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Risk aversion keeps universities safe and effective. Discuss
Masud Husain
doi : 10.1093/brain/awac324
Volume 145, Issue 10, October 2022
Cranial trepanation in pre-Columbian Peruvian cultures: was it an option to treat epilepsy?
Poul H Espino, Juan E Toro-Perez, Stephanie Shkrum, Jorge G Burneo
doi : 10.1093/brain/awac277
Seronegative autoimmune encephalitis: exploring the unknown
Robin W van Steenhoven, Maarten J Titulaer
doi : 10.1093/brain/awac338
Sex differences in Alzheimer’s disease risk: are immune responses the key?
Rachel F Buckley
doi : 10.1093/brain/awac316
Loss of PTEN phosphorylation via single point mutation alters cortical connectivity and behaviour
Matthew Binder, Angélique Bordey
doi : 10.1093/brain/awac350
Exciting insights into tumour-associated epilepsy with electrophysiological and optical recording
Chris R French
doi : 10.1093/brain/awac351
Towards network-guided neuromodulation for epilepsy
Rory J Piper, R Mark Richardson, Gregory Worrell, David W Carmichael, Torsten Baldeweg, Brian Litt, Timothy Denison, Martin M Tisdall
doi : 10.1093/brain/awac234
Contribution of B cells to cortical damage in multiple sclerosis
Pavan Bhargava, Hans-Peter Hartung, Peter A Calabresi
doi : 10.1093/brain/awac233
Recurrent de novo mutations in CLDN5 induce an anion-selective blood–brain barrier and alternating hemiplegia
Yosuke Hashimoto, Karine Poirier, Nathalie Boddaert, Laurence Hubert, Melodie Aubart, Anna Kaminska, Marianne Alison, Isabelle Desguerre, Arnold Munnich, Matthew Campbell
doi : 10.1093/brain/awac215
Endocannabinoid dysfunction in neurological disease: neuro-ocular DAGLA-related syndrome
Matthew N Bainbridge, Aloran Mazumder, Daisuke Ogasawara, Rami Abou Jamra, Geneviève Bernard, Enrico Bertini, Lydie Burglen, Heidi Cope, Ali Crawford, Alexa Derksen, Leon Dure, Emily Gantz, Margarete Koch-Hogrebe, Anna C E Hurst, Sonal Mahida, Paige Marshall, Alessia Micalizzi, Antonio Novelli, Hongfan Peng, Rady Children's Institute for Genomic Medicine, Diana Rodriguez, Shira L Robbins, S Lane Rutledge, Roberta Scalise, Sophia Schließke, Vandana Shashi, Siddharth Srivastava, Isabella Thiffault, Sarah Topol, Undiagnosed Disease Network , Leila Qebibo, Dagmar Wieczorek, Benjamin Cravatt, Svasti Haricharan, Ali Torkamani, Jennifer Friedman
doi : 10.1093/brain/awac223
Self-modulation of motor cortex activity after stroke: a randomized controlled trial
Zeena-Britt Sanders, Melanie K Fleming, Tom Smejka, Marilien C Marzolla, Catharina Zich, Sebastian W Rieger, Michael Lührs, Rainer Goebel, Cassandra Sampaio-Baptista, Heidi Johansen-Berg
doi : 10.1093/brain/awac239
Double administration of self-complementary AAV9NDUFS4 prevents Leigh disease in Ndufs4−/− mice
Samantha Corrà , Raffaele Cerutti, Valeria Balmaceda, Carlo Viscomi, Massimo Zeviani
doi : 10.1093/brain/awac182
CHCHD10 and SLP2 control the stability of the PHB complex: a key factor for motor neuron viability
Emmanuelle C Genin, Sylvie Bannwarth, Baptiste Ropert, Françoise Lespinasse, Alessandra Mauri-Crouzet, Gaelle Augé, Konstantina Fragaki, Charlotte Cochaud, Erminia Donnarumma, Sandra Lacas-Gervais, Timothy Wai, Véronique Paquis-Flucklinger
doi : 10.1093/brain/awac197
Characteristics, surgical outcomes, and influential factors of epilepsy in Sturge-Weber syndrome
