BMC Pediatrics




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Single-parenthood and health conditions among children receiving public assistance in Japan: a cohort study

Daisuke Nishioka, Junko Saito, Keiko Ueno & Naoki Kondo

doi : 10.1186/s12887-021-02682-4

BMC Pediatrics volume 21, Article number: 214 (2021) 

Children’s healthy development is important. While governmental public assistance benefits financially troubled families, it cannot compensate for a lack of social support. Single-parenthood is a health risk factor for children owing to low-income-associated food insecurity and stress. No study has investigated the association between single-parenthood and health status in children from families receiving public assistance. This study aimed to examine the association between single-parent households and children’s health among public assistance recipients in Japan by using linkage data of two municipal public assistance databases and administrative medical assistance data.

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Sociodemographic characteristics are associated with prevalence of high-risk waist circumference and high-risk waist-to-height ratio in U.S. adolescents

Felicia J. Setiono, Laura A. Guerra, Cindy Leung & Tashara M. Leak

doi : 10.1186/s12887-021-02685-1

BMC Pediatrics volume 21, Article number: 215 (2021)

Adiposity status in adolescence is associated with various health outcomes in adulthood. Waist circumference [WC] and waist-to-height ratio [WHtR] are measures of abdominal obesity and have shown to be valid predictors of future chronic diseases. However, the relationship between sociodemographic characteristics and WC, as well as WHtR in U.S. adolescents remain unclear. Thus, the study aims to examine associations between sociodemographic characteristics and abdominal obesity among a nationally representative sample of U.S. adolescents.

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Medication-related knowledge, administration practice and adherence among caregivers of chronically ill children in Malaysia

Chii-chii Chew, Huan-keat Chan, Chee-tao Chang, Amar-singh HSS & Mohamed azmi Hassali

doi : 10.1186/s12887-021-02691-3

BMC Pediatrics volume 21, Article number: 216 (2021) 

Caregivers’ knowledge, practice and adherence in medication administration who care for children with chronic illness requiring long-term pharmacological treatments are factors associating with children medication safety at home. This study aimed to determine the medication-related knowledge, administration practice and adherence among caregivers of chronically ill children in Malaysia. This cross-sectional study was conducted at the paediatric outpatient clinic of a tertiary public hospital. Caregivers of chronically ill children, who engaged in medication administration at home for at least 3?months, were conveniently recruited. Their medication-related knowledge and administration practice were evaluated based on a checklist, while their adherence to medication administration was assessed using a validated 5-point scale. The associated factors were also explored.

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The effect of care provided by paediatric critical care transport teams on mortality of children transported to paediatric intensive care units in England and Wales: a retrospective cohort study

Sarah E. Seaton, Elizabeth S. Draper, Christina Pagel, Fatemah Rajah, Jo Wray & Padmanabhan Ramnarayan on behalf of the DEPICT Study Team

doi : 10.1186/s12887-021-02689-x

BMC Pediatrics volume 21, Article number: 217 (2021) 

Centralisation of paediatric intensive care units (PICUs) has the increased the need for specialist paediatric critical care transport teams (PCCT) to transport critically ill children to PICU. We investigated the impact of care provided by PCCTs for children on mortality and other clinically important outcomes.

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A Niemann?pick C1 disease child with BCG-itis: a case report and analysis

Jing-jing Lin, Xu-hui Liu, Lu Xia, Yan-ling Feng, Xiu-hong Xi & Shui-hua Lu

doi : 10.1186/s12887-021-02671-7

BMC Pediatrics volume 21, Article number: 218 (2021) 

Niemann-Pick C disease is a rare autosomal recessive lysosomal lipid storage disorder. Some primary immunodeficiency diseases patients developed regional disease or disseminated disease after vaccinating BCG. It is unclear whether NPC gene deficiency is associated with Mycobacteria infection.

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Gastrointestinal failure score in children with traumatic brain injury

Ying Zhou, Weifeng Lu & Weibing Tang

doi : 10.1186/s12887-021-02673-5

BMC Pediatrics volume 21, Article number: 219 (2021) 

To review the value of the gastrointestinal failure (GIF) score in children with different degrees of traumatic brain injury (TBI) by analyzing the correlation between outcome and gastrointestinal function.

