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Peptide Receptor Radionuclide Therapy
Johannes Hofland, Tessa Brabander, Frederik A Verburg, Richard A Feelders, Wouter W de Herder
doi : 10.1210/clinem/dgac574
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 12, December 2022, Pages 3199–3208
The concept of using a targeting molecule labeled with a diagnostic radionuclide for using positron emission tomography or single photon emission computed tomography imaging with the potential to demonstrate that tumoricidal radiation can be delivered to tumoral sites by administration of the same or a similar targeting molecule labeled with a therapeutic radionuclide termed “theranostics.� Peptide receptor radionuclide therapy (PRRT) with radiolabeled somatostatin analogs (SSAs) is a well-established second/third-line theranostic treatment for somatostatin receptor-positive well-differentiated (neuro-)endocrine neoplasms (NENs).
Prognostic Effect of Lymph Node Metastases and Mesenteric Deposits in Neuroendocrine Tumors of the Small Bowel
Federica Grillo, Manuela Albertelli, Pasqualino Malandrino, Andrea Dotto, Genoveffa Pizza, Giuseppe Cittadini, Annamaria Colao, Antongiulio Faggiano
doi : 10.1210/clinem/dgac326
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 12, December 2022, Pages 3209–3221
Well-differentiated, low-grade neuroendocrine tumors (NETs) are the most frequent tumor types of the small bowel. Despite their generally indolent growth patterns and grade, these tumors tend to metastasize; indeed, at presentation, approximately 50% show nodal metastases and 30% of patients have distant metastases, even though they potentially show long survival. Little is available in the literature concerning the optimal nodal yield in small-bowel resections, and the clinical significance of nodal metastases and lymph node ratio (LNR) at this site is still debated.
Machine Learning–Based Prediction of Elevated PTH Levels Among the US General Population
Hajime Kato, Yoshitomo Hoshino, Naoko Hidaka, Nobuaki Ito, Noriko Makita, Masaomi Nangaku, Kosuke Inoue
doi : 10.1210/clinem/dgac544
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 12, December 2022, Pages 3222–3230
Although elevated parathyroid hormone (PTH) levels are associated with higher mortality risks, the evidence is limited as to when PTH is expected to be elevated and thus should be measured among the general population.
Aging Impairs Adaptive Unfolded Protein Response and Drives Beta Cell Dedifferentiation in Humans
Jiaxi Song, Qicheng Ni, Jiajun Sun, Jing Xie, Jianmin Liu, Guang Ning, Weiqing Wang, Qidi Wang
doi : 10.1210/clinem/dgac535
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 12, December 2022, Pages 3231–3241
Diabetes is an age-related disease; however, the mechanism underlying senescent beta cell failure is still unknown.
Circulating Plasma Concentrations of ACE2 in Primary Aldosteronism and Cardiovascular Outcomes
Vin-Cent Wu, Kang-Yung Peng, Ya-Hui Hu, Chin-Chen Chang, Chieh-Kai Chan, Tai-Shuan Lai, Yen-Hung Lin, Shuo-Meng Wang, Ching-Chu Lu, Yu-Chun Liu, Yao-Chou Tsai, Jeff S Chueh
doi : 10.1210/clinem/dgac539
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 12, December 2022, Pages 3242–3251
The plasma concentrations of angiotensin-converting enzyme 2 (pACE2) has been independently associated with cardiovascular diseases.
The SELFI Study: Iodine Excess and Thyroid Dysfunction in Women Undergoing Oil-Soluble Contrast Hysterosalpingography
Divya M Mathews, Jane M Peart, Robert G Sim, Neil P Johnson, Susannah O'Sullivan, José G B Derraik, Paul L Hofman
doi : 10.1210/clinem/dgac546
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 12, December 2022, Pages 3252–3260
Hysterosalpingography (HSG) with oil-soluble contrast medium (OSCM) improves pregnancy rates. However, OSCM has high iodine content and long half-life, leading to potential iodine excess.
