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Prevalence and risk factors for antibiotic utilization in Chinese children
Shasha Guo, Qiang Sun, Xinyang Zhao, Liyan Shen and Xuemei Zhen
doi : 10.1186/s12887-021-02706-z
BMC Pediatrics 2021 21:255
Antibiotic resistance poses a significant threat to public health globally. Irrational utilization of antibiotics being one of the main reasons of antibiotic resistant. Children as a special group, there's more chance of getting infected. Although most of the infection is viral in etiology, antibiotics still are the most frequently prescribed medications for children. Therefore, high use of antibiotics among children raises concern about the appropriateness of antibiotic prescribing. This systematic review aims to measuring prevalence and risk factors for antibiotic utilization in children in China.
A Chinese patient with developmental and epileptic encephalopathies (DEE) carrying a TRPM3 gene mutation: a paediatric case report
Qingyun Kang, Liming Yang, Hongmei Liao, Sai Yang, Xiaojun Kuang, Zeshu Ning, Caishi Liao and Bo Chen
doi : 10.1186/s12887-021-02719-8
BMC Pediatrics 2021 21:256
Developmental and epileptic encephalopathies (DEEs) are a heterogeneous group of chronic encephalopathies characterized by epilepsy with comorbid intellectual disability that are frequently associated with de novo nonsynonymous coding variants in ion channels, cell-surface receptors, and other neuronally expressed genes. Mutations in TRPM3 were identified as the cause of DEE. We report a novel patient with DEE carrying a de novo missense mutation in TRPM3, p.(S1202T); this missense mutation has never been reported.
Restrained eating in Lebanese adolescents: scale validation and correlates
Tracy Boulos Nakhoul, Anthony Mina, Michel Soufia, Sahar Obeid and Souheil Hallit
doi : 10.1186/s12887-021-02728-7
BMC Pediatrics 2021 21:257
Restrained eating disorder is prevalent worldwide across both ethnic and different cultural groups, and most importantly within the adolescent population. Additionally, comorbidities of restrained eating present a large burden on both physical and mental health of individuals. Moreover, literature is relatively scarce in Arab countries regarding eating disorders, let alone restrained eating, and among adolescent populations; hence, the aim of this study was to (1) validate the Dutch Restrained Eating Scale in a sample of Lebanese adolescents and (2) assess factors correlated with restrained eating (RE), while taking body dissatisfaction as a moderator between body mass index (BMI) and RE.
The Great Gut Mimicker: A case report of MIS-C and appendicitis clinical presentation overlap in a teenage patient
Michelle Hwang, Kelsey Wilson, Lisa Wendt, Joshua Pohlman, Emily Densmore, Caitlin Kaeppler, Kyle Van Arendonk and Sarah Yale
doi : 10.1186/s12887-021-02724-x
BMC Pediatrics 2021 21:258
Abdominal pain and other gastrointestinal symptoms are common presenting features of multisystem inflammatory syndrome in children (MIS-C) and can overlap with infectious or inflammatory abdominal conditions, making accurate diagnosis challenging.
UGT1A1 mutation association with increased bilirubin levels and severity of unconjugated hyperbilirubinemia in ABO incompatible newborns of China
Hui Yang, Fen Lin, Zi-kai Chen, Lin Zhang, Jia-Xin Xu, Yong-Hao Wu, Jing-Ying Gu, Yu-Bin Ma, Jian-Dong Li and Li-Ye Yang
doi : 10.1186/s12887-021-02726-9
BMC Pediatrics 2021 21:259
Neonatal hyperbilirubinemia causing jaundice is common in East Asian population. Uridine diphosphate glucuronosyltransferase isoenzyme (UGT1A1) glucuronidates bilirubin and converts the toxic form of bilirubin to its nontoxic form.
