One-year access to more than 500 world journals available in the system
-
http://medilib.ir
- Duration of Time : 365 Day
Price : 300$- Special Price : 100$
Aatrilal (Ammi majus L.), an important drug of Unani system of medicine: A review
Qamrul Islam Usmani, Nasreen Jahan, Mohd Aleem, Syed Ameer Hasan
doi : 10.1016/j.jep.2021.114144
Volume 276, 10 August 2021, 114144
Ammi majus L. (Aatrilal) a member of the family Apiaceae, is native to Egypt and widely distributed in Europe, the Mediterranean, and West Asia. It has been used for the treatment of various dermatological disorders particularly vitiligo in the Unani system of Medicine for ages. In traditional medicine, fruits are used as an emmenagogue as well as a diuretic, blood purifier and to treat leprosy, urinary and digestive disorders.
Phytochemical properties, biological activities and medicinal use of Centaurium erythraea Rafn
Naoual El Menyiy, Fatima-Ezzahrae Guaouguaou, Aicha El Baaboua, Nasreddine El Omari, Abdelhakim Bouyahya
doi : 10.1016/j.jep.2021.114171
Volume 276, 10 August 2021, 114171
Centaurium erythraea is an important medicinal plant in many countries, e.g. Morocco, Algeria, Italy, Spain, Portugal, and countries of Balkan Peninsula. It is used in folk medicine to treat various illnesses. It is also used as an antiapoplectic, anticoagulant, anticholagogue, antipneumonic, hematocathartic, and as a hypotensive agent.
Morinda lucida Benth (Rubiaceae): A review of its ethnomedicine, phytochemistry and pharmacology
K.E. Adewole, A.F. Attah, J.O. Adebayo
doi : 10.1016/j.jep.2021.114055
Volume 276, 10 August 2021, 114055
Natural products derived from plants have served the primary healthcare needs of millions of indigenous people for centuries, many of which have been documented and scientifically validated. Morinda lucida Benth (Rubiaceae), also referred to as brimstone tree, is an ethnomedicinal plant which has been widely used in traditional medicine for several decades, particularly in the African continent.
A review of the botany, traditional uses, phytochemistry, and pharmacology of the Flos Inulae
Liu Yang, Xuejiao Wang, Ajiao Hou, Jiaxu Zhang, Haixue Kuang
doi : 10.1016/j.jep.2021.114125
Volume 276, 10 August 2021, 114125
Plants of the genus Inula have long been used as an ethnomedicine in Asia, Europe, and North America for its high medicinal value and health benefits. Inula japonica Thunb. (I. japonica) and Inula britanica L. (I. britanica) are included in Chinese Pharmacopoeia (2020 edition) as the traditional Chinese medicine Flos inulae (FI). In TCM, FI tastes bitter, pungent, and salt, with warm nature and has the functions of water removal, reduction in nausea, and prevention of vomiting and is often used for cold-related coughs, sputum, wheezing coughs, vomiting, belching and other related diseases. In addition, Inula japonica Thunb is used as a botanical medicine in Korea and Inula britannica L. is also used as a traditional plant medicine in Iran.
Phytochemistry and pharmacological activities of Arundina graminifolia (D.Don) Hochr. And other common Orchidaceae medicinal plants
Xingyu Zhang, Weichi Chen, Yimei Du, Pengwen Su, Meifeng Liu
doi : 10.1016/j.jep.2021.114143
Volume 276, 10 August 2021, 114143
Arundina graminifolia (Orchidaceae) has been widely used for heat clearance and detoxification, anti-inflammatory diuretic, and anti-microbes for two thousand years in national minorities, especially among the Dai people. It was known as “Zhuyelan” (Chinese: ???), “Wenshanghai” (Chinese: ???) and “Baiyangjie” (Chinese: ???) in the Dai nationality, and mainly used as antidote, which is characterized by “relieving the poison before getting sick and treating illness”. Therefore, it has been typically applied in the treatment of food poisoning, snake bites, rheumatism, stomachache and traumatic injuries. It is also used to treat bronchitis, tuberculosis and pneumonia in the Bulang and the Wa ethnic people.