Shu Wang, Junhong Pan, Meng Zhao, Xiongfei Wang, Chunsheng Zhang, Tianfu Li, Mengyang Wang, Jing Wang, Jian Zhou, Changqing Liu, Yongxing Sun, Mingwang Zhu, Xueling Qi, Guoming Luan, Yuguang Guan
doi : 10.1093/brain/awab470
A Mendelian randomization study investigating the causal role of inflammation on Parkinson’s disease
Daniele Bottigliengo, Luisa Foco, Philip Seibler, Christine Klein, Inke R König, Fabiola Del Greco M
doi : 10.1093/brain/awac193
Tau accelerates α-synuclein aggregation and spreading in Parkinson’s disease
Lina Pan, Chunrui Li, Lanxia Meng, Ye Tian, Mingyang He, Xin Yuan, Guoxin Zhang, Zhaohui Zhang, Jing Xiong, Guiqin Chen, Zhentao Zhang
doi : 10.1093/brain/awac171
Lipid pathway dysfunction is prevalent in patients with Parkinson’s disease
Jasmin Galper, Nicholas J Dean, Russell Pickford, Simon J G Lewis, Glenda M Halliday, Woojin S Kim, Nicolas Dzamko
doi : 10.1093/brain/awac176
Amphetamine-induced dopamine release and impulsivity in Parkinson’s disease
Alexander K Song, Kaitlyn R Hay, Paula Trujillo, Megan Aumann, Adam J. Stark, Yan Yan, Hakmook Kang, Manus J Donahue, David H Zald, Daniel O Claassen
doi : 10.1093/brain/awab487
Mild motor impairment as prodromal state in amyotrophic lateral sclerosis: a new diagnostic entity
Michael Benatar, Volkan Granit, Peter M Andersen, Anne-Laure Grignon, Caroline McHutchison, Stephanie Cosentino, Andrea Malaspina, Joanne Wuu
doi : 10.1093/brain/awac185
Seronegative autoimmune encephalitis: clinical characteristics and factors associated with outcomes
Woo-Jin Lee, Han-Sang Lee, Do-Yong Kim, Hye-Sung Lee, Jangsup Moon, Kyung-Il Park, Sang Kun Lee, Kon Chu, Soon-Tae Lee
doi : 10.1093/brain/awac166
Linking lesions in sensorimotor cortex to contralateral hand function in multiple sclerosis: a 7 T MRI study
Mads A J Madsen, Vanessa Wiggermann, Marta F M Marques, Henrik Lundell, Stefano Cerri, Oula Puonti, Morten Blinkenberg, Jeppe Romme Christensen, Finn Sellebjerg, Hartwig R Siebner
doi : 10.1093/brain/awac203
Sex-specific effects of microglial activation on Alzheimer’s disease proteinopathy in older adults
Kaitlin B Casaletto, Emma Nichols, Vahan Aslanyan, Stephanie M Simone, Jennifer S Rabin, Renaud La Joie, Adam M Brickman, Kristen Dams-O’Connor, Priya Palta, Raj G Kumar, Kristen M George, Claudia L Satizabal, Julie Schneider, Judy Pa
doi : 10.1093/brain/awac257
Ante-mortem plasma phosphorylated tau (181) predicts Alzheimer’s disease neuropathology and regional tau at autopsy
Madeline S Morrison, Hugo J Aparicio, Kaj Blennow, Henrik Zetterberg, Nicholas J Ashton, Thomas K Karikari, Yorghos Tripodis, Brett Martin, Joseph N Palmisano, Michael A Sugarman, Brandon Frank, Eric G Steinberg, Katherine W Turk, Andrew E Budson, Rhoda Au, Lee E Goldstein, Gyungah R Jun, Neil W Kowall, Ronald Killiany, Wei Qiao Qiu, Robert A Stern, Jesse Mez, Ann C McKee, Thor D Stein, Michael L Alosco
doi : 10.1093/brain/awac175
Seeding, maturation and propagation of amyloid β-peptide aggregates in Alzheimer’s disease
Xiaohang Li, Simona Ospitalieri, Tessa Robberechts, Linda Hofmann, Christina Schmid, Ajeet Rijal Upadhaya, Marta J Koper, Christine A F von Arnim, Sathish Kumar, Michael Willem, Kathrin Gnoth, Meine Ramakers, Joost Schymkowitz, Frederic Rousseau, Jochen Walter, Alicja Ronisz, Karthikeyan Balakrishnan, Dietmar Rudolf Thal