Coughing children in family practice and primary care: a systematic review of prevalence, aetiology and prognosis
Milena Bergmann, J?rg Haasenritter, Dominik Beidatsch, Sonja Schwarm, Kaja H?rner, Stefan B?sner, Paula Grevenrath, Laura Schmidt, Annika Viniol, Norbert Donner-Banzhoff and Annette Becker
doi : 10.1186/s12887-021-02739-4
BMC Pediatrics 2021 21:260
For evidence-based decision making, primary care physicians need to have specific and reliable information on the pre-test probabilities of underlying diseases and a symptom’s course. We performed a systematic review of symptom-evaluating studies in primary care, following three research questions: (1) What is the prevalence of the symptom cough in children consulting primary care physicians? (2) What are the underlying aetiologies of cough and the respective frequencies? (3) What is the prognosis of children with cough?
Neonatal hypoxic-ischemic encephalopathy diagnosis and treatment: a National Survey in China
Zheng Wang, Peng Zhang, Wenhao Zhou, Shiwen Xia, Wei Zhou, Xiaoyu Zhou, Xiuyong Cheng, Yuan Shi, Zhenlang Lin, Dongli Song and Guoqiang Cheng
doi : 10.1186/s12887-021-02737-6
BMC Pediatrics 2021 21:261
Neonatal hypoxic-ischemic encephalopathy (HIE) affects as many as 100,000 infants each year in China. Therapeutic hypothermia reduces HIE related mortality and long-term neurodevelopmental disabilities. National guidelines for HIE management were published a decade ago. This study aimed to investigate the current status of HIE diagnosis and treatment in China.
Gender-role behaviour and gender identity in girls with classical congenital adrenal hyperplasia
Sumudu Nimali Seneviratne, Umesh Jayarajah, Shamaali Gunawardana, Malik Samarasinghe and Shamya de Silva
doi : 10.1186/s12887-021-02742-9
BMC Pediatrics 2021 21:262
Girls with classical congenital adrenal hyperplasia (CAH) are exposed to excess fetal adrenal androgens in-utero, and often born with masculinised genitalia. They are conventionally reared as females, but show more “boyish” gender-role behaviour (GRB) and gender-identity (GI) issues in childhood and adolescence. Male-rearing is also reported mainly due to delayed treatment and/or socio-cultural factors. We compared GRB/GI in girls with CAH with healthy age matched children, and explored for associations with socio-demographic and diagnosis/treatment related factors.
A pilot study to evaluate the role of circulation CD4+ CCR6+ CRTh2+ cell in predicting risk of asthma in wheezing children
Jingyang Li, Jinhong Wu, Haipei Liu, Li Hua, Quanhua Liu, Dingzhu Fang, Yi Chen, Ruoxu Ji, Jianhua Zhang and Wenwei Zhong
doi : 10.1186/s12887-021-02746-5
BMC Pediatrics 2021 21:263
Wheezing is common in younger children and often related to viral infection. It is lack of reliable indicators for asthma prediction.
Prevalence and predictive factors of transient and permanent congenital hypothyroidism in Fars province, Iran
Ashkan Habib, Alireza Shojazadeh, Mohadeseh Molayemat, Asadollah Habib, Marjan Jeddi, Rita Arabsolghar, Mitra Nahas, Nazila Rahimi and Fariba Moradi Ardekani
doi : 10.1186/s12887-021-02729-6
BMC Pediatrics 2021 21:264
There is no data on the number as well as the prevalence of congenital hypothyroidism (CH) in the Fars province. Hence, we designed this study to analyze the latest data and the possible predictive factors on transient and permanent CH in this province.
Infected simple renal cyst due to Streptococcus pneumoniae rapidly diagnosed by the melting temperature mapping method: a case report
Yoji Uejima, Hideki Niimi, Reiko Kato, Mihoko Furuichi, Satoshi Sato, Isao Kitajima, Yutaka Kawano, Tsutomu Oh-Ishi, Hiroshi Kawashima and Eisuke Suganuma
doi : 10.1186/s12887-021-02736-7
BMC Pediatrics 2021 21:265
Spontaneous infection of preexisting solitary renal cysts has been documented in adults but is extremely rare in children. To date, no cases of simple renal cysts infected with Streptococcus pneumoniae have been described. Recently, reports have described the diagnosis of bacterial infection using the 16 S rRNA gene as well as the accompanying antimicrobial stewardship for microorganisms that are difficult to culture and for culture-negative cases after preceding antibacterial administration.
