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Defibrotide Has a Role in COVID-19 Therapy
Antonio Macciò, MDGiorgio La Nasa, MDSara Oppi, MDClelia Madeddu, MD
Balancing the Benefits and Harms of Lung Cancer Screening: Much Work to Be Done
A. Cole Burks, MDJason Long, MD, MPHM. Patricia Rivera, MD
Swimming-Induced Pulmonary Edema: A Swedish Experience
Peter Wilmshurst, MB, ChB
Loss of Heterozygosity for Tuberous Sclerosis Complex and Mammalian Target of Rapamycin Signaling: The Keys to Understanding the Pathogenesis of Diffuse Cystic Lung Diseases?
Callaghan, MDCormac McCarthy, MD, PhD
We Must Keep Our Cool Regarding the Effect of Therapeutic Hypothermia After In-Hospital Cardiac Arrest
Markus B. Skrifvars, MD, PhDJanus C. Jakobsen, MD, PhD
Spirometry as a Predictor of Cardiometabolic Disease
Tianshi David Wu, MD, MHS
Implications of the COVID-19 Pandemic for the Well-Being of the ICU Workforce Considerations for the ICU Interprofessional Team
Michelle E. Kho, PhDJulie C. Reid, PhD
POINT: Does Normothermic Regional Perfusion Violate the Ethical Principles Underlying Organ Procurement? Yes
Matthew DeCamp, MD, PhDLois Snyder Sulmasy, JDJoseph J. Fins, MD
COUNTERPOINT: Does Normothermic Regional Perfusion Violate the Ethical Principles Underlying Organ Procurement? No
Les James, MDBrendan Parent, JDNader Moazami, MDDeane E. Smith, MD
Rebuttal From Dr DeCamp et al
Matthew DeCamp, MD, PhDJoseph J. Fins, MDLois Snyder Sulmasy, JD
Rebuttal From Dr James et al
Les James, MD, MPHBrendan Parent, JDNader Moazami, MDDeane E. Smith, MD
Smokefree New Zealand 2025: A Beacon for Global Tobacco and Nicotine Policy Reform
Adam Edward Lang, PharmDAlain Braillon, MD, PhD
Results of a Phase 2b Trial With GB001, a Prostaglandin D2 Receptor 2 Antagonist, in Moderate to Severe Eosinophilic Asthma
Mark H. Moss, MD; Njira L. Lugogo, MD; Mario Castro, MD; Nicola A. Hanania, MD; Andrea Ludwig-Sengpiel, MD;Dinesh Saralaya, MD; Rafal Dobek, MD; Iñigo Ojanguren, MD; Ivan Vyshnyvetskyy, MD; Jean-Marie Bruey, PhD;Robin Osterhout, PhD; Cindy-ann Tompkins, MS; Karen Dittrich, PhD; Kartik Raghupathi, MS; andHector Ortega, MD, ScD; on behalf of the LEDA Investigators*
The Radiographic and Mycobacteriologic Correlates of Subclinical Pulmonary TB in Canada: A Retrospective Cohort Study
Angela Lau, MD; Christopher Lin, MD; James Barrie, MD; Christopher Winter, MD; Gavin Armstrong, MD;Mary Lou Egedahl, BScN; Alexander Doroshenko, MD, MPH; Courtney Heffernan, PhD; Leyla Asadi, MD, MPH;Dina Fisher, MD; Catherine Paulsen, MSc; Jalal Moolji, MD; and Richard Long, MD
Optimizing COPD Acute Care Patient Outcomes Using a Standardized Transition Bundle and Care Coordinator: A Randomized Clinical Trial