Traditional uses, phytochemistry and pharmacological attributes of Pterocarpus santalinus and future directions: A review
Yogita Dahat, Priyanka Saha, J.T. Mathew, Sushil K. Chaudhary Deepak Kumar
doi : 10.1016/j.jep.2021.114127
Volume 276, 10 August 2021, 114127
Pterocarpus santalinus, an ancient folk medicine, is endemic to the eastern ghats of south India, and the heartwood is prescribed since time immemorial for the mitigation of inflammatory disorders in traditional practice and ayurvedic system of medicines.
Systematic review of Ethiopian medicinal plants used for their anti-inflammatory and wound healing activities
Dereje Nigussie, Eyasu Makonnen, Takele Beyene Tufa, Malcolm Brewster, Gail Davey
doi : 10.1016/j.jep.2021.114179
Volume 276, 10 August 2021, 114179
Plant materials are used worldwide as complementary and alternative therapeutics for the treatment of various illnesses. In Ethiopia, folk medicines are utilized across a wide range of cultures and settings. Ethiopia has numerous plant species of which around 12% are endemic, making it a rich source of medicinal plants that are potentially important for human wellbeing.
Genus Ribes Linn. (Grossulariaceae): A comprehensive review of traditional uses, phytochemistry, pharmacology and clinical applications
Qing Sun, Na Wang, Wenhua Xu, Huakun Zhou
doi : 10.1016/j.jep.2021.114166
Volume 276, 10 August 2021, 114166
The genus Ribes Linn., which belongs to the Grossulariaceae family, contains 160 species distributed mainly in temperate and cold regions of the Northern Hemisphere. There are 59 species in southwest, northwest and northeast China. Some species of Ribes have been used as traditional and local medicines for the treatment of glaucoma, cardiovascular disease, stomachache, hepatitis, hyperlipidemia, hypertension and other ailments. However, the data provided in recent years have not been collated and compared.
Traditional uses, phytochemistry, pharmacology and toxicology of the genus Gynura (Compositae): A comprehensive review
Xiuhua Meng, Jiawei Li, Mimi Li, Hongjiang Wang, Weilin Li
doi : 10.1016/j.jep.2021.114145
Volume 276, 10 August 2021, 114145
Gynura cass., belonging to the tribe Senecoineae of the family Compositae, contains more than 40 accepted species as annual or perennial herbs, mainly distributed in Asia, Africa and Australia. Among them, 11 species are distributed in China. Many of the Gynura species have been used as traditional herbal medicines for the treatment of diabetes mellitus, rheumatism, eruptive fever, gastric ulcer, bleeding, abscesses, bruises, burning pains, rashes and herpes zoster infection in tropical Asia countries such as China, Thailand, Indonesia, Malaysia, and Vietnam. Some of the species have been used as vegetables, tea beverage or ornamental plants by the local people.
Characterization of the chemical profile and the effects of ethanolic extracts of Maytenus ilicifolia Mart. ex Reissek on glucose metabolism in normal hyperglycemic rats
Monica Santin Zanatta Schindler, Jean Felipe Foss? Calisto, Katiuska Marins, Alissara Regginato, Leila Zanatta
doi : 10.1016/j.jep.2021.114173
Volume 276, 10 August 2021, 114173
Maytenus ilicifolia Mart. ex Reissek, Celastraceae, is popularly known as “espinheira-santa” and used to treat pathologies related to the stomach. However, in popular culture, this species has also been used to treat other disorders such as diabetes, but without scientific evidence, requiring more phytochemical and pharmacological studies on the plant.
Anti-breast cancer potential of Anonidium mannii (Oliv.) Engl. & Diels barks ethanolic extract: UPLC-ESI-QTOF-MS detection of anticancer alkaloids
Francine Azegha Mefegue, Thomas Michel, Eutrophe Le Doux Kamto, Larissa Vanelle Kenmogne, Stéphane Zingue
doi : 10.1016/j.jep.2021.114131
Volume 276, 10 August 2021, 114131
Breast cancer is a serious threat in low-income as well as developed countries. To face this, many herbal preparations are prescribed by traditional healers in Cameroon, among which is Anonidium mannii commonly called “wild soursop”.
