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Spotlight on the November 8 Issue.
Merino, Jose G. MD, MPhil; Editor-in-Chief, Neurology(R)
doi : 10.1212/WNL.0000000000201326
Volume 99(19) pgs. 821-869,e2081-e2211 November 8, 2022
Spatial Navigation and Dementia: A Sense of Place Misplaced.
Verghese, Joe MBBS; Blumen, Helena M. PhD
Taking the Eyes of the Stroke Neurologist to the Ambulance: The Kiwi Experience.
Garcia-Esperon, Carlos MD, PhD; Majersik, Jennifer Juhl MD, MS
Influenza Vaccination and Ischemic Stroke Prevention: Two for the Price of One.
Yang, Dixon MD; Elkind, Mitchell S.V. MD
Spatial Navigation and Its Association With Biomarkers and Future Dementia in Memory Clinic Patients Without Dementia.
Tangen, Gro Gujord PhD; Nilsson, Maria H. PhD; Stomrud, Erik MD, PhD; Palmqvist, Sebastian MD, PhD; Hansson, Oskar MD, PhD
doi : 10.1212/WNL.0000000000201106
Impaired spatial navigation is considered an early sign in many neurodegenerative diseases. We aimed to determine whether spatial navigation was associated with future dementia in patients with subjective cognitive decline (SCD) or mild cognitive impairment (MCI) and to explore associations between spatial navigation and biomarkers of Alzheimer disease (AD) and neurodegeneration.
Incidence of Amyloid-Related Imaging Abnormalities in Patients With Alzheimer Disease Treated With Anti-[beta]-Amyloid Immunotherapy: A Meta-analysis.
Jeong, So Yeong MD; Suh, Chong Hyun MD, PhD; Shim, Woo Hyun PhD; Lim, Jae-Sung MD, PhD; Lee, Jae-Hong MD, PhD; Kim, Sang Joon MD, PhD
doi : 10.1212/WNL.0000000000201019
To assess the incidence of amyloid-related imaging abnormalities (ARIA) in clinical trials of anti-[beta]-amyloid (A[beta]) immunotherapy and compare the incidence among different agents and clinical characteristics to identify possible predisposing factors for ARIA. Methods: The PubMed and Embase databases were searched for clinical trials of anti-A[beta] immunotherapy published on or before January 12, 2022.
[beta]-Amyloid, Tau, Neurodegeneration Classification and Eligibility for Anti-amyloid Treatment in a Memory Clinic Population.
Rosenberg, Anna PhD; Ohlund-Wistbacka, Ulf MD; Hall, Anette PhD; Bonnard, Alexandre MD; Hagman, Goran MSc; Ryden, Marie MD; Thunborg, Charlotta PhD; Wiggenraad, Fleur MD; Sandebring-Matton, Anna PhD; Solomon, Alina MD, PhD *; Kivipelto, Miia MD, PhD*
doi : 10.1212/WNL.0000000000201043
ATN ([beta]-amyloid [A[beta]], tau, neurodegeneration) system categorizes individuals based on their core Alzheimer disease (AD) biomarkers. An important potential future use for ATN is therapeutic decision-making in clinical practice once disease-modifying treatments (e.g., anti-amyloid), become widely available. In this cross-sectional study, we applied ATN and estimated potential eligibility for anti-amyloid treatment in a real-life memory clinic with biomarker assessments integrated into the routine diagnostic procedure and all specialized resources available for the implementation of novel treatments.
Socioeconomic Status, Biological Aging, and Memory in a Diverse National Sample of Older US Men and Women.
Avila-Rieger, Justina PhD; Turney, Indira C. PhD; Vonk, Jet M.J. PhD; Esie, Precious MPH; Seblova, Dominika PhD; Weir, Vanessa R. BA; Belsky, Daniel W. PhD; Manly, Jennifer J. PhD
doi : 10.1212/WNL.0000000000201032
Exposure to socioeconomic disadvantage is associated with early-onset cognitive aging. Biological aging, the progressive loss of system integrity that occurs as we age, is proposed as a modifiable process mediating this health inequality. We examined whether socioeconomic disparities in cognitive aging in mid-to late-life adults is explained by accelerated biological aging similarly across race, ethnicity, and sex/gender.
Prehospital Telestroke vs Paramedic Scores to Accurately Identify Stroke Reperfusion Candidates: A Cluster Randomized Controlled Trial.