doi : 10.1093/brain/awac202
Genetically identical twins show comparable tau PET load and spatial distribution
Emma M Coomans, Jori Tomassen, Rik Ossenkoppele, Sandeep S V Golla, Marijke den Hollander, Lyduine E Collij, Emma Weltings, Sophie M van der Landen, Emma E Wolters, Albert D Windhorst, Frederik Barkhof, Eco J C de Geus, Philip Scheltens, Pieter Jelle Visser, Bart N M van Berckel, Anouk den Braber
doi : 10.1093/brain/awac004
APOE4 derived from astrocytes leads to blood–brain barrier impairment
Rosemary J Jackson, Jonah C Meltzer, Huong Nguyen, Caitlin Commins, Rachel E Bennett, Eloise Hudry, Bradley T Hyman
doi : 10.1093/brain/awab478
Autosomal dominant and sporadic late onset Alzheimer's disease share a common in vivo pathophysiology
John C Morris, Michael Weiner, Chengjie Xiong, Laurel Beckett, Dean Coble, Naomi Saito, Paul S Aisen, Ricardo Allegri, Tammie L S Benzinger, Sarah B Berman, Nigel J Cairns, Maria C Carrillo, Helena C Chui, Jasmeer P Chhatwal, Carlos Cruchaga, Anne M Fagan, Martin Farlow, Nick C Fox, Bernardino Ghetti, Alison M Goate, Brian A Gordon, Neill Graff-Radford, Gregory S Day, Jason Hassenstab, Takeshi Ikeuchi, Clifford R Jack, Jr, William J Jagust, Mathias Jucker, Johannes Levin, Parinaz Massoumzadeh, Colin L Masters, Ralph Martins, Eric McDade, Hiroshi Mori, James M Noble, Ronald C Petersen, John M Ringman, Stephen Salloway, Andrew J Saykin, Peter R Schofield, Leslie M Shaw, Arthur W Toga, John Q Trojanowski, Jonathan Vöglein, Stacie Weninger, Randall J Bateman, Virginia D Buckles
doi : 10.1093/brain/awac181
The impact of phosphorylated PTEN at threonine 366 on cortical connectivity and behaviour
Julia M T Ledderose, Jorge A Benitez, Amanda J Roberts, Rachel Reed, Willem Bintig, Matthew E Larkum, Robert N S Sachdev, Frank Furnari, Britta J Eickholt
doi : 10.1093/brain/awac188
Alpha-synuclein supports type 1 interferon signalling in neurons and brain tissue
Brendan Monogue, Yixi Chen, Hadrian Sparks, Ranya Behbehani, Andrew Chai, Alexander J Rajic, Aaron Massey, B K Kleinschmidt-Demasters, Matthieu Vermeren, Tilo Kunath, J David Beckham
doi : 10.1093/brain/awac192
Nav1.7 is required for normal C-low threshold mechanoreceptor function in humans and mice
Steven J Middleton, Irene Perini, Andreas C Themistocleous, Greg A Weir, Kirsty McCann, Allison M Barry, Andrew Marshall, Michael Lee, Leah M Mayo, Manon Bohic, Georgios Baskozos, India Morrison, Line S Löken, Sarah McIntyre, Saad S Nagi, Roland Staud, Isac Sehlstedt, Richard D Johnson, Johan Wessberg, John N Wood, Christopher G Woods, Aziz Moqrich, Håkan Olausson, David L Bennett
doi : 10.1093/brain/awab482
Regional healthy brain activity, glioma occurrence and symptomatology
Tianne Numan, Lucas C Breedt, Bernardo de A P C Maciel, Shanna D Kulik, Jolanda Derks, Menno M Schoonheim, Martin Klein, Philip C de Witt Hamer, Julie J Miller, Elizabeth R Gerstner, Steven M Stufflebeam, Arjan Hillebrand, Cornelis J Stam, Jeroen J G Geurts, Jaap C Reijneveld, Linda Douw
doi : 10.1093/brain/awac180
Single unit analysis and wide-field imaging reveal alterations in excitatory and inhibitory neurons in glioma
Brian J A Gill, Farhan A Khan, Alexander R Goldberg, Edward M Merricks, Xiaoping Wu, Alexander A Sosunov, Tejaswi D Sudhakar, Athanassios Dovas, Wudu Lado, Andrew J Michalak, Jia Jie Teoh, Jyun-you Liou, Wayne N Frankel, Guy M McKhann, II, Peter Canoll, Catherine A Schevon