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The facial nerve palsy and cortisone evaluation (FACE) study in children: protocol for a randomized, placebo-controlled, multicenter trial, in a Borrelia burgdorferi endemic area

Sofia Karlsson, Sigurdur Arnason, Nermin Hadziosmanovic, ?sa Laestadius, Malou Hultcrantz, Elin Marsk & Barbro H. Skogman

doi : 10.1186/s12887-021-02571-w

BMC Pediatrics volume 21, Article number: 220 (2021) 

Children with acute peripheral facial nerve palsy cannot yet be recommended corticosteroid treatment based on evidence. Adults with idiopathic facial nerve palsy are treated with corticosteroids, according to guidelines resulting from a meta-analysis comprising two major randomized placebo-controlled trials. Corresponding trials in children are lacking. Furthermore, acute facial nerve palsy in childhood is frequently associated with Lyme neuroborreliosis, caused by the spirochete Borrelia burgdorferi. The efficacy and safety of corticosteroid treatment of acute facial nerve palsy associated with Lyme neuroborreliosis, has not yet been determined in prospective trials in children, nor in adults.

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Iranian children with overweight and obesity: an internet-based interventional study

Farnaz Khatami, Ghazal Shariatpanahi, Hamid Barahimi, Rezvan Hashemi, Leila Khedmat & Mahta Gheirati

doi : 10.1186/s12887-021-02684-2

BMC Pediatrics volume 21, Article number: 221 (2021)

Obesity or overweight in children is an excessive accumulation of adipose tissue that can potentially regress health indicators and increase the likelihood of various diseases.

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Epidemiology of pediatric sepsis in the pediatric intensive care unit of king Abdulaziz Medical City, Jeddah, Saudi Arabia

Mohamed O. Humoodi, Mona A. Aldabbagh, Maher M. Salem, Yousef M. Al Talhi, Sara M. Osman, Mohammed Bakhsh, Abdullah M. Alzahrani & Maha Azzam

doi : 10.1186/s12887-021-02686-0

BMC Pediatrics volume 21, Article number: 222 (2021) 

Pediatric sepsis remains a significant cause of morbidity and mortality worldwide. This study aimed to identify the incidence of sepsis and septic shock among patients admitted to the pediatric intensive care unit (PICU) of a tertiary center in Saudi Arabia.  Patients' demographics and risk factors associated with sepsis-related mortality were also investigated.

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Quality of pediatric clinical practice guidelines

Yali Liu, Yuan Zhang, Shu Wang, Ling Liu, Gang Che, Jiahui Niu & Yuan Ma

doi : 10.1186/s12887-021-02693-1

BMC Pediatrics volume 21, Article number: 223 (2021) 

There is a lack of a comprehensive evaluation for pediatric clinical practice guidelines (CPGs) published in recent years. Here, we assessed the quality of pediatric CPGs, considering factors that might affect their quality. The aim of the study is to promote a more coherent development and application of CPGs.

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Short?term outcomes in infants with mild neonatal encephalopathy: a retrospective, observational study

Yoshinori Aoki, Tatsuo Kono, Mikako Enokizono & Kaoru Okazaki

doi : 10.1186/s12887-021-02688-y

BMC Pediatrics volume 21, Article number: 224 (2021)

Neonatal encephalopathy due to acute perinatal asphyxia is a major cause of perinatal brain damage. Moderate to severe neonatal encephalopathy is associated with high mortality and morbidity rates. However, the neurodevelopmental outcomes in neonates with mild neonatal encephalopathy are unclear. The primary aim of this single-center observational study was to assess the short-term outcomes in term neonates with mild neonatal encephalopathy due to perinatal asphyxia. A secondary aim was to identify predictors of poor prognosis by identifying the characteristics of these infants according to their short-term outcomes.

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The heritability of body composition

Avivit Brener, Yarden Waksman, Talya Rosenfeld, Sigal Levy, Itai Peleg, Adi Raviv, Hagar Interator & Yael Lebenthal

doi : 10.1186/s12887-021-02695-z

BMC Pediatrics volume 21, Article number: 225 (2021) 

Physical growth during childhood and adolescence is influenced by both genetic and environmental factors. Heritability, the proportion of phenotypic variance explained by genetic factors, has been demonstrated for stature and weight status. The aim of this study was to explore the heritability of body composition.

