred on the vaginal stump, which showed a complete histotype shift toward a gastrointestinal-type carcinoma after chemotherapy. The recurrent tumor increased in volume during chemotherapy.
Uterine Sarcoma With FGFR1-TACC1 Gene Fusion: A Case Report and Review of the Literature.
Zyla, Roman E. M.D.; Goebel, Emily A. M.D.; Jang, Ji-Hyun M.D., M.P.H.; Turashvili, Gulisa M.D., Ph.D.
doi : 10.1097/PGP.0000000000000846
AB With the growing availability of RNA sequencing technology in the pathology laboratory, new gene fusion-associated malignancies are increasingly being characterized. In this article, we describe the second ever reported case of a uterine sarcoma harboring a FGFR1-TACC1 gene fusion.
T-Cadherin, E-Cadherin, PR-A, and ER-[alpha] Levels in Deep Infiltrating Endometriosis.
Kalkan, Uzeyir M.D.; Biyik, Ismail M.D.; Simsek, Sercan M.D.
Adult Granulosa Cell Tumor With Sarcomatous Transformation: A Case Study With Emphasis on Molecular Alterations.
Dahoud, Wissam M.D.; Handler, Jesse M.D., Ph.D.; Parimi, Vamsi M.D., M.P.H.; Meyer, Christian F. M.D., Ph.D.; Wethington, Stephanie L. M.D.; Eshleman, James R. M.D., Ph.D.; Vang, Russell M.D.; Ronnett, Brigitte M. M.D.; Xing, Deyin M.D., Ph.D.
doi : 10.1097/PGP.0000000000000845
AB Adult granulosa cells tumors (AGCTs) are typically low-grade indolent tumors. On rare occasions, they undergo high-grade/sarcomatous transformation and behave aggressively. This transformation is postulated to occur as the result of acquired genetic alterations, some of which may be eligible for targeted therapy.
Sebaceous Carcinoma Arising in Ovarian Teratoma: First Report Associated With Germline Mismatch Repair Gene Mutation.
Murray, Jacinta M.B.; McIlwaine, Patrick M.R.C.O.G.; Morrison, Patrick J. D.Sc.; McCluggage, W. Glenn F.R.C.Path.
doi : 10.1097/PGP.0000000000000847
AB Sebaceous carcinoma is an uncommon primary cutaneous neoplasm which may be associated with mismatch repair (MMR) abnormalities and sometimes with Muir-Torre syndrome. These neoplasms rarely arise in the ovary within a teratoma/ dermoid cyst.
Well-developed Cerebellum in an Ovarian Mature Teratoma From a Pregnant Female.
Sauer, Madeline A. B.S.; Coy, Shannon M.D.; Quade, Bradley J. M.D., Ph.D.; Nucci, Marisa R. M.D.
doi : 10.1097/PGP.0000000000000848
AB Teratomas are the most common neoplasm of the ovary, comprising over half of all diagnosed tumors in patients under 50. Most lesions are classified as benign mature teratomas and are histologically defined by the presence of mature tissues from one or more of the embryological germ layers: ectoderm, mesoderm, and endoderm. Neuroectodermal
A Constellation of Rare Gynecological Malignancies and Familial Adenomatous Polyposis Gastrointestinal Adenocarcinoma: A Case Report.
Gill, Stephanie J. M.D., M.Sc.; Pirzada, Amrah M.D., D.A.B.P.; Power, Patti M.D., F.R.C.S.C.; Neveu, Joannie M.D., F.R.C.S.C.
doi : 10.1097/PGP.0000000000000836
AB Ovarian microcystic stromal tumors (MST) are a rare subtype of sex-cord stromal tumors. We are presenting a case of a MST arising in a patient with familial adenomatous polyposis (FAP) and concurrent colonic adenocarcinoma.
Expression of Potential Biomarker Targets by Immunohistochemistry in Cervical Carcinomas.
Sun, Lulu M.D., Ph.D.; Schroeder, Molly C. Ph.D.; Hagemann, Ian S. M.D., Ph.D.; Pfeifer, John D. M.D., Ph.D.; Schwarz, Julie K. M.D., Ph.D.; Grigsby, Perry W. M.D., M.S., M.B.A.; Markovina, Stephanie M.D., Ph.D.; Lin, Alexander J. M.D., Ph.D.
doi : 10.1097/PGP.0000000000000853
AB There have been few clinically useful targetable biomarkers in uterine cervical carcinomas. Estrogen receptor (ER), HER2, and fibroblast activation protein (FAP) are potential therapeutic or theranostic targets in other gynecologic and genitourinary carcinoma types.
