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Semisolid Extrusion 3D Printing of Propranolol Hydrochloride Gummy Chewable Tablets: an Innovative Approach to Prepare Personalized Medicine for Pediatrics

Chunxiao Zhu, Yang Tian, Enhui Zhang, Xiang Gao, Hui Zhang, Nan Liu, Xiaolu Han, Yong Sun, Zengming Wang & Aiping Zheng

doi : 10.1208/s12249-022-02304-x

Volume 23, issue 5, July 2022

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Correction: Oxidative Stability in Lipid Formulations: A Review of the Mechanisms, Drivers, and Inhibitors of Oxidation

Jasmine Musakhanian, Jean-David Rodier & Masumi Dave

doi : 10.1208/s12249-022-02318-5

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Dry Powder Inhalers Based on Chitosan-Mannitol Binary Carriers: Effect of the Powder Properties on the Aerosolization Performance

Ziyu Zhao, Guanlin Wang, Zhengwei Huang, Ying Huang, Hangping Chen, Xin Pan & Xuejuan Zhang

doi : 10.1208/s12249-022-02287-9

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Chitosan-Coated Liposomes: The Strategy to Reduce Intestinal Toxicity and Improve Bioavailability of Oral Vinorelbine

Chen Guo, Xichun Zhu, Haoyang Yuan, Haoyu Liu, Yu Zhang, Tian Yin, Haibing He, Jingxin Gou & Xing Tang

doi : 10.1208/s12249-022-02308-7

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Correction to: Fabrication of Three-Dimensional Bioactive Composite Scaffolds for Hemostasis and Wound Healing

Divya Tripathi, Arpit Sharma, Priyanka Tyagi, Chandra Shekhar Beniwal, Gaurav Mittal, Abhinav Jamini, Harpal Singh & Amit Tyagi

doi : 10.1208/s12249-022-02317-6

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Ionic Liquids Assisted Topical Drug Delivery for Permeation Enhancement: Formulation Strategies, Biomedical Applications, and Toxicological Perspective

Prerana D. Navti, Abhijeet Pandey, Ajinkya Nitin Nikam, Bharath Singh Padya, Guruprasad Kalthur, Kunnatur B. Koteshwara & Srinivas Mutalik

doi : 10.1208/s12249-022-02313-w

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Formulation and Pharmacokinetic Evaluation of Ethyl Cellulose/HPMC-Based Oral Expandable Sustained Release Dosage of Losartan Potassium

Taha Umair Wani, Abdul Aala Fazli, Syed Naiem Raza, Nisar Ahmad Khan & Faheem A. Sheikh

doi : 10.1208/s12249-022-02295-9

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Development and Optimization of Osimertinib-loaded Biodegradable Polymeric Nanoparticles Enhance In-vitro Cytotoxicity in Mutant EGFR NSCLC Cell Models and In-vivo Tumor Reduction in H1975 Xenograft Mice Models

Sanjay Kumar K & Asha deepti Choppala

doi : 10.1208/s12249-022-02314-9

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SIRT 1 Activator Loaded Inhaled Antiangiogenic Liposomal Formulation Development for Pulmonary Hypertension

Sagar Dhoble & Vandana Patravale

doi : 10.1208/s12249-022-02312-x

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Gastroretentive Sustained-Release Tablets Combined with a Solid Self-Micro-Emulsifying Drug Delivery System Adsorbed onto Fujicalin®

Yoshihiro Omachi 

doi : 10.1208/s12249-022-02311-y

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Development of Optimized Sumatriptan–Prochlorperazine Combined Orodispersible Films Without Disintegrant: in vitro, ex vivo and in vivo Characterization

Sana Javed, Amjad Hussain, Pervaiz Akhtar Shah, Syed Atif Raza, Ubaid Ullah Anwer, Rahat Shamim, Fatima Rasool, Muhammad Ahsan Hafiz & Nadeem Irfan Bukhari

doi : 10.1208/s12249-022-02307-8

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Retraction Note: Bimatoprost-Loaded Silica Shell–Coated Nanoparticles-Laden Soft Contact Lenses to Manage Glaucoma: In Vitro and In Vivo Studies

He Xiaojie, Jiang Fagang, Jing Jun, Wang Chunfang, Li Chengquan & Wang Xinghua

doi : 10.1208/s12249-022-02306-9

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Correction to: Puerarin-Loaded PLGA Nanoparticles: Optimization Processes of Preparation and Anti-Alcohol Intoxication Effects in Mice

