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Practical ethical concerns in allocation of pig kidneys to humans
George Bayliss
doi : 10.1093/ckj/sfac125
Clinical Kidney Journal, Volume 15, Issue 12, December 2022, Pages 2161–2168
The fundamental ethical question of whether pig organs should be transplanted into humans has been settled, as recent surgeries demonstrating proof of concept demonstrate. Other issues need to be considered and reconciled before xenotransplantation of pig kidneys becomes a solution to the organ shortage for people waiting for a kidney transplant or as a viable alternative to the deceased donor or living donor human kidneys. Human trials will be needed beyond brain-dead individuals to show that xenotransplantation is safe from immunologic and infectious standpoints.
Who killed Bruce Lee? The hyponatraemia hypothesis
Priscila Villalvazo, Raul Fernandez-Prado, Maria Dolores Sánchez Niño, Sol Carriazo, Beatriz Fernández-Fernández, Alberto Ortiz, Maria Vanessa Perez-Gomez
doi : 10.1093/ckj/sfac071
Clinical Kidney Journal, Volume 15, Issue 12, December 2022, Pages 2169–2176
Bruce Lee brought attention to martial arts in the Western world and popularized the quote ‘Be water, my friend’. Lee died at the age of 32 years in Hong Kong on 20 July 1973, under mysterious circumstances. The cause of death is unknown, although numerous hypotheses have been proposed, from assassination by gangsters to the more recent suggestion in 2018 that he died from heatstroke. The necropsy showed cerebral oedema.
Peritoneal catheter insertion: combating barriers through policy change
Vivekanand Jha, Alferso C Abrahams, Abdullah Al-Hwiesh, Edwina A Brown, Brett Cullis, Frank J M F Dor, Mallika Mendu, Daniela Ponce, José Carolino Divino-Filho
doi : 10.1093/ckj/sfac136
Clinical Kidney Journal, Volume 15, Issue 12, December 2022, Pages 2177–2185
Barriers to accessing home dialysis became a matter of life and death for many patients with kidney failure during the coronavirus disease 2019 (COVID-19) pandemic.
Left ventricular dysfunction with preserved ejection fraction: the most common left ventricular disorder in chronic kidney disease patients
Patrick B Mark, Kenneth Mangion, Alastair J Rankin, Elaine Rutherford, Ninian N Lang, Mark C Petrie, Sokratis Stoumpos, Rajan K Patel
doi : 10.1093/ckj/sfac146
Clinical Kidney Journal, Volume 15, Issue 12, December 2022, Pages 2186–2199
Chronic kidney disease (CKD) is a risk factor for premature cardiovascular disease. As kidney function declines, the presence of left ventricular abnormalities increases such that by the time kidney replacement therapy is required with dialysis or kidney transplantation, more than two-thirds of patients have left ventricular hypertrophy.
Repurposing drugs for highly prevalent diseases: pentoxifylline, an old drug and a new opportunity for diabetic kidney disease
Javier Donate-Correa, MarÃa Dolores Sanchez-Niño, Ainhoa González-Luis, Carla Ferri, Alberto MartÃn-Olivera, Ernesto MartÃn-Núñez, Beatriz Fernandez-Fernandez, VÃctor G Tagua, Carmen Mora-Fernández, Alberto Ortiz, Juan F Navarro-González
doi : 10.1093/ckj/sfac143
Clinical Kidney Journal, Volume 15, Issue 12, December 2022, Pages 2200–2213
Diabetic kidney disease is one of the most frequent complications in patients with diabetes and constitutes a major cause of end-stage kidney disease. The prevalence of diabetic kidney disease continues to increase as a result of the growing epidemic of diabetes and obesity. Therefore, there is mounting urgency to design and optimize novel strategies and drugs that delay the progression of this pathology and contain this trend. The new approaches should go beyond the current therapy focussed on the control of traditional risk factors such as hyperglycaemia and hypertension.
Decreasing microbiota-derived uremic toxins to improve CKD outcomes
Braian M Beker, Iara Colombo, Henry Gonzalez-Torres, Carlos G Musso
doi : 10.1093/ckj/sfac154
Clinical Kidney Journal, Volume 15, Issue 12, December 2022, Pages 2214–2219,
Chronic kidney disease (CKD) is set to become the fifth-leading global cause of death by 2040. This illustrates the many unknowns regarding its pathogenesis and therapy. A key unknown relates to the therapeutic impact of the interaction between CKD and the gut microbiome.
Point-of-care ultrasonography in nephrology comes of age
Daniel W Ross, Andrew A Moses, Vandana Dua Niyyar
doi : 10.1093/ckj/sfac160
Clinical Kidney Journal, Volume 15, Issue 12, December 2022, Pages 2220–2227
The physical exam is changing. Many have argued that the physical exam of the 21st century should include point-of-care ultrasound (POCUS). POCUS is being taught in medical schools and has been endorsed by the major professional societies of internal medicine. In this review we describe the trend toward using POCUS in medicine and describe where the practicing nephrologist fits in.