Scott, Imogene Mary MBChB; Manoczki, Csilla MBChB; Swain, Andrew Herbert MBChB, PhD; Ranjan, Abhishek MS; McGovern, Michael Garth; Shyrell Tyson, Alicia Lucy BNurs PGDip; Hyslop, Melissa Claire BHSc; Punter, Martin Michael MBBS, PhD; Ranta, Annemarei MD, PhD, FRACP
doi : 10.1212/WNL.0000000000201104
Stroke reperfusion therapy is time critical. Improving prehospital diagnostic accuracy including the likelihood of large vessel occlusion can aid with efficient and appropriate diversion decisions to optimize onset-to-treatment time. In this study, we investigated whether prehospital telestroke improves diagnostic accuracy when compared with paramedic assessments and assessed feasibility
Associations of Prestroke Physical Activity With Stroke Severity and Mortality After Intracerebral Hemorrhage Compared With Ischemic Stroke.
Viktorisson, Adam MD; Buvarp, Dongni MD, PhD; Reinholdsson, Malin PT; Danielsson, Anna PT, PhD; Palstam, Annie PT, PhD; Stibrant Sunnerhagen, Katharina MD, PhD
doi : 10.1212/WNL.0000000000201097
Prestroke physical activity may protect the brain from severe consequences of stroke. However, previous studies on this subject included mainly ischemic stroke cases, and the association between prestroke physical activity and outcomes after intracerebral hemorrhage is uncertain.
Influenza Vaccination and Risk of Ischemic Stroke: A Population-Based Case-Control Study.
Rodriguez-Martin, Sara PharmD, PhD; Barreira-Hernandez, Diana PharmD; Gil, Miguel MD, MPH, PhD; Garcia-Lledo, Alberto MD, PhD; Izquierdo-Esteban, Laura MD, PhD; De Abajo, Francisco MD, MPH, PhD
doi : 10.1212/WNL.0000000000201123
To assess the relationship between influenza vaccination in the general population and risk of a first ischemic stroke (IS) during pre-epidemic, epidemic, and postepidemic periods. Methods: A nested case-control study was conducted in a Spanish primary care database over 2001-2015.
Six-Minute Walk as a Measure of Walking Capacity and Endurance in Patients With Pediatric-Onset Multiple Sclerosis.
Brenton, J. Nicholas MD; Florenzo, Brian BS; Koshiya, Hitoshi MD; Min, Seulgi BA; Woolbright, Emma BS; Coleman, Rachael MPH; Chen, Shanshan PhD; Goldman, Myla MD, MSc
doi : 10.1212/WNL.0000000000201098
Despite low levels of disability, youth with pediatric-onset multiple sclerosis (POMS) engage in less physical activity compared with peers. The contribution of walking capacity, endurance, behavior, and MS comorbidities remains relatively undefined and may provide valuable insights into the limitations toward physical activity in youth with MS.
Prioritizing Hormone Therapy Over Vigabatrin as the First Treatment for Infantile Spasms: A Quality Improvement Initiative.
Mytinger, John R. MD; Parker, William MHA, CPHQ; Rust, Steven W. PhD; Ahrens, Stephanie M. DO; Albert, Dara V.F. DO, MEd; Beatty, Christopher W. MD; Chrisman, Julie BSN, RN; Clark, Daniel J. MD, PhD; Debs, Andrea MS; Denney, Danielle; Karn, Mary NP; Herbst, James PharmD; Ostendorf, Adam P. MD; Taylor, Mary C. BSN, CNRN; Twanow, Jaime D.E. MD; Vidaurre, Jorge MD; Patel, Anup D. MD
doi : 10.1212/WNL.0000000000201113
Infantile spasms (IS) are early childhood seizures with potentially devastating consequences. Standard therapies (adrenocorticotropic hormone [ACTH], high-dose prednisolone, and vigabatrin) are strongly recommended as the first treatment for IS.
Structural Neuroimaging in Adults and Adolescents With Newly Diagnosed Focal Epilepsy: The Human Epilepsy Project.
Bank, Anna M. MD; Kuzniecky, Ruben MD; Knowlton, Robert C. MD; Cascino, Gregory D. MD; Jackson, Graeme MBBS, FRACP, PhD; Pardoe, Heath R. PhD; for the Human Epilepsy Project Investigators
doi : 10.1212/WNL.0000000000201125
Identification of an epileptogenic lesion on structural neuroimaging in individuals with focal epilepsy is important for management and treatment planning. The objective of this study was to determine the frequency of MRI-identified potentially epileptogenic structural abnormalities in a large multicenter study of adolescent and adult patients with newly diagnosed focal epilepsy.
D313Y Variant in Fabry Disease: A Systematic Review and Meta-analysis.
Palaiodimou, Lina MD *; Stefanou, Maria-Ioanna MD *; Bakola, Eleni MD; Papadopoulou, Marianna MD; Kokotis, Panagiotis MD; Vrettou, Agathi-Rosa MD; Kapsia, Eleni MD; Petras, Dimitrios MD; Anastasakis, Aris MD; Xifaras, Nikolaos MD; Karachaliou, Eleni MD; Touloumi, Giota MD; Vlachopoulos, Charalambos MD; Boletis, Ioannis N. MD; Giannopoulos, Sotirios MD; Tsivgoulis, Georgios MD +; Zompola, Christina MD +
doi : 10.1212/WNL.0000000000201102
There is accumulating evidence in the literature indicating a strong correlation between Fabry disease (FD) phenotypes and specific sequence variations in the Galactosidase Alpha (GLA) gene.