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Spatial distribution of under immunization among children 12–23?months old in Butajira HDSS, southern Ethiopia

Admassu Ketsela, Seifu Hagos Gebreyesus & Wakgari Deressa

doi : 10.1186/s12887-021-02690-4

BMC Pediatrics volume 21, Article number: 226 (2021)

Immunization is essential to prevent between 2 and 3 million deaths globally each year and it is widely accepted that it is one of the most cost-effective health interventions. Despite all its advantages, immunization in Ethiopia is still far from the target set by the United Nations Sustainable Development Goals to achieve universal immunization by all countries in 2030. The 2016 Ethiopian Demographic and Health Survey (EDHS) reported an overall full immunization rate of only 38.3%. The objective of this study was to evaluate the spatial distribution of under immunization in 12 to 23?months old children and further identify the determinants of under immunization clustering in the Butajira Health and Demographic Surveillance Site (HDSS).

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Prevalence of acute diarrhea and water, sanitation, and hygiene (WASH) associated factors among children under five in Woldia Town, Amhara Region, northeastern Ethiopia

Weldehawariyat Getahun & Metadel Adane

doi : 10.1186/s12887-021-02668-2

BMC Pediatrics volume 21, Article number: 227 (2021) 

Diarrhea among children under five is one of the significant public health concerns in developing countries, such as Ethiopia that is mainly attributed to inadequate water, sanitation and hygiene (WASH) services. Lack of data on the prevalence and factors associated with acute diarrhea in Woldia Town impedes the effectiveness of WASH programs in the area. Therefore, the aim of this study was to investigate the prevalence and WASH-associated factors of acute diarrhea among under-five children in this area. This study will help guide local diarrhea prevention and control programs.

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Children’s experiences of participating in a school-based health promotion parental support programme – a qualitative study

Mahnoush Etminan Malek, Gisela Nyberg, Liselotte Sch?fer Elinder, Emma Patterson & ?sa Norman

doi : 10.1186/s12887-021-02694-0

BMC Pediatrics volume 21, Article number: 228 (2021) 

Children’s voices are seldom heard in process evaluations concerning health promotion programmes. A Healthy School Start Plus (HSSP) is a parental support programme, conducted in Sweden, with the aim of promoting healthy diet, physical activity and preventing obesity in preschool class children. The 6-month programme includes: (1) Health information to parents; (2) Motivational Interviewing with parents by school nurses; (3) Classroom activities and home assignments for children; (4) A self-test of type-2 diabetes risk for parents. We aimed to describe children’s experiences of the third component regarding barriers and facilitators of participating in and learning from the classroom activities in the HSSP.

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Assessing causality by means of the Naranjo scale in a paediatric patient with life threatening respiratory failure after alemtuzumab administration: a case report

Nori J. L. Smeets, Ruud J. R. Eijk, Saskia N. de Wildt & Charlotte M. H. H. T. Bootsma-Robroeks

doi : 10.1186/s12887-021-02698-w

BMC Pediatrics volume 21, Article number: 229 (2021) 

Alemtuzumab is a T cell depleting antibody agent used as induction immunosuppressant therapy in solid organ transplant recipients. In addition, it is being increasingly used to treat severe or glucocorticoid-resistant graft rejection. Despite the effectiveness of the treatment, severe adverse events have been reported related to alemtuzumab administration. We present a similar event illustrating the severity of this adverse drug reaction (ADR) and we highlight the structure causality assessment provides in approaching such a case.

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Correction to: The effect of vitamin D and magnesium supplementation on the mental health status of attention-deficit hyperactive children: a randomized controlled trial

Mostafa Hemamy, Naseh Pahlavani, Alireza Amanollahi, Sheikh Mohammed Shriful Islam, Jenna McVicar, Gholamreza Askari & Mahsa Malekahmadi

doi : 10.1186/s12887-021-02683-3

BMC Pediatrics volume 21, Article number: 230 (2021) 

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Interviewing children: the impact of the COVID-19 quarantine on children’s perceived psychological distress and changes in routine

G. Segre, R. Campi, F. Scarpellini, A. Clavenna, M. Zanetti, M. Cartabia & M. Bonati

doi : 10.1186/s12887-021-02704-1

BMC Pediatrics volume 21, Article number: 231 (2021) 

The COVID-19 outbreak has resulted in governments implementing disease containment measures such as school closures, social distancing, and home quarantine.

