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Creating room for innovation in the treatment of psoriasis
Peter C. M. van de Kerkhof
doi : 10.1080/09546634.2022.2138396
Journal of Dermatological Treatment, Volume 33, Issue 7 (2022)
Bullous pemphigoid induced by biologic drugs in psoriasis: a systematic review
Husein Husein-ElAhmed & Martin Steinhoff
doi : 10.1080/09546634.2022.2089331
Several therapies for psoriasis have been described as triggers of biologic-induced bullous pemphigoid (BIBP). The real incidence of BIBP in psoriatic patients is still unknown. Hence, we compilated and analyzed current literature to identify the frequency and burden of this adverse event for psoriasis patients treated with biologics.
Angiotensin II receptor blockers in dermatology: a narrative review
Yang Lo & Tsen-Fang Tsai
doi : 10.1080/09546634.2022.2089332
Angiotensin II receptor blockers (ARBs) are commonly used for cardiovascular diseases, especially for patients who can’t tolerate the side effects of cough and angioedema caused by angiotensin converting enzyme inhibitors (ACEIs). However, the evidence of using ARBs in dermatology is mostly anecdotal and limited to case reports or small case series. Here we present a narrative review focusing on the therapeutic use of ARBs in dermatology and adverse cutaneous reactions due to the administration of ARBs.
Potential use of microwave technology in dermatology
A. K. Gupta, M. Venkataraman, L. T. Joshi & E. A. Cooper
doi : 10.1080/09546634.2022.2089333
Microwaves are used in medicine for diagnostics, and treatment of cancer. Recently, novel microwave devices (Swift®, Emblation Ltd, UK and miraDry®, Miramar Labs Inc., CA) have been cleared by the FDA and Health Canada for various dermatological conditions.
Generalized pustular psoriasis: the new era of treatment with IL-36 receptor inhibitors
Cláudia Oliveira Maçães, Ana Maria Lé & Tiago Torres
doi : 10.1080/09546634.2022.2089335
Generalized pustular psoriasis (GPP) is a rare yet severe variant of psoriasis, characterized by the eruption of superficial sterile pustules that appear suddenly and widely distributed, potentially life-threatening.
Exploring the potential of nanocarriers in antipsoriatic therapeutics
Mohammad Shaif, Poonam Kushwaha, Shazia Usmani & Supriya Pandey
doi : 10.1080/09546634.2022.2089616
Psoriasis is an autoimmune disease characterized by erythematous, scaly patches on the skin. It can be effectively managed with topical therapies since they deliver drugs to target sites of disease efficiently and can minimize systemic side-effects while ensuring high patient compliance.
Probiotics for the prevention of atopic dermatitis in infants from different geographic regions: a systematic review and Meta-analysis
Lifeng Chen, Yongshan Ni, Xingdong Wu & Guixia Chen
doi : 10.1080/09546634.2022.2091101
Atopic dermatitis (AD) is a common skin disease during infancy, but the preventive effect of probiotics on AD remains unclear.
Perioperative anticoagulation recommendations for cutaneous oncologic surgery: a review of the literature
Hemali Shah, Fabio Stefano Frech, Isabella Dreyfuss, Loren Hernandez &Keyvan Nouri
doi : 10.1080/09546634.2022.2097161
Consistent perioperative management is important to the practice of dermatologic surgery. With the widespread use of anticoagulant medications, such as aspirin, warfarin, clopidogrel, factor Xa inhibitors, and thrombin inhibitors for a number of cardiovascular indications, it is important to standardize the use of these drugs in the setting of skin cancer surgery.
Comparison of oral minoxidil, finasteride, and dutasteride for treating androgenetic alopecia
Aditya K. Gupta, Mesbah Talukder & Greg Williams
doi : 10.1080/09546634.2022.2109567
Androgenetic alopecia (AGA) is the most common cause of hair loss, often challenging to treat. While oral finasteride (1 mg/d) is an FDA-approved treatment for male AGA, oral minoxidil and oral dutasteride are not approved yet. However, clinicians have been increasingly using these two drugs off-label for hair loss. Recently, Japan and South Korea have approved oral dutasteride (0.5 mg/d) for male AGA.
On and off-label uses of interleukin-17 inhibitors for patients with plaque-type psoriasis in Thailand: a real-world study
Pim Sermsaksasithorn, Chanidapa Wongtada, Varin Chaaim, YudaChongpison & Pravit Asawanonda
doi : 10.1080/09546634.2022.2089328
Off-label uses of biologics in the treatment of psoriasis are usually implemented in limited-resource settings and studies regarding their response profiles are limited.
