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REFINE special issue
Kathleen Spring, Klaus-M. Weltring, Adriele Prina-Mello & Ruth Schmid
doi : 10.1007/s13346-022-01209-3
Volume 12, issue 9, September 2022
Regulatory safety evaluation of nanomedical products: key issues to refine
Wim H. De Jong, Robert E. Geertsma & Gerrit Borchard
Three-dimensional (3D) liver cell models - a tool for bridging the gap between animal studies and clinical trials when screening liver accumulation and toxicity of nanobiomaterials
Melissa Anne Tutty, Dania Movia & Adriele Prina-Mello
Subcellular detection of PEBCA particles in macrophages: combining darkfield microscopy, confocal Raman microscopy, and ToF–SIMS analysis
Antje Vennemann, Daniel Breitenstein, Elke Tallarek, ?rr M?rch, Ruth Schmid & Martin Wiemann
A multistep in vitro hemocompatibility testing protocol recapitulating the foreign body reaction to nanocarriers
Valeria Perugini, Ruth Schmid, ?rr M?rch, Isabelle Texier, Martin Brodde & Matteo Santin
A Decision Support System for preclinical assessment of nanomaterials in medical products: the REFINE DSS
Alex Zabeo, Fabio Rosada, Lisa Pizzol, Fanny Caputo, Sven Even Borgos, Jeremie Parot, Robert E. Geertsma, Joost Jacob Pouw, Rob J. Vandebriel, Oihane Ibarrola Moreno & Danail Hristozov
A comparative biodistribution study of polymeric and lipid-based nanoparticles
Andreas K. O. ?slund, Rob J. Vandebriel, Fanny Caputo, Wim H. de Jong, Christiaan Delmaar, Astrid Hyldbakk, Emilie Rustique, Ruth Schmid, Sofie Snipstad, Isabelle Texier, Kai Vernstad & Sven Even F. Borgos
Physiologically based pharmacokinetic modeling of intravenously administered nanoformulated substances
Jordi Minnema, Sven Even F. Borgos, Neill Liptrott, Rob Vandebriel & Christiaan Delmaar
Future perspectives for advancing regulatory science of nanotechnology-enabled health products
Blanka Halamoda-Kenzaoui, Robert Geertsma, Joost Pouw, Adriele Prina-Mello, Moreno Carrer, Matthias Roesslein, Adrienne Sips,Klaus Michael Weltring, Kathleen Spring & Susanne Bremer-Hoffmann
Pre-clinical 2D and 3D toxicity response to a panel of nanomaterials; comparative assessment of NBM-induced liver toxicity
Melissa Anne Tutty, Gabriele Vella & Adriele Prina-Mello
A physiologically based pharmacokinetic model to predict pegylated liposomal doxorubicin disposition in rats and human
Maiara Camotti Montanha, Alice Howarth, Doaa Ahmed Mohamed, Estelle Loier, Lauren Main, Matthias R?sslein, Christiaan Delmaar, Adriele Prina-Mello & Marco Siccardi
Standardization of an in vitro assay matrix to assess cytotoxicity of organic nanocarriers: a pilot interlaboratory comparison
Kai Moritz Eder, Anne Marzi, Ane Marit W?gb?, Jolanda P. Vermeulen, Liset J. J. de la Fonteyne-Blankestijn, Matthias R?sslein, Rainer Ossig, Geir Klinkenberg, Rob J. Vandebriel & Jürgen Schnekenburger
Interlaboratory evaluation of a digital holographic microscopy–based assay for label-free in vitro cytotoxicity testing of polymeric nanocarriers
Anne Marzi, Kai Moritz Eder, ?lvaro Barroso, Ane Marit W?gb?, ?rr M?rch, Anne Rein Hatletveit, Torkild Visnes, Ruth B. Schmid, Geir Klinkenberg, Bj?rn Kemper & Jürgen Schnekenburger
An inter-laboratory comparison of an NLRP3 inflammasome activation assay and dendritic cell maturation assay using a nanostructured lipid carrier and a polymeric nanomedicine, as exemplars
Rob J. Vandebriel, Christopher A. W. David, Jolanda P. Vermeulen & Neill J. Liptrott
Evaluating nanobiomaterial-induced DNA strand breaks using the alkaline comet assay
Melissa Anne Tutty, Gabriele Vella, Antje Vennemann, Martin Wiemann & Adriele Prina-Mello
Correction: Evaluating nanobiomaterial-induced DNA strand breaks using the alkaline comet assay
Melissa Anne Tutty, Gabriele Vella, Antje Vennemann, Martin Wiemann & Adriele Prina-Mello
