One-year access to more than 500 world journals available in the system
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Human Molecular Genetics and Genomics — Important Advances and Exciting Possibilities
Francis S. Collins, M.D., Ph.D., Jennifer A. Doudna, Ph.D., Eric S. Lander, Ph.D., and Charles N. Rotimi, Ph.D.
doi : 10.1056/NEJMp2030694
N Engl J Med 2021; 384:1-4
Lessons We’ve Learned — Covid-19 and the Undocumented Latinx Community
Kathleen R. Page, M.D., and Alejandra Flores-Miller
doi : 10.1056/NEJMp2024897
N Engl J Med 2021; 384:5-7
The Stress of Bayesian Medicine — Uncomfortable Uncertainty in the Face of Covid-19
J. Niels Rosenquist, M.D., Ph.D.
doi : 10.1056/NEJMp2018857
N Engl J Med 2021; 384:7-9
Dipeptidyl Peptidase 4 Inhibition for Prophylaxis of Acute Graft-versus-Host Disease
Sherif S. Farag, M.D., Ph.D., Mohammad Abu Zaid, M.D., Jennifer E. Schwartz, M.D., Teresa C. Thakrar, Pharm.D., Ann J. Blakley, B.S., Rafat Abonour, M.D., Michael J. Robertson, M.D., Hal E. Broxmeyer, Ph.D., and Shuhong Zhang, Ph.D.
doi : 10.1056/NEJMoa2027372
N Engl J Med 2021; 384:11-19
Dipeptidyl peptidase 4 (DPP-4; also known as CD26), a transmembrane receptor expressed on T cells, has a costimulatory function in activating T cells. In a mouse model, down-regulation of CD26 prevented graft-versus-host disease (GVHD) but preserved graft-versus-tumor effects. Whether inhibition of DPP-4 with sitagliptin may prevent acute GVHD after allogeneic stem-cell transplantation is not known.
Tocilizumab in Patients Hospitalized with Covid-19 Pneumonia
Carlos Salama, M.D., Jian Han, Ph.D., Linda Yau, Ph.D., William G. Reiss, Pharm.D., Benjamin Kramer, M.D., Jeffrey D. Neidhart, M.D., Gerard J. Criner, M.D., Emma Kaplan-Lewis, M.D., Rachel Baden, M.D., Lavannya Pandit, M.D., Miriam L. Cameron, M.D., Julia Garcia-Diaz, M.D.,
doi : 10.1056/NEJMoa2030340
N Engl J Med 2021; 384:20-30
Coronavirus disease 2019 (Covid-19) pneumonia is often associated with hyperinflammation. Despite the disproportionate incidence of Covid-19 among underserved and racial and ethnic minority populations, the safety and efficacy of the anti–interleukin-6 receptor antibody tocilizumab in patients from these populations who are hospitalized with Covid-19 pneumonia are unclear.
Phase 3 Trial of Interleukin-1 Trap Rilonacept in Recurrent Pericarditis
Allan L. Klein, M.D., Massimo Imazio, M.D., Paul Cremer, M.D., Antonio Brucato, M.D., Antonio Abbate, M.D., Ph.D., Fang Fang, Ph.D., Antonella Insalaco, M.D., Martin LeWinter, M.D., Basil S. Lewis, M.D., David Lin, M.D., Sushil A. Luis, M.B., B.S., Stephen J. Nicholls, M.B., B.S., Ph.D.,
doi : 10.1056/NEJMoa2027892
N Engl J Med 2021; 384:31-41
Interleukin-1 has been implicated as a mediator of recurrent pericarditis. The efficacy and safety of rilonacept, an interleukin-1? and interleukin-1? cytokine trap, were studied previously in a phase 2 trial involving patients with recurrent pericarditis.
Vaginal Transmission of Cancer from Mothers with Cervical Cancer to Infants
Ayumu Arakawa, M.D., Hitoshi Ichikawa, Ph.D., Takashi Kubo, Ph.D., Noriko Motoi, M.D., Ph.D., Tadashi Kumamoto, M.D., Ph.D., Miho Nakajima, M.D., Kan Yonemori, M.D., Ph.D., Emi Noguchi, M.D., Ph.D., Kuniko Sunami, M.D., Ph.D., Kouya Shiraishi, Ph.D., Hiroki Kakishima, Hiroshi Yoshida, M.D., Ph.D.,
doi : 10.1056/NEJMoa2030391
N Engl J Med 2021; 384:42-50
Osteoarthritis of the Knee
Leena Sharma, M.D.
doi : 10.1056/NEJMcp1903768
N Engl J Med 2021; 384:51-59
Open-Book Pelvic Fracture
Ting-Han Tai, M.D., and Chih-Yu Chen, M.D., Ph.D.
doi : 10.1056/NEJMicm2013030
N Engl J Med 2021; 384:60
Visible Intestinal Peristalsis in a Neonate
Seigo Okada, M.D., Ph.D., and Shunji Hasegawa, M.D., Ph.D.
doi : 10.1056/NEJMicm2007997
N Engl J Med 2021; 384:e1
Breathing for Two
Meghan Rudder, M.D., Melissa Russo, M.D., and Corey E. Ventetuolo, M.D.
doi : 10.1056/NEJMcps2006666
N Engl J Med 2021; 384:61-68
Sitagliptin to Prevent Acute Graft-versus-Host Disease
Paul J. Martin, M.D.
doi : 10.1056/NEJMe2032581
N Engl J Med 2021; 384:70-71
Audio Interview: Planning for the SARS-CoV-2 Vaccine Rollout
Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., Thomas H. Lee, M.Sc., M.D., and Stephen Morrissey, Ph.D.
doi : 10.1056/NEJMe2100295
N Engl J Med 2021; 384:e13
The Rapid Rise in Cutaneous Melanoma Diagnoses
H. Gilbert Welch, M.D., M.P.H., Benjamin L. Mazer, M.D., M.B.A., and Adewole S. Adamson, M.D., M.P.P.
doi : 10.1056/NEJMsb2019760
N Engl J Med 2021; 384:72-79
Durability of Responses after SARS-CoV-2 mRNA-1273 Vaccination
doi : 10.1056/NEJMc2032195
N Engl J Med 2021; 384:80-82
Trial of Upadacitinib or Abatacept in Rheumatoid Arthritis
doi : 10.1056/NEJMc2033206
N Engl J Med 2021; 384:83-84
Evolocumab in Pediatric Heterozygous Familial Hypercholesterolemia
doi : 10.1056/NEJMc2032399
N Engl J Med 2021; 384:84-85
Randomized Trial of Nocturnal Oxygen in Chronic Obstructive Pulmonary Disease
doi : 10.1056/NEJMc2032006
N Engl J Med 2021; 384:85-86
Life Expectancy after Bariatric Surgery — the Swedish Obese Subjects Study
doi : 10.1056/NEJMc2033331
N Engl J Med 2021; 384:88-89
Single or Dual Antiplatelet Treatment after TAVI
doi : 10.1056/NEJMc2032808
N Engl J Med 2021; 384:89-91
Case 26-2020: A Woman with Altered Mental Status and Left-Sided Weakness
doi : 10.1056/NEJMc2030849
N Engl J Med 2021; 384:92
More on STAT1 Gain of Function, Type 1 Diabetes, and JAK Inhibition
doi : 10.1056/NEJMc2032806
N Engl J Med 2021; 384:93-94
