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External validation of urinary C–C motif chemokine ligand 14 (CCL14) for prediction of persistent acute kidney injury
Sean M. Bagshaw, Ali Al-Khafaji, Antonio Artigas, Danielle Davison, Michael Haase, Matthew Lissauer, Kai Zacharowski, Lakhmir S. Chawla, Thomas Kwan, J. Patrick Kampf, Paul McPherson & John A. Kellum
doi : 10.1186/s13054-021-03618-1
Critical Care volume 25, Article number: 185 (2021)
Persistent acute kidney injury (AKI) portends worse clinical outcomes and remains a therapeutic challenge for clinicians. A recent study found that urinary C–C motif chemokine ligand 14 (CCL14) can predict the development of persistent AKI. We aimed to externally validate urinary CCL14 for the prediction of persistent AKI in critically ill patients.
Optimising the timing of renal replacement therapy in acute kidney injury
Matthew E. Cove, Graeme MacLaren, Daniel Brodie & John A. Kellum
doi : 10.1186/s13054-021-03614-5
Critical Care volume 25, Article number: 184 (2021)
The optimal timing of renal replacement therapy (RRT) in critically ill patients with acute kidney injury (AKI) has been much debated. Over the past five years several studies have provided new guidance for evidence-based decision-making. High-quality evidence now supports an approach of expectant management in critically ill patients with AKI, where RRT may be deferred up to 72 h unless a life-threatening indication develops. Nevertheless, physicians’ judgment still plays a central role in identifying appropriate patients for expectant management.
Adverse events associated with administration of vasopressor medications through a peripheral intravenous catheter: do not confound access route and specific drug complications!
Romain Jouffroy & Benoît Vivien
doi : 10.1186/s13054-021-03605-6
Critical Care volume 25, Article number: 183 (2021)
Accuracy of pancreatic stone protein for the diagnosis of infection in hospitalized adults: a systematic review and individual patient level meta-analysis
Josef Prazak, Irina Irincheeva, Martin J. Llewelyn, Daiana Stolz, Luis Garc?a de Guadiana Romualdo, Rolf Graf, Theresia Reding, Holger J. Klein, Philippe Eggimann & Yok-Ai Que
doi : 10.1186/s13054-021-03609-2
Critical Care volume 25, Article number: 182 (2021)
Accurate biomarkers to diagnose infection are lacking. Studies reported good performance of pancreatic stone protein (PSP) to detect infection. The objective of the study was to determine the performance of PSP in diagnosing infection across hospitalized patients and calculate a threshold value for that purpose.
Factors associated with death in children with purpura fulminans: a French national prospective cohort study
Fouad Madhi, Naim Ouldali, Corinne Levy, Muhamed-Kheir Taha, Robert Cohen on behalf of The French Pediatric Meningitis Network
doi : 10.1186/s13054-021-03603-8
Critical Care volume 25, Article number: 181 (2021)
Slicing and dicing ARDS: we almost forgot the lungs
Marry R. Smit & Lieuwe D. J. Bos
doi : 10.1186/s13054-021-03611-8
Critical Care volume 25, Article number: 180 (2021)
When should we start renal-replacement therapy in critically ill patients with acute kidney injury: do we finally have the answer?
Sean M. Bagshaw, Eric A. Hoste & Ron Wald
doi : 10.1186/s13054-021-03600-x
Critical Care volume 25, Article number: 179 (2021)
Tailored modulation of the inflammatory balance in COVID-19 patients admitted to the ICU?—a viewpoint
Marnix Kuindersma, Rocio Ramos Diaz & Peter E. Spronk
doi : 10.1186/s13054-021-03607-4
Critical Care volume 25, Article number: 178 (2021)
A growing consensus seems to be emerging that dexamethasone is a crucial component in the treatment of COVID-19-associated oxygen-dependent respiratory failure. Although dexamethasone has an undeniably beneficial effect on the inflammatory response in a subgroup of patients, the potential negative effects of corticosteroids must also be considered. In view of these negative effects, we argue that a one-size-fits-all dexamethasone approach may be potentially harmful in specific subsets of patients with COVID-19-associated ARDS. We propose a different individually tailored treatment strategy based on the patient’s inflammatory response.
Relationship between ventilator-associated pneumonia and mortality in COVID-19 patients: a planned ancillary analysis of the coVAPid cohort
Saad Nseir, Ignacio Martin-Loeches, […]the coVAPid study group
doi : 10.1186/s13054-021-03588-4
Critical Care volume 25, Article number: 177 (2021)
Patients with SARS-CoV-2 infection are at higher risk for ventilator-associated pneumonia (VAP). No study has evaluated the relationship between VAP and mortality in this population, or compared this relationship between SARS-CoV-2 patients and other populations. The main objective of our study was to determine the relationship between VAP and mortality in SARS-CoV-2 patients.
Clinical outcomes and safety of passive leg raising in out-of-hospital cardiac arrest: a randomized controlled trial
Youcef Azeli, Alfredo Bardaj?, Eneko Barber?a, Vanesa Lopez-Madrid, Jordi Bladé-Creixenti, Laura Fern?ndez-Sender, Gil Bonet, Elena Rica, Susana ?lvarez, Alberto Fern?ndez, Christer Axelsson & Maria F. Jiménez-Herrera
doi : 10.1186/s13054-021-03593-7
Critical Care volume 25, Article number: 176 (2021)
There are data suggesting that passive leg raising (PLR) improves hemodynamics during cardiopulmonary resuscitation (CPR). This trial aimed to determine the effectiveness and safety of PLR during CPR in out-of-hospital cardiac arrest (OHCA).