The determinants of 5th minute low Apgar score among newborns who delivered at public hospitals in Hawassa City, South Ethiopia
Alex Yeshaneh, Andargachew Kassa, Zemenu Yohannes Kassa, Daniel Adane, Yohannes Fikadu, Semahegn Tilahun Wassie, Biresaw Wassihun Alemu, Mesfin Tadese, Solomon Shitu and Haimanot Abebe
doi : 10.1186/s12887-021-02745-6
BMC Pediatrics 2021 21:266
Newborn morbidity and mortality are forecasted using the Apgar scores. Obstetricians worldwide have used the Apgar score for more than half a century for the assessment of immediate newborn conditions. It is a simple and convenient evaluation system that offers a standardized and effective assessment of newborn infants. Neonatal morbidity and mortality can be reduced if high-risk neonates are identified and managed adequately. This study aimed to assess the determinants of 5th minute low Apgar score among newborns at Public hospitals in Hawassa city, South Ethiopia.
COVID-19 related multisystem inflammatory syndrome in children (MIS-C): a case series from a tertiary care pediatric hospital in Qatar
Mohammad Rubayet Hasan, Khaled Al Zubaidi, Karim Diab, Yahia Hejazi, Sharon Bout-Tabaku, Buthaina Al-Adba, Eman Al Maslamani, Mohammad Janahi, Diane Roscoe, Andres Perez Lopez and Patrick Tang
doi : 10.1186/s12887-021-02743-8
BMC Pediatrics 2021 21:267
Multisystem Inflammatory Syndrome in Children (MIS-C) is a severe complication of coronavirus disease 2019 (COVID-19) in children, which is increasingly being reported worldwide. Here we report the first case series of 7 children diagnosed with MIS-C in Qatar.
The application of artificial intelligence methods to gene expression data for differentiation of uncomplicated and complicated appendicitis in children and adolescents - a proof of concept study –
Josephine Reismann, Natalie Kiss and Marc Reismann
doi : 10.1186/s12887-021-02735-8
BMC Pediatrics 2021 21:268
Genome wide gene expression analysis has revealed hints for independent immunological pathways underlying the pathophysiologies of phlegmonous (PA) and gangrenous appendicitis (GA). Methods of artificial intelligence (AI) have successfully been applied to routine laboratory and sonographic parameters for differentiation of the inflammatory manifestations. In this study we aimed to apply AI methods to gene expression data to provide evidence for feasibility.
Early combined rehabilitation intervention to improve the short-term prognosis of premature infants
Yang Liu, Zheng-feng Li, Yun-huan Zhong, Zhi-hui Zhao, Wen-xin Deng, Ling-ling Chen, Bei-bei Liu, Tao-jun Du and Yong Zhang
doi : 10.1186/s12887-021-02727-8
BMC Pediatrics 2021 21:269
To explore the clinical effect of early combined rehabilitation intervention on premature infants in the neonatal intensive care unit (NICU).
Surgical management of patent ductus arteriosus in pre-term infants - a british paediatric surveillance study
A. Warnock, L. Szatkowski, A. Lakshmanan, L. Lee and W. Kelsall
doi : 10.1186/s12887-021-02734-9
BMC Pediatrics 2021 21:270
This study aimed to provide UK data describing the incidence of patent ductus arteriosus (PDA) surgery in the neonatal population, including: pre-ligation management, and outcomes until discharge. We used British Paediatric Surveillance Unit (BPSU) methodology; collecting data via questionnaires for preterm neonates undergoing PDA ligation (PDAL) between 1st Sept 2012 – 30th Sept 2013. Infants born less than 37?weeks gestation, who underwent PDAL prior to discharge home, with no other structural cardiac abnormality, were included. Information collected included: patient demographics, pre and post-operative clinical characteristics, pre-operative medical management, post-operative complications and outcome.