Identification of the molecular targets and mechanisms of compound mylabris capsules for hepatocellular carcinoma treatment through network pharmacology and bioinformatics analysis
Junwei Wei, Luyuan Ma, Wenpeng Liu, Yadong Wang, Caiyan Zhao
doi : 10.1016/j.jep.2021.114174
Volume 276, 10 August 2021, 114174
Traditional Chinese herbal formulas have been proven to exert an inhibitory effect on tumor. Compound mylabris capsules (CMC) has been used for treating cancer, especially hepatocellular carcinoma (HCC), for years in China. However, its therapeutic mechanisms on HCC remain unclear.
Amazonian medicinal smokes: Chemical analysis of Burseraceae pitch (breu) oleoresin smokes and insights into their use on headache
Rayane da Cruz Albino, Marcelle Magalh?es Braz, Humberto Ribeiro Bizzo, Raquel Vieira Santana da Silva, Danilo Ribeiro de Oliveira
doi : 10.1016/j.jep.2021.114165
Volume 276, 10 August 2021, 114165
In Latin American Traditional Medicine, the use of Burseraceae oleoresins for headache relief is widespread. In the quilombola (maroon) communities of the municipality of Oriximin?, Par? State, Brazil, Burseraceae oleoresins are burned as incenses to treat headache; an effect attained by inhaling the smokes.
Chemical characterization and bioactive potential of Artemisia campestris L. subsp. maritima (DC) Arcang. essential oil and hydrodistillation residual water
Maria Inês Rocha, Maria José Gonçalves, Carlos Cavaleiro, Maria Teresa Cruz,Artur Figueirinha
doi : 10.1016/j.jep.2021.114146
Volume 276, 10 August 2021, 114146
Artemisia campestris L. is widely used in traditional medicine for their anti-inflammatory, antirheumatic, antimicrobial and antioxidant properties. A. campestris subsp. maritima Arcang., a halophyte plant (“madorneira” or “erva-lombrigueira” in Portugal), is traditionally used for gastric disorders, rheumatism and hypertension.
In vitro biochemical characterization and genotoxicity assessment of Sapindus saponaria seed extract
Gustavo Duarte Bocayuva Tavares, Claudia Alessandra Fortes Aiub, Israel Felzenszwalb, Eduardo Kennedy Carr?o Dantas, César Luis Siqueira J?nior
doi : 10.1016/j.jep.2021.114170
Volume 276, 10 August 2021, 114170
Sapindus saponaria, also popularly known as soapberry, has been used in folk medicinal values because of its therapeutic properties and several compounds in its composition, which represent a target in potential for drug discovery. However, few data about its potential toxicity has been reported.
Experimental and molecular docking studies of estrogen-like and anti-osteoporosis activity of compounds in Fructus Psoraleae
Xin-yin Cai, Zi-jia Zhang, Jing-lin Xiong, Meng Yang, Zheng-tao Wang
doi : 10.1016/j.jep.2021.114044
Volume 276, 10 August 2021, 114044
Fructus Psoraleae (FP), dry mature fruits of Cullen corylifolium (L.) Medik., has been used clinically to treat kidney yang deficiency-induced impotence, asthma and cold pain in waist and knee caused by kidney deficiency. A study of the source of the significant kidney-enhancing effect of FP revealed that it may be due to its strong estrogen-like activity.
Anti-inflammatory activity of the Tongmai Yangxin pill in the treatment of coronary heart disease is associated with estrogen receptor and NF-?B signaling pathway
Yadong Fan, Jianwei Liu, Jing Miao, Xiaoyu Zhang, Huifang Zhou
doi : 10.1016/j.jep.2021.114106
Volume 276, 10 August 2021, 114106
The Tongmai Yangxin Pill (TMYX) is a patented traditional Chinese medicine originating from two classic prescriptions, Zhigancao Decoction and Shenmai Yin, which composed of 11 Chinese medicinal herbs: Rehmannia glutinosa (Gaertn.) DC., Spatholobus suberectus Dunn, Ophiopogon japonicus (Thunb.) Ker Gawl., Glycyrrhiza uralensis Fisch., Polygonum multiflorum Thunb., Equus asinus L., Schisandra chinensis (Turcz.) Baill., Codonopsis pilosula (Franch.) Nannf., Chinemys reevesii (Gray), Ziziphus jujuba Mill. and Cinnamomum cassia (L.) J.Presl (Committee of the Pharmacopoeia of PR China, 2015). TMYX has marketed in China for the treatment of chest pain, palpitation, angina, irregular heartbeat and coronary heart disease (CHD) for several decades. Previous studies have confirmed that TMYX can treat CHD by reducing inflammation, but the underlying pharmacological mechanism remains unclear.