GIP Affects Hepatic Fat and Brown Adipose Tissue Thermogenesis but Not White Adipose Tissue Transcriptome in Type 1 Diabetes
Sebastian Møller Nguyen Heimbürger, Bjørn Hoe, Chris Neumann Nielsen, Natasha Chidekel Bergman, Kirsa Skov-Jeppesen, Bolette Hartmann, Jens Juul Holst, Flemming Dela, Julie Overgaard, Joachim Størling, Tina Vilsb?ll, Thomas Fremming Dejgaard, Jesper Foged Havelund, Vladimir Gorshkov, Frank Kjeldsen, Nils Joakim F?rgeman, Martin R?nn Madsen, Mikkel B Christensen, Filip Krag Knop
doi : 10.1210/clinem/dgac542
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 12, December 2022, Pages 3261–3274
Glucose-dependent insulinotropic polypeptide (GIP) has been proposed to exert insulin-independent effects on lipid and bone metabolism.
X-Linked Hypophosphatemia, Not Only a Skeletal Disease But Also a Chronic Inflammatory State
Marie-Noëlle Méaux, Candide Alioli, Agnès Linglart, Sandrine Lemoine, Emmanuelle Vignot, Aurélia Bertholet-Thomas, Olivier Peyruchaud, Sacha Flammier, Irma Machuca-Gayet, Justine Bacchetta
doi : 10.1210/clinem/dgac543
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 12, December 2022, Pages 3275–3286
X-linked hypophosphatemia (XLH) is a rare genetic disease caused by a primary excess of fibroblast growth factor 23 (FGF23). FGF23 has been associated with inflammation and impaired osteoclastogenesis, but these pathways have not been investigated in XLH.
Safety and Efficacy of Pediatric Growth Hormone Therapy: Results From the Full KIGS Cohort
Mohamad Maghnie, Michael B Ranke, Mitchell E Geffner, Elpis Vlachopapadopoulou, Lourdes Ibáñez, Martin Carlsson, Wayne Cutfield, Raoul Rooman, Roy Gomez, Michael P Wajnrajch, Agnès Linglart, Renata Stawerska, Peter E Clayton, Feyza Darendeliler, Anita C S Hokken-Koelega, Reiko Horikawa, Toshiaki Tanaka, Helmuth-Günther D?rr, Kerstin Albertsson-Wikland, Michel Polak, Adda Grimberg
doi : 10.1210/clinem/dgac517
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 12, December 2022, Pages 3287–3301
The Kabi/Pfizer International Growth Database (KIGS) is a large, international database (1987-2012) of children treated with recombinant human growth hormone (rhGH) in real-world settings.
Identification of 4 New Loci Associated With Primary Hyperparathyroidism (PHPT) and a Polygenic Risk Score for PHPT
Enrique Soto-Pedre, Paul J Newey, Sundararajan Srinivasan, Moneeza K Siddiqui, Colin N A Palmer, Graham P Leese
doi : 10.1210/clinem/dgac527
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 12, December 2022, Pages 3302–3308
A hypothesis-free genetic association analysis has not been reported for patients with primary hyperparathyroidism (PHPT).
Clinical Use of Raman Spectroscopy Improves Diagnostic Accuracy for Indeterminate Thyroid Nodules
Andrea Palermo, Armida Sodo, Anda Mihaela Naciu, Michael Di Gioacchino, Alessio Paolucci, Alessandra di Masi, Daria Maggi, Pierfilippo Crucitti, Filippo Longo, Eleonora Perrella, Chiara Taffon, Martina Verri, Maria Antonietta Ricci, Anna Crescenzi
doi : 10.1210/clinem/dgac537
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 12, December 2022, Pages 3309–3319
Molecular analysis of thyroid fine-needle aspiration (FNA) specimens is believed to improve the management of indeterminate nodules. Raman spectroscopy (RS) can differentiate benign and malignant thyroid lesions in surgically removed tissues, generating distinctive structural profiles. Herein, the diagnostic performance of RS was tested on FNA biopsies of thyroid gland.
Growth Patterns of Children With Short Stature in Adulthood According to Auxological Status and Maturity at Birth
Roland Pfäffle, Matthias Knüpfer, Melanie Göbert, Mandy Vogel, Ruth Gausche, Christoph Beger, Eberhard Keller, Antje Körner, Ulrich Thome, Wieland Kiess
doi : 10.1210/clinem/dgac510
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 12, December 2022, Pages 3320–3327
Prematurity carries a risk for impaired postnatal growth and long-term growth restriction. Especially children born SGA seem vulnerable for poor growth, as a persistent short stature can be observed in app 10-15% of these children.