doi : 10.1093/brain/awac168
Stimulation of the cuneiform nucleus enables training and boosts recovery after spinal cord injury
Anna-Sophie Hofer, Myriam I Scheuber, Andrea M Sartori, Nicolas Good, Stephanie A Stalder, Nicole Hammer, Kai Fricke, Sina M Schalbetter, Anne K Engmann, Rebecca Z Weber,
doi : 10.1093/brain/awac184
Sensory experience modulates the reorganization of auditory regions for executive processing
Barbara Manini, Valeria Vinogradova, Bencie Woll, Donnie Cameron, Martin Eimer, Velia Cardin
doi : 10.1093/brain/awac205
Biallelic variants in SLC35B2 cause a novel chondrodysplasia with hypomyelinating leukodystrophy
Alessandra Guasto, Johanne Dubail, Sergio Aguilera-Albesa, Chiara Paganini, Catherine Vanhulle, Walid Haouari, Nerea GorrÃa-Redondo, Elena Aznal-Sainz, Nathalie Boddaert, Laura Planas-Serra, Agatha Schlüter, Valentina Vélez-SantamarÃa, Edgard Verdura, Arnaud Bruneel, Antonio Rossi, Céline Huber, Aurora Pujol, Valérie Cormier-Daire
doi : 10.1093/brain/awac110
Deisseroth’s connections: the rapprochement of brain and mind
David Okai
doi : 10.1093/brain/awac284
Is it time to rename hereditary cases of cerebral palsy?
Anamarija Kav�i�
doi : 10.1093/brain/awac230
Reply: Is it time to rename hereditary cases of cerebral palsy?
Hao Hu, Kaishou Xu
doi : 10.1093/brain/awac231
Bi-allelic FRA10AC1 variants in a multisystem human syndrome
Siddharth Banka, Stavit Shalev, Soo-Mi Park, Katherine A Wood, Huw B Thomas, Helen L Wright, Mohammed Alyahya, Sean Bankier, Ola Alimi, Elena Chervinsky, Leo A H Zeef, Raymond T O’Keefe
doi : 10.1093/brain/awac262
Methodological drawbacks in the alleged association between foetal sonographic anomalies and autism
Lena Sagi-Dain, Boaz Weisz, Karina Haratz Krajden, Amihood Singer, Yuval Yaron, Ron Maymon
doi : 10.1093/brain/awac246
Reply: Methodological drawbacks in the alleged association between foetal sonographic anomalies and autism
Idan Menashe, Ohad Regev, Amnon Hadar, Gal Meiri, Analya Michaelovski, Ilan Dinstein, Reli Hershkovitz
doi : 10.1093/brain/awac247
Expanding PRDX3 disease: broad range of onset age and infratentorial MRI signal changes
Adriana P Rebelo, Benjamin Bender, Tobias B Haack, Stephan Zuchner, PREPARE consortium, A Nazli Basak, Matthis Synofzik
doi : 10.1093/brain/awac240
A novel MLIP truncating variant in an 80-year-old patient with late-onset progressive weakness
Laura Bermejo-Guerrero, Ana Arteche-López, Carlos de Fuenmayor Fernández de la Hoz, Aurelio Hernández-LaÃn, Miguel A MartÃn, Cristina DomÃnguez-González
doi : 10.1093/brain/awac286
Correction to: TMEM63C mutations cause mitochondrial morphology defects and underlie hereditary spastic paraplegia
doi : 10.1093/brain/awac254
Real-Time Monitoring of Cannabis and Prescription Opioid Co-Use Patterns, Analgesic Effectiveness, and the Opioid-Sparing Effect of Cannabis in Individuals With Chronic Pain
Chung JungMun*†CourtneyNordeck‡Erin M. AndersonGoodell‡RyanVandrey†VadimZipunnikov§Kelly E.Dunn†Patrick H.Finan†JohannesThrul‡¶‖
Error Processing and Pain: A New Perspective
JulianeTraxler*†Diana M.Torta*Andreasvon Leupoldt*Johan W.S.Vlaeyen*â€
To Calibrate or not to Calibrate? A Methodological Dilemma in Experimental Pain Research