Cardiometabolic multimorbidity is common among patients with psoriasis and is associated with poorer outcomes compared to those without comorbidity
Clinton W. Enos, Vanessa L. Ramos, Robert R. McLean, Tin-Chi Lin, NicoleFoster, Blessing Dube & Abby S. Van Voorhees
doi : 10.1080/09546634.2022.2089329
Associations between cardiometabolic multimorbidity and response to therapy in psoriasis are unknown.
Age-based treatment differences in and reluctance to treating older adults with systemic antipsoriatic therapy – a mixed-method pilot study
Elke L. M. ter Haar, Marcia Tummers, Ewald M. Bronkhorst, Peter C. M. vande Kerkhof, Elke M. G. J. de Jong & Satish F. K. Lubeek
doi : 10.1080/09546634.2022.2089330
Evidence-based guidance in older adults (≥65 years) with psoriasis is sparse and undertreatment might be present.
Switching to risankizumab from ustekinumab or adalimumab in plaque psoriasis patients improves PASI and DLQI outcomes for sub-optimal responders
Bruce Strober, April Armstrong, Simone Rubant, Manish Patel, TianshuangWu, Huzefa Photowala & Jeffrey Crowley
doi : 10.1080/09546634.2022.2095328
Psoriasis is often treated with biologic therapies. While many patients see improvement in their symptoms with treatment, some achieve only partial success.
Multiarm study comparing patient-reported and clinical outcome measures in patients undergoing antipsoriatic therapy with non-biological systemic agents in a real-world setting
Christine Fink, Christina Alt, Timo E. Schank, Katharina Sies, Samuel Kilian &Knut Schäkel
doi : 10.1080/09546634.2022.2095329
Although the inclusion of patients’ preferences and needs is essential for therapy adherence, the assessment of patient-reported outcome measures in clinical trials is often neglected. Therefore, the aim of this study was to quantify several patient-reported outcome measures in psoriasis patients undergoing systemic therapy in a real-life clinical setting.
Matching-adjusted indirect comparison of efficacy outcomes in trials of calcipotriol plus betamethasone dipropionate foam and cream formulations for the treatment of plaque psoriasis
Kim A. Papp, Henrik Thoning, Sascha Gerdes, Matteo Megna, Henrik Brandi,Marie Y. Jablonski Bernasconi & Oriol Yélamos
doi : 10.1080/09546634.2022.2095330
Once-daily, fixed-combination calcipotriol 50 μg/g (Cal) plus betamethasone dipropionate 0.5 mg/g (BD) is available in aerosol foam and cream formulations. As no head-to-head data are available, we use a matching-adjusted indirect comparison (MAIC) approach to compare Cal/BD foam and cream.
Complementary and alternative treatment methods practiced by parents in pediatric cases diagnosed with atopic dermatitis
Ayşe Akbaş, Zeynep Şengül Emeksiz, Ahu Yorulmaz, Yıldız Hayran, FadimeKılınç, Halil Ibrahim Yakut, Müge Toyran & Kezban İpek Demir
doi : 10.1080/09546634.2022.2097159
Atopic dermatitis (AD) is a chronic, recurrent, and inflammatory skin disease experienced mostly in childhood. Chronicity of the disease, relapses, constant need of regular skin care causes seeking for alternative treatments.
Hemodynamic changes during conventional and daylight photodynamic therapy of actinic keratoses – a randomized controlled trial
J. Hartmann, A. Keller, A. Enk & P. Gholam
doi : 10.1080/09546634.2022.2097160
Photodynamic therapy (PDT) is an effective treatment for actinic keratosis (AK). However, pain and hypertension are important side effects of conventional PDT (c-PDT). Several studies have demonstrated that daylight PDT (dl-PDT) is less painful while being as effective as c-PDT.
Dupilumab for the treatment of adult atopic dermatitis in special populations
Cataldo Patruno, Luca Potestio, Massimiliano Scalvenzi, Teresa Battista,Flavia Raia, Vincenzo Picone, Gabriella Fabbrocini & Maddalena Napolitano
doi : 10.1080/09546634.2022.2102121
Special populations (SPs) involve people who require additional consideration in clinical research. Effectiveness of treatment or occurrence of side effects may be different in SPs with respect to not-SPs.