Glaucocalyxin A suppresses osteoclastogenesis induced by RANKL and osteoporosis induced by ovariectomy by inhibiting the NF-?B and Akt pathways
Meisong Zhu, Jing Shan, Huaen Xu, Guoming Xia, Min Dai
doi : 10.1016/j.jep.2021.114176
Volume 276, 10 August 2021, 114176
Glaucocalyxin A (GLA), the most abundant active component of the aboveground sections of Rabdosia japonica (Burm. f.) Hara var. glaucocalyx (Maxim.) Hara, possesses various pharmacological activities, such as antioxidant, antithrombosis, anticoagulation, antibacterial, antitumor, anti-inflammatory activities. According to previous studies, inflammation is closely associated with osteoclast differentiation and activity. Although GLA has demonstrated effective anti-inflammatory properties, its effects on osteoclast differentiation remain unclear.
In silico network pharmacology and in vivo analysis of berberine-related mechanisms against type 2 diabetes mellitus and its complications
Sha Di, Lin Han, Xuedong An, Ran Kong, Xiaolin Tong
doi : 10.1016/j.jep.2021.114180
Volume 276, 10 August 2021, 114180
Berberine (BBR), extracted from the traditional medicinal plant Coptis chinensis Franch., has been widely used for the treatment of type 2 diabetes mellitus (T2DM) and its complications.
The role and mechanism of hyperoside against myocardial infarction in mice by regulating autophagy via NLRP1 inflammation pathway
Yongkang Yang, Jing Li, Tingcai Rao, Zhirui Fang, Junyan Zhang
doi : 10.1016/j.jep.2021.114187
Volume 276, 10 August 2021, 114187
The genus Hypericum are widely distributed in China. Hypericum perforatum L. (genus Hypericum, family Hypericaceae) has a long history as a traditional Chinese medicine, which was traditionally used for the treatment of emotional distress, cardiothoracic depression, and acute mastitis. Hyperoside (Hyp) extracted from Hypericum perforatum L. has been affirmed to exert therapeutic effects on cardiovascular diseases, with widespread existence in plants of genus Hypericum.
Anti-inflammatory effects of three withanolides isolated from Physalis angulata L. in LPS-activated RAW 264.7 cells through blocking NF-?B signaling pathway
Luqiong Wang, Shiqing Lu, Liying Wang, Min Xin, Feng Zhao
doi : 10.1016/j.jep.2021.114186
Volume 276, 10 August 2021, 114186
Physalis angulata L. is commonly used in many countries as popular medicine for the treatment of a variety of diseases such as malaria, hepatitis, dermatitis and rheumatism. But the anti-inflammatory active constituents of this medicinal plant and their molecular mechanism are still not elucidated clearly.
Amelioration of diabetic retinopathy in db/db mice by treatment with different proportional three active ingredients from Tibetan medicine Berberis dictyophylla F
Rui Li, Xiaopeng Ai, Ya Hou, Xianrong Lai,Xiaobo Wang
doi : 10.1016/j.jep.2021.114190
Volume 276, 10 August 2021, 114190
Berberis dictyophylla F., a famous Tibetan medicine, has been used to prevent and treat diabetic retinopathy (DR) for thousands of years in clinic. However, its underlying mechanisms remain unclear.
Central and peripheral pain intervention by Ophiorrhiza rugosa leaves: Potential underlying mechanisms and insight into the role of pain modulators
Md. Nazim Uddin Chy, Md. Adnan, Md. Riad Chowdhury, Ester Pagano, Raffaele Capasso
doi : 10.1016/j.jep.2021.114182
Volume 276, 10 August 2021, 114182
Ophiorrhiza rugosa var. prostrata is a traditional medicinal plant used by the indigenous and local tribes (Chakma, Marma and Tanchangya) of Bangladesh for the management of chest pain, body ache, and earache. However, the knowledge of anti-nociceptive and anti-inflammatory potentials of this plant is scarce.
