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Appropriate Use of Telehealth Visits in Endocrinology: Policy Perspective of the Endocrine Society
Varsha G Vimalananda, Juan P Brito, Leslie A Eiland, Rayhan A Lal, Spyridoula Maraka, Marie E McDonnell, Radhika R Narla, Mara Y Roth, Stephanie S Crossen
doi : 10.1210/clinem/dgac494
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 11, November 2022, Pages 2953–2962
This work aims to guide clinicians practicing endocrinology in the use of telehealth (synchronous patient-clinician visits conducted over video or telephone) for outpatient care.
Targeted Therapies in Pheochromocytoma and Paraganglioma
Katharina Wang, Joakim Crona, Felix Beuschlein, Ashley B Grossman, Karel Pacak, Svenja Nölting
doi : 10.1210/clinem/dgac471
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 11, November 2022, Pages 2963–2972
Molecular targeted therapy plays an increasingly important role in the treatment of metastatic pheochromocytomas and paragangliomas (PPGLs), which are rare tumors but remain difficult to treat. This mini-review provides an overview of established molecular targeted therapies in present use, and perspectives on those currently under development and evaluation in clinical trials.
Thyroid, Diet, and Alternative Approaches
Dana Larsen, Sargun Singh, Maria Brito
doi : 10.1210/clinem/dgac473
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 11, November 2022, Pages 2973–2981
Increasingly, patients are asking their physicians about the benefits of dietary and alternative approaches to manage their diseases, including thyroid disease. We seek to review the evidence behind several of the vitamins, minerals, complementary medicines, and elimination diets that patients are most commonly using for the treatment of thyroid disorders.
Predictive Factors of Somatostatin Receptor Ligand Response in Acromegaly—A Prospective Study
Mirela-Diana Ilie, Antoine Tabarin, Alexandre Vasiljevic, Jean-François Bonneville, Lucile Moreau-Grangé, Franck Schillo, Brigitte Delemer, Anne Barlier, Dominique Figarella-Branger, Ségolène Bisot-Locard, Alexandre Santos, Philippe Chanson, Gérald Raverot
doi : 10.1210/clinem/dgac512
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 11, November 2022, Pages 2982–2991
Somatostatin receptor ligands (SRLs) are the cornerstone medical treatments for acromegaly; however, many patients remain unresponsive to SRLs. Well-established predictive markers of response are needed.
Sleep Duration and Visceral Adipose Tissue: Linear and Nonlinear Mendelian Randomization Analyses
Yuefeng Yu, Yingchao Chen, Haojie Zhang, Sizhi Ai, Jihui Zhang, Christian Benedict, Ningjian Wang, Yingli Lu, Xiao Tan
doi : 10.1210/clinem/dgac551
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 11, November 2022, Pages 2992–2999
Increasing evidence suggests that sleep is important for fat metabolism. However, the causal relationship between sleep duration and visceral adipose tissue (VAT) needs to be further clarified.
Granulosa Cell Dysfunction Is Associated With Diminished Ovarian Response in FMR1 Premutation Carriers
Ilana Boustanai, Hila Raanani, Adva Aizer, Raoul Orvieto, Shai E Elizur
doi : 10.1210/clinem/dgac536
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 11, November 2022, Pages 3000–3009
FMR1 premutation (PM) carriers are at increased risk of ovarian impairment resulting in diminished ovarian response (DOR) to exogenous follicle-stimulating hormone (FSH) stimulation.
Cervical MUC5B and MUC5AC are Barriers to Ascending Pathogens During Pregnancy
Yusuke Ueda, Haruta Mogami, Yosuke Kawamura, Masahito Takakura, Asako Inohaya, Eriko Yasuda, Yu Matsuzaka, Yoshitsugu Chigusa, Shinji Ito, Masaki Mandai, Eiji Kondoh
doi : 10.1210/clinem/dgac545
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 11, November 2022, Pages 3010–3021
Cervical excision is a risk factor for preterm birth. This suggests that the cervix plays an essential role in the maintenance of pregnancy.
Association Between DPP4 Inhibitor Use and the Incidence of Cirrhosis, ESRD, and Some Cancers in Patients With Diabetes
Yewon Na, Soo Wan Kim, Ie Byung Park, Soo Jung Choi, Seungyoon Nam, Jaehun Jung, Dae Ho Lee
doi : 10.1210/clinem/dgac540
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 11, November 2022, Pages 3022–3034
There are relatively few data on noncardiovascular (non-CV) long-term clinical outcomes of dipeptidyl peptidase 4 inhibitor (DPP4i) treatment.
