Jorrell Rush-Kittle, Laura Gámez-DÃÂaz, Bodo Grimbacher
doi : 10.1111/pai.13886
One of the causes of inborn errors of immunity is immune dysregulation. The inability of the immune system to regulate the extent of its activity has several deleterious effects, including autoimmunity, recurrent infections, and malignancy. In recent years, many proteins in the CD28 family – CD28, ICOS, CTLA-4, PD-1, and BTLA – have come into the focus of several research areas for their consequential role in the upregulation or downregulation of the immune response.
Gabriela P. Peralta, Raquel Granell, Annabelle Bédard, Anne-Elie Carsin, Elaine Fuertes, Laura D. Howe, Sandra Márquez, Deborah L. Jarvis, Judith Garcia-Aymerich
doi : 10.1111/pai.13894
We previously reported an association of high fat mass levels from age 9 to 15 years with lower forced expiratory flow in 1 s (FEV1)/forced vital capacity (FVC) ratio (i.e., increased risk of airflow limitation) at 15 years. Here, we aimed to assess whether insulin resistance and C-reactive protein (CRP) at 15 years partially mediate this association.
Mattia Giovannini, Francois Graham, Helen A. Brough, Jean-Christoph Caubet, Philippe Eigenmann, George du Toit
doi : 10.1111/pai.13884
Andrea C. Blackman, Kristen A. Staggers, Aikaterini Anagnostou
doi : 10.1111/pai.13888
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