Health-Related Quality of Life in Adults With Classical Infratentorial Superficial Siderosis: A Cross-sectional Study.
Kharytaniuk, Natallia MRCS(ENT), MRCS(I), MCh; Mazaheri, Amir Ala MSc; Pavlou, Menelaos MSc; Werring, David J. FRCP, PhD; Bamiou, Doris-Eva MD, MSc, FRCP, PhD
doi : 10.1212/WNL.0000000000201115
Infratentorial superficial siderosis (iSS) is a rare but disabling neurologic condition characterized by progressive hearing loss and balance and mobility problems. The functional decline in these neurologic domains with iSS progression is likely to adversely affect health-related quality of life (HRQoL). We studied the HRQoL of adults with iSS using 2 common generic HRQoL measures (Health Utilities Index Mark III [HUI3] and EuroQoL EQ5D [5 Level]) to determine the most affected domains and evaluate the association between HRQoL scores and disease duration.
Role of Calcitonin Gene-Related Peptide on the Gastrointestinal Symptoms of Migraine-Clinical Considerations: A Narrative Review.
Ailani, Jessica MD; Kaiser, Eric A. MD, PhD; Mathew, Paul G. MD; McAllister, Peter MD; Russo, Andrew F. PhD; Velez, Christopher MD; Ramajo, Angela Pozo PhD; Abdrabboh, Ahmad PharmD, MPH; Xu, Cen PhD; Rasmussen, Soeren MD; Tepper, Stewart J. MD
doi : 10.1212/WNL.0000000000201332
AB Calcitonin gene-related peptide (CGRP) is involved in several of the pathophysiologic processes underpinning migraine attacks. Therapies that target CGRP or its receptor have shown efficacy as preventive or acute treatments for migraine.
Journal Club: Neurofilament Light Chain Levels in Anti-NMDAR Encephalitis and Primary Psychiatric Psychosis.
Deerhake, M. Elizabeth MD, PhD; Giarraputo, James MD; Gupta, Megha MD; Eckstein, Christopher MD
Pearls & Oy-sters: Tumefactive Demyelinating Lesions With MOG Antibodies Preceding Late Infantile Metachromatic Leukodystrophy.
Olive-Cirera, Gemma MD; Martinez-Gonzalez, Maria Jesus MD; Armangue, Thais MD, PhD
doi : 10.1212/WNL.0000000000201230
AB The development of acute neurologic dysfunction associated with tumefactive demyelinating lesions and mild diffuse involvement of the corpus callosum has been described in children as a sentinel event that may allow diagnosis of juvenile metachromatic leukodystrophy (MLD) at an early and potentially treatable stage.
Teaching Video NeuroImage: Subacute Cerebellar Ataxia in an Adolescent With Antibodies Against Metabotropic Glutamate Receptor Type 1.
Goh, LiTing MBBS; Wang, Furene Sijia; Han, Velda Xinying MRCPCH; Lin, Jeremy Bingyuan MRCPCH
Teaching Video NeuroImage: Slow Axial Myoclonus in Subacute Sclerosing Panencephalitis.
Gupta, Dhananjay DM; Gupta, Haripriya MBBS; Patel, Anuja BPT; Dugani, Pooja DM; Pradeep, R. DM; Mehta, Anish DM; Javali, Mahendra DM; Acharya, Purshottam T. DM; Srinivasa, Rangasetty DM
Editors' Note: Impact of the COVID-19 Pandemic on Epilepsy Center Practice in the United States.
Siegler, James E. MD; Galetta, Steven MD, FAAN
Reader Response: Impact of the COVID-19 Pandemic on Epilepsy Center Practice in the United States.
Saluja, Alvee; Parihar, Jasmine; Dhamija, Rajinder K.
Author Response: Impact of the COVID-19 Pandemic on Epilepsy Center Practice in the United States.
Ahrens, Stephanie M.
Editors' Note: NfL as Analogue of C-Reactive Protein in Neurologic Diseases: Instructions for Use.
Siegler, James E. MD; Galetta, Steven MD, FAAN
Reader Response: NfL as Analogue of C-Reactive Protein in Neurologic Diseases: Instructions for Use.
Ziemssen, Tjalf
Author Response: NfL as Analogue of C-Reactive Protein in Neurologic Diseases: Instructions for Use.
Parnetti, Lucilla; Gaetani, Lorenzo