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The association between ambient air pollution and birth defects in five major ethnic groups in Liuzhou, China

Xiaoli Huang, Jichang Chen, Dingyuan Zeng, Zhong Lin, Carly Herbert, Lesley Cottrell, Liu Liu, Arlene Ash & Bo Wang

doi : 10.1186/s12887-021-02687-z

BMC Pediatrics volume 21, Article number: 232 (2021) 

Studies suggest that exposure to ambient air pollution during pregnancy may be associated with increased risks of birth defects (BDs), but conclusions have been inconsistent. This study describes the ethnic distribution of major BDs and examines the relationship between air pollution and BDs among different ethnic groups in Liuzhou city, China.

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The role of tobacco smoking and illicit drug use in adolescent acute alcohol intoxication

Loes de Veld, Inge M. Wolberink, Joris J. van Hoof & Nico van der Lely

doi : 10.1186/s12887-021-02710-3

BMC Pediatrics volume 21, Article number: 233 (2021)

This study aims to determine the prevalence of tobacco smoking and illicit drug use among Dutch adolescents admitted to hospital for acute alcohol intoxication treatment. Furthermore, socio-demographic predictors for smoking and illicit drug use in the sample population will be studied. The relationship between illicit drug use and specific characteristics of intoxication, such as blood alcohol concentration (BAC) and duration of reduced consciousness is also investigated.

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Neck circumference and cardiometabolic risk in children and adolescents: the moderator role of cardiorespiratory fitness

Ana Paula Sehn, Caroline Brand, Let?cia Welser, Anelise Reis Gaya, Cesar Agostinis-Sobrinho, Carlos Cristi-Montero, Elza Daniel de Mello & Cézane Priscila Reuter

doi : 10.1186/s12887-021-02696-y

BMC Pediatrics volume 21, Article number: 234 (2021)

The increased incidence of cardiometabolic risk factors has become a public health issue, especially in childhood and adolescence. Thus, early identification is essential to avoid or reduce future complications in adulthood. In this sense, the present study aimed to verify the influence of cardiorespiratory fitness (CRF) as a moderator in the association between neck circumference (NC) and cardiometabolic risk in children and adolescents.

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Risk factors for metabolic bone disease among preterm infants less than 32?weeks gestation with Bronchopulmonary dysplasia

Wenwen Chen, Zhenhai Zhang, Shuzhen Dai & Liping Xu

doi : 10.1186/s12887-021-02705-0

BMC Pediatrics volume 21, Article number: 235 (2021)

Bronchopulmonary dysplasia (BPD) infants present an increased incidence of metabolic bone disease (MBD), but it is unknown which factors contribute to this. The aim of this study was to determine the risk factors for developing MBD in BPD infants.

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Awareness screening and referral patterns among pediatricians in the United States related to early clinical features of spinal muscular atrophy (SMA)

Mary Curry, Ros?ngel Cruz, Lisa Belter, Mary Schroth, Megan Lenz & Jill Jarecki

doi : 10.1186/s12887-021-02692-2

BMC Pediatrics volume 21, Article number: 236 (2021)

Spinal Muscular Atrophy (SMA), a leading genetic cause of death in infants, is an autosomal recessive neuromuscular disease characterized by progressive muscle weakness and atrophy. While early diagnosis of SMA is critical to modifying disease progression and improving outcomes, serious diagnostic delays persist. There is a need to improve SMA awareness, screening, and referral patterns.

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Neonatal intrahepatic cholestasis caused by citrin deficiency with no hepatic steatosis: a case report

Ryosuke Miyamoto, Jun Sada, Koki Ota, Kenitiro Kaneko, Hironori Kusano, Yoshiteru Azuma & Akihisa Okumura

doi : 10.1186/s12887-021-02717-w

BMC Pediatrics volume 21, Article number: 237 (2021) 

Neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD) is a common form of neonatal jaundice. Histopathological examination of the liver in patients with NICCD typically shows fatty liver, steatohepatitis, and liver fibrosis. Jaundice and fatty liver often improve by 1?year of age. We herein describe a girl who was diagnosed with NICCD based on an SLC25A13 mutation, although no fatty deposits were found on pathologic examination of the liver.