Chantal E. Atwood, PhD; Mohit Bhutani, MD; Maria B. Ospina, PhD; Brian H. Rowe, MD; Richard Leigh, MD;Lesly Deuchar, MN; Peter Faris, PhD; Marta Michas, PhD; Kelly J. Mrklas, PhD; Jim Graham, RN;Raymond Aceron, NP; Ron Damant, MD; Lee Green, MD; Naushad Hirani, MD; Kelly Longard, RN;Virginia Meyer, MBA; Patrick Mitchell, MD; Willis Tsai, MD; Brandie Walker, MD; and Michael K. Stickland, PhD
The Influence of the COVID-19 Pandemic on Intensivists’ Well-Being: A Qualitative Study
Kelly C. Vranas, MD; Sara E. Golden, PhD; Shannon Nugent, PhD; Thomas S. Valley, MD; Amanda Schutz, PhD;Abhijit Duggal, MD, MPH; Kevin P. Seitz, MD; Steven Y. Chang, MD, PhD; Christopher G. Slatore, MD;Donald R. Sullivan, MD; Catherine L. Hough, MD; and Kusum S. Mathews, MD, MPH
Defibrotide Therapy for SARS-CoV-2 ARDS
David Frame, PharmD; Gianni B. Scappaticci, PharmD; Thomas M. Braun, PhD; Mary Maliarik, PhD;Thomas H. Sisson, MD; Steven W. Pipe, MD; Daniel A. Lawrence, PhD; Paul G. Richardson, MD;Michael Holinstat, PhD; Robert C. Hyzy, MD; Daniel R. Kaul, MD; Kevin S. Gregg, MD; Vibha N. Lama, MD;and Gregory A. Yanik, MD
Targeted Temperature Management After In-Hospital Cardiac Arrest: An Ancillary Analysis of Targeted Temperature Management for Cardiac Arrest With Nonshockable Rhythm Trial Data
Alexiane Blanc, MD; Gwenhael Colin, MD; Alain Cariou, MD, PhD; Hamid Merdji, MD, PhD; Guillaume Grillet, MD;Patrick Girardie, MD; Elisabeth Coupez, MD; Pierre-François Dequin, MD, PhD; Thierry Boulain, MD;Jean-Pierre Frat, MD, PhD; Pierre Asfar, MD, PhD; Nicolas Pichon, MD; Mickael Landais, MD; Gaëtan Plantefeve, MD;Jean-Pierre Quenot, MD, PhD; Jean-Charles Chakarian, MD; Michel Sirodot, MD; Stéphane Legriel, MD;Nicolas Massart, MD; Didier Thevenin, MD; Arnaud Desachy, MD; Arnaud Delahaye, MD; Vlad Botoc, MD;Sylvie Vimeux, MD; Frederic Martino, MD; Jean Reignier, MD, PhD; F. S. Taccone, MD, PhD; and J. B. Lascarrou, MD
Positive Stimulation for Medically Sedated Patients: A Music Therapy Intervention to Treat Sedation-Related Delirium in Critical Care
John Head, MM; Virginia Gray, BM; Faisal Masud, MD; and Jennifer Townsend, MMT
Provider Perspectives on and Access to Palliative Care for Patients With Interstitial Lung Disease
Rebecca A. Gersten, MD; Bhavna Seth, MBBS, MHS; Luis Arellano, BA; Jessica Shore, PhD, RN;Lanier O’Hare, MSN, CRNP; Nina Patel, MD; Zeenat Safdar, MD, FCCP; Rachana Krishna, MD;Yolanda Mageto, MD, MPH; Darlene Cochran; Kathleen Lindell, PhD, RN; and Sonye K. Danoff, MD, PhD;on behalf of the Pulmonary Fibrosis Foundation*
Pulmonary Langerhans Cell Histiocytosis and Lymphangioleiomyomatosis Have Circulating Cells With Loss of Heterozygosity of the TSC2 Gene
Davide Elia, MD; Olga Torre, MD; Chiara Vasco, PhD; Jens Geginat, PhD; Sergio Abrignani, MD, PhD;Elisabetta Bulgheroni, MSc; Elena Carelli, MSc; Roberto Cassandro, MD; Gustavo Pacheco-Rodriguez, PhD;Wendy K. Steagall, PhD; Joel Moss, MD, PhD; and Sergio Harari, MD