Familial Male-limited Precocious Puberty (FMPP) and Testicular Germ Cell Tumors
Cezanne D Kooij, Annelies M C Mavinkurve-Groothuis, Idske C L Kremer Hovinga, Leendert H J Looijenga, Tuula Rinne, Jacques C Giltay, Laetitia M O de Kort, Aart J Klijn, Ronald R de Krijger, Annemarie A Verrijn Stuart
doi : 10.1210/clinem/dgac516
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 11, November 2022, Pages 3035–3044
The purpose of this study is to report development of a malignant testicular germ cell tumor (GCT) in 2 young adult males with familial male-limited precocious puberty (FMPP) because of LHCGR pathogenic variants in 2 families. Secondarily, to study the possible relation between FMPP and testicular tumors and to investigate whether FMPP might predispose to development of malignant testicular tumors in adulthood a literature review is conducted.
Aldosterone-Producing Adenomas of Increased Size Are Associated With Higher Steroidogenic Activity
Kazuki Nakai, Katsunori Manaka, Junichiro Sato, Maki Takeuchi, Yuto Yamazaki, Hironobu Sasano, Yuya Tsurutani, Jun Saito, Tetsuo Nishikawa, Taroh Iiri, Masaomi Nangaku, Noriko Makita
doi : 10.1210/clinem/dgac530
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 11, November 2022, Pages 3045–3054
There are inconsistent results and insufficient evidence as to whether an association exists between the size and aldosterone-producing ability of aldosterone-producing adenomas.
Low Serum Bicarbonate Levels Increase the Risk of All-Cause, Cardiovascular Disease, and Cancer Mortality in Type 2 Diabetes
Yilan Li, Rong Gao, Bing Zhao, Yao Zhang
doi : 10.1210/clinem/dgac504
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 11, November 2022, Pages 3055–3065
The evidence regarding bicarbonate status and mortality among diabetes is scarce.
Aspirin Mediates Its Antitumoral Effect Through Inhibiting PTTG1 in Pituitary Adenoma
Borbála Szabó, Kinga Németh, Katalin Mészáros, Lilla Krokker, István Likó, Éva Saskői, Krisztina Németh, Pál Tamás Szabó, Nikolette Szücs, Sándor Czirják, G?bor Szal?ki, Attila Pat?cs, Henriett Butz
doi : 10.1210/clinem/dgac496
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 11, November 2022, Pages 3066–3079
DNA demethylation and inhibitory effects of aspirin on pituitary cell proliferation have been demonstrated.
Calcium, Its Regulatory Hormones, and Their Causal Role on Blood Pressure: A Two-Sample Mendelian Randomization Study
Alice Giontella, Luca A Lotta, Aris Baras, Pietro Minuz, Dipender Gill, Olle Melander, Cristiano Fava
doi : 10.1210/clinem/dgac501
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 11, November 2022, Pages 3080–3085
Vitamin D (Vit-D), parathyroid hormone (PTH), and fibroblast growth factor 23 (FGF23) are the major calciotropic hormones involved in the regulation of blood calcium levels from the intestine, kidney, and bone through a tight endocrine feedback loop system.
Weight Loss, Lifestyle Intervention, and Metformin Affect Longitudinal Relationship of Insulin Secretion and Sensitivity
Elsa Vazquez Arreola, William C Knowler, Robert L Hanson
doi : 10.1210/clinem/dgac509
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 11, November 2022, Pages 3086–3099
Insulin secretion and sensitivity regulate glycemia, with inadequately compensated deficiencies leading to diabetes.
Inflammatory Cytokines Rewire the Proinsulin Interaction Network in Human Islets
Duc T Tran, Anita Pottekat, Kouta Lee, Megha Raghunathan, Salvatore Loguercio, Saiful A Mir, Adrienne W Paton, James C Paton, Peter Arvan, Randal J Kaufman, Pamela Itkin-Ansari
doi : 10.1210/clinem/dgac493
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 11, November 2022, Pages 3100–3110
Aberrant biosynthesis and secretion of the insulin precursor proinsulin occurs in both type I and type II diabetes. Inflammatory cytokines are implicated in pancreatic islet stress and dysfunction in both forms of diabetes, but the mechanisms remain unclear.
The Androgen Metabolome of Preterm Infants Reflects Fetal Adrenal Gland Involution
Christa E Flück, Tanja Kuiri-Hänninen, Sanna Silvennoinen, Ulla Sankilampi, Michael Groessl
doi : 10.1210/clinem/dgac482
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 11, November 2022, Pages 3111–3119
The human adrenal cortex changes with fetal-neonatal transition from the fetal to the adult organ, accompanied by changes in the steroid metabolome.