What's the choice for goji: Lycium barbarum L. or L. chinense Mill.?
Ruyu Yao, Michael Heinrich, Xinning Zhao, Qiuling Wang, Peigen Xiao
doi : 10.1016/j.jep.2021.114185
Volume 276, 10 August 2021, 114185
For over one millennium, goji berries have been used traditionally as food and medicine in eastern Asia. In recent decades, it has become increasingly popular globally. However, the biocultural development of goji is poorly known. The botanical origin of goji is controversial: in many but not all modern regional or international quality standards, L. barbarum is accepted exclusively as the botanical origin of goji.
Effect of Si-Miao-Yong-An decoction on the differentiation of monocytes, macrophages, and regulatory T cells in ApoE?/? mice
Xin-Nong Chen, Qi-Hui Ge, Yi-Xuan Zhao, Xiao-Chen Guo, Jun-Ping Zhang
doi : 10.1016/j.jep.2021.114178
Volume 276, 10 August 2021, 114178
Si-Miao-Yong-An decoction (SMYAD) is a renowned traditional Chinese medicinal formula. SMYAD was originally recorded in the “Shi Shi Mi Lu”, which was edited by medical scientist Chen Shi'duo during the Qing Dynasty. SMYAD has been traditionally used to treat thromboangiitis obliterans. At present, it is mainly used in clinical applications and research of cardiovascular diseases.
Network pharmacology integrated with experimental validation reveals the regulatory mechanism of plastrum testudinis in treating senile osteoporosis
Peng Zhang, Honglin Chen, Gengyang Shen, Zhida Zhang, ... Hui Ren
doi : 10.1016/j.jep.2021.114198
Volume 276, 10 August 2021, 114198
Plastrum testudinis (PT) has been used in traditional Chinese medicine to treat bone diseases such as senile osteoporosis (SOP) for thousands of years. However, the underlying mechanisms remain largely unknown.
Xuebijing injection in septic rats mitigates kidney injury, reduces cortical microcirculatory disorders, and suppresses activation of local inflammation
Jingfeng Liu, Zhenzhou Wang, Jin Lin, Tian Li, Meili Duan
doi : 10.1016/j.jep.2021.114199
Volume 276, 10 August 2021, 114199
Xuebijing injections originate from the traditional Chinese medicine (TCM) prescription XuefuZhuyu Decoction. It is composed of five Chinese herbal extracts; Carthami flos, Paeoniae radix rubra, Chuanxiong rhizoma, Salviae miltiorrhizae, and Angelicae Sinensis radix. The China Food and Drug Administration approved Xuebijing injections as a TCM preparation for the adjuvant treatment of sepsis.
Chinese herbal medicine Feiyanning cooperates with cisplatin to enhance cytotoxicity to non-small-cell lung cancer by inhibiting protective autophagy
Zhan Zheng, Yue Ma, Lifang Wang, Haibin Deng, Zhenye Xu
doi : 10.1016/j.jep.2021.114196
Volume 276, 10 August 2021, 114196
Feiyanning (FYN), the Chinese herbal medicine (CHM), has been used to manage non-small cell lung cancer (NSCLC) for the past 23 years. Chemotherapeutic drugs can induce autophagy in cancer cells to protect themselves from death. However, FYN can inhibit the protective autophagy in cancer cells. We investigated the biological mechanisms on the synergistic effects of FYN combined with chemotherapy in lung cancer cells.
A combination of cecum microbiome and metabolome in CUMS depressed rats reveals the antidepressant mechanism of traditional Chinese medicines: A case study of Xiaoyaosan
Meng Lv, Yaze Wang, Ping Qu, Shunyong Li, Xiaojie Liu
doi : 10.1016/j.jep.2021.114167
Volume 276, 10 August 2021, 114167
Xiaoyaosan (XYS), a representative and classic prescription in traditional Chinese medicines (TCMs), has been used for thousands of years for treating depression. The anti-depression effect of XYS has been demonstrated both clinically and experimentally. However, it is still unclear that whether XYS could regulate the abnormalities of gut microbiota and metabolites of cecum induced by depression, and in which way. This study aimed to explore the underlying mechanism of the anti-depressant effects of XYS from the perspective of cecal microbiota and metabolites.