The Role of Genetic Testing in Pulmonary Fibrosis: A Perspective From the Pulmonary Fibrosis Foundation Genetic Testing Work Group
Chad A. Newton, MD; Justin M. Oldham, MD; Carolyn Applegate, MGC; Nikkola Carmichael, PhD, CGC;Karen Powell, MS, CGC; Dan Dilling, MD; Shelley L. Schmidt, MD; Mary Beth Scholand, MD; Mary Armanios, MD;Christine Kim Garcia, MD, PhD; Jonathan A. Kropski, MD; and Janet Talbert, MS, CGC; and the Pulmonary FibrosisFoundation Genetic Testing Work Group
Outbreak of Silicosis in Workers Producing Artificial Stone Skirting Boards: A Novel Application of Silica-Based Composites
Steven Ronsmans, MD, PhDPieter Goeminne, MD, PhDNaïm Jerjir, MDSint-Niklaas, BelgiumVicky Nowé, MD, PhDEline Vandebroek, MDStephan Keirsbilck, MDBirgit Weynand, MD, PhDPeter H. M. Hoet, PhDJeroen A. J. Vanoirbeek, PhDWim A. Wuyts, MD, PhDLeuven, BelgiumJonas Yserbyt, MD, PhDBenoit Nemery, MD, PhD
Swimming-Induced Pulmonary Edema: Evaluation of Prehospital Treatment With CPAP or Positive Expiratory Pressure Device
Claudia Seiler, MD; Linda Kristiansson, MD; Cecilia Klingberg, MD; Josefin Sundh, MD, PhD;Annika Braman Eriksson, MD; Daniel Lundeqvist, MD; Kristofer F. Nilsson, MD, PhD; andMaria HÃ¥rdstedt, MD, PhD
Role of Pulmonary Function in Predicting New-Onset Cardiometabolic Diseases and Cardiometabolic Multimorbidity
Guochen Li, MD; Yanqiang Lu, MD; Yanan Qiao, MD; Die Hu; and Chaofu Ke, MD, PhD
The Vexing Voyage of Vasopressin: The Consequences of Granting Market Exclusivity to Unapproved Drugs
Liam BendicksenAaron S. Kesselheim, MD, JDBenjamin N. Rome, MD
BMI and Treatment Response in Patients With Pulmonary Arterial Hypertension: A Meta-analysis
Breanne E. McCarthy, MD; Robyn L. McClelland, PhD; Dina H. Appleby, MS; Jude S. Moutchia, MD;Jasleen K. Minhas, MD; Jeff Min, MD; Jeremy A. Mazurek, MD; K. Akaya Smith, MD; Jason S. Fritz, MD;Steven C. Pugliese, MD; Ryan J. Urbanowicz, PhD; John H. Holmes, PhD; Harold I. Palevsky, MD; Steven M. Kawut, MD;and Nadine Al-Naamani, MD
Comparison of Full-Dose vs Moderate-Dose Systemic Thrombolysis for the Treatment of Patients With Acute Pulmonary Embolism
Ana JaureguÃzar, MDCassius Iyad Ochoa Chaar, MDAlfonso Muriel, PhDJerónimo Ramón Vela Moreno, MDIdo Weinberg, MDAntonella Tufano, MD, PhDJosé F. Varona, MD, PhDBehnood Bikdeli, MDDavid Jiménez, MD, PhDManuel Monreal, MD, PhD
Cannabinoids, Insomnia, and Other Sleep Disorders
Isobel Lavender, BPsych (Hons); Iain S. McGregor, PhD; Anastasia Suraev, MPsych (ClinNeuro);Ronald R. Grunstein, MBBS, MD, PhD; and Camilla M. Hoyos, MPH, PhD
Rapid FEV1 Decline and Lung Cancer Incidence in South Korea
