New England Journal of Medicine




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The Purdue Pharma Opioid Settlement — Accountability, or Just the Cost of Doing Business?

Corey S. Davis, J.D., M.S.P.H.

doi : 10.1056/NEJMp2033382

N Engl J Med 2021; 384:97-99

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Drug-Coated Devices for Peripheral Arterial Disease

Andrew Farb, M.D., Misti Malone, Ph.D., and William H. Maisel, M.D., M.P.H.

doi : 10.1056/NEJMp2031360

N Engl J Med 2021; 384:99-101

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Doctor as Street-Level Bureaucrat

Elvin H. Geng, M.D., M.P.H.

doi : 10.1056/NEJMp2019939

N Engl J Med 2021; 384:101-103

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Placebo-Controlled Trials of Covid-19 Vaccines — Why We Still Need Them

doi : 10.1056/NEJMp2033538

N Engl J Med 2021; 384:e2

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Cardiac Myosin Activation with Omecamtiv Mecarbil in Systolic Heart Failure

John R. Teerlink, M.D., Rafael Diaz, M.D., G. Michael Felker, M.D., M.H.S., John J.V. McMurray, M.D., Marco Metra, M.D., Scott D. Solomon, M.D., Kirkwood F. Adams, M.D., Inder Anand, M.D., D.Phil., Alexandra Arias-Mendoza, M.D., Tor Biering-S?rensen, M.D., Michael B?hm, M.D., Diana Bonderman, M.D.,

doi : 10.1056/NEJMoa2025797

N Engl J Med 2021; 384:105-116

The selective cardiac myosin activator omecamtiv mecarbil has been shown to improve cardiac function in patients with heart failure with a reduced ejection fraction. Its effect on cardiovascular outcomes is unknown.

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Sotagliflozin in Patients with Diabetes and Recent Worsening Heart Failure

Deepak L. Bhatt, M.D., M.P.H., Michael Szarek, Ph.D., P. Gabriel Steg, M.D., Christopher P. Cannon, M.D., Lawrence A. Leiter, M.D., Darren K. McGuire, M.D., M.H.Sc., Julia B. Lewis, M.D., Matthew C. Riddle, M.D., Adriaan A. Voors, M.D., Ph.D., Marco Metra, M.D., Lars H. Lund, M.D., Ph.D., Michel Komajda, M.D.,

doi : 10.1056/NEJMoa2030183

N Engl J Med 2021; 384:117-128

Sodium–glucose cotransporter 2 (SGLT2) inhibitors reduce the risk of hospitalization for heart failure or death from cardiovascular causes among patients with stable heart failure. However, the safety and efficacy of SGLT2 inhibitors when initiated soon after an episode of decompensated heart failure are unknown.

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Sotagliflozin in Patients with Diabetes and Chronic Kidney Disease

Deepak L. Bhatt, M.D., M.P.H., Michael Szarek, Ph.D., Bertram Pitt, M.D., Christopher P. Cannon, M.D., Lawrence A. Leiter, M.D., Darren K. McGuire, M.D., M.H.Sc., Julia B. Lewis, M.D., Matthew C. Riddle, M.D., Silvio E. Inzucchi, M.D., Mikhail N. Kosiborod, M.D., David Z.I. Cherney, M.D., Ph.D., Jamie P. Dwyer, M.D.,

doi : 10.1056/NEJMoa2030186

N Engl J Med 2021; 384:129-139

The efficacy and safety of sodium–glucose cotransporter 2 inhibitors such as sotagliflozin in preventing cardiovascular events in patients with diabetes with chronic kidney disease with or without albuminuria have not been well studied.

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Bupropion and Naltrexone in Methamphetamine Use Disorder

Madhukar H. Trivedi, M.D., Robrina Walker, Ph.D., Walter Ling, M.D., Adriane dela Cruz, M.D., Ph.D., Gaurav Sharma, Ph.D., Thomas Carmody, Ph.D., Udi E. Ghitza, Ph.D., Aimee Wahle, M.S., Mora Kim, M.P.H., Kathy Shores-Wilson, Ph.D., Steven Sparenborg, Ph.D., Phillip Coffin, M.D., M.I.A.,

doi : 10.1056/NEJMoa2020214

N Engl J Med 2021; 384:140-153

The use of naltrexone plus bupropion to treat methamphetamine use disorder has not been well studied.

