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The spatial and temporal trends of severe periodontitis burden in Asia, 1990–2019: A population-based epidemiological study
Li-Sha Luo, Hang-Hang Luan, Jun-Feng Jiang, Lan Wu, Cheng Li, Wei-Dong Leng, Xian-Tao Zeng
doi : 10.1002/JPER.21-0625
To investigate the long-term and spatial patterns of incidence, prevalence, and disability-adjusted life year (DALY) rates of severe periodontitis in Asia from 1990 to 2019, and to estimate the associations between disease burden and socioeconomic development using the Socio-Demographic Index (SDI).
Common complement factor H polymorphisms are linked with periodontitis in elderly patients
Aino Salminen, Milla Pietiäinen, Susanna Paju, Timo Sorsa, Päivi Mäntylä, Kåre Buhlin, Juha Sinisalo, Pirkko J. Pussinen
doi : 10.1002/JPER.22-0005
In our recent genome-wide association study, we found that genetic polymorphisms in the complement factor H (CFH) gene and S100A gene region are strongly associated with serum matrix metalloproteinase 8 (MMP-8) concentration and the release of MMP-8 from neutrophils. As MMP-8 is centrally involved in the pathogenesis of periodontitis, we aimed to evaluate the presence of genetic polymorphisms of S100A8/A9/A12, MMP8, and CFH in periodontitis. In addition, we studied whether polymorphisms of these genes affect the concentrations of S100A8, S100A12, MMP-8, or complement activation marker in saliva.
Relationship between the subgingival microbiome and menopausal hormone therapy use: The Buffalo OsteoPerio study
Ahmed I. Soliman, Michael J. LaMonte, Kathleen M. Hovey, Daniel I. McSkimming, Chris A. Andrews, Patricia I. Diaz, Michael J. Buck, Yijun Sun, Amy E. Millen, Jean Wactawski-Wende
doi : 10.1002/JPER.22-0027
This study investigated the association between menopausal hormone therapy (HT) use and the subgingival microbiome, for which published information is limited.
Evaluation of periodontal status and cytokine levels in saliva and gingival crevicular fluid of patients with inflammatory bowel diseases
Ayaz Enver, Nurdan Ozmeric, Sila Cagri Isler, Murat Toruner, Cigdem Fidan, Gulsah Demirci, Serenay Elgun, Andre Paes B. da Silva
doi : 10.1002/JPER.22-0065
Periodontal diseases and inflammatory bowel diseases (IBD, ulcerative colitis [UC] and Crohn disease [CD]) have been reported to present with increased salivary and gingival crevicular fluid (GCF) concentrations of cytokines. The aim of this study was to evaluate the salivary and GCF levels of TNF-α, IL-1β, IL-10, and IL-17A and their associations with the periodontal statuses of UC, CD, and non-IBD patients, and to analyze the interrelationships among these cytokines, IBD conditions, and periodontal diseases.
Stability of contour augmentation of implant-supported single crowns in the esthetic zone: One-year cone-beam computed tomography results of a comparative, randomized, prospective, two-center clinical study using two different bone grafting techniques in early implant placement
Yu-Ling Tsai, Jui-Pin Tsao, Chung-Li Wang, Evan Grodin, Jung-Jen Lin, Chun-Jung Chen, Chung-Han Ho, David Cochran, Jimmy Lian Ping Mau
doi : 10.1002/JPER.21-0588
Early implant placement with contour augmentation could provide support and volume to the hard and soft tissues. Herein, we aimed to ascertain whether freeze-dried bone allograft (FDBA) shares with deproteinized bovine bone material (DBBM) the results for esthetic outcomes for anterior teeth and stability of peri-implant facial bone thickness and height by conducting guided bone regeneration.
Open flap debridement compared to repeated applications of photodynamic therapy in the treatment of residual pockets: A randomized clinical trial
Naira M. R. B. Andere, NÃdia C. Castro dos Santos, Cássia F. Araújo, Hélvis E. S. Paz, Luciana M. Shaddox, Renato C. V. Casarin, Mauro P. Santamaria
doi : 10.1002/JPER.22-0059
The aim of the present study was to compare repeated applications of antimicrobial photodynamic therapy (aPDT) to open flap debridement (OFD) in the treatment of residual periodontal pockets in non-furcation sites.