Clinical efficacy analysis of 110 cases of childhood vitiligo with non-surgical combined therapy
Yuan-Yuan Liu, Jun-Feng Zhou, Yu Zhen, Yan Cui, Yang Song, Lei Yao & Shan-Shan Li
doi : 10.1080/09546634.2022.2104443
Vitiligo has a negative effect on children’s physical and psychological health. Few studies have examined long-term treatment efficacy for childhood vitiligo. Therefore, we evaluated the long-term effectiveness of non-surgical combination therapy in pediatric patients with vitiligo and analyzed factors that affect its efficacy.
Efficacy and safety of oral methotrexate versus oral mini pulse betamethasone therapy in the treatment of lichen planus: a comparative study
Nour alhuda Gamal Alsakaan, Sherief Abd-Elsalam, Mohamed M. Fawzy &Nagwa Mohammad Elwan
doi : 10.1080/09546634.2022.2104446
Lichen planus (LP) is a chronic inflammatory mucocutaneous disease. Systemic corticosteroids are the treatment of choice for generalized LP but their use is limited due to side effects. Oral mini pulse (OMP) therapy represents a good alternative. Also, Methotrexate (MTX) can be used as an alternative and safe modality in LP.
Comparison of the onset, depth, and duration of cutaneous anesthesia between topical 10% lidocaine and EMLA creams: a randomized, intraindividual, comparative trial
Nichchanun Junputipong, Salinee Rojhirunsakool, Poonnapa Deewongkij,Nanticha Kamanamool & Montree Udompataikul
doi : 10.1080/09546634.2022.2109566
The eutectic mixture of local anesthetics (EMLA) is an effective cutaneous anesthetic, although its application is time consuming and poses a risk of methemoglobinemia. Currently, the efficacy of topical 10% lidocaine cream is unclear.
Real-world clinical outcomes of treatment with brodalumab in patients with moderate-to-severe psoriasis: a retrospective, 24-month experience from four academic dermatology centers in Greece
Evangelia Papadavid, Efterpi Zafeiriou, Sophia Georgiou, Angeliki-ViktoriaRoussaki-Schulze, Theofanis Spiliopoulos, Eleftheria Vryzaki, ChrysaOikonomou, Ourania Drongoula, Maria Boziou, Georgios Goudouras,Konstantinos Sfaelos, Zoi Apalla & Elisavet Lazaridou
doi : 10.1080/09546634.2022.2110836
To assess the real-world clinical treatment outcomes with brodalumab in patients with moderate-to-severe plaque psoriasis in Greece.
Biologic use in hidradenitis suppurativa: patient perspectives and barriers
Devea R. De, Terri Shih, Denise Fixsen, Brindley Brooks, Jennifer L. Hsiao &Vivian Y. Shi
doi : 10.1080/09546634.2022.2089336
Hidradenitis suppurativa (HS) is an inflammatory dermatosis for which the treatment paradigm is rapidly expanding. We aimed to identify HS patient perspectives and barriers on biologics.
Invasive Aspergillus infection of middle ear in a patient treated with secukinumab, methotrexate, and corticosteroids for psoriasis and psoriatic arthritis
Filip Rob, Lukáš Å koloudÃk, Viktor Chrobok, Jana DÄ›dková, Petra KaÅ¡parová &Lucie Podrazilová
doi : 10.1080/09546634.2022.2104442
Mucocutaneous mycotic infections are common complications in patients on IL-17 inhibitor therapy. We report a case of a 33-year-old male with severe psoriasis and psoriatic arthritis on secukinumab combined with methotrexate and prednisone with swelling, otorrhea, and pain of the right ear and external auditory canal. Due to progressive hypacusis, a surgical solution was chosen. Tissue samples taken during surgery revealed the presence of Aspergillus fumigatus. Aspergillosis should be suspected in prolonged otorrhea, especially in immunocompromised patients. Without intervention, the disease could be fatal.
Letter to the editor submitted in response to ‘Incidence and prognosis of COVID-19 in patients with atopic diseases on dupilumab: a multicentre retrospective cohort study’
Maddalena Napolitano, Luca Potestio, Francesca Di Vico, GabriellaFabbrocini & Cataldo Patruno
Periocular molluscum contagiosum in an atopic dermatitis patient treated with upadacitinib
E. De Luca, N. Gori, A. Chiricozzi, A. Di Stefani & K. Peris