Premature Ovarian Insufficiency in CLPB Deficiency: Transcriptomic, Proteomic and Phenotypic Insights
Elena J Tucker, Megan J Baker, Daniella H Hock, Julia T Warren, Sylvie Jaillard, Katrina M Bell, Rajini Sreenivasan, Shabnam Bakhshalizadeh, Chloe A Hanna, Nikeisha J Caruana, Saskia B Wortmann, Shamima Rahman, Robert D S Pitceathly, Jean Donadieu, Aurelia Alimi, Vincent Launay, Paul Coppo, Sophie Christin-Maitre, Gorjana Robevska, Jocelyn van den Bergen, Brianna L Kline, Katie L Ayers, Phoebe N Stewart, David A Stroud, Diana Stojanovski, Andrew H Sinclair
doi : 10.1210/clinem/dgac528
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 12, December 2022, Pages 3328–3340
Premature ovarian insufficiency (POI) is a common form of female infertility that usually presents as an isolated condition but can be part of various genetic syndromes. Early diagnosis and treatment of POI can minimize comorbidity and improve health outcomes.
The High Relevance of 21-Deoxycortisol, (Androstenedione + 17α-Hydroxyprogesterone)/Cortisol, and 11-Deoxycortisol/17α-Hydroxyprogesterone for Newborn Screening of 21-Hydroxylase Deficiency
Kazuhiro Watanabe, Atsumi Tsuji-Hosokawa, Atsuko Hashimoto, Kaoru Konishi, Nobuyuki Ishige, Harumi Yajima, Akito Sutani, Hisae Nakatani, Maki Gau, Kei Takasawa, Toshihiro Tajima, Tomonobu Hasegawa, Tomohiro Morio, Kenichi Kashimada
doi : 10.1210/clinem/dgac521
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 12, December 2022, Pages 3341–3352
There are limited reports on the detailed examination of steroid profiles for setting algorithms for 21-hydroxylase deficiency (21OHD) screening by liquid chromatography–tandem mass spectrometry (LC-MS/MS).
Reproductive Markers of Testicular Function and Size During Puberty in Boys With and Without a History of Cryptorchidism
Wiwat Rodprasert, Jaakko J Koskenniemi, Helena E Virtanen, Sergey Sadov, Antti Perheentupa, Helena Ollila, Jakob Albrethsen, Anna-Maria Andersson, Anders Juul, Niels E Skakkebaek, Katharina M Main, Jorma Toppari
doi : 10.1210/clinem/dgac520
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 12, December 2022, Pages 3353–3361
Longitudinal data on levels of hypothalamic-pituitary-gonadal axis hormones and insulin-like growth factor I (IGF-I) during puberty in boys with a history of cryptorchidism are largely missing.
Three-Year Observation of Glucose Metabolism After Pancreaticoduodenectomy: A Single-Center Prospective Study in Japan
Fumimaru Niwano, Naru Babaya, Yoshihisa Hiromine, Ippei Matsumoto, Keiko Kamei, Yasunori Taketomo, Sawa Yoshida, Yoshifumi Takeyama, Shinsuke Noso, Hiroshi Ikegami
doi : 10.1210/clinem/dgac529
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 12, December 2022, Pages 3362–3369
The glucose tolerance of patients changes considerably from before to after pancreaticoduodenectomy wherein approximately half of the pancreas is resected.
Circulating Dickkopf1 Parallels Metabolic Adaptations and Predicts Disease Trajectories in Patients With COVID-19
Nikolai P Jaschke, Alexander M Funk, Sophie Jonas, Romy M Riffel, Anupam Sinha, Andrew Wang, Sophie Pählig, Maura Hofmann, Heidi Altmann, Simone Von Bonin, Thea Koch, Peter Spieth, Kristin Tausche, Katja Akgün, Martina Rauner, Romy Kronstein-Wiedemann, Marcus Odendahl, Torsten Tonn, Andy G?bel, Lorenz C Hofbauer, Tilman D Rachner
doi : 10.1210/clinem/dgac514
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 12, December 2022, Pages 3370–3377
Coronavirus disease 19 (COVID-19) trajectories show high interindividual variability, ranging from asymptomatic manifestations to fatal outcomes, the latter of which may be fueled by immunometabolic maladaptation of the host. Reliable identification of patients who are at risk of severe disease remains challenging.