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A multicenter evaluation of viral bloodstream detections in children presenting to the Emergency Department with suspected systemic infection

Christina A. Rostad, Neena Kanwar, Jumi Yi, Claudia R. Morris, Jennifer Dien Bard, Amy Leber, James Dunn, Kimberle C. Chapin, Anne J. Blaschke, Judy A. Daly, Leslie A. Hueschen, Matthew Jones, Elizabeth Ott, Jeffrey Bastar, Kevin M. Bourzac & Rangaraj Selvarangan

doi : 10.1186/s12887-021-02699-9

BMC Pediatrics volume 21, Article number: 238 (2021) 

Fever is a common symptom in children presenting to the Emergency Department (ED). We aimed to describe the epidemiology of systemic viral infections and their predictive values for excluding serious bacterial infections (SBIs), including bacteremia, meningitis and urinary tract infections (UTIs) in children presenting to the ED with suspected systemic infections.

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Minimum acceptable diet among children aged 6–23?months in South Kivu, Democratic Republic of Congo: a community-based cross-sectional study

Richard Mbusa Kambale, Gaylord Amani Ngaboyeka, Joe Bwija Kasengi, Sarah Niyitegeka, Boss Rutakaza Cinkenye, Armand Baruti, Kizito Chentwali Mutuga & Dimitri Van der Linden

doi : 10.1186/s12887-021-02713-0

BMC Pediatrics volume 21, Article number: 239 (2021)

Suboptimal child nutrition remains the main factor underlying child undernutrition in Democratic Republic of Congo (DRC). This study aimed to assess the prevalence of minimum acceptable diet and associated factors among children aged 6–23?months old.

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Pediatric dentists’ perspectives of children with special health care needs in Japan: developmental disabilities, phobia, maltreatment, and multidisciplinary collaboration

Ayako Ide-Okochi, Hiromi Funayama & Yoshinobu Asada

doi : 10.1186/s12887-021-02711-2

BMC Pediatrics volume 21, Article number: 240 (2021) 

The number of children diagnosed with developmental disabilities (DDs) or other chronic difficulties has risen. However, each professional’s awareness of children with developmental, emotional and behavioural difficulties may differ, allowing their special needs to be overlooked at child health checkups until secondary difficulties appear. Therefore, it is necessary to explore the multi-professional views of children with such chronic difficulties. This study investigates pediatric dentists’ perception of children with potential chronic difficulties.

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Reference intervals for hemoglobin and mean corpuscular volume in an ethnically diverse community sample of Canadian children 2 to 36?months

Jemila S. Hamid, Eshetu G. Atenafu, Cornelia M. Borkhoff, Catherine S. Birken, Jonathon L. Maguire, Mary Kathryn Bohn, Khosrow Adeli, Mohamed Abdelhaleem & Patricia C. Parkin

doi : 10.1186/s12887-021-02709-w

BMC Pediatrics volume 21, Article number: 241 (2021)

To establish reference intervals for hemoglobin and mean corpuscular volume (MCV) in an ethnically diverse community sample of Canadian children 36?months and younger.

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Spinal arteriovenous malformation in a pediatric patient with a history of congenital syphilis: a case report

Mia J. Bertoli, Kruti Parikh, David Klyde, Catherine A. Mazzola & Shridevi Pandya Shah

doi : 10.1186/s12887-021-02707-y

BMC Pediatrics volume 21, Article number: 242 (2021) 

Spinal arteriovenous malformations in children are extremely rare and pose great risk for intraoperative hemorrhage. Congenital syphilis sometimes presents with vascular symptoms, however, there is little published on patients with a history of congenital syphilis presenting with spinal arteriovenous malformations.

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The clinical value of passive leg raising plus ultrasound to predict fluid responsiveness in children after cardiac surgery

Deqiang Luo, Wei Dai, Lei Lei & Xueying Cai

doi : 10.1186/s12887-021-02703-2

BMC Pediatrics volume 21, Article number: 243 (2021) 

There are few non-invasive monitoring methods that can reliably predict fluid responsiveness (FR) in children. Here, we interrogate the value of doppler ultrasound evaluation of passive leg raising (PLR)-induced changes in stroke volume (SV) and cardiac output (CO) as a predictor of FR in children with mechanical ventilation after congenital cardiac surgery.