Prevalence of increased transaminases and its association with sex, age, and metabolic parameters in children and adolescents with obesity – a nationwide cross-sectional cohort study
Resthie R. Putri, Thomas Casswall and Emilia Hagman
doi : 10.1186/s12887-021-02747-4
BMC Pediatrics 2021 21:271
Childhood obesity increases the risk of non-alcoholic fatty liver disease marked by elevated alanine aminotransferase (ALT). This study investigated the prevalence of increased ALT in children and adolescents with obesity, and its associations with sex, age, degree of obesity, and metabolic parameters.
Age related gene DST represents an independent prognostic factor for MYCN non-amplified neuroblastoma
Haiwei Wang, Xinrui Wang, Liangpu Xu, Ji Zhang and Hua Cao
doi : 10.1186/s12887-021-02753-6
BMC Pediatrics 2021 21:272
MYCN amplification and age are two critical prognostic factors of pediatric neuroblastoma. Previously, we had revealed the prognosis of MYCN target genes. However, the prognostic effects of age related genes in neuroblastoma are unclear.
Superabsorbent polymer balls as foreign bodies in the nasal cavities of children: our clinical experience
Sai-hong Han, Yong-chao Chen, Zhi-xiong Xian and Yi-shu Teng
doi : 10.1186/s12887-021-02740-x
BMC Pediatrics 2021 21:273
To summarize the clinical diagnosis and treatment of superabsorbent polymer balls as nasal foreign bodies in children.
State-level trends in sudden unexpected infant death and immunization in the United States: an ecological study
Jacqueline Müller-Nordhorn, Konrad Neumann, Thomas Keil, Stefan N. Willich and Sylvia Binting
doi : 10.1186/s12887-021-02733-w
BMC Pediatrics 2021 21:274
Sudden unexpected infant death (SUID) continues to be a major contributor to infant mortality in the United States. The objective was to analyze time trends in SUID and their association with immunization coverage.
Umbilical cord blood hematological parameters reference interval for newborns from Addis Ababa, Ethiopia
Ammanuel Angelo, Girma Derbie, Asrat Demtse and Aster Tsegaye
doi : 10.1186/s12887-021-02722-z
BMC Pediatrics 2021 21:275
Several factors like altitude, age, sex, pregnancy, socioeconomic status, life style and race influence hematological reference interval (RIs), which are critical to support clinical decisions and to interpret laboratory data in research. Currently there are no well-established RIs for cord blood hematological parameters of newborns in Ethiopia. This study aims to generate RIs for umbilical cord blood hematological parameters of newborns from Addis Ababa, Ethiopia.
Normal sonographic liver and spleen dimensions in a central European pediatric population
Stephan Waelti, Tim Fischer, Simon Wildermuth, Sebastian Leschka, Tobias Dietrich, Sabine Guesewell, Pascal Mueller, Michael Ditchfield and Stefan Markart
doi : 10.1186/s12887-021-02756-3
BMC Pediatrics 2021 21:276
Organ size is influenced by a number of factors. Age, height, weight, and ethnicity are known influencing factors. Pediatric populations have changed over time, puberty beginning earlier resulting in a changing growth pattern of their organs. Hence, contemporary charts using local data are considered the most appropriate for a given population. Sonographic charts for liver size for a predominantly Caucasian population are limited, which has implications for clinical practice. The aim of this study was to define a contemporary normative range of liver and spleen sizes for a healthy, predominantly Caucasian population and for all pediatric age groups (0–18?years) and to investigate whether there is a size difference between genders and ethnicities.
Utilizing single-cell RNA sequencing for analyzing the characteristics of PBMC in patients with Kawasaki disease
Xue Fan, Yuhan Zhou, Xin Guo and Mingguo Xu
doi : 10.1186/s12887-021-02754-5
BMC Pediatrics 2021 21:277
Kawasaki disease (KD) is the main cause of acquired heart disease in children and can lead to coronary artery lesions. This present study was designed to analyze the characteristics of KD peripheral blood mononuclear cells (PBMC) through single-cell RNA sequencing (scRNA-seq) and to explore the potential molecular mechanism of KD.