Weekly Somapacitan is Effective and Well Tolerated in Children With GH Deficiency: The Randomized Phase 3 REAL4 Trial
Bradley S Miller, Joanne C Blair, Michael Højby Rasmussen, Aristides Maniatis, Rasmus Juul Kildemoes, Jun Mori, Michel Polak, Rikke Beck Bang, Volker Böttcher, Stefano Stagi, Reiko Horikawa
doi : 10.1210/clinem/dgac513
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 12, December 2022, Pages 3378–3388
Somapacitan, a once-weekly reversible albumin-binding GH derivative, is evaluated in children with GH deficiency (GHD).
Analysis of Delayed Surgery and Clinical Outcomes in Intermediate- and High-risk Papillary Thyroid Cancer
Huijun Zhou, Jie Wu, Lei Shi, Yu Wang, Bin Liu
doi : 10.1210/clinem/dgac502
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 12, December 2022, Pages 3389–3397
The optimal timing to performing thyroid surgery following a diagnosis of papillary thyroid cancer (PTC) has yet to be fully defined.
Effect of Degarelix Administration on Bone Health in Prostate Cancer Patients Without Bone Metastases. The Blade Study
Carlotta Palumbo, Alberto Dalla Volta, Stefania Zamboni, Gherardo Mazziotti, Manuel Zamparini, Luca Triggiani, Paolo Borghetti, Filippo Maffezzoni, Roberto Bresciani, Luca Rinaudo, Francesca Valcamonico, Davide Farina, Stefano Maria Magrini, Alessandro Antonelli, Claudio Simeone, Alfredo Berruti
doi : 10.1210/clinem/dgac489
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 12, December 2022, Pages 3398–3407
As patients are now living with prostate cancer for longer, the long-term impact of hormonal treatment on bone health is an increasingly debated subject.
Approach to the Patient: Management and the Long-term Consequences of Graves' Disease in Children
Scott A Rivkees
doi : 10.1210/clinem/dgac573
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 12, December 2022, Pages 3408–3417
In children, Graves' disease (GD) is the most common cause of hyperthyroidism. Most pediatric patients with GD will not go into lasting remission, even following many years of antidrug therapy. Thus, most pediatric patients will require radioactive iodine (RAI) or surgery.
Approach to the Patient With Congenital Hypothyroidism
Athanasia Stoupa, Dulanjalee Kariyawasam, Adrien Nguyen Quoc, Michel Polak, Aurore Carré
doi : 10.1210/clinem/dgac534
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 12, December 2022, Pages 3418–3427
Congenital hypothyroidism (CH) is the most frequent neonatal endocrine disorder and the most common preventable cause of development delay and growth failure if diagnosed and treated early. The thyroid is the first endocrine gland to develop during embryonic life and to be recognizable in humans.
Metabolic Efficacy of Time-Restricted Eating in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Lili Liu, Wei Chen, Dan Wu, Fang Hu
doi : 10.1210/clinem/dgac570
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 12, December 2022, Pages 3428–3441
Time-restricted eating (TRE), which restricts food intake to a limited duration of the day, is a key regimen of intermittent fasting.
Sodium-Glucose Cotransporter 2 Inhibitors and the Risk of Pneumonia and Septic Shock
Hang-Long Li, Yi-Kei Tse, Chanchal Chandramouli, Nicole Wing-Lam Hon, Ching-Lung Cheung, Lok-Yee Lam, Meizhen Wu, Jia-Yi Huang, Si-Yeung Yu, Ka-Lam Leung, Yue Fei, Qi Feng, Qingwen Ren, Bernard M Y Cheung, Hung-Fat Tse, Subodh Verma, Carolyn S P Lam, Kai-Hang Yiu
doi : 10.1210/clinem/dgac558
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 12, December 2022, Pages 3442–3451
Individuals with type 2 diabetes mellitus (DM) have an increased risk of pneumonia and septic shock. Traditional glucose-lowering drugs have recently been found to be associated with a higher risk of infections. It remains unclear whether sodium-glucose cotransporter 2 inhibitors (SGLT2is), which have pleiotropic/anti-inflammatory effects, may reduce the risk of pneumonia and septic shock in DM.