Characterization of pharmaco-EEG fingerprint and sleep-wake profiles of Lavandula angustifolia Mill. essential oil inhalation and diazepam administration in rats
Rodiya Manor, Ekkasit Kumarnsit, Nifareeda Samerphob, Thitima Rujiralai, Dania Cheaha
doi : 10.1016/j.jep.2021.114193
Volume 276, 10 August 2021, 114193
Lavandula angustifolia Mill. Essential oil (Lavender EO) has a long history of medicinal use and is particularly claimed to possess anxiolytic and sedative properties. Lavender EO aromatherapy has been used to reduce distress and improve insomnia naturally. Increasing evidence appeared to show similarities between the effects of lavender EO and the anxiolytic drugs, benzodiazepines. However, its effects on sleep-wake and electrical brain patterns in comparison to that of the standard anxiolytic, diazepam, remained to be explored.
Antidepressant-like effects of water extract of Cordyceps militaris (Linn.) Link by modulation of ROCK2/PTEN/Akt signaling in an unpredictable chronic mild stress-induced animal model
Yu-En Lin, Yi-Chun Chen, Kuan-Hung Lu, Yun-Ju Huang, Lee-Yan Sheen
doi : 10.1016/j.jep.2021.114194
Volume 276, 10 August 2021, 114194
Cordyceps militaris (Linn.) Link (CM) is a medicinal mushroom traditionally used in tonics for treating several neurological disorders, including epilepsy and anxiety, in Asia. Reports have shown that CM has anti-inflammatory and anti-oxidative effects and may be beneficial for depression management.
Remedies of animal origin and their indications in Nikolaos Myrepsos? Dynameron
E. Valiakos, M. Marselos, M.E. Grafakou, H. Skaltsa, N. Sakellaridis
doi : 10.1016/j.jep.2021.114191
Volume 276, 10 August 2021, 114191
Dynameron is a Byzantine medical compendium, divided into 24 sections, in accordance with the letters of the Greek alphabet. Being the largest medical and pharmaceutical book ever written in Byzantium, Dynameron contains 2667 recipes intended to treat many pathological conditions. A lot of information convey to us through prescriptions. In addition to plants, Nikolaos Myrepsos proposes the use of many animals, animal parts and animal by-products, for the treatment of various diseases. This article presents for the first time a full account of the animal products included in Dynameron.
Hypoglycemic and hypolipidemic effects of total glycosides of Cistanche tubulosa in diet/streptozotocin-induced diabetic rats
Kuiniu Zhu, Zhaoqing Meng, Yushan Tian, Rui Gu, Wei Xiao
doi : 10.1016/j.jep.2021.113991
Volume 276, 10 August 2021, 113991
Cistanche tubulosa (Schrenk) R. Wight (Orobanchaceae) is a frequently prescribed component in many traditional herbal prescriptions which are used to treat diabetes in China. In recent studies, the antidiabetic activity of Cistanche tubulosa extracts have been confirmed. However, no systematic investigation has been reported on the total glycosides of Cistatnche tubulosa (TGCT).
Plastrum testudinis extract suppresses osteoclast differentiation via the NF-?B signaling pathway and ameliorates senile osteoporosis
Honglin Chen, Gengyang Shen, Qi Shang, Peng Zhang, Hui Ren
doi : 10.1016/j.jep.2021.114195
Volume 276, 10 August 2021, 114195
Plastrum testudinis (PT) is a kind of single traditional Chinese medicine that can tonify kidney and strengthen bone. Plastrum testudinis extract (PTE) has been approved to promote the osteogenic differentiation of bone marrow-derived mesenchymal stem cells in vitro. However, the mechanism by which PTE reduces osteoclast differentiation has not yet been reported.