Parental risk factors for congenital diaphragmatic hernia – a large German case-control study
Felicitas Schulz, Ekkehart Jenetzky, Nadine Zwink, Charlotte Bendixen, Florian Kipfmueller, Neysan Rafat, Andreas Heydweiller, Lucas Wessel, Heiko Reutter, Andreas Mueller and Thomas Schaible
doi : 10.1186/s12887-021-02748-3
BMC Pediatrics 2021 21:278
Evidence for periconceptional or prenatal environmental risk factors for the development of congenital diaphragmatic hernia (CDH) is still scarce. Here, in a case-control study we investigated potential environmental risk factors in 199 CDH patients compared to 597 healthy control newborns.
Hydrocele in a case of atypical Kawasaki disease: case report and review of diagnostic criteria
Y. R. L. Tan, C.-T. C. Chow, I. Ganesan and H. M. E. Leow
doi : 10.1186/s12887-021-02758-1
BMC Pediatrics 2021 21:279
Kawasaki Disease (KD) is a self-limiting vasculitis of unknown etiology. Although there are well-recognized clinical features associated with classic KD, there have been increasing numbers of atypical clinical presentations with increased dependence on the American Heart Association diagnostic algorithm for incomplete KD.
Prediction of arrhythmia after intervention in children with atrial septal defect based on random forest
Hongxiao Sun, Yuhai Liu, Bo Song, Xiaowen Cui, Gang Luo and Silin Pan
doi : 10.1186/s12887-021-02744-7
BMC Pediatrics 2021 21:280
Using random forest to predict arrhythmia after intervention in children with atrial septal defect.
Reintubation rates after extubation to different non-invasive ventilation modes in preterm infants
Alaa Masry, Nuha A. M. A. Nimeri, Olfa Koobar, Samer Hammoudeh, Prem Chandra, Einas E. Elmalik, Amr M. Khalil, Nasir Mohammed, Nazla A. M. Mahmoud, Lisa J. Langtree and Mohammad A. A. Bayoumi
doi : 10.1186/s12887-021-02760-7
BMC Pediatrics 2021 21:281
Respiratory Distress Syndrome (RDS) is a common cause of neonatal morbidity and mortality in premature newborns. In this study, we aim to compare the reintubation rate in preterm babies with RDS who were extubated to Nasal Continuous Positive Airway Pressure (NCPAP) versus those extubated to Nasal Intermittent Positive Pressure Ventilation (NIPPV).
Implications of ACMG guidelines to identify high-risk acute lymphoblastic leukemia patients with hereditary cancer susceptibility syndromes (HCSS) in a highly consanguineous population
Sara Aslam, Shabana and Mehboob Ahmed
doi : 10.1186/s12887-021-02749-2
BMC Pediatrics 2021 21:282
Hereditary cancer susceptibility syndrome (HCSS) contributes to the cancer predisposition at an early age, therefore, identification of HCSS has found to be crucial for surveillance, managing therapeutic interventions and refer the patients and their families for genetic counselling. The study aimed to identify ALL patients who meet the American College of Medical Genetics (ACMG) criteria and refer them for the genetic testing for HCSS as hereditary leukemia and hematologic malignancy syndrome, and to elucidate the significance of high consanguinity with the prevalence of inherited leukemia in Pakistani population.
Accuracy of pre-operative fistula diagnostics in anorectal malformations
Louise Tofft, Martin Sal?, Einar Arnbj?rnsson and Pernilla Stenstr?m
doi : 10.1186/s12887-021-02761-6
BMC Pediatrics 2021 21:283
Surgical safety during posterior sagittal anorectal plasty (PSARP) for anorectal malformations (ARM) depends on accurate pre-operative fistula localization. This study aimed to evaluate accuracy of pre-operative fistula diagnostics.
Epidemiological and clinical characteristics of respiratory viruses in 4403 pediatric patients from multiple hospitals in Guangdong, China
Yajie Zhang, Lin Qiao, Jinxiu Yao, Nan Yu, Xiaoping Mu, Shengqi Huang, Bo Hu, Weixuan Li, Feng Qiu, Fangyin Zeng, Cong Chen, Yuqiu Zhou, Bashan Zhang, Tian Cai, Weijia Wang, Xianjin Wu
doi : 10.1186/s12887-021-02759-0
BMC Pediatrics 2021 21:284
Acute respiratory infections (ARI) cause considerable morbidity and mortality worldwide, especially in children. Unfortunately, there are limited multi-center data on common viral respiratory infections in south China.