Qin Han, Kejie Chen, Cunli Su, Xin Liu & Xiaoming Luo

doi : 10.1208/s12249-022-02309-6

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Correction to: Co-spray Drying Drugs with Aqueous Polymer Dispersions (APDs)—a Systematic Review

Nizar Al-Zoubi, Ioannis Partheniadis, Ahmad Aljaberi & Ioannis Nikolakakis

doi : 10.1208/s12249-022-02305-w

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Nano-strategies as Oral Drug Delivery Platforms for Treatment of Cancer: Challenges and Future Perspectives

Sheikh Shahnawaz Quadir, Vinod Saharan, Deepak Choudhary, Harish, C. P. Jain & Garima Joshi

doi : 10.1208/s12249-022-02301-0

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Oxidative Stability in Lipid Formulations: a Review of the Mechanisms, Drivers, and Inhibitors of Oxidation

Jasmine Musakhanian, Jean-David Rodier & Masumi Dave

doi : 10.1208/s12249-022-02282-0

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Current Status and Challenges of Analytical Methods for Evaluation of Size and Surface Modification of Nanoparticle-Based Drug Formulations

Yuki Takechi-Haraya, Takashi Ohgita, Yosuke Demizu, Hiroyuki Saito, Ken-ichi Izutsu & Kumiko Sakai-Kato

doi : 10.1208/s12249-022-02303-y

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Venlafaxine HCl Encapsulated in Niosome: Green and Eco-friendly Formulation for the Management of Pain

Seyyed Mohammad Hassan Hashemi, Reza Enayatifard, Jafar Akbari, Majid Saeedi, Mohammad Seyedabadi, Katayoun Morteza-Semnani, Amirhossein Babaei, Kofi Asare-Addo & Ali Nokhodchi

doi : 10.1208/s12249-022-02299-5

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Enhancing Atorvastatin In Vivo Oral Bioavailability in the Presence of Inflammatory Bowel Disease and Irritable Bowel Syndrome Using Supercritical Fluid Technology Guided by wbPBPK Modeling in Rat and Human

Mo’tasem M. Alsmadi, Nour M. AL-Daoud, Rana M. Obaidat & Niazy A. Abu-Farsakh

doi : 10.1208/s12249-022-02302-z

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Preparation of 2-Methoxyestradiol Self-emulsified Drug Delivery System and the Effect on Combination Therapy with Doxorubicin Against MCF-7/ADM Cells

Chuan Yu, Chen Li, Haofeng Pan, Tian Li & Suna He

doi : 10.1208/s12249-022-02298-6

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Choline-Amino Acid-Derived Bio-ionic Liquids for Solubility Enhancement of Zafirlukast

Namrata Gaikwad, Swapna Kudal & Amelia M. Avachat

doi : 10.1208/s12249-022-02296-8

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Spray Pattern and Plume Geometry Testing and Methodology: An IPAC-RS Working Group Overview

Sherryl Baxter, Ben Myatt, Stephen Stein, Adrian Parkinson, Frank Chambers, Bill Doub, Jernej Grmas, Julie Suman, Keith Miller, Biswadip Sinha, Linda Liao, Ian Carter, Dino Farina, Segolene Sarrailh, Manfred Fischer, Declan Walsh & Lee Nagao

doi : 10.1208/s12249-022-02278-w

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Effect of Different Molecular Weights of Chitosan on Formulation and Evaluation of Allopurinol-Loaded Nanoparticles for Kidney Targeting and in Management of Hyperuricemic Nephrolithiasis

Gurpreet Kandav, Dinesh Chandra Bhatt & Shailendra Kumar Singh

doi : 10.1208/s12249-022-02297-7

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Effect of Different Absorption Enhancers on the Nasal Absorption of Nalmefene Hydrochloride

Ting Zhang, Meng Li, Xiaolu Han, Guangjun Nie & Aiping Zheng

doi : 10.1208/s12249-022-02252-6

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Nanoemulsions Containing Megestrol Acetate: Development, Characterization, and Stability Evaluation

Tahir Emre Yalcin, Emre Tuncel, Cigdem Yucel & Figen Tirnaksiz

doi : 10.1208/s12249-022-02289-7

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Stiripentol Enteric Solid Dispersion-Loaded Effervescent Tablets: Enhanced Dissolution, Stability, and Absorption