Hyun Woo Lee, MD; Hyo-Jin Lee, MD; Jung-Kyu Lee, MD; Tae Yeon Park, MD; Eun Young Heo, MD;and Deog Kyeom Kim, MD
Invasive Procedures and Associated Complications After Initial Lung Cancer Screening in a National Cohort of Veterans
Eduardo R. Núñez, MD; Tanner J. Caverly, MD, MPH; Sanqian Zhang, PhD; Mark E. Glickman, PhD; Shirley X. Qian, MS;Jacqueline H. Boudreau, MPH; Donald R. Miller, ScD; and Renda Soylemez Wiener, MD, MPH
Frailty in Patients With Lung Cancer: A Systematic Review and Meta-Analysis
Klara Komici, MD; Leonardo Bencivenga, MD; Neal Navani, PhD; Vito D’Agnano, MD; Germano Guerra, PhD;Andrea Bianco, PhD; Giuseppe Rengo, PhD; and Fabio Perrotta, MD
Bilateral Bronchoscopic Lung Volume Reduction After Surgical Fissure Completion
Majid Shafiq, MD, MPH; Emily Polhemus, BS; Ryan Perkins, MD; Victoria Forth, MA, MMS, PA-C;and M. Blair Marshall, MD
A Young Child With Recurrent Pneumonia and Hemoptysis During the COVID-19 Pandemic
Zirun Zhao, MD; Rachel Choe Kim; Felix Tavernier, MD; Rachana Choksi, MD; Trevor Van Brunt; James Earl Davis, MD;Katharine Kevill, MD; and Helen Hsieh, MD, PhD
A 60-Year-Old Woman With Posterior Mediastinal Tumor
Nobuyasu Wakazono, MD; Arei Mizushima, MD; Yukiko Maeda, MD, PhD; Natsuko Taniguchi, MD, PhD;Katsura Nagai, MD, PhD; Atsuo Hattori, MD, PhD; and Toshiyuki Harada, MD, PhD
A 54-Year-Old Man With Migratory Pulmonary Consolidation and Progressive Dyspnea
Juei-Yang Ma, MD; and Cheng-Hao Chuang, MD
An Adolescent With a Retropharyngeal Swelling: To Drain or Not to Drain?: Keeping a Broad Vision During the COVID-19 Pandemic
Sybren Robijn, MD; Stan van Keulen, MD, PhD; Godelieve Verhage-Damen, MD, PhD; and Stijn Bekkers, MD
An Unusual Source of Tension
Patrick J. Sylvester, MD; Akshay B. Vijayaraman, MD; and Carleen R. Spitzer, MD
Sudden Hemodynamic Instability After Unproning a Patient With COVID-19 Pneumonia
André C. G. Hirano, MD; Livia M. G. Melro, MD; and Bruno A. M. P. Besen, PhD
In Real-World Studies, Comparisons of Predictive Values Are Confounded by Prevalence
Gene Pennello, PhD
Response
In Valeria S. M. Valbuena, MDRyan P. Barbaro, MDDru Claar, MDThomas S. Valley, MDRobert P. Dickson, MDSteven E. Gay, MDMichael W. Sjoding, MDTheodore J. Iwashyna, MD, PhD
A Nonrigorous and Incorrect Evaluation of the Fast Fit Test
testsLisa M. Brosseau, ScD, CIHRachael M. Jones, PhD, CIH
Response
Adrian Regli, MD, PhDAine Sommerfield, PhDBritta S. von Ungern-Sternberg, MD, PhD
Occupational Exposures in Nontuberculous Mycobacterial Pulmonary Disease
Paul D. Blanc, MD, MSPHJohn R. Balmes, MDCarrie Redlich, MD, MPH
Response
Kartik Kumar, MA, MBBS, MSMichael R. Loebinger, MA, BMBCh, PhD
Prehospital Management of Swimming-Induced Pulmonary Edema: Is CPAP the Best Lifeguard?
Paolo Ruggeri, MDAlastair Glossop, MDAntonio M. Esquinas, MD, PhD
