Pediatric Allergy and Immunology




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Issue Information

doi : 10.1111/pai.13598

Volume 33, Issue 12

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Inborn errors of immunity associated with defects of self-tolerance checkpoints: The CD28 family

Jorrell Rush-Kittle, Laura Gámez-Díaz, Bodo Grimbacher

doi : 10.1111/pai.13886

One of the causes of inborn errors of immunity is immune dysregulation. The inability of the immune system to regulate the extent of its activity has several deleterious effects, including autoimmunity, recurrent infections, and malignancy. In recent years, many proteins in the CD28 family – CD28, ICOS, CTLA-4, PD-1, and BTLA – have come into the focus of several research areas for their consequential role in the upregulation or downregulation of the immune response.

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Mid-childhood fat mass and airflow limitation at 15 years: The mediating role of insulin resistance and C-reactive protein

Gabriela P. Peralta, Raquel Granell, Annabelle Bédard, Anne-Elie Carsin, Elaine Fuertes, Laura D. Howe, Sandra Márquez, Deborah L. Jarvis, Judith Garcia-Aymerich

doi : 10.1111/pai.13894

We previously reported an association of high fat mass levels from age 9 to 15 years with lower forced expiratory flow in 1 s (FEV1)/forced vital capacity (FVC) ratio (i.e., increased risk of airflow limitation) at 15 years. Here, we aimed to assess whether insulin resistance and C-reactive protein (CRP) at 15 years partially mediate this association.

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Comparing pediatric cashew oral food challenges practice between London and Geneva

Mattia Giovannini, Francois Graham, Helen A. Brough, Jean-Christoph Caubet, Philippe Eigenmann, George du Toit

doi : 10.1111/pai.13884

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Anaphylaxis during Peanut Oral Immunotherapy: Looking beyond dose escalation

Andrea C. Blackman, Kristen A. Staggers, Aikaterini Anagnostou

doi : 10.1111/pai.13888

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