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Ewing’s Sarcoma

Nicol? Riggi, M.D., Ph.D., Mario L. Suvà, M.D., Ph.D., and Ivan Stamenkovic, M.D.

doi : 10.1056/NEJMra2028910

N Engl J Med 2021; 384:154-164

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Placement of an External Ventricular Drain

Rimal H. Dossani, M.D., Devi P. Patra, M.D., Danielle L. Terrell, M.D., and Brian Willis, M.D.

doi : 10.1056/NEJMvcm1805314

N Engl J Med 2021; 384:e3

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Primary Adrenal Lymphoma

Tara McDonnell, M.B., B.Ch., B.A.O., and Eamon Mulkerrin, M.B., B.Ch., B.A.O.

doi : 10.1056/NEJMicm2017821

N Engl J Med 2021; 384:165

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Left Ventricular Rupture

?yvind H. Lie, M.D., Ph.D., and Ketil Lunde, M.D., Ph.D.

doi : 10.1056/NEJMicm2020871

N Engl J Med 2021; 384:e4

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Case 1-2021: A 76-Year-Old Woman with Lethargy and Altered Mental Status

Lisa M. Bebell, M.D., R. Gilberto Gonzalez, M.D., Ph.D., Amy K. Barczak, M.D., and Melis N. Anahtar, M.D., Ph.D.

doi : 10.1056/NEJMcpc2027084

N Engl J Med 2021; 384:166-176

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Stimulation of Contractility in Systolic Heart Failure

Karl Swedberg, M.D., Ph.D.

doi : 10.1056/NEJMe2033311

N Engl J Med 2021; 384:178-179

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Cardioprotection with Yet Another SGLT2 Inhibitor — An Embarrassment of Riches

Frank C. Brosius, M.D., and Per O. Vandvik, M.D., Ph.D.

doi : 10.1056/NEJMe2033176

N Engl J Med 2021; 384:179-181

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Audio Interview: Covid-19 in South Africa and a New SARS-CoV-2 Variant

Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., Salim S. Abdool Karim, M.B., Ch.B., Ph.D., and Stephen Morrissey, Ph.D.

doi : 10.1056/NEJMe2100736

N Engl J Med 2021; 384:e14

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Spinal Cord Injury — Healing from Within

Michelle Monje, M.D., Ph.D.

doi : 10.1056/NEJMcibr2030836

N Engl J Med 2021; 384:182-184

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Distribution of KRASG12C Somatic Mutations across Race, Sex, and Cancer Type

doi : 10.1056/NEJMc2030638

N Engl J Med 2021; 384:185-187

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Belimumab in Lupus Nephritis

doi : 10.1056/NEJMc2032520

N Engl J Med 2021; 384:187-188

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Neutralizing Antibody LY-CoV555 for Outpatient Covid-19

doi : 10.1056/NEJMc2033787

N Engl J Med 2021; 384:189

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Hydroxychloroquine with or without Azithromycin in Covid-19

doi : 10.1056/NEJMc2031780

N Engl J Med 2021; 384:190-191

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Sensory Ganglionopathy

doi : 10.1056/NEJMc2033783

N Engl J Med 2021; 384:192-194

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Vaccinating Detained Migrants against SARS-CoV-2 — Preventing Another Tragedy

Carlo Foppiano Palacios, M.D., and Mark A. Travassos, M.D.

doi : 10.1056/NEJMpv2035416

N Engl J Med 2021; 384:e5

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Business Not as Usual — Covid-19 Vaccination in Persons with Substance Use Disorders

Joshua A. Barocas, M.D.

doi : 10.1056/NEJMpv2035709

N Engl J Med 2021; 384:e6

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