Probability of chronic kidney disease and associated risk factors in Chinese adults: a cross-sectional study of 9 million Chinese adults in the Meinian Onehealth screening survey
Zhenhuang Zhuang, Mingkun Tong, Robert Clarke, Bo Wang, Tao Huang, Liming Li
doi : 10.1093/ckj/sfac176
Clinical Kidney Journal, Volume 15, Issue 12, December 2022, Pages 2228–2236
Chronic kidney disease (CKD) is an increasing global health problem, but little is known about the age- and sex-specific prevalence of CKD and the associated risk factors in low- and middle-income populations. We examined the age- and sex-specific prevalence of CKD and the associated risk factors in a population-based study of 9 million Chinese adults.
Infectious consequences of the AKI-to-CKD transition
Ana Sánchez Horrillo, Laura Salanova Villanueva, Alicia Cabrera Cárdenas, Patricia Muñoz Ramos, Alberto Ortiz, Borja Quiroga
doi : 10.1093/ckj/sfac178
Clinical Kidney Journal, Volume 15, Issue 12, December 2022, Pages 2237–2244
Acute kidney injury (AKI) is associated with short- and long-term complications but the consequences of the AKI-to-CKD transition are still poorly understood. We aimed to evaluate the association between the AKI-to-CKD transition and the long-term risk of infection.
Association between cause of kidney failure and fracture incidence in a national US dialysis population cohort study
Susan Ziolkowski, Sai Liu, Maria E Montez-Rath, Michelle Denburg, Wolfgang C Winkelmayer, Glenn M Chertow, Michelle M O'Shaughnessy
doi : 10.1093/ckj/sfac193
Clinical Kidney Journal, Volume 15, Issue 12, December 2022, Pages 2245–2257
Whether fracture rates, overall and by fracture site, vary by cause of kidney failure in patients receiving dialysis is unknown.
Standardization of serum creatinine is essential for accurate use of unbiased estimated GFR equations: evidence from three cohorts matched on renal function
Hans Pottel, Etienne Cavalier, Jonas Björk, Ulf Nyman, Anders Grubb, Natalie Ebert, Elke Schaeffner, Björn O Eriksen, Toralf Melsom, Edmund J Lamb, Christophe Mariat, Laurence Dubourg, Magnus Hansson, Karin Littmann, Per-Ola Sundin, Anna ?kesson, Anders Larsson, Andrew Rule, Pierre Delanaye
doi : 10.1093/ckj/sfac182
Clinical Kidney Journal, Volume 15, Issue 12, December 2022, Pages 2258–2265,
Differences in the performance of estimated glomerular filtration rate (eGFR) equations have been attributed to the mathematical form of the equations and to differences between patient demographics and measurement methods. We evaluated differences in serum creatinine (SCr) and eGFR in cohorts matched for age, sex, body mass index (BMI) and measured GFR (mGFR).
Machine learning models for predicting acute kidney injury: a systematic review and critical appraisal
Iacopo Vagliano, Nicholas C Chesnaye, Jan Hendrik Leopold, Kitty J Jager, Ameen Abu-Hanna, Martijn C Schut
doi : 10.1093/ckj/sfac181
Clinical Kidney Journal, Volume 15, Issue 12, December 2022, Pages 2266–2280
The number of studies applying machine learning (ML) to predict acute kidney injury (AKI) has grown steadily over the past decade. We assess and critically appraise the state of the art in ML models for AKI prediction, considering performance, methodological soundness, and applicability.
Associations of time-dependent changes in phosphorus levels with cardiovascular diseases in patients undergoing hemodialysis: results from the Japan Dialysis Active Vitamin D (J-DAVID) randomized clinical trial
Eri Koshi-Ito, Daijo Inaguma, Haruka Ishii, Yukio Yuzawa, Daijiro Kabata, Ayumi Shintani, Masaaki Inaba, Masanori Emoto, Katsuhito Mori, Tomoaki Morioka, Shinya Nakatani, Tetsuo Shoji
doi : 10.1093/ckj/sfac172
Clinical Kidney Journal, Volume 15, Issue 12, December 2022, Pages 2281–2291
While the risk of exceeding the standard range of phosphorus levels has been investigated, the impact of the degree of fluctuations has not been investigated.
Comparison of four medium cut-off dialyzers
Francisco Maduell, José Jesús Broseta, Diana RodrÃguez-Espinosa, Jimena del Risco, Lida MarÃa Rodas, Marta Arias-Guillén, Manel Vera, Néstor Fontseré, Maria del Carmen Salgado, Nayra Rico
doi : 10.1093/ckj/sfac167
Clinical Kidney Journal, Volume 15, Issue 12, December 2022, Pages 2292–2299
Recently, several pharmaceutical companies have developed new medium cut-off (MCO) dialyzers for expanded hemodialysis (HDx). This study aimed to compare the safety and efficacy of four MCO dialyzers, against each other and versus high-flux hemodialysis (HD) and post-dilution hemodiafiltration (HDF).