New Horizons: Emerging Antidiabetic Medications
Geltrude Mingrone, Lidia Castagneto-Gissey, Stefan R Bornstein
doi : 10.1210/clinem/dgac499
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 12, December 2022, Pages e4333–e4340
Over the past century, since the discovery of insulin, the therapeutic offer for diabetes has grown exponentially, in particular for type 2 diabetes (T2D). However, the drugs in the diabetes pipeline are even more promising because of their impressive antihyperglycemic effects coupled with remarkable weight loss.
Islet Autoantibody Level Distribution in Type 1 Diabetes and Their Association With Genetic and Clinical Characteristics
Sian Louise Grace, Jack Bowden, Helen C Walkey, Akaal Kaur, Shivani Misra, Beverley M Shields, Trevelyan J McKinley, Nick S Oliver, Timothy J McDonald, Desmond G Johnston, Angus G Jones, Kashyap A Patel
doi : 10.1210/clinem/dgac507
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 12, December 2022, Pages e4341–e4349
The importance of the autoantibody level at diagnosis of type 1 diabetes (T1D) is not clear.
Lower Bone Turnover and Skeletal PTH Responsiveness in Japanese Compared to European Patients on Hemodialysis
Pieter Evenepoel, Hanne Skou Jørgensen, Hirotaka Komaba, Sandro Mazzaferro, Marc Vervloet, Etienne Cavalier, Masafumi Fukagawa
doi : 10.1210/clinem/dgac522
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 12, December 2022, Pages e4350–e4359
Parathyroid hormone (PTH) treatment targets for patients receiving hemodialysis (HD) are lower in Japan than in Europe. Whether this translates to lower bone turnover is unknown and could depend on skeletal PTH responsiveness.
Association of Systemic Trimethyllysine With Heart Failure With Preserved Ejection Fraction and Cardiovascular Events
Haoran Wei, Mingming Zhao, Junfang Wu, Chenze Li, Man Huang, Jianing Gao, Qi Zhang, Liang Ji, Yan Wang, Chunxia Zhao, Erdan Dong, Lemin Zheng, Dao Wen Wang
doi : 10.1210/clinem/dgac519
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 12, December 2022, Pages e4360–e4370
Carnitine has been associated with cardiac energy metabolism and heart failure, but the association between its precursors—trimethyllysine (TML) and γ-butyrobetaine (GBB)—and heart failure with preserved ejection fraction (HFpEF) remains unclear.
Fracture Risk in Pediatric Patients With MEN2B
Iris Li, Iris R Hartley, Joanna Klubo-Gwiedzdzinska, James C Reynolds, Barbara J Thomas, Julie Hogan, Mahider M Enyew, Eva Dombi, Alexander Ling, Srivandana Akshintala, David J Venzon, Jaydira Del Rivero, Michael Collins, John W Glod
doi : 10.1210/clinem/dgac500
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 12, December 2022, Pages e4371–e4378
The skeletal phenotype of patients with MEN2B has been described but fracture risk in these patients has not yet been evaluated.
Understanding Epigenetic Factors on Adiponectin
Fabio Vasconcellos Comim, Melissa Orlandin Premaor
doi : 10.1210/clinem/dgac593
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 12, December 2022, Page e4379
Cardiometabolic Outcomes in Transgender Youth
Michele A O’Connell, Ken C Pang
doi : 10.1210/clinem/dgac592
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 12, December 2022, Pages e4380–e4381
Routine Evaluation of Somatostatin Receptor Type 2 in Patients With Acromegaly: Do We Still Need More Evidence?
Federico Gatto, Luiz Eduardo Wildemberg, Diego Ferone, Monica R Gadelha
doi : 10.1210/clinem/dgac584
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 12, December 2022, Pages e4382–e4383