Patterns of risk exposure in first 1,000 days of life and health, behavior, and education-related problems at age 4.5: evidence from Growing Up in New Zealand, a longitudinal cohort study
Jan L. Wallander, Sarah Berry, Polly Atatoa Carr, Elizabeth R. Peterson, Karen E. Waldie, Emma Marks, Stephanie D’Souza and Susan M. B. Morton
doi : 10.1186/s12887-021-02652-w
BMC Pediatrics 2021 21:285
Children who are high priority candidates for early intervention need to be identified to reduce their risk for experiencing problems in development. Those exposed to multiple risk factors are more likely to exhibit problems in development than those exposed to a single or no risk factor. We examined the longitudinal associations between persistence and timing of exposure to cumulative risk (CR) on three occasions by age 2 and problems in development at age 4.5 in health, behavior, and education-related domains.
Patent ductus arteriosus, systemic NT-proBNP concentrations and development of bronchopulmonary dysplasia in very preterm infants: retrospective data analysis from a randomized controlled trial
Solomiia Potsiurko, Dmytro Dobryanskyy and Lesya Sekretar
doi : 10.1186/s12887-021-02750-9
BMC Pediatrics 2021 21:286
Patent ductus arteriosus (PDA) is a common complication in very preterm infants. It is known that there is an association between PDA and development of bronchopulmonary dysplasia (BPD) or death before the postmenstrual age (PMA) of 36?weeks, but this association remains one of the most controversial aspects of the problem. The study aimed to evaluate the relationship between PDA, serum NT-proBNP levels at 2–3 and 8–9?days of life, and BPD/death in very preterm infants.
Risk of Mycoplasma pneumoniae-related hepatitis in MP pneumonia pediatric patients: a predictive model construction and assessment
Yuna Bi, Yan Ma, Jinhua Zhuo, Lili Zhang, Liyan Yin, Hongling Sheng, Jie Luan and Tao Li
doi : 10.1186/s12887-021-02732-x
BMC Pediatrics 2021 21:287
A predictive model for risk of Mycoplasma pneumoniae (MP)-related hepatitis in MP pneumonia pediatric patients can improve treatment selection and therapeutic effect. However, currently, no predictive model is available.
Anxiety among Lebanese adolescents: scale validation and correlates
Georges Merhy, Vanessa Azzi, Pascale Salameh, Sahar Obeid and Souheil Hallit
doi : 10.1186/s12887-021-02763-4
BMC Pediatrics 2021 21:288
The Lebanese population has undergone several conflicts and were the most afflicted by shelling and chaos during the civil war from 1975 to 1990, or even by displacement, bereavement, emigration, family separations, not to mention the economic crises that have hit the country since 2019 under which young adults are still succumbing. Our study aims to validate the Lebanese Anxiety Scale and assess correlates of anxiety among Lebanese adolescents.
The role of early-onset-sepsis in the neurodevelopment of very low birth weight infants
Tjark Ortgies, Michael Rullmann, Dorothée Ziegelh?fer, Annett Bl?ser and Ulrich H. Thome
doi : 10.1186/s12887-021-02738-5
BMC Pediatrics 2021 21:289
The study investigated a putative association between early-onset-sepsis (EOS) and poor neurodevelopmental outcomes at 2?years corrected age in very low birth weight infants.
Prevalence of acute diarrhea and associated factors among children under five in semi-urban areas of northeastern Ethiopia
Tarikuwa Natnael, Mistir Lingerew and Metadel Adane
doi : 10.1186/s12887-021-02762-5
BMC Pediatrics 2021 21:290
Diarrheal disease is still one of the most common causes of mortality and morbidity in children under five in developing countries, including Ethiopia. Lack of specific data on the prevalence of acute diarrhea and associated factors among under-five children in the semi-urban areas of Gelsha, found in northeastern Ethiopia’s South Wollo zone, remains a major gap. Therefore, this study was designed to provide data that is important for proper planning of intervention measures to reduce the problem in this area.