Ying Wang, Siyuan Xu, Ziyue Xiao, Yuxin Jiang, Qi Jiang, Jun Li & Wei He

doi : 10.1208/s12249-022-02261-5

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Co-spray Drying Drugs with Aqueous Polymer Dispersions (APDs)—a Systematic Review

Nizar Al-Zoubi, Ioannis Partheniadis, Ahmad Aljaberi & Ioannis Nikolakakis

doi : 10.1208/s12249-022-02293-x

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3D Bioprinting of Human Hollow Organs

Nabanita Panja, Sumana Maji, Sabyasachi Choudhuri, Kazi Asraf Ali & Chowdhury Mobaswar Hossain

doi : 10.1208/s12249-022-02279-9

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Preparation and Spectroscopic Characterization of Inclusion Complexes of 3D Ball-Milled Rifampicin with β-cyclodextrin and γ-cyclodextrin

Yutaka Inoue, Mari Shigematsu, Takanori Komatsu, Toshio Oguchi, Florencio Jr Arce & Gerard Lee See

doi : 10.1208/s12249-022-02290-0

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Transformation of Ritonavir Nanocrystal Suspensions into a Redispersible Drug Product via Vacuum Drum Drying

Barbara V. Sch?nfeld, Ulrich Westedt, Benjamin-Luca Keller & Karl G. Wagner

doi : 10.1208/s12249-022-02283-z

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The Molecular Mechanism of Propylene Glycol Monocaprylate on Skin Retention: Probing the Dual Roles on the Molecular Mobility and Collagen Connection in Roflumilast Cream

Yuxue Liu, Chao Liu, Wenxuan Jia, Wenwen Xu, Peng Quan & Liang Fang

doi : 10.1208/s12249-022-02284-y

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Optimization of DOTAP/chol Cationic Lipid Nanoparticles for mRNA, pDNA, and Oligonucleotide Delivery

Mengwei Sun, Utkarsh J. Dang, Yuhao Yuan, Alexandra Maria Psaras, Ositomiwa Osipitan, Tracy A. Brooks, Fake Lu & Anthony J. Di Pasqua

doi : 10.1208/s12249-022-02294-w

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Self-Emulsifying Systems for Delivery of Bioactive Compounds from Natural Origin

Mariana Carla de Oliveira & Marcos Luciano Bruschi

doi : 10.1208/s12249-022-02291-z

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Pharmacotechnical Evaluation by SeDeM Expert System to Develop Orodispersible Tablets

Monica R. P. Rao, Sharwari Sapate & Ashwini Sonawane

doi : 10.1208/s12249-022-02285-x

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A Non-destructive Quantitative Transmission Raman Spectroscopy Method for Active Pharmaceutical Ingredient in Drug Product In-Use Samples Prepared in Dosing Vehicles

Gregory Doddridge, Edwin Hong, David Cheng Thiam Tan & Yemin Liu

doi : 10.1208/s12249-022-02286-w

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Co-crystallization of Amoxicillin Trihydrate and Potassium Clavulanate Provides a Promising Approach for Preparation of Sustained-Release Microspheres

Rana Obaidat, Batool Al-Ghzawi, Bashar Al-Taani & Nizar Al-Shar’i

doi : 10.1208/s12249-022-02273-1

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Sorafenib-Loaded PLGA-TPGS Nanosystems Enhance Hepatocellular Carcinoma Therapy Through Reversing P-Glycoprotein-Mediated Multidrug Resistance

Maomao Tang, Yuzhe Huang, Xiao Liang, Yaotian Tao, Ning He, Zhenbao Li, Jian Guo & Shuangying Gui

doi : 10.1208/s12249-022-02214-y

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Formulation and Evaluation of Topical Linezolid Nanoemulsion for Open Incision Wound in Diabetic Animal Model

Faheem Haider, Barkat Ali Khan & Muhammad Khalid Khan

doi : 10.1208/s12249-022-02288-8

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Spray-Dried Microspheres of Carboplatin: Technology to Develop Longer-Acting Injectable with Improved Physio-Chemical Stability, Toxicity, and Therapeutics

Shubham Thakur, Rasdeep Kour, Satwinderjeet Kaur & Subheet Kumar Jain

doi : 10.1208/s12249-022-02281-1

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Evaluation of Piperine as Natural Coformer for Eutectics Preparation of Drugs Used in the Treatment of Cardiovascular Diseases