Effect of locally applied simvastatin on clinical attachment level and alveolar bone in periodontal maintenance patients: A randomized clinical trial
Amy C. Killeen, Lauren E. Krell, Mattie Bertels, Mary M. Christiansen, Laura Anderson, Robin L. Hattervig, Kaeli K. Samson, Dong Wang, Richard A. Reinhardt
doi : 10.1002/JPER.21-0708
The purpose of this double-masked, randomized, controlled trial was to determine if the local application of simvastatin (SIM), combined with minimally invasive papilla reflection and root planing (PR/RP), is effective in improving clinical attachment level (CAL), probing depth (PD) reduction, and increasing interproximal bone height (IBH) in persistent 6–9 mm periodontal pockets in patients receiving periodontal maintenance therapy (PMT).
Comparing the histological assessment following ridge preservation using a composite bovine-derived xenograft versus an alloplast hydroxyapatite-sugar cross-linked collagen matrix
Alicia Casarez-Quintana, Brian L. Mealey, Georgios Kotsakis, Archontia Palaiologou
doi : 10.1002/JPER.22-0149
This randomized controlled trial was designed to evaluate the histological wound healing and alveolar ridge dimensional changes following ridge preservation using two different xenograft/collagen matrices.
Multiscale analysis of craniomaxillofacial bone repair: A preclinical mini-pig study
Pavla Ticha, Igor Pilawski, Jill A. Helms
doi : 10.1002/JPER.21-0426
The rate of reparative osteogenesis controls when an implant is sufficiently stable as to allow functional loading. Using a mini pig model, the rate of reparative osteogenesis in two types of implant sites for example, an osteotomy versus a fresh extraction socket were compared.
M101, a therapeutic oxygen carrier derived from Arenicola marina, decreased Porphyromonas gingivalis-induced hypoxia and improved periodontal healing
Fareeha Batool, Catherine Petit, Céline Stutz, Hayriye Özçelik, Pierre-Yves Gegout, Nadia Benkirane-Jessel, Eric Delpy, Franck Zal, Elisabeth Leize-Zal, Olivier Huck
doi : 10.1002/JPER.22-0006
Porphyromonas gingivalis exacerbates tissue hypoxia and worsens periodontal inflammation. This study investigated the effect of a therapeutic oxygen carrier (M101), derived from Arenicola marina, on hypoxia and associated inflammation in the context of periodontitis.
Canonical Wnt/β-catenin signaling has positive effects on osteogenesis, but can have negative effects on cementogenesis
Tiancheng Li, Han Wang, Yukun Jiang, Yuzhe Guan, Shuo Chen, Zuping Wu, Shujuan Zou, Lynda Faye Bonewald, Peipei Duan
doi : 10.1002/JPER.21-0599
To date, therapeutic approaches for cementum regeneration are limited and outcomes remain unpredictable. A significant barrier to improve therapies for cementum regeneration is that the cementocyte and its intracellular signal transduction mechanisms remain poorly understood. This study aims to elucidate the regulatory mechanism of Wnt pathway in cementogenesis.
Apoptotic extracellular vesicles alleviate Pg-LPS induced inflammatory responses of macrophages via AMPK/SIRT1/NF-κB pathway and inhibit osteoclast formation
Qingyuan Ye, Haokun Xu, Shiyu Liu, Zihan Li, Jun Zhou, Feng Ding, Xige Zhang, Yazheng Wang, Yan Jin, Qintao Wang
doi : 10.1002/JPER.21-0657
Periodontitis is caused by the imbalance of anti-bacteria immune response and excessive inflammation whereas macrophages play an important role in inflammation. Thus, it is critical for finding efficient anti-inflammatory strategies to alleviate periodontal inflammation and prevent bone destruction.