Waclaw M.Adamczyk�†Tibor M.Szikszay†HadasNahman-Averbuch§JacekSkalski*JakubNastaj*PhilipGouverneur¶KerstinLuedtke†‡
Effect of Physiotherapeutic Interventions on Biomarkers of Neuropathic Pain: A Systematic Review of Preclinical Literature
LuisMatesanz-GarcÃa*†Annina B.Schmid‡Julio EduardoCáceres-Pajuelo§FerranCuenca-MartÃnez¶AlbertoArribas-Romano*‖YerayGonzález-Zamorano*#CarlosGoicoechea-GarcÃaâ�Žâ�ŽJosuéFernández-Carnero‖#††‡‡§§
Individualized Exercise in Chronic Non-Specific Low Back Pain: A Systematic Review with Meta-Analysis on the Effects of Exercise Alone or in Combination with Psychological Interventions on Pain and Disability
JohannesFleckenstein*†PhilippFloessel‡TilmanEngel§LauraKrempel‖JosefineStoll§MartinBehrens#¶DanielNiederer*��
Histone Deacetylase Inhibitors Counteract CGRP Signaling and Pronociceptive Sensitization in a Rat Model of Medication Overuse Headache
MatteoUrru#DanielaBuonvicino#AlessandraPistolesiSaraPaccosiAlbertoChiarugi
Sociocultural Context and Pre-Clinical Pain Facilitation: Multiple Dimensions of Racialized Discrimination Experienced by Latinx Americans are Associated With Enhanced Temporal Summation of Pain
Kaitlyn T.Walsh*Brandon L.Boring*NamrataNanavaty*HananGuzman‡‡Vani A.Mathur�†‡
Profiles of Pain Acceptance and Values-Based Action in the Assessment and Treatment of Chronic Pain
EricKruger�JulieAshworth†‡GailSowden§JayneHickman‖Kevin E.Vowles¶
Analyses of Cross-Sectional Data to Link the PEG With the Patient Reported Outcomes Measurement and Information System (PROMIS) Global Physical Health Scale
Ron D.Hays*MarySlaughter†AnthonyRodriguez‡Maria OrlandoEdelen§Patricia M.Hermanâ€
The Pain-Invalidation Scale: Measuring Patient Perceptions of Invalidation Toward Chronic Pain
MelindaNicolaHelenCorreiaGraemeDitchburnPeter D.Drummond
Symptomatic but not Asymptomatic COVID-19 Impairs Conditioned Pain Modulation in Young Adults
Jessica A.Peterson�†‡Michael G.Bemben‡Rebecca D.Larson‡HugoPereira‡H. MichaelCrowson†§Christopher D.Black‡
Fitbit Activity, Quota-Based Pacing, and Physical and Emotional Functioning Among Adults With Chronic Pain
Victoria A.Grunberg*†‡JonathanGreenberg*†Ryan A.Mace*†JafarBakhshaie*†Karmel W.Choi§‖Ana-MariaVranceanu*â€
Initial Content Validation and Roadmap for a New Patient-Reported Outcome Measure of Pain Intensity
Dale J.Langford*Jennifer S.Gewandter†DagmarAmtmann‡Bryce B.Reeve§AmyCorneli§KevinMcKenna§TeresaSwezey‖MollyMcFatrich§Mark P.Jensen‡Dennis C.Turk¶Robert H.Dworkinâ€
Comparing the Effects of Thought Suppression and Focused Distraction on Pain-Related Attentional Biases in Men and Women
NinaKreddigâ�Žâ€ Monika IlonaHasenbringâ�ŽEdmundKeoghâ€
Astrocytic ERK/STAT1 Signaling Contributes to Maintenance of Stress-Related Visceral Hypersensitivity in Rats
ZhiyuDong*1TingtingZhan*1HuihuiSun*JunwenWang*GuangbingDuan*YanZhang*YingChen*YingHuang†ShuchangXu*
Key Learning Statements for Persistent Pain Education: An Iterative Analysis of Consumer, Clinician and Researcher Perspectives and Development of Public Messaging
Hayley B.Leake*†‡1AmeliaMardon*1Tasha R.Stanton*†Daniel S.Harvie*†David S.Butler*†Emma L.Karran*†DianneWilson*†JohnBooth†§TrevorBarker†‖PeneWood†#KalFried†¶ChrisHayes†��LissantheaTaylor†††‡‡MelanieMacoun†§§AmandaSimister†‖‖G. LorimerMoseley*†2CarolynBerryman�†##2