Genotoxicity of Asiasari Radix et Rhizoma (Aristolochiaceae) ethanolic extract in vitro and in vivo
Ji-Hye Jang, Chang-Seob Seo, Hyekyung Ha, Su-Cheol Han, Hyeun-Kyoo Shin
doi : 10.1016/j.jep.2021.114122
Volume 276, 10 August 2021, 114122
Traditional herbal medicines have diverse efficacy and are increasingly used worldwide. However, some of these herbal medicines have toxicities or side effects, but the scientific understanding of traditional herbal medicine toxicity has not yet been established. Asiasari Radix et Rhizoma (ARE) is known as a herbal medicine used to relieve pain, and recent studies have shown that ARE has anticancer and antimelanogenesis efficacy.
Ophiocordyceps lanpingensis polysaccharides alleviate chronic kidney disease through MAPK/NF-?B pathway
Shubo Zhou, Yifeng He, Weiping Zhang, Yin Xiong, Feng Ge
doi : 10.1016/j.jep.2021.114189
Volume 276, 10 August 2021, 114189
Ophiocordyceps lanpingensis (O. lanpingensis) is a traditional ethno-medicine distributed in Eastern Himalayas, which has been used by local minorities to prevent and treat urinary diseases for hundreds of years. However, the corresponding active components and related pharmacological mechanism of such medication are not clear yet.
Ethnobotanical study of traditionally used medicinal plants of Pauri district of Uttarakhand, India
Arun Kumar Khajuria, R.K. Manhas, Harish Kumar, N.S. Bisht
doi : 10.1016/j.jep.2021.114204
Volume 276, 10 August 2021, 114204
The indigenous knowledge of medicinal plants is important part of primary health care system in almost every society, especially the far–flung areas. These areas, one of the last storehouses of traditional knowledge are under the constant threat of losing this valuable information as it moves from one generation to another through word of mouth. Modernization, migration, education, and changing socio–economic status of people also affect the perpetuality of traditional knowledge. Therefore, time-to-time updation of information regarding the ethnomedicinal plants must be carried out so that any addition to the traditional knowledge is recorded and further phytochemical and pharmacological studies may be conducted for developing new drugs.
Kamikihito, a traditional Japanese Kampo medicine, increases the secretion of oxytocin in rats with acute stress
Mana Tsukada, Hideshi Ikemoto, Xiao-Pen Lee, Takashi Takaki,Masataka Sunagawa
doi : 10.1016/j.jep.2021.114218
Volume 276, 10 August 2021, 114218
Kamikihito (KKT) is a Kampo medicine that is prescribed in Japan for the treatment of anemia, insomnia and mental anxiety in Japan. However, its precise mechanism of action remains unclear.
Evaluation of cytotoxic and antioxidant potential of Dittrichia viscosa (L.) Greuter used in traditional medicine
Ece Sevgi, Aydan Dag, ?a?la K?z?larslan-Hançer, Sezen Atasoy, ?znur Aksakal
doi : 10.1016/j.jep.2021.114211
Volume 276, 10 August 2021, 114211
Dittrichia viscosa (L.) Greuter (“Sar? ot, Yap??kan and?z otu” in Turkish) is a medicinal plant that has been traditionally used in the Mediterranean area. This plant is used by the local population for the treatment of cancer. Investigation of their biological activities is therefore very important to be supported by scientific basis for traditional use.
The effect of Melissa officinalis L. extract on learning and memory: Involvement of hippocampal expression of nitric oxide synthase and brain-derived neurotrophic factor in diabetic rats
Mohsen Naseri, Reza Arabi Mianroodi, Zeynab Pakzad, Peyman Falahati, Sima Nasri
doi : 10.1016/j.jep.2021.114210
Volume 276, 10 August 2021, 114210
Diabetes is a systemic disease, which can cause synaptic defects in the hippocampus. Hippocampus plays a crucial role in learning and memory. Melissa officinalis L. has been used as for memory enhancement in Persian Medicine.