Metabolic and Genetic Markers Improve Prediction of Incident Type 2 Diabetes: A Nested Case-Control Study in Chinese
Jia Liu, Lu Wang, Yun Qian, Qian Shen, Man Yang, Yunqiu Dong, Hai Chen, Zhijie Yang, Yaqi Liu, Xuan Cui, Hongxia Ma, Guangfu Jin
doi : 10.1210/clinem/dgac487
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 11, November 2022, Pages 3120–3127
It is essential to improve the current predictive ability for type 2 diabetes (T2D) risk.
Salivary Steroid Collection in Children Under Conditions Replicating Home Sampling
Joseph J Tonge, Brian G Keevil, Jessica N Craig, Martin J Whitaker, Richard J Ross, Charlotte J Elder
doi : 10.1210/clinem/dgac419
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 11, November 2022, Pages 3128–3136
Measurement of salivary glucocorticoids is an accepted method for testing adrenal function but there are few data on stability during home collection. Current salivary collection techniques require active participation or present a choking hazard and are unsuitable for young children.
Diabetic Ketoacidosis in Pregnancy: Clinical Risk Factors, Presentation, and Outcomes
Maheswaran Dhanasekaran, Sneha Mohan, Dana Erickson, Pankaj Shah, Linda Szymanski, Vella Adrian, Aoife M Egan
doi : 10.1210/clinem/dgac464
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 11, November 2022, Pages 3137–3143
Diabetic ketoacidosis (DKA) in pregnancy is an obstetric emergency with risk of maternofetal death.
Radioactive Iodine Therapy Does not Improve Cancer-specific Survival in Hürthle Cell Carcinoma of the Thyroid
Xiaofei Wang, Xun Zheng, Jingqiang Zhu, Zhihui Li, Tao Wei
doi : 10.1210/clinem/dgac448
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 11, November 2022, Pages 3144–3151
It is unclear whether radioactive iodine (RAI) therapy could improve cancer-specific survival (CSS) in patients with Hürthle cell carcinoma (HCC) of the thyroid.
The Joint Secular Trends of Sleep Quality and Diabetes Among US Adults, 2005-2018
Xuan Wang, Hao Ma, Shaveta Gupta, Yoriko Heianza, Vivian Fonseca, Lu Qi
doi : 10.1210/clinem/dgac401
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 11, November 2022, Pages 3152–3161
Sleep quality has been related to the risk of diabetes; however, little is known about the prevalence of diabetes in the United States according to the levels of sleep quality.
Approach to the Patient: Diagnosis of Cushing Syndrome
Mesut Savas, Sonal Mehta, Nidhi Agrawal, Elisabeth F C van Rossum, Richard A Feelders
doi : 10.1210/clinem/dgac492
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 11, November 2022, Pages 3162–3174
Cushing syndrome results from supraphysiological exposure to glucocorticoids and is associated with significant morbidity and mortality. The pathogenesis includes administration of corticosteroids (exogenous Cushing syndrome) or autonomous cortisol overproduction, whether or not ACTH-dependent (endogenous Cushing syndrome).
Approach to the Patient on Antihypertensive Therapy: Screen for Primary Aldosteronism
Paolo Mulatero, Chiara Bertello, Franco Veglio, Silvia Monticone
doi : 10.1210/clinem/dgac460
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 11, November 2022, Pages 3175–3181
Primary aldosteronism (PA) is a condition that is still largely overlooked, resulting in a considerable burden of mortality and morbidity. This is despite decades of clinical and translational research on the deleterious effects of aldosterone on the cardiovascular system and the publication of several guidelines and consensuses on its diagnosis and treatment.
Effects of Roux-en-Y Gastric Bypass and Sleeve Gastrectomy on β-Cell Function at 1 Year After Surgery: A Systematic Review
Angeline Buser, Chloé Joray, Michele Schiavon, Christophe Kosinski, Beatrice Minder, Christos T Nakas, Chiara Dalla Man, Taulant Muka, David Herzig, Lia Bally
doi : 10.1210/clinem/dgac446
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 11, November 2022, Pages 3182–3197
Bariatric surgery is a highly effective obesity treatment resulting in substantial weight loss and improved glucose metabolism. We hereby aimed to summarize available evidence of the effect of the 2 most common bariatric surgery procedures, Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG), on dynamic measures of β-cell function (BCF)
New Horizons: Revival of Lipoprotein (a) as a Risk Factor for Cardiovascular Disease
Paul Nestel, Wann Jia Loh, Natalie C Ward, Gerald F Watts
doi : 10.1210/clinem/dgac541
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 11, November 2022, Pages e4281–e4294
The status of lipoprotein (a) [Lp(a)] as a cardiovascular risk factor has been resurrected by advances in genetics. Mendelian randomization studies show a causal link of Lp(a) with coronary artery disease (CAD), peripheral artery disease (PAD), and calcific aortic valve stenosis (CAVS).