Vitamin K1 and progression of cardiovascular calcifications in hemodialysis patients: the VitaVasK randomized controlled trial
Turgay Saritas, Sebastian Reinartz, Thilo Krüger, Markus Ketteler, Orfeas Liangos, Laura Labriola, Peter Stenvinkel, Christoph Kopp, Ralf Westenfeld, Pieter Evenepoel, Robert Siepmann, Stephanie Wied, Ralf-Dieter Hilgers, Leon Schurgers, Jürgen Floege, VitaVasK Investigators
doi : 10.1093/ckj/sfac184
Clinical Kidney Journal, Volume 15, Issue 12, December 2022, Pages 2300–2311
Cardiovascular calcifications are prevented by matrix Gla protein (MGP), a vitamin K–dependent protein. Haemodialysis patients exhibit marked vitamin K deficiency. The randomized, prospective, open-label, multicentre VitaVasK trial analysed whether vitamin K1 supplementation reduces progression of coronary artery calcifications (CACs) and thoracic aortic calcifications (TACs).
Comparison of the profiles of patients defined by age-adapted and fixed threshold CKD criteria: a nationwide, cross-sectional study
Yixin Ma, Jianfeng Lin, Peng Xia, Hua Zheng, Xinqi Cheng, Peili Ji, Wei Wu, Lian Hou, Li Wang, Guangjin Zhu, Ling Qiu, Yali Zheng, Limeng Chen
doi : 10.1093/ckj/sfac188
Clinical Kidney Journal, Volume 15, Issue 12, December 2022, Pages 2312–2321
Kidney function declines naturally with advancing age. Therefore an age-adapted estimated glomerular filtration rate (eGFR) threshold has been proposed instead of the fixed threshold for CKD definition. This study aims to describe and compare the profile of CKD patients defined by these two criteria in a Chinese population.
Dysnatremia and risk of bloodstream infection in dialysis patients
Robin H Lo, Kamyar Kalantar-Zadeh, Amy S You, Juan Carlos Ayus, Elani Streja, Christina Park, Peter Sohn, Tracy Nakata, Yoko Narasaki, Steven M Brunelli, Csaba P Kovesdy, Danh V Nguyen, Connie M Rhee
doi : 10.1093/ckj/sfac197
Clinical Kidney Journal, Volume 15, Issue 12, December 2022, Pages 2322–2330
Emerging data suggest that sodium disarrays including hyponatremia are potential risk factors for infection ensuing from impairments in host immunity, which may be exacerbated by coexisting conditions (i.e. mucosal membrane and cellular edema leading to breakdown of microbial barrier function). While dysnatremia and infection-related mortality are common in dialysis patients, little is known about the association between serum sodium levels and the risk of bloodstream infection in this population.
Visit-to-visit variability in blood pressure and kidney disease progression in IgA nephropathy
Chen Tang, Xiao-Yan Zhang, Ji-Cheng Lv, Su-Fang Shi, Xu-Jie Zhou, Li-Jun Liu, Hong Zhang
doi : 10.1093/ckj/sfac200
Clinical Kidney Journal, Volume 15, Issue 12, December 2022, Pages 2331–2339
The visit-to-visit variability (VVV) in blood pressure (BP) is an important risk factor for stroke and coronary heart disease and may also be associated with kidney damage and the development of chronic kidney disease (CKD). Data on the association between VVV in BP and the risk of CKD progression among patients with immunoglobulin A nephropathy (IgAN) are limited. We aimed to evaluate the relationships of VVV in BP with the progression of IgAN.
Development of crescentic membranoproliferative glomerulonephritis after COVID-19 vaccination
Gabor Göndör, Sara H Ksiazek, Heinz Regele, Andreas Kronbichler, Maarten Knechtelsdorfer, Marcus D Säemann
doi : 10.1093/ckj/sfac222
Clinical Kidney Journal, Volume 15, Issue 12, December 2022, Pages 2340–2342
Membranoproliferative glomerulonephritis (MPGN) comprises a histologic pattern of glomerular injury with different underlying diseases. Here we report on a 47-year-old female with rapidly progressive glomerulonephritis (RPGN) on top of a previously diagnosed idiopathic MPGN after receiving the first dose of the Pfizer-BioNTech coronavirus disease 2019 (COVID-19) mRNA vaccine.
Humoral response to a fourth dose of mRNA vaccine in kidney transplant recipient responders to three doses of mRNA vaccine
Tristan de Nattes, Sophie Candon, Véronique Lemée, Charlotte Laurent, Dominique Guerrot, Dominique Bertrand
doi : 10.1093/ckj/sfac183
Clinical Kidney Journal, Volume 15, Issue 12, December 2022, Pages 2343–2345
Increasing but insufficient neutralizing activity against Omicron-BA.1 after a second booster dose of mRNA-1273 vaccine in chronic haemodialysis patients
Eugen Ovcar, Sammy Patyna, Niko Kohmer, Elisabeth Heckel-Kratz, Sandra Ciesek, Holger F Rabenau, Ingeborg A Hauser, Kirsten de Groot
doi : 10.1093/ckj/sfac211
Clinical Kidney Journal, Volume 15, Issue 12, December 2022, Pages 2346–2348