Mechanisms of Gegen Qinlian Pill to ameliorate irinotecan-induced diarrhea investigated by the combination of serum pharmacochemistry and network pharmacology
Yihan Wu, Yanfen Cheng, Yuhan Yang, Di Wang, Yichen Hu
doi : 10.1016/j.jep.2021.114200
Volume 276, 10 August 2021, 114200
Traditional Chinese medicine suggests the use of natural extracts and compounds is a promising strategy to prevent irinotecan (CPT-11)-induced gut toxicity and resulting diarrhea. Previous work from our lab indicated the protective effect of Gegen Qinlian decoction; given this, we further speculated that Gegen Qinlian Pill (GQP) would exhibit similar therapeutic effects. The effective material basis as well as potential mechanisms underlying the effect of GQP for the treatment of CPT-11-induced diarrhea have not been fully elucidated.
Reverse tracing anti-thrombotic active ingredients from dried Rehmannia Radix based on multidimensional spectrum-effect relationship analysis of steaming and drying for nine cycles
Pu-Yang Gong, Yu-Jie Guo, Yu-Shan Tian, Li-Fei Gu, Bo-Yang Yu
doi : 10.1016/j.jep.2021.114177
Volume 276, 10 August 2021, 114177
In traditional Chinese medicine (TCM) and modern pharmacodynamics, dried Rehmannia Radix (DRR) possesses prominent anti-thrombotic activity that decreases after processing by nine steaming and drying cycles to develop processed Rehmannia Radix (PRR). Due to the complexity of the DRR components, the chemical mechanism leading to efficacy changes of DRR caused by processing is still unclear.
Polysaccharides from Premna microphylla turcz ameliorate inflammation via the enhancement of intestinal resistance in host
Guanglei Song, Fangyuan Chen, Shubo Chen, Shuhui Ye
doi : 10.1016/j.jep.2021.114208
Volume 276, 10 August 2021, 114208
Premna microphylla turcz is traditionally used as a folk remedy. Its roots, stems and leaves can be invoked as medicines, which have the functions of detoxification, swelling and hemostasis. It belongs to the Premna in the Verbenaceae and is mainly distributed in the mountains of southeastern China. However, there are few reports of in-depth studies on the anti-inflammatory effects of polysaccharide, which was the main component in Premna microphylla turcz.
8-hydroxypinoresinol-4-O-?-D-glucoside from Valeriana officinalis L. Is a Novel Kv1.5 Channel Blocker
Xingxing Liu, Xueyun Duan, Heng Fan, Hongfei Wang, Qian Li
doi : 10.1016/j.jep.2021.114168
Volume 276, 10 August 2021, 114168
In folkloric medicine of many cultures, one of the medical uses of Valeriana officinalis Linn is to treat heart-related disease. Recently, it was shown that the ethanol extracts from V. officinalis could effectively prevent auricular fibrillation, and 8-hydroxypinoresinol-4-O-?-D-glucoside (HPG) from the extracts is one of the two active compounds showing antiarrhythmia activities.
Rational use of Ashwagandha in Ayurveda (Traditional Indian Medicine) for health and healing
Vinod Kumar Joshi, Apurva Joshi
doi : 10.1016/j.jep.2021.114101
Volume 276, 10 August 2021, 114101
Withania somnifera (L.) Dunal (Physalis somnifera L.) is a fairly known perennial shrub of Solanaceae family, and is used in Ayurveda- Traditional Indian Medicine (TIM), since ancient times. It is well known as Ashwagandha in Sanskrit language in Ayurvedic classics. Its Mula (root) is recommended for health and healing, and the number of single and compound formulation is prescribed rationally. It is believed that the species name-somnifera is coined based on popular use to “induce sleep” in Ayurveda.
Toxicity, mutagenicity and trace metal constituent of Termitomyces schimperi (Pat.) R. Heim (Lyophyllaceae) and kaolin, a recipe used traditionally in cancer management in Cote d'Ivoire
Benoit Banga N'guessan, Seth Kwabena Amponsah, Ifeanyichukwu Benedict Iheagwara, Mahmood Abdulai Seidu, Isaac Julius Asiedu-Gyekye
doi : 10.1016/j.jep.2021.114147
Volume 276, 10 August 2021, 114147
Some local communities in Cote d'Ivoire use the mushroom Termitomyces schimperi combined with kaolin (TSK) to manage various cancers in patients. However, there is a paucity of data on toxicity, mutagenicity and trace metal constituent of TSK.