Acquired Elastotic Hemangioma-like Change of the Vulva Associated With Lichen Sclerosus.
Val-Bernal, Jose-Fernando M.D., Ph.D.; Hermana, Sandra M.D.; Aller, Laura M.D.
doi : 10.1097/PGP.0000000000000829
AB Acquired elastotic hemangioma (AEH) is a rare variant of hemangioma that usually presents as an asymptomatic, solitary, slow-growing red plaque on a sun-exposed site of an adult. Ultraviolet radiation can contribute to the pathogenesis of this hemangioma.
NTRK-Fusion Sarcoma of the Uterine Cervix: Report of 2 Cases With Comparative Clinicopathologic Features.
Nilforoushan, Neshat M.D.; Wethington, Stephanie L. M.D., M.Sc.; Nonogaki, Hiro M.S.; Gross, John M.D.; Vang, Russell M.D.; Xing, Deyin M.D., Ph.D.
doi : 10.1097/PGP.0000000000000834
AB NTRK1/2/3 rearrangements have been identified as oncogenic drivers in a variety of tumors including those in the uterine cervix, and rarely, the uterine corpus. We report 2 cases of cervical sarcoma with NTRK gene rearrangements.
HPV42-associated Seborrhoeic Keratosis-like Lesion of the Cervix: First Reported Case With High-grade Morphology.
Talia, Karen L. F.R.C.P.A.; Rahimi, Siavash F.R.C.Path.; Hawkes, David Ph.D.; McCluggage, W. Glenn F.R.C.Path.
doi : 10.1097/PGP.0000000000000835
AB Seborrheic keratosis-like lesion (SKLL) is an extremely rare, morphologically distinct lesion occurring in the cervix and vagina that differs histologically from usual squamous intraepithelial lesions in these sites, by bearing close resemblance to cutaneous seborrheic keratosis and lacking koilocytosis.
International Collaboration on Cancer Reporting (ICCR) Gynecological Cancer Datasets: A Move Towards International Standardization.
McCluggage, W. Glenn F.R.C.Path.
The International Collaboration on Cancer Reporting (ICCR): 10 Years Progress in the Development of Cancer Pathology Datasets.
Helliwell, Timothy R. M.D.; Judge, Meagan J. B.Sc.; Birdsong, George G. M.D.; Ellis, David W. M.B.B.S.; Srigley, John R. M.D.
Data Set for the Reporting of Carcinomas of the Vulva: Recommendations From the International Collaboration on Cancer Reporting (ICCR).
Hoang, Lynn M.D.; Webster, Fleur M.Sc.; Bosse, Tjalling M.D., Ph.D.; Focchi, Gustavo M.D., Ph.D.; Gilks, C. Blake M.D.; Howitt, Brooke E. M.D.; McAlpine, Jessica N. M.D.; Ordi, Jaume M.D.; Singh, Naveena F.R.C.Path.; Wong, Richard Wing-Cheuk F.R.C.P.A.; Lax, Sigurd F. M.D.; McCluggage, W. Glenn F.R.C.Path.
doi : 10.1097/PGP.0000000000000900
AB A cogent and comprehensive pathologic report is essential for optimal patient management, cancer staging, and prognostication. This article details the International Collaboration on Cancer Reporting (ICCR) process and the development of the vulval carcinoma reporting data set.
Data Set for the Reporting of Carcinomas of the Vagina: Recommendations From the International Collaboration on Cancer Reporting (ICCR).
Wong, Richard Wing-Cheuk F.R.C.P.A.; Webster, Fleur M.Sc.; Bosse, Tjalling M.D., Ph.D.; Focchi, Gustavo M.D., Ph.D.; Gilks, C. Blake M.D.; Hoang, Lynn M.D.; Howitt, Brooke E. M.D.; McAlpine, Jessica M.D.; Ordi, Jaume M.D.; Singh, Naveena F.R.C.Path.; Lax, Sigurd F. M.D., Ph.D.; McCluggage, W. Glenn F.R.C.Path.
doi : 10.1097/PGP.0000000000000883
AB Primary carcinomas of the vagina are uncommon and currently detailed recommendations for the reporting of resection specimens of these neoplasms are not widely available.
Dataset for the Reporting of Gestational Trophoblastic Neoplasia: Recommendations From the International Collaboration on Cancer Reporting (ICCR).
Hui, Pei M.D., Ph.D.; Webster, Fleur M.S.c.; Baergen, Rebecca N. M.D.; Buza, Natalia M.D.; Cheung, Annie N.Y. M.D.; Kaur, Baljeet F.R.C.Path., M.D.; Ronnett, Brigitte M. M.D.; Shih, Ie-Ming M.D., Ph.D.; Seckl, Michael J. F.Med.Sci.; Lax, Sigurd F. M.D., Ph.D.; McCluggage, W. Glenn F.R.C.Path.
doi : 10.1097/PGP.0000000000000876
AB Comprehensive pathology reporting of cancers is important for patient management, tumor staging, and prognostication. Standardized cancer datasets are essential in guiding pathology reporting in a consistent and concise manner and this facilitates effective global cancer information exchange and comparison.
Data Set for Reporting of Uterine Malignant and Potentially Malignant Mesenchymal Tumors: Recommendations From the International Collaboration on Cancer Reporting (ICCR).
Nucci, Marisa R. M.D.; Webster, Fleur M.Sc.; Croce, Sabrina M.D.; George, Suzanne M.D.; Howitt, Brooke E. M.D.; Ip, Philip P.C. F.R.C.Path.; Lee, Cheng-Han M.D.-Ph.D., F.R.C.P.C.; Rabban, Joseph T. M.D., M.P.H.; Soslow, Robert A. M.D.; van der Griend, Rachael F.R.C.P.A.; Lax, Sigurd F. M.D., Ph.D.; McCluggage, W. Glenn F.R.C.Path.
doi : 10.1097/PGP.0000000000000911
AB The International Collaboration on Cancer Reporting (ICCR) seeks to produce standardized, evidence-based protocols for the reporting of tumors with the aim of ensuring that all cancer reports generated worldwide will be of similar high quality and record the same elements.
Dataset for the Reporting of Carcinoma of the Cervix: Recommendations From the International Collaboration on Cancer Reporting (ICCR).
Park, Kay J. M.D.; Selinger, Christina I. Ph.D.; Alvarado-Cabrero, Isabel M.D., Ph.D.; Duggan, Maire A. M.D.; Kiyokawa, Takako M.D., Ph.D.; Mills, Anne M. M.D.; Ordi, Jaume M.D.; Otis, Christopher N. M.D.; Plante, Marie M.D.; Stolnicu, Simona M.D., Ph.D.; Talia, Karen L. F.R.C.P.A.; Wiredu, Edwin K. M.D., F.W.A.C.P., F.R.C.Path.; Lax, Sigurd F. M.D.; McCluggage, W. Glenn F.R.C.Path.
doi : 10.1097/PGP.0000000000000909
AB Cervical carcinoma remains one of the most common cancers affecting women worldwide, despite effective screening programs being implemented in many countries for several decades.
Data Set for the Reporting of Endometrial Cancer: Recommendations From the International Collaboration on Cancer Reporting (ICCR).
Matias-Guiu, Xavier M.D., Ph.D.; Selinger, Christina I. Ph.D.; Anderson, Lyndal F.R.C.P.A., M.Phil.; Buza, Natalia M.D.; Ellenson, Lora H. M.D.; Fadare, Oluwole M.D.; Ganesan, Raji M.B.B.S., M.D., F.R.C.Path.; Ip, Philip P.C. M.B.Ch.B., F.R.C.Path.; Palacios, Jose M.D., Ph.D.; Parra-Herran, Carlos M.D.; Raspollini, Maria R. M.D., Ph.D.; Soslow, Robert A. M.D.; Werner, Henrica M.J. M.D., Ph.D.; Lax, Sigurd F. M.D.; McCluggage, W. Glenn F.R.C.Path.
doi : 10.1097/PGP.0000000000000901
AB Endometrial cancer is one of the most common cancers among women. The International Collaboration on Cancer Reporting (ICCR) developed a standardized endometrial cancer data set in 2011, which provided detailed recommendations for the reporting of resection specimens of these neoplasms.
Data Set for the Reporting of Ovarian, Fallopian Tube and Primary Peritoneal Carcinoma: Recommendations From the International Collaboration on Cancer Reporting (ICCR).
Gilks, C. Blake M.D., F.R.C.P.C.; Selinger, Christina I. Ph.D.; Davidson, Ben M.D.; Kobel, Martin M.D.; Ledermann, Jonathan A. M.D., F.Med.Sci.; Lim, Diana M.D., F.R.C.Path., F.R.C.P.A.; Malpica, Anais M.D.; Mikami, Yoshiki M.D.; Singh, Naveena M.D., F.R.C.Path.; Srinivasan, Radhika M.D.; Vang, Russell M.D.; Lax, Sigurd F. M.D.; McCluggage, W. Glenn F.R.C.Path.
doi : 10.1097/PGP.0000000000000908
AB The move toward consistent and comprehensive surgical pathology reports for cancer resection specimens has been a key development in supporting evidence-based patient management and consistent cancer staging.
