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CAR T cells induce drug-free SLE remission
doi : 10.1038/s41584-022-00865-6
Volume 18 Issue 12, December 2022
Single-cell-based platform maps response to candidate DMOADs
Sarah OnuoraÂÂ
In-joint photocatalytic hydrogen production prevents RA in mice
Robert PhillipsÂÂ
Small wonder: nanoparticles feed hydroxychloroquine to activated neutrophils
Somanathapura K. NaveenKumar & Jason S. KnightA
Paediatric glucocorticoid toxicity index: new possibilities in assessment
Charlotte King & Daniel B. HawcuttA
The value of comparative efficacy studies in informing rheumatology guidelines
Raveendhara R. BannuruÂÂ
Keeping immunostimulatory self-RNA under the rADAR
Christine Wolf & Min Ae Lee-KirschA
Immune cell dysregulation as a mediator of fibrosis in systemic sclerosis
Dan Fang, Beidi Chen, Alain Lescoat, Dinesh Khanna & Rong MuA
doi : 10.1038/s41584-022-00864-7
Systemic sclerosis (SSc) is a destructive connective tissue disease characterized by dysregulation of the immune system and fibrosis in the skin and internal organs. The pathogenesis of SSc is complex and remains to be determined. So far, limited specific disease-modifying treatments are available for the effective control of fibrosis in patients with SSc.
Age-related mechanisms in the context of rheumatic disease
Ghada Alsaleh, Felix C. Richter & Anna K. SimonA
doi : 10.1038/s41584-022-00863-8
Ageing is characterized by a progressive loss of cellular function that leads to a decline in tissue homeostasis, increased vulnerability and adverse health outcomes. Important advances in ageing research have now identified a set of nine candidate hallmarks that are generally considered to contribute to the ageing process and that together determine the ageing phenotype, which is the clinical manifestation of age-related dysfunction in chronic diseases.
A comprehensive guide for managing the reproductive health of patients with vasculitis
Catherine Sims & Megan E. B. ClowseA
doi : 10.1038/s41584-022-00842-z
Vasculitides and their therapies affect all areas of the reproductive life cycle. The ACR, EULAR and the Drugs and Lactation database offer guidance on the management of the reproductive health of patients with rheumatic diseases; however, these guidelines do not address patients with vasculitis specifically.
Precision medicine: the precision gap in rheumatic disease
Chung M. A. Lin, Faye A. H. Cooles & John D. IsaacsA
doi : 10.1038/s41584-022-00845-w
For many oncological conditions, the application of timely and patient-tailored targeted therapies, or precision medicine, is a major therapeutic development that has provided considerable clinical benefit.
Publisher Correction: The impact of COVID-19 on rare and complex connective tissue diseases: the experience of ERN ReCONNET
Rosaria Talarico, Silvia Aguilera, Tobias Alexander, Zahir Amoura, Ana M. Antunes, Laurent Arnaud, TadejAvcin,Lorenzo Beretta, Stefano Bombardieri, Gerd R. Burmester, Sara Cannizzo, Lorenzo Cavagna, Benjamin Chaigne, Alain Cornet,Nathalie Costedoat-Chalumeau, Andrea Doria, Alessandro Ferraris, Rebecca Fischer- Betz, João E. Fonseca, Charissa Frank,Andrea Gaglioti, Ilaria Galetti, Jürgen Grunert, Vera Guimarães, Eric Hachulla, Frederic Houssiau, Luca Iaccarino,Thomas Krieg, Marteen Limper, Fransiska Malfait, Xavier Mariette, Diana Marinello, Thierry Martin, Lisa Matthews,Marco Matucci-Cerinic, Alain Meyer, Carlomaurizio Montecucco, Luc Mouthon, Ulf Müller-Ladner, Simona Rednic,Vasco C. Romão, Matthias Schneider, Vanessa Smith, Alberto Sulli, Farah Tamirou, Domenica Taruscio, Anna V. Taulaigo,Enrique Terol, Angela Tincani, Simone Ticciati, Giuseppe Turchetti, P. Martin van Hagen, Jacob M. van Laar, Ana Vieira,Jeska K. de Vries- Bouwstra, Maurizio Cutolo and Marta Mosca
Author Correction: Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA): updated treatment recommendations for psoriatic arthritis 2021
Laura C. Coates, Enrique R. Soriano, Nadia Corp, Heidi Bertheussen, Kristina Callis Duffin, Cristiano B. Campanholo,Jeffrey Chau, Lihi Eder, Daniel G. Fernández- �vila, Oliver FitzGerald, Amit Garg, Dafna D. Gladman, NitiGoel,Philip S. Helliwell, M. Elaine Husni, Deepak R. Jadon, Arnon Katz, Dhruvkumar Laheru, John Latella, Ying- Ying LeungChristine Lindsay, EnnioLubrano, LuisDanielMazzuoccolo , PhilipJ.Mease , Denis O’Sullivan, Alexis Ogdie,Wendy Olsder, Penelope Esther Palominos, Lori Schick, Ingrid Steinkoenig, Maarten de Wit, D.A.vanderWindt,Arthur Kavanaugh and the GRAPPA Treatment Recommendations domain subcommittees*