Andrea Mariela Araya-Sibaja 

doi : 10.1208/s12249-022-02270-4

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Assessment of Resonant Acoustic Mixing for Low-Dose Pharmaceutical Powder Blends

Shashwat Gupta, Yu Elaine Pu, Minglu Li, Zhengmao Li & Juan G. Osorio

doi : 10.1208/s12249-022-02262-4

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Silymarin-Encapsulated Xanthan Gum–Stabilized Selenium Nanocarriers for Enhanced Activity Against Amyloid Fibril Cytotoxicity

Vanshul Saini, Ajit Singh, Rahul Shukla, Keerti Jain & A. K. Yadav

doi : 10.1208/s12249-022-02274-0

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Drotaverine Hydrochloride Superporous Hydrogel Hybrid System: a Gastroretentive Approach for Sustained Drug Delivery and Enhanced Viscoelasticity

Michael M. Farag, Mina M. Louis, Alia A. Badawy, Demiana I. Nessem & Nevine S. Abd Elmalak

doi : 10.1208/s12249-022-02280-2

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Design and Development of Solid SMEDDS and Liquisolid Formulations of Lovastatin, for Improved Drug Dissolution and In vivo Effects—a Pharmacokinetic and Pharmacodynamic Assessment

Dinesh Suram & Kishan Veerabrahma

doi : 10.1208/s12249-022-02272-2

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Fluocinolone Acetonide Microemulsion in Combination with a Fractional Laser for the Treatment of Scalp Psoriasis

Voraphol Vejjabhinanta, Walaisiri Muangsiri & Pornpen Werawatganone

doi : 10.1208/s12249-022-02249-1

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In Vitro Testing of Sunscreens for Dermal Absorption: Method Comparison and Rank Order Correlation with In Vivo Absorption

Yang Yang, Ann-Marie Ako-Adounvo, Jiang Wang, Sergio G. Coelho, Steven A. Adah, Murali K. Matta, David Strauss, Theresa M. Michele, Jian Wang, Patrick

doi : 10.1208/s12249-022-02275-z

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An Integrative QbD Approach for the Development and Optimization of Controlled Release Compressed Coated Formulation of Water-Soluble Drugs

Viral Shah, Ekta Khambhla, Manish Nivsarkar, Riddhi Trivedi & Rakesh K. Patel

doi : 10.1208/s12249-022-02225-9

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A New Approach for Characterizing the Thixotropic Properties of Gel Formulations as Sprayable Agents Based on Rheological Analysis

Takayuki Terukina, Yoshiki Uchiyama, Fumiya Kikuma, Saki Fukumitsu, Nana Iwata, Takanori Kanazawa & Hiromu Kondo

doi : 10.1208/s12249-022-02276-y

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Impact of Amylose-Amylopectin Ratio of Starches on the Mechanical Strength and Stability of Acetylsalicylic Acid Tablets

Natalia Veronica, Celine Valeria Liew & Paul Wan Sia Heng

doi : 10.1208/s12249-022-02266-0

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Investigation of Quantitative X-ray Microscopy for Assessment of API and Excipient Microstructure Evolution in Solid Dosage Processing

Aiden Zhu, Chen Mao, Paul E. Luner, Joshua Lomeo, Chi So, Stephanie Marchal & Shawn Zhang

doi : 10.1208/s12249-022-02271-3

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Formulation Development and Pharmaceutical Evaluation of Lysiphyllum strychnifolium Topical Patches for Their Anti-inflammatory Potential

Yupaporn Sampaopan & Jirapornchai Suksaeree

doi : 10.1208/s12249-022-02269-x

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Curcumin and Derivatives in Nanoformulations with Therapeutic Potential on Colorectal Cancer

Sourour Idoudi, Takwa Bedhiafi, Yousef Mohammad Hijji & Nashiru Billa

doi : 10.1208/s12249-022-02268-y

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Characterizing the Effects of Nasal Prong Interfaces on Aerosol Deposition in a Preterm Infant Nasal Model

Karl Bass, Mohammad A. M. Momin, Connor Howe, Ghali Aladwani, Sarah Strickler, Arun V. Kolanjiyil, Michael Hindle, Robert M. DiBlasi & Worth Longest

doi : 10.1208/s12249-022-02259-z

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Design and Evaluation of Two-Step Biorelevant Dissolution Methods for Docetaxel Oral Formulations

Brijesh Shah & Xiaowei Dong

doi : 10.1208/s12249-022-02256-2

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