Implications of early respiratory support strategies on disease progression in critical COVID-19: a matched subanalysis of the prospective RISC-19-ICU cohort
Pedro D. Wendel Garcia, Hern?n Aguirre-Bermeo, […]RISC-19-ICU Investigators
doi : 10.1186/s13054-021-03580-y
Critical Care volume 25, Article number: 175 (2021)
Uncertainty about the optimal respiratory support strategies in critically ill COVID-19 patients is widespread. While the risks and benefits of noninvasive techniques versus early invasive mechanical ventilation (IMV) are intensely debated, actual evidence is lacking. We sought to assess the risks and benefits of different respiratory support strategies, employed in intensive care units during the first months of the COVID-19 pandemic on intubation and intensive care unit (ICU) mortality rates.
Mechanical circulatory support for refractory out-of-hospital cardiac arrest: a Danish nationwide multicenter study
Sivagowry Rasalingam M?rk, Carsten Stengaard, Louise Linde, Jacob Eifer M?ller, Lisette Okkels Jensen, Henrik Schmidt, Lars Peter Riber, Jo B?nding Andreasen, Sisse Anette Thomassen, Helle Laugesen, Phillip Michael Freeman, Steffen Christensen, Jacob Raben Greisen, Mariann Tang, Peter Hasse M?ller-S?rensen, Lene Holmvang, Emilie Gregers, Jesper Kjaergaard, Christian Hassager, Hans Eiskj?r & Christian Juhl Terkelsen
doi : 10.1186/s13054-021-03606-5
Critical Care volume 25, Article number: 174 (2021)
Mechanical circulatory support (MCS) with either extracorporeal membrane oxygenation or Impella has shown potential as a salvage therapy for patients with refractory out-of-hospital cardiac arrest (OHCA). The objective of this study was to describe the gradual implementation, survival and adherence to the national consensus with respect to use of MCS for OHCA in Denmark, and to identify factors associated with outcome.
Timing of Intubation in Covid-19 ARDS: What “time” really matters?
Vasiliki Tsolaki & George E. Zakynthinos
doi : 10.1186/s13054-021-03598-2
Critical Care volume 25, Article number: 173 (2021)
The impact of right ventricular injury on the mortality in patients with acute respiratory distress syndrome: a systematic review and meta-analysis
Ryota Sato, Siddharth Dugar, Wisit Cheungpasitporn, Mary Schleicher, Patrick Collier, Saraschandra Vallabhajosyula & Abhijit Duggal
doi : 10.1186/s13054-021-03591-9
Critical Care volume 25, Article number: 172 (2021)
Previous studies have found various incidences of right ventricular (RV) injury and its association with clinical outcome in patients with acute respiratory distress syndrome (ARDS). In this systematic review and meta-analysis, we aimed to investigate the impact of the presence of RV injury on mortality in patients with ARDS.
Dead space estimates may not be independently associated with 28-day mortality in COVID-19 ARDS
Luis Morales-Quinteros, Ary Serpa Neto, Antonio Artigas, Lluis Blanch, Michela Botta, David A. Kaufman, Marcus J. Schultz, Anissa M. Tsonas, Frederique Paulus, Lieuwe D. Bos on behalf of the PRoVENT-COVID Study Group
doi : 10.1186/s13054-021-03570-0
Critical Care volume 25, Article number: 171 (2021)
Estimates for dead space ventilation have been shown to be independently associated with an increased risk of mortality in the acute respiratory distress syndrome and small case series of COVID-19-related ARDS.
Non-intubated COVID-19 patients despite high levels of supplemental oxygen
Samuel Chosidow, Gaëtan Plantefève, Megan Fraissé, Hervé Mentec, Radj Cally & Damien Contou
doi : 10.1186/s13054-021-03599-1
Critical Care volume 25, Article number: 170 (2021)
Distinct temporal characteristics of circulating alveolar epithelial and endothelial injury markers in ARDS with COVID-19
Kentaro Tojo, Natsuhiro Yamamoto, Takahiro Mihara, Miyo Abe & Takahisa Goto
doi : 10.1186/s13054-021-03596-4
Critical Care volume 25, Article number: 169 (2021)
Blind placement of postpyloric feeding tubes at the bedside in intensive care
Qianwen Wang, Yongbo Xuan, Cuiping Liu, Mei Lu, Zhanguo Liu & Ping Chang
doi : 10.1186/s13054-021-03587-5
Critical Care volume 25, Article number: 168 (2021)
Comparison of culture-negative and culture-positive sepsis or septic shock: a systematic review and meta-analysis
Yuting Li, Jianxing Guo, Hongmei Yang, Hongxiang Li, Yangyang Shen & Dong Zhang
doi : 10.1186/s13054-021-03592-8
Critical Care volume 25, Article number: 167 (2021)
Mortality and other clinical outcomes between culture-negative and culture-positive septic patients have been documented inconsistently and are very controversial. A systematic review and meta-analysis was performed to compare the clinical outcomes of culture-negative and culture-positive sepsis or septic shock.
A high blood endocan profile during COVID-19 distinguishes moderate from severe acute respiratory distress syndrome
Tiffany Pascreau, Colas Tcherakian, Benjamin Zuber, Eric Farfour, Marc Vasse & Philippe Lassalle
doi : 10.1186/s13054-021-03589-3
Critical Care volume 25, Article number: 166 (2021)
Temporal patterns of organ dysfunction after severe trauma
Jesper Eriksson, David Nelson, Anders Holst, Elisabeth Hellgren, Ola Friman & Anders Oldner
doi : 10.1186/s13054-021-03586-6
Critical Care volume 25, Article number: 165 (2021)
Understanding temporal patterns of organ dysfunction (OD) may aid early recognition of complications after trauma and assist timing and modality of treatment strategies. Our aim was to analyse and characterise temporal patterns of OD in intensive care unit-admitted trauma patients.