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Low compliance contribute to insufficient Desmopressin response of primary monosymptomatic nocturnal enuresis and the role of voiding school

Zoran Radojicic, Sasa Milivojevic, Irena Koricanac, Jelena Milin Lazovic, Darko Laketic, Ognjen Radojicic & Natasa Milic

doi : 10.1186/s12887-021-02714-z

BMC Pediatrics volume 21, Article number: 244 (2021) 

To evaluate the impact of compliance on the therapeutic effects of Desmopressin, as well as the importance of establishing the voiding school for low-compliance children in primary monosymptomatic enuresis treatment.

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Influences of persistent overweight on perceptual-motor proficiency of primary school children: the North-West CHILD longitudinal study

Elna de Waal & Anita Elizabeth Pienaar

doi : 10.1186/s12887-021-02708-x

BMC Pediatrics volume 21, Article number: 245 (2021) 

Overweight can be a precursor of poor motor execution, negatively impacting the overall development of school-aged children on various levels. This study determined the long-term influences of overweight on perceptual-motor proficiency (PMP) of primary school children in the North-West Province of South Africa.

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Family-based intervention to prevent childhood obesity among school-age children of low socioeconomic status: study protocol of the FIVALIN project

C. Homs, P. Berruezo, G. Seg?n, L. Estrada, J. de Bont, J. Riera-Roman?, E. Carrillo-?lvarez, H. Schr?der, R. Milà & S. F. G?mez

doi : 10.1186/s12887-021-02697-x

BMC Pediatrics volume 21, Article number: 246 (2021)

Childhood obesity represents a global public health crisis: the number of obese children and adolescents (aged 5–19?years) worldwide has risen tenfold in the past four decades. The vast majority of overweight and obese children live in high-income countries, and low socio-economic status (SES) is a significant risk factor. Family Based Interventions (FBI) have demonstrated positive results in preventing obesity, although these results are strongly influenced by SES. Moreover, we still poorly understand how FBI can determine a positive trend in weight status in low-income communities. Therefore, there is an urgent need to define and evaluate innovative and multi-target projects to reduce obesity risk behaviors and health inequalities and the present study aims to present the study protocol of FIVALIN a FBI that pretends to achieve this goal.

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The education word gap emerges by 18?months: findings from an Australian prospective study

Mary E. Brushe, John Lynch, Sheena Reilly, Edward Melhuish, Murthy N. Mittinty & Sally A. Brinkman

doi : 10.1186/s12887-021-02712-1

BMC Pediatrics volume 21, Article number: 247 (2021) 

The idea of the ‘30 million word gap’ suggests families from more socioeconomically advantaged backgrounds engage in more verbal interactions with their child than disadvantaged families. Initial findings from the Language in Little Ones (LiLO) study up to 12?months showed no word gap between maternal education groups.

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Rickets manifestations in a child with metaphyseal anadysplasia, report of a spontaneously resolving case

Patricia Diaz Escagedo, Melissa Fiscaletti, Patricia Olivier, Chloé Hudon, Valancy Miranda, Marie-Claude Miron, Philippe M. Campeau & Nathalie Alos

doi : 10.1186/s12887-021-02716-x

BMC Pediatrics volume 21, Article number: 248 (2021) 

Rickets is not an unusual diagnosis for pediatricians even currently in developed countries. Children typically present with leg bowing, enlargement of wrists, rachitic rosary (swelling of costochondral junctions) and/or waddling gait. But not every child with growth delay and enlarged metaphyses is diagnosed with rickets. Metaphyseal anadysplasia (MAD) is a disorder of variable severity with metaphyseal flaring and irregularities, without vertebral abnormalities. MAD is characterized by an early onset and a regressive course in late childhood without treatment, despite persistent short stature. Autosomal dominant or recessive variants in the matrix metalloproteinase 13 gene (MMP13) are responsible for these transient metaphyseal changes.