Is Desmopressin Useful in the Evaluation of Cushing Syndrome?
Frederic Castinetti, André Lacroix
doi : 10.1210/clinem/dgac533
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 11, November 2022, Pages e4295–e4301
The desmopressin test was first described 30 years ago. Based on the differential secretagogue properties of desmopressin on adrenocorticotropin (ACTH) release between normal and corticotroph tumor cells, this test was intended to facilitate the diagnosis of Cushing syndrome (CS). The distinct expression of the various arginine vasopressin receptors between normal pituitary, corticotroph tumors, or neuroendocrine tumors cells secreting ACTH ectopically suggested that this test could facilitate the etiological diagnosis of ACTH-dependent CS.
Thyroid Function Rather Than Thyroid Antibodies Affects Pregnancy and Perinatal Outcomes: Results of a Prospective Study
Francesca Orsolini, Elena Gianetti, Chiara Terrenzio, Lucia Montanelli, Elena Benelli, Brunella Bagattini, Emilio Fiore, Massimo Tonacchera
doi : 10.1210/clinem/dgac497
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 11, November 2022, Pages e4302–e4310
Thyroid autoantibody positivity has been associated with an increased rate of obstetrical complications.
The Role of Early Pregnancy Maternal pGCD59 Levels in Predicting Neonatal Hypoglycemia—Subanalysis of the DALI Study
Delia Bogdanet, Miguel Angel Luque-Fernandez, Michelle Toth-Castillo, Gernot Desoye, Paula M O’Shea, Fidelma P Dunne, Jose A Halperin
doi : 10.1210/clinem/dgac498
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 11, November 2022, Pages e4311–e4319
Neonatal hypoglycaemia (NH) is the most common metabolic problem in infants born of mothers with gestational diabetes. Plasma glycated CD59 (pGCD59) is an emerging biomarker that has shown potential in identifying women at risk of developing gestational diabetes. The aim of this study was to assess the association between early maternal levels of pGCD59 and NH.
Back to Basics—When Should Cushing Syndrome Be Suspected?
Oskar Ragnarsson
doi : 10.1210/clinem/dgac531
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 11, November 2022, Pages e4320–e4321
Branched Chain Amino Acids and Gestational Diabetes Mellitus
Adegbenga Bolanle Ademolu
doi : 10.1210/clinem/dgac481
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 11, November 2022, Pages e4322–e4323
TSH Receptor Antibody Testing in Early Pregnancy
Jennifer S R Mammen, David S Cooper
doi : 10.1210/clinem/dgac490
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 11, November 2022, Pages e4324–e4325
Insulin Resistance and Adrenal Androgen Synthesis Viewed Through a Monogenic Lens
Robert K Semple
doi : 10.1210/clinem/dgac475
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 11, November 2022, Pages e4326–e4327
Response to Letter to the Editor From Xu and Yang: “Laser Ablation Versus Radiofrequency Ablation for Thyroid Nodules: 12-Month Results of a Randomized Trial (LARA II Study)�
Andrea Palermo, Roberto Cesareo
doi : 10.1210/clinem/dgac505
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 11, November 2022, Pages e4328–e4329
Correction to: “Cardiovascular Benefits of Empagliflozin Are Associated With Gut Microbiota and Plasma Metabolites in Type 2 Diabetes�
doi : 10.1210/clinem/dgac506
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 11, November 2022, Page e4330
Correction to “A Simple Test to Identify the Risk of NASH and Cirrhosis in People With Obesity or Diabetes: The Time to Screen Is Now�
doi : 10.1210/clinem/dgac495
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 11, November 2022, Page e4331
Correction to: “Pituitary MRI Features in Acromegaly Resulting From Ectopic GHRH Secretion From a Neuroendocrine Tumor: Analysis of 30 Cases�
doi : 10.1210/clinem/dgac491
The Journal of Clinical Endocrinology & Metabolism, Volume 107, Issue 11, November 2022, Page e4332
