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The role of neoadjuvant denosumab in the treatment of aneurysmal bone cysts: a case series and review of the literature
Alexandra M. Giantini-Larsen , Vikram B. Chakravarthy , Ori Barzilai , William Christopher Newman , Leonard Wexler , and Mark H. Bilsky
doi : 10.3171/2022.8.PEDS22314
Can tumor treating fields induce DNA damage and reduce cell motility in medulloblastoma cell lines?
Ryan T. Nitta  PhD , Emily J. Luo  BSc , Michael Lim  MD , and Gordon Li  MD
doi : 10.3171/2022.8.PEDS22300
Postoperative MRI features of cerebellar mutism syndrome: a retrospective cohort study
Wei Yang  MD , Hong Zhang  MD , Yingjie Cai  MD , Xiaojiao Peng  MD , Hailang Sun  MD , Jiashu Chen  MD , Zesheng Ying  MD , Kaiyi Zhu  PhD , Yun Peng  MD , and Ming Ge  MD
doi : 10.3171/2022.8.PEDS22294
In this study, the authors aimed to investigate the relationship between postoperative MRI features and cerebellar mutism syndrome.
Natural history and treatment of deep-seated brain arteriovenous malformations in pediatric patients
*Shahab Aldin Sattari, MD, Wuyang Yang, MD, Risheng Xu, MD, PhD, James Feghali, MD,Rafael J. Tamargo, MD, and Judy Huang, MD
doi : 10.3171/2022.8.PEDS22213
Pediatric deep brain arteriovenous malformations (bAVMs) represent a unique management challenge given their higher cumulative risk of hemorrhage as well as a higher risk of treatment. Better understanding of hemorrhage risk in this patient population will lead to a better decision-making process for patient management.
A robotic MR-guided high-intensity focused ultrasound platform for intraventricular hemorrhage: assessment of clot lysis efficacy in a brain phantom
Hrishikesh Raghuram, MASc,Thomas Looi, PhD, MBA,Samuel Pichardo, PhD,Adam C. Waspe, PhD,1,3and James M. Drake, MBBCh
doi : 10.3171/2022.8.PEDS22144
Intraventricular hemorrhage (IVH) is a neurovascular complication due to premature birth that results in blood clots forming within the ventricles. Magnetic resonance–guided high-intensity focused ultrasound (MRgHIFU) has been investigated as a noninvasive treatment to lyse clots. The authors designed and constructed a robotic MRgHIFU platform to treat the neonatal brain that facilitates ergonomic patient positioning. The clot lysis efficacy of the platform is quantified using a brain phantom and clinical MRI system.
Impact of age at endoscopic metopic synostosis repair on anthropometric outcomes
Sarah N. Chiang, BS,1 Erin C. Peterson, MD,1 David C. Lauzier, BS, 2,3 Sean D. McEvoy, MD, 2 Gary B. Skolnick, MBA,1 Sybill D. Naidoo, PhD, RN, CPNP,1 Matthew D. Smyth, MD, 2 and Kamlesh B. Patel, MD, MSc
doi : 10.3171/2022.8.PEDS22214
Endoscopic strip craniectomy for metopic craniosynostosis relies on rapid growth and postoperative helmeting for correction. Endoscopic repair is generally performed before patients reach 4 months of age, and outcomes in older patients have yet to be quantified. Here, the authors examined a cohort of patients treated with endoscopic repair before or after 4 months of age to determine aesthetic outcomes of delayed repairs.
Postoperative general medical ward admission following Chiari malformation decompression
Megan M. Finneran, DO,1 Sarah Graber, CCRP, 2,3 Kim Poppleton, MPH, 2 Allyson L. Alexander, MD, PhD, 3,4 C. Corbett Wilkinson, MD, 3,4 Brent R. O’Neill, MD, 3,4 Todd C. Hankinson, MD, 3,4 and Michael H. Handler, MD
doi : 10.3171/2022.7.PEDS22226
Prior to 2019, the majority of patients at Children’s Hospital Colorado were admitted to the pediatric intensive care unit (PICU) following Chiari malformation (CM) decompression surgery. This study sought to identify the safety and efficacy of postoperative general ward management for these patients.
The Vestibular/Ocular Motor Screening–Child (VOMS-C) tool for concussion evaluation in 5- to 9-year-old pediatric patients: preliminary evidence
Alicia M. Trbovich, PhD,1 Anne Mucha, DPT, 2 Shawn Eagle, PhD, ATC,1,3 Bindal Makwana Mehmel, PhD,1 Nathan Kegel, PhD,1 Vanessa Fazio Sumrok, PhD,1 Michael W. Collins, PhD,1 and Anthony P. Kontos, PhD
doi : 10.3171/2022.8.PEDS22234
Vestibular and ocular motor dysfunction occurs in an estimated 60%–90% of concussion patients. The Vestibular/Ocular Motor Screening (VOMS) tool is validated for use in concussion patients older than 9 years. The goal of the current study was to adapt the current VOMS tool for a pediatric sample of children aged 5–9 years and establish its clinical utility in this patient population.
Repeat surgery for pediatric epilepsy: a systematic review and meta-analysis of resection and disconnection approaches
Victor M. Lu  MD, PhD , Erik C. Brown  MD, PhD , John Ragheb  MD , and Shelly Wang  MD, MPH
doi : 10.3171/2022.9.PEDS22344
Resection and disconnection surgeries for epilepsy in the pediatric demographic (patients ≤ 18 years of age) are two separate, definitive intervention options in medically refractory cases. Questions remain regarding the role of surgery when seizures persist after an initial incomplete surgery. The aim of this study was to review the contemporary literature and summarize the metadata on the outcomes of repeat surgery in this specific demographic.
Wound closure with a mesh and liquid tissue adhesive (Dermabond Prineo) system in pediatric spine surgery: a prospective single-center cohort study incorporating parent-reported outcome measures
Sarah Stricker , Noëmi Eberhard , Maria Licci , Ladina Greuter , Christian Zweifel , Raphael Guzman , and Jehuda Soleman
doi : 10.3171/2022.8.PEDS22270
Letter to the Editor. Recovery of physical signs in Chiari malformation type I and syringomyelia after surgery
Yuankun Cai  MD , Guo Li  MD , and Kui Liu  MD
doi : 10.3171/2022.6.PEDS22266
Letter to the Editor. Intrathecal baclofen pump insertion versus selective dorsal rhizotomy
Anna Bruna Ronchetti  MD , Marta Bertamino  MD, PhD , Chiara Maria Tacchino  MD , Paolo Moretti  MD , and Marco Pavanello  MD
doi : 10.3171/2022.7.PEDS22276