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Risk factors associated with scabies infestation among primary schoolchildren in a low socio-economic area in southeast of Iran

Alireza Sanei-Dehkordi, Moussa Soleimani-Ahmadi, Mehdi Zare & Seyed Aghil Jaberhashemi

doi : 10.1186/s12887-021-02721-0

BMC Pediatrics volume 21, Article number: 249 (2021)

Scabies is a neglected tropical disease caused by the mite Sarcoptes scabiei that burrows under the skin. It is a major health problem in tropical areas, largely affecting children. Scabies is common and highly contagious and in schoolchildren spreads quite rapidly, due to overcrowding and close contact within the schools. This study aimed to determine the risk factors associated with scabies infestation among primary schoolchildren in Bashagard County, one of the low socio-economic areas in southeast of Iran.

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Childhood obesity prevention policies in Iran: a policy analysis of agenda-setting using Kingdon’s multiple streams

Shahnaz Taghizadeh, Rahim Khodayari-Zarnaq and Mahdieh Abbasalizad Farhangi

doi : 10.1186/s12887-021-02731-y

BMC Pediatrics volume 21, Article number: 250 (2021) 

Pediatric obesity is one of the most important health challenges of the twenty-first century. Primary prevention of childhood obesity, can lessen its consequences. This study aims to assess childhood obesity prevention policies in Iran through a policy analysis of agenda-setting using Kingdon’s multiple streams.

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Correction to: Study protocol and rationale of the “Cogniaction project” a cross-sectional and randomized controlled trial about physical activity, brain health, cognition, and educational achievement in schoolchildren

Patricio Solis-Urra, Jorge Olivares-Arancibia, Ernesto Suarez-Cadenas, Javier Sanchez-Martinez, Fernando Rodr?guez-Rodr?guez, Francisco B. Ortega, Irene Esteban-Cornejo, Cristina Cadenas-Sanchez, Jose Castro-Pi?ero, Alejandro Veloz, Steren Chabert, Kabir P. Sadarangani, Juan Pablo Zavala-Crichton, Jairo H. Migueles, Jose Mora-Gonzalez, Milton Quiroz-Escobar

doi : 10.1186/s12887-021-02718-9

BMC Pediatrics volume 21, Article number: 251 (2021) 

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Racial and ethnic disparities in opioid use for adolescents at US emergency departments

Michael T. Phan, Daniel M. Tomaszewski, Cody Arbuckle, Sun Yang, Candice Donaldson, Michelle Fortier, Brooke Jenkins, Erik Linstead and Zeev Kain

doi : 10.1186/s12887-021-02715-y

BMC Pediatrics volume 21, Article number: 252 (2021) 

Racial/ethnic disparities in the use of opioids to treat pain disorders have been previously reported in the emergency department (ED). Further research is needed to better evaluate the impact race/ethnicity may have on the use of opioids in adolescents for the management of pain disorders in the ED.

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Successful rescue of a lethal Griscelli syndrome type 2 presenting with neurological involvement and hemophagocytic lymphohistiocytosis: a case report

Qing Zhang, Yun-Ze Zhao, Hong-Hao Ma, Dong Wang, Nan Zhang, Zhi-Gang Li and Rui Zhang

doi : 10.1186/s12887-021-02720-1

BMC Pediatrics volume 21, Article number: 253 (2021) 

Griscelli syndrome type 2 (GS2) is a rare autosomal recessive disease caused by mutations in RAB27A gene. It is primarily characterized by a combination of partial albinism, hemophagocytic lymphohistiocytosis (HLH) or other immunodeficiency. However, neurological involvement at onset in GS2 and treatment has rarely been described.

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A de novo 10q11.23q22.1 deletion detected by whole genome mate-pair sequencing: a case report

Dalin Fu, Weisheng Lin, Fen Lu, Senjie Du, Min Zhu, Xiaoke Zhao, Jian Tang, Chuan Chen, Xiaoli Chui, Shanmei Tang, Kai Wang, Chuanchun Yang and Bei Han

doi : 10.1186/s12887-021-02723-y

BMC Pediatrics volume 21, Article number: 254 (2021)

Interstitial deletions of chromosome band 10q11-q22 was a genomic disorder distinguished by developmental delay, congenital cleft palate and muscular hypotonia. The phenotypes involved were heterogeneous, hinge on the variable breakpoints and size.

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