Identification of a novel heterozygous SPTB mutation by whole genome sequencing in a Chinese patient with hereditary spherocytosis and atrial septal defect: a case report
Zhanhui Du, Gang Luo, Kuiliang Wang, Zhen Bing and Silin Pan
doi : 10.1186/s12887-021-02771-4
BMC Pediatrics 2021 21:291
Hereditary spherocytosis (HS) is a common inherited red blood cell membrane disorder characterized by an abnormal increase of spherocytes in peripheral blood. SPTB gene mutation is one of the most common causes of HS; however, few cases of HS resulting from SPTB mutation in the Chinese population have been reported so far.
MR-Proadrenomedullin as biomarker of renal damage in urinary tract infection in children
Rafael Pe?alver Penedo, Marta Rupérez Lucas, Luis Antonio ?lvarez-Sala Walther, Alicia Torregrosa Benavent, Mar?a Luisa Casas Losada, Luis Ba?uelos Andrio, Ana Belén Rebolledo Poves and Mercedes Bueno Campa?a
doi : 10.1186/s12887-021-02765-2
BMC Pediatrics 2021 21:292
Midregional-proadrenomedullin (MR-proADM) is a useful prognostic peptide in severe infectious pathologies in the adult population. However, there are no studies that analyze its utility in febrile urinary tract infection (fUTI) in children. An accurate biomarker would provide an early detection of patients with kidney damage, avoiding other invasive tests like renal scintigraphy scans. Our objective is to study the usefulness of MR-proADM as a biomarker of acute and chronic renal parenchymal damage in fUTI within the pediatric population.
Report of two siblings with spondylodysplastic Ehlers-Danlos syndrome and B4GALT7 deficiency
Delia Lorenz, Wolfram Kress, Ann-Kathrin Zaum, Christian P. Speer and Helge Hebestreit
doi : 10.1186/s12887-021-02767-0
BMC Pediatrics 2021 21:293
The spondylodysplastic Ehlers-Danlos subtype (OMIM #130070) is a rare connective tissue disorder characterized by a combination of connective tissue symptoms, skeletal features and short stature. It is caused by variants in genes encoding for enzymes involved in the proteoglycan biosynthesis or for a zinc transporter.
Comparison of a pediatric practice-based therapy and an interdisciplinary ambulatory treatment in social pediatric centers for migraine in children: a nation-wide randomized-controlled trial in Germany: “moma – modules on migraine activity”
Mirjam N. Landgraf, Florian Heinen, Lucia Gerstl, Christine Kainz, Ruth Ruscheweyh, Andreas Straube, Joerg Scheidt, Sabine von Mutius, Viola Obermeier and Ruediger von Kries
doi : 10.1186/s12887-021-02757-2
BMC Pediatrics 2021 21:294
Migraine is common in childhood, peaks in adolescents and persists into adulthood in at least 40% of patients. There is need for early interventions to improve the burden of disease and, if possible, reduce chronification. The aim of the project is to compare two types of ambulatory treatment strategies regarding their effect on headache days and quality of life in 6 to 11?year old children with migraine: 1) the routine care in pediatricians’ practices (intervention group A) and 2) a structured interdisciplinary multimodal intervention administered at social pediatric centers (intervention group B).
BCL-xL is correlated with disease severity in neonatal infants with early sepsis
Wu Wenshen, Peng Qi, Huang Tianli, Liao Jinfeng and Li Ning
doi : 10.1186/s12887-021-02764-3
BMC Pediatrics 2021 21:295
Sepsis is the most common cause of morbidity and mortality in neonatal infants. It is essential to find an accurate and sensitive biomarker to confirm and treat neonatal sepsis in order to decrease the rate of mortality. The aim of this study was to investigate the association between disease severity in patients with sepsis and TNF-?, B cell lymphoma-extra-large (BCL-xL), and serum Mitochondrial membrane potential (